产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
EGFRvIII重组兔单克隆抗体(RM419)
目录 :
MA5-36216
规格 :
100微升
价格 :
美国450.00
克隆性 :
重组
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
RM419
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
产品信息
产品类型 :
抗体
产品名称 :
EGFRvIII重组兔单克隆抗体(RM419)
目录# :
MA5-36216
规格 :
100微升
价格 :
美国450.00
克隆性 :
重组单克隆
纯度 :
蛋白质A
宿主 :
反应物种 :
人类
应用 :
ELISA: 1:100-1:1,000, Flow Cytometry: 1:10-1:100, Immunohistochemistry (Paraffin): 1:100-1:200, Western Blot: 1:1,000-1:2,000
物种 :
人类
克隆 :
RM419
抗体亚型 :
IgG
储存 :
-20°C
描述 :
EGFRvIII is included in receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Isoform 2 may act as an antagonist of EGF action.
免疫原 :
A peptide corresponding to epidermal growth factor receptor variant III (EGFRvIII)
格式 :
液体
应用w/稀释 :
ELISA: 1:100-1:1,000, Flow Cytometry: 1:10-1:100, Immunohistochemistry (Paraffin): 1:100-1:200, Western Blot: 1:1,000-1:2,000
别名 :
6720426O10Rik; 9030024J15Rik; A830025P08Rik; AI552599; avian erythroblastic leukemia viral (v-erbB) oncogene homolog; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; Cntn5; CNTN6; contactin 5; contactin 6; contactin-5; Contactin-6; EGFR; EGFR-related peptide; epidermal growth factor receptor; Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); Erbb; ERBB1; ErbB-1; erb-b2 receptor tyrosine kinase 1; Errb1; Errp; Gm507; HER1; hNB-2; HNB-2s; hNB-3; mENA; mNB-3; Nb-2; NB3; NB-3; neural adhesion molecule; neural recognition molecule NB-2; Neural recognition molecule NB-3; NISBD2; PIG61; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; wa2; wa-2; Wa5; waved 2
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公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国