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抗体

CDK4单克隆抗体(GT624)

MA5-38246

100微升

美国446.00

单克隆

小鼠

未共轭

GT624

CDK4单克隆抗体(GT624)

MA5-38246

100微升

美国446.00

单克隆

蛋白质G

小鼠

人类

Western Blot: 1:500-1:3,000

人类

GT624

IgG2b

-20° C, 避免反复冷冻/解冻

CDK4/cyclin D3 serine/threonine kinase is dimeric protein complex. CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle. CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 can mediate phosphorylation of the C-terminal region of Rb protein leading to an active transcriptional repression of E2F complex. CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivity in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein.

Recombinant protein encompassing a sequence within the center region of human CDK4. The exact sequence is proprietary.

液体

Western Blot: 1:500-1:3,000

Cdk4; Cell division protein kinase 4; CMM3; Crk3; cyclin dependent kinase 4; cyclin-dependent kinase 4; MGC14458; p34. /cdk4; PSK-J3; serine/threonine kinase; Unknown (protein for MGC:133903)