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抗体

AKT1/AKT2重组兔单克隆抗体(1G0K5)

MA5-42793

100微升

美国440.00

重组

domestic rabbit

未共轭

1G0K5

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫组化-石蜡切片

AKT1/AKT2重组兔单克隆抗体(1G0K5)

MA5-42793

100微升

美国440.00

重组单克隆

亲和色谱

兔

人类, 小鼠, 大鼠

Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:2,000

人类, 小鼠, 大鼠

1G0K5

IgG

-20° C, 避免反复冷冻/解冻

AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity.

A synthetic peptide corresponding to a sequence within amino acids 381-480 of human AKT1/2 (P31749).

液体

Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:2,000

AKT; AKT serine/threonine kinase 1; AKT serine/threonine kinase 2; AKT1; AKT1m; AKT2; CWS6; HIHGHH; murine thymoma viral (v-akt) homolog-2; PKB; PKB alpha; PKB beta; PKB-ALPHA; PKBB; PKBBETA; PRKBA; PRKBB; Protein kinase Akt-2; Protein kinase B; Protein kinase B alpha; protein kinase B beta; Proto-oncogene c-Akt; putative v-akt murine thymoma viral oncoprotein 2; RAC; rac protein kinase alpha; rac protein kinase beta; RAC-ALPHA; RAC-alpha serine/threonine-protein kinase; RAC-BETA; RAC-beta serine/threonine-protein kinase; RAC-PK-alpha; RAC-PK-beta; serine-threonine protein kinase; v-akt murine thymoma viral oncogene homolog 1; v-akt murine thymoma viral oncogene homolog 2; v-akt murine thymoma viral oncogene-like protein 1