产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD8 alpha Monoclonal Antibody (5H10), Pacific Orange™
目录 :
MCD0830
规格 :
1毫升
价格 :
美国345.00
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
pacific orange
克隆名称 :
5H10
反应物种 :
小鼠
应用 :
流式细胞仪
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 37
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 小鼠; 图 s7c
Thompson P, Shah A, Ntranos V, Van Gool F, Atkinson M, Bhushan A. Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes. Cell Metab. 2019;29:1045-1060.e10 pubmed 出版商
  • 流式细胞仪; 小鼠
Castro Rojas C, Deason K, Hussain R, Hayardeny L, Cravens P, Yarovinsky F, et al. Testing effects of glatiramer acetate and fingolimod in an infectious model of CNS immune surveillance. J Neuroimmunol. 2014;276:232-5 pubmed 出版商
  • 流式细胞仪; 小鼠
Sreedharan R, Chen S, Miller M, Haribhai D, Williams C, Van Why S. Mice with an absent stress response are protected against ischemic renal injury. Kidney Int. 2014;86:515-24 pubmed 出版商
  • 流式细胞仪; 小鼠
Murphy K, Erickson J, Johnson C, Seiler C, Bedi J, Hu P, et al. CD8+ T cell-independent tumor regression induced by Fc-OX40L and therapeutic vaccination in a mouse model of glioma. J Immunol. 2014;192:224-33 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 3
Schmitt E, Haribhai D, Jeschke J, Co D, Ziegelbauer J, Yan K, et al. Chronic follicular bronchiolitis requires antigen-specific regulatory T cell control to prevent fatal disease progression. J Immunol. 2013;191:5460-76 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
Bittner Eddy P, Fischer L, Costalonga M. Identification of gingipain-specific I-A(b) -restricted CD4+ T cells following mucosal colonization with Porphyromonas gingivalis in C57BL/6 mice. Mol Oral Microbiol. 2013;28:452-66 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
Fuertbauer E, Zaujec J, Uhrin P, Raab I, Weber M, Schachner H, et al. Thymic medullar conduits-associated podoplanin promotes natural regulatory T cells. Immunol Lett. 2013;154:31-41 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1
Cravens P, Kieseier B, Hussain R, Herndon E, Arellano B, Ben L, et al. The neonatal CNS is not conducive for encephalitogenic Th1 T cells and B cells during experimental autoimmune encephalomyelitis. J Neuroinflammation. 2013;10:67 pubmed 出版商
  • 流式细胞仪; 小鼠
Hogan T, Shuvaev A, Commenges D, Yates A, Callard R, Thiebaut R, et al. Clonally diverse T cell homeostasis is maintained by a common program of cell-cycle control. J Immunol. 2013;190:3985-93 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
Sag D, Wingender G, Nowyhed H, Wu R, Gebre A, Parks J, et al. ATP-binding cassette transporter G1 intrinsically regulates invariant NKT cell development. J Immunol. 2012;189:5129-38 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1
Pagán A, Pepper M, Chu H, Green J, Jenkins M. CD28 promotes CD4+ T cell clonal expansion during infection independently of its YMNM and PYAP motifs. J Immunol. 2012;189:2909-17 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
Hurez V, Daniel B, Sun L, Liu A, Ludwig S, Kious M, et al. Mitigating age-related immune dysfunction heightens the efficacy of tumor immunotherapy in aged mice. Cancer Res. 2012;72:2089-99 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 5
Lumsden J, Nurmukhambetova S, Klein J, Sattabongkot J, Bennett J, Bertholet S, et al. Evaluation of immune responses to a Plasmodium vivax CSP-based recombinant protein vaccine candidate in combination with second-generation adjuvants in mice. Vaccine. 2012;30:3311-9 pubmed 出版商
  • 流式细胞仪; 小鼠
Sun L, Hurez V, Thibodeaux S, Kious M, Liu A, Lin P, et al. Aged regulatory T cells protect from autoimmune inflammation despite reduced STAT3 activation and decreased constraint of IL-17 producing T cells. Aging Cell. 2012;11:509-19 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
Salti S, Hammelev E, Grewal J, Reddy S, Zemple S, Grossman W, et al. Granzyme B regulates antiviral CD8+ T cell responses. J Immunol. 2011;187:6301-9 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1
Kastenmuller W, Gasteiger G, Subramanian N, Sparwasser T, Busch D, Belkaid Y, et al. Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction. J Immunol. 2011;187:3186-97 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s1
Sun J, Sukhova G, Zhang J, Chen H, Sjoberg S, Libby P, et al. Cathepsin K deficiency reduces elastase perfusion-induced abdominal aortic aneurysms in mice. Arterioscler Thromb Vasc Biol. 2012;32:15-23 pubmed 出版商
  • 流式细胞仪; 小鼠; 表 1
Zavitz C, Bauer C, Gaschler G, Fraser K, Strieter R, Hogaboam C, et al. Dysregulated macrophage-inflammatory protein-2 expression drives illness in bacterial superinfection of influenza. J Immunol. 2010;184:2001-13 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 5
Seavey M, Mosmann T. Estradiol-induced vaginal mucus inhibits antigen penetration and CD8(+) T cell priming in response to intravaginal immunization. Vaccine. 2009;27:2342-9 pubmed 出版商
  • 流式细胞仪; 小鼠
Moon J, Chu H, Hataye J, Pagán A, Pepper M, McLachlan J, et al. Tracking epitope-specific T cells. Nat Protoc. 2009;4:565-81 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
Koehn B, Ford M, Ferrer I, Borom K, Gangappa S, Kirk A, et al. PD-1-dependent mechanisms maintain peripheral tolerance of donor-reactive CD8+ T cells to transplanted tissue. J Immunol. 2008;181:5313-22 pubmed
  • 流式细胞仪; 小鼠; 图 1
Willoughby J, Costello P, Nicolas R, Robinson N, Stamp G, Powrie F, et al. Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development. J Immunol. 2007;179:6836-44 pubmed
  • 流式细胞仪; 小鼠; 图 1
Choi E, Chen J, Wooldridge L, Salio M, Lissina A, Lissin N, et al. High avidity antigen-specific CTL identified by CD8-independent tetramer staining. J Immunol. 2003;171:5116-23 pubmed
  • 流式细胞仪; 小鼠; 图 4
Shinkai K, Mohrs M, Locksley R. Helper T cells regulate type-2 innate immunity in vivo. Nature. 2002;420:825-9 pubmed
Chryplewicz A, Scotton J, Tichet M, Zomer A, Shchors K, Joyce J, et al. Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity. Cancer Cell. 2022;40:1111-1127.e9 pubmed 出版商
Sun Y, Anyalebechi J, Sun H, Yumoto T, Xue M, Liu D, et al. Anti-TIGIT differentially affects sepsis survival in immunologically experienced versus previously naive hosts. JCI Insight. 2021;6: pubmed 出版商
Kamemura K, Chen C, Okumura M, Miura M, Chihara T. Amyotrophic lateral sclerosis-associated Vap33 is required for maintaining neuronal dendrite morphology and organelle distribution in Drosophila. Genes Cells. 2021;26:230-239 pubmed 出版商
Sun Y, Xie J, Anyalebechi J, Chen C, Sun H, Xue M, et al. CD28 Agonism Improves Survival in Immunologically Experienced Septic Mice via IL-10 Released by Foxp3+ Regulatory T Cells. J Immunol. 2020;205:3358-3371 pubmed 出版商
Kretschmer L, Flossdorf M, Mir J, Cho Y, Plambeck M, Treise I, et al. Differential expansion of T central memory precursor and effector subsets is regulated by division speed. Nat Commun. 2020;11:113 pubmed 出版商
Fay K, Chihade D, Chen C, Klingensmith N, Lyons J, Ramonell K, et al. Increased mortality in CD43-deficient mice during sepsis. PLoS ONE. 2018;13:e0202656 pubmed 出版商
Klingensmith N, Fay K, Lyons J, Chen C, Otani S, Liang Z, et al. Chronic Alcohol Ingestion Worsens Survival and Alters Gut Epithelial Apoptosis and CD8+ T Cell Function After Pseudomonas Aeruginosa Pneumonia-Induced Sepsis. Shock. 2019;51:453-463 pubmed 出版商
Publicover J, Gaggar A, Jespersen J, Halac U, JOHNSON A, Goodsell A, et al. An OX40/OX40L interaction directs successful immunity to hepatitis B virus. Sci Transl Med. 2018;10: pubmed 出版商
Catakovic K, Gassner F, Ratswohl C, Zaborsky N, Rebhandl S, Schubert M, et al. TIGIT expressing CD4+T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia. Oncoimmunology. 2017;7:e1371399 pubmed 出版商
Ramonell K, Zhang W, Hadley A, Chen C, Fay K, Lyons J, et al. CXCR4 blockade decreases CD4+ T cell exhaustion and improves survival in a murine model of polymicrobial sepsis. PLoS ONE. 2017;12:e0188882 pubmed 出版商
Prenek L, Boldizsár F, Kugyelka R, Ugor E, Berta G, Németh P, et al. The regulation of the mitochondrial apoptotic pathway by glucocorticoid receptor in collaboration with Bcl-2 family proteins in developing T cells. Apoptosis. 2017;22:239-253 pubmed 出版商
Zhu M, Bakhru P, Conley B, Nelson J, Free M, Martin A, et al. Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator. Nat Commun. 2016;7:11350 pubmed 出版商
Pepper M, Linehan J, Pagán A, Zell T, Dileepan T, Cleary P, et al. Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells. Nat Immunol. 2010;11:83-9 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
CD8 alpha Monoclonal Antibody (5H10), Pacific Orange™
目录# :
MCD0830
规格 :
1毫升
价格 :
美国345.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
大鼠
反应物种 :
小鼠
应用 :
Flow Cytometry: Assay-dependent
物种 :
小鼠
克隆 :
5H10
抗体亚型 :
IgG2b
储存 :
4° C
描述 :
Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. Once activated, CTLs play a crucial role in the clearance of pathogens and tumor cells. Differentiation of naive CD8+ T cells into CTLs is strongly enhanced by IL-2, IL-12 and TGF-beta1.
免疫原 :
Con A-stimulated BALB/c splenic T cells
格式 :
液体
应用w/稀释 :
Flow Cytometry: Assay-dependent
别名 :
BB154331; CD8; CD8 alpha; CD8 alpha chain; CD8 alpha chain precursor; CD8 antigen; CD8 antigen 32 kDa chain; CD8 antigen 37 kDa chain; CD8 antigen alpha polypeptide; CD8 antigen alpha protein; CD8 antigen alpha protein precursor; CD8 antigen alpha-chain; CD8 antigen beta polypeptide; CD8 antigen beta polypeptide precursor; CD8 antigen beta-chain; CD8 antigen, alpha chain; CD8 antigen, alpha polypeptide; CD8 antigen, alpha polypeptide (p32); CD8 antigen, alpha-chain; CD8 antigen, beta chain; CD8 antigen, beta chain 1; CD8 antigen, beta polypeptide; CD8 antigen, beta polypeptide 1 (p37); CD8 antigen, beta-chain; CD8 beta; CD8 beta chain; CD8 beta-2; CD8a; CD8A antigen alpha; CD8a molecule; CD8A; T-cell surface glycoprotein; CD8alpha; CD8B; CD8b antigen; CD8b molecule; CD8b molecule pseudogene; Cd8b1; CD8beta; CD8BP; fCD8; LEU2; Leu-2; Leu2 T-lymphocyte antigen; leu-2a; Ly-2; LY3; Ly-3; Ly-35; Ly-B; Ly-C; Lymphocyte antigen 3; Lyt2; Lyt-2; Lyt-2.1 lymphocyte differentiation antigen (AA at 100); Lyt3; Lyt-3; MAL; membrane glycoprotein; membrane protein; OKT8 T-cell antigen; OX-8 membrane antigen; p32; P37; RHACD8-4; T cell co-receptor; T lymphocyte surface glycoprotein beta chain; T8 T-cell antigen; T-cell antigen Leu2; T-cell membrane glycoprotein Ly-3; T-cell surface glycoprotein; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 beta chain; T-cell surface glycoprotein Lyt-2; T-cell surface glycoprotein Lyt-3; T-cell surface molecule; T-lymphocyte differentiation antigen T8/Leu-2; type I transmembrane glycoprotein
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国