产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD45 Monoclonal Antibody (30-F11), Pacific Orange™
目录 :
MCD4530
规格 :
1毫升
价格 :
美国341.00
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
pacific orange
克隆名称 :
30-F11
反应物种 :
小鼠
应用 :
免疫组化, 免疫细胞化学, 流式细胞仪
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 19
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 小鼠; 图 s4
Cheng L, Ma J, Li J, Li D, Li G, Li F, et al. Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs. J Clin Invest. 2017;127:269-279 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s1d
Kirschbaum K, Sonner J, Zeller M, Deumelandt K, Bode J, Sharma R, et al. In vivo nanoparticle imaging of innate immune cells can serve as a marker of disease severity in a model of multiple sclerosis. Proc Natl Acad Sci U S A. 2016;113:13227-13232 pubmed
  • 流式细胞仪; 小鼠; 图 4c
Keil M, Sonner J, Lanz T, Oezen I, Bunse T, Bittner S, et al. General control non-derepressible 2 (GCN2) in T cells controls disease progression of autoimmune neuroinflammation. J Neuroimmunol. 2016;297:117-26 pubmed 出版商
  • 流式细胞仪; 小鼠
Kim K, Skora A, Li Z, Liu Q, Tam A, Blosser R, et al. Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells. Proc Natl Acad Sci U S A. 2014;111:11774-9 pubmed 出版商
  • 流式细胞仪; 小鼠
Zhang Y, Yan W, Mathew E, Bednar F, Wan S, Collins M, et al. CD4+ T lymphocyte ablation prevents pancreatic carcinogenesis in mice. Cancer Immunol Res. 2014;2:423-35 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
Zhang Y, Yan W, Collins M, Bednar F, Rakshit S, Zetter B, et al. Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance. Cancer Res. 2013;73:6359-74 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:200
Jones S, Roberts R, Robbins G, Perry J, Kai M, Chen K, et al. Nanoparticle clearance is governed by Th1/Th2 immunity and strain background. J Clin Invest. 2013;123:3061-73 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1
Mead A, Chowdhury O, Pecquet C, Dusa A, Woll P, Atkinson D, et al. Impact of isolated germline JAK2V617I mutation on human hematopoiesis. Blood. 2013;121:4156-65 pubmed 出版商
  • 流式细胞仪; 小鼠
Koning J, Kooij G, de Vries H, Nolte M, Mebius R. Mesenchymal stem cells are mobilized from the bone marrow during inflammation. Front Immunol. 2013;4:49 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1
Chabtini L, Mfarrej B, Mounayar M, Zhu B, Batal I, Dakle P, et al. TIM-3 regulates innate immune cells to induce fetomaternal tolerance. J Immunol. 2013;190:88-96 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 6
Goodyear A, Troyer R, Bielefeldt Ohmann H, Dow S. MyD88-dependent recruitment of monocytes and dendritic cells required for protection from pulmonary Burkholderia mallei infection. Infect Immun. 2012;80:110-20 pubmed 出版商
Crespo M, González Terán B, Nikolic I, Mora A, Folgueira C, Rodriguez E, et al. Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism. elife. 2020;9: pubmed 出版商
Abdul Pari A, Singhal M, Hübers C, Mogler C, Schieb B, Gampp A, et al. Tumor Cell-Derived Angiopoietin-2 Promotes Metastasis in Melanoma. Cancer Res. 2020;80:2586-2598 pubmed 出版商
Halbrook C, Pontious C, Kovalenko I, Lapienyte L, Dreyer S, Lee H, et al. Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer. Cell Metab. 2019;: pubmed 出版商
Williams S, Fairless R, Maier O, Liermann P, Pichi K, Fischer R, et al. Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis. Sci Rep. 2018;8:13628 pubmed 出版商
Li W, Tanikawa T, Kryczek I, Xia H, Li G, Wu K, et al. Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer. Cell Metab. 2018;28:87-103.e6 pubmed 出版商
Ye C, Wang W, Cheng L, Li G, Wen M, Wang Q, et al. Glycosylphosphatidylinositol-Anchored Anti-HIV scFv Efficiently Protects CD4 T Cells from HIV-1 Infection and Deletion in hu-PBL Mice. J Virol. 2017;91: pubmed 出版商
Farrar C, Tran D, Li K, Wu W, Peng Q, Schwaeble W, et al. Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury. J Clin Invest. 2016;126:1911-25 pubmed 出版商
Bi X, Zhu X, Gao C, Shewale S, Cao Q, Liu M, et al. Myeloid cell-specific ATP-binding cassette transporter A1 deletion has minimal impact on atherogenesis in atherogenic diet-fed low-density lipoprotein receptor knockout mice. Arterioscler Thromb Vasc Biol. 2014;34:1888-99 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
CD45 Monoclonal Antibody (30-F11), Pacific Orange™
目录# :
MCD4530
规格 :
1毫升
价格 :
美国341.00
克隆性 :
单克隆
纯度 :
纯化
宿主 :
大鼠
反应物种 :
小鼠
应用 :
Flow Cytometry: Assay-dependent, Immunocytochemistry: Assay-Dependent, Immunohistochemistry: Assay-Dependent
物种 :
小鼠
克隆 :
30-F11
抗体亚型 :
IgG2b, kappa
储存 :
4° C, store in dark
描述 :
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 is absent on non-hematopoietic cell lines, normal and malignant, non-hematopoietic tissues. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions.
免疫原 :
CD45抗原
格式 :
液体
应用w/稀释 :
Flow Cytometry: Assay-dependent, Immunocytochemistry: Assay-Dependent, Immunohistochemistry: Assay-Dependent
别名 :
B220; cd45; CD45 antigen; CD45 antigen isoform 1 precursor; CD45 antigen isoform 2 precursor; CD45 antigen isoform 3 precursor; CD45 antigen isoform 4 precursor; CD45 antigen isoform 5 precursor; CD45 antigen isoform 6 precursor; CD45R; GP180; Lca; L-CA; leucocyte common antigen; leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; leukocyte common antigen, CD45; loc; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase C; LY5; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; membrane tyrosine phosphatase; protein tyrosine phosphatase lambda; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; Protein tyrosine phosphatase, receptor-type, c polypeptide; protein tyrosine phosphatase; alternatively spliced; Ptprc; Receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein; T200 leukocyte common antigen; T220 and B220
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国