CD27单克隆抗体(CLB-27/1), PE | 赛默飞世尔 MHCD2704 产品信息

产品简要

公司名称 :

赛默飞世尔

其他品牌 :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

产品类型 :

抗体

产品名称 :

CD27单克隆抗体(CLB-27/1), PE

MHCD2704

规格 :

500微升

价格 :

美国479

克隆性 :

单克隆

宿主 :

小鼠

共轭标签 :

克隆名称 :

CLB-27/1

反应物种 :

人类

应用 :

流式细胞仪

更多信息或购买 :

赛默飞世尔产品网页

文章摘录数: 5

出版应用/物种/样本/稀释	参考文献
流式细胞仪; 人类; 图 2a	Malkiel S, Jeganathan V, Wolfson S, Manjarrez Orduno N, Marasco E, Aranow C, et al. Checkpoints for Autoreactive B Cells in the Peripheral Blood of Lupus Patients Assessed by Flow Cytometry. Arthritis Rheumatol. 2016;68:2210-20 pubmed 出版商
流式细胞仪; 人类; 图 3	Manjarrez Orduno N, Marasco E, Chung S, Katz M, Kiridly J, Simpfendorfer K, et al. CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation. Nat Genet. 2012;44:1227-30 pubmed 出版商
	Piepenbrink M, Park J, Oladunni F, Deshpande A, Basu M, Sarkar S, et al. Therapeutic activity of an inhaled potent SARS-CoV-2 neutralizing human monoclonal antibody in hamsters. Cell Rep Med. 2021;2:100218 pubmed 出版商
	Sevigny L, Booth B, Rowley K, Leav B, Cheslock P, GARRITY K, et al. Identification of a human monoclonal antibody to replace equine diphtheria antitoxin for treatment of diphtheria intoxication. Infect Immun. 2013;81:3992-4000 pubmed 出版商
	Smith K, Garman L, Wrammert J, Zheng N, Capra J, Ahmed R, et al. Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen. Nat Protoc. 2009;4:372-84 pubmed 出版商

产品信息

产品类型 :

抗体

产品名称 :

CD27单克隆抗体(CLB-27/1), PE

目录# :

MHCD2704

规格 :

500微升

价格 :

美国479

克隆性 :

单克隆

纯度 :

纯化

宿主 :

小鼠

反应物种 :

人类

应用 :

Flow Cytometry: Assay-Dependent

物种 :

人类

克隆 :

CLB-27/1

抗体亚型 :

IgG2a

储存 :

4° C, store in dark

描述 :

CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily that includes CD40 and CD30. The TNF superfamily members are known for the regulation of cell proliferation and death. In contrast to the expression of other TNFR/TNF family members, expression of CD27 and its ligand CD70 is predominantly confined to lymphocytes. High expression levels of CD27 appear to be dependent on proper ligation of antigen receptors. CD70 expression requires additional co-stimulatory and/or pro-inflammatory signals. CD27 is expressed as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells and a subpopulation of B cells. Activation of T cells via TCR-CD3 complex results in upregulation of CD27 expression on the plasma membrane as well as in the release of its soluble 28-32 kDa form, sCD27, detected in the plasma, urine or spinal fluid. Soluble CD27 is an important prognostic marker of acute and chronic B cell malignancies. RgpA, a cystein proteinase, although activating T cells through the protease-activated receptors (PARs), degradates CD27 and counteracts T cell activation mediated by CD27 and its ligand CD70. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. Diseases associated with CD27 dysfunction include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Syndrome.

免疫原 :

人类CD27

格式 :

液体

应用w/稀释 :

Flow Cytometry: Assay-Dependent

别名 :

CD antigen 27; CD27; CD27 antigen; CD27 molecule; CD27L receptor; LPFS2; S152; S152. LPFS2; sCD27; soluble CD27; T cell activation antigen S152; T14; T-cell activation antigen CD27; TNFRSF7; TNFSF7; Tp55; Tumor necrosis factor receptor superfamily member 7; tumor necrosis factor receptor superfamily, member 7

更多信息或购买 :

赛默飞世尔产品网页

公司信息

赛默飞世尔

上海浦东新金桥路27号7号楼

analyze.cn@thermofisher.com

http://www.thermo.com.cn

1084193588

公司总部: 美国