产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD45 Monoclonal Antibody (HI30), Alexa Fluor™ 488
目录 :
MHCD4520
规格 :
500微升
价格 :
美国457
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
AF488
克隆名称 :
HI30
反应物种 :
人类
应用 :
免疫细胞化学, 流式细胞仪
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 13
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 人类
Quarta M, Brett J, DiMarco R, de Morrée A, Boutet S, Chacon R, et al. An artificial niche preserves the quiescence of muscle stem cells and enhances their therapeutic efficacy. Nat Biotechnol. 2016;34:752-9 pubmed 出版商
  • 免疫细胞化学; 人类; 图 6b
Shaw Bagnall J, Byun S, Miyamoto D, Kang J, Maheswaran S, Stott S, et al. Deformability-based cell selection with downstream immunofluorescence analysis. Integr Biol (Camb). 2016;8:654-64 pubmed 出版商
  • 流式细胞仪; 人类; 图 5
Yawata N, Selva K, Liu Y, Tan K, Lee A, Siak J, et al. Dynamic change in natural killer cell type in the human ocular mucosa in situ as means of immune evasion by adenovirus infection. Mucosal Immunol. 2016;9:159-70 pubmed 出版商
  • 流式细胞仪; 人类; 图 3
Mokry J, Soukup T, Micuda S, Karbanova J, Visek B, Brcakova E, et al. Telomere attrition occurs during ex vivo expansion of human dental pulp stem cells. J Biomed Biotechnol. 2010;2010:673513 pubmed 出版商
Cheng K, Pan R, Pan H, Li B, Meena S, Xing H, et al. ALICE: a hybrid AI paradigm with enhanced connectivity and cybersecurity for a serendipitous encounter with circulating hybrid cells. Theranostics. 2020;10:11026-11048 pubmed 出版商
Labib M, Wang Z, Ahmed S, Mohamadi R, Duong B, Green B, et al. Tracking the expression of therapeutic protein targets in rare cells by antibody-mediated nanoparticle labelling and magnetic sorting. Nat Biomed Eng. 2020;: pubmed 出版商
Sarkar T, Quarta M, Mukherjee S, Colville A, Paine P, Doan L, et al. Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells. Nat Commun. 2020;11:1545 pubmed 出版商
Sun Y, Wu G, Cheng K, Chen A, Neoh K, Chen S, et al. CTC phenotyping for a preoperative assessment of tumor metastasis and overall survival of pancreatic ductal adenocarcinoma patients. EBioMedicine. 2019;46:133-149 pubmed 出版商
Lin T, Chen S, Chuang Y, Lan M, Chuang J, Wang P, et al. Mitochondrial Transfer of Wharton's Jelly Mesenchymal Stem Cells Eliminates Mutation Burden and Rescues Mitochondrial Bioenergetics in Rotenone-Stressed MELAS Fibroblasts. Oxid Med Cell Longev. 2019;2019:9537504 pubmed 出版商
Larmour L, Cousins F, Teague J, Deane J, Jobling T, Gargett C. A patient derived xenograft model of cervical cancer and cervical dysplasia. PLoS ONE. 2018;13:e0206539 pubmed 出版商
Labib M, Mohamadi R, Poudineh M, Ahmed S, Ivanov I, Huang C, et al. Single-cell mRNA cytometry via sequence-specific nanoparticle clustering and trapping. Nat Chem. 2018;10:489-495 pubmed 出版商
Quarta M, Cromie M, Chacon R, Blonigan J, Garcia V, Akimenko I, et al. Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss. Nat Commun. 2017;8:15613 pubmed 出版商
Shaw Bagnall J, Byun S, Begum S, Miyamoto D, Hecht V, Maheswaran S, et al. Deformability of Tumor Cells versus Blood Cells. Sci Rep. 2015;5:18542 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
CD45 Monoclonal Antibody (HI30), Alexa Fluor™ 488
目录# :
MHCD4520
规格 :
500微升
价格 :
美国457
克隆性 :
单克隆
纯度 :
纯化
宿主 :
小鼠
反应物种 :
人类
应用 :
Flow Cytometry: Assay-Dependent
物种 :
人类
克隆 :
HI30
抗体亚型 :
IgG1
储存 :
4° C, store in dark
描述 :
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 is absent on non-hematopoietic cell lines, normal and malignant, non-hematopoietic tissues. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions.
免疫原 :
CD45抗原
格式 :
液体
应用w/稀释 :
Flow Cytometry: Assay-Dependent
别名 :
B220; cd45; CD45 antigen; CD45 antigen isoform 1 precursor; CD45 antigen isoform 2 precursor; CD45 antigen isoform 3 precursor; CD45 antigen isoform 4 precursor; CD45 antigen isoform 5 precursor; CD45 antigen isoform 6 precursor; CD45R; GP180; Lca; L-CA; leucocyte common antigen; leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; leukocyte common antigen, CD45; loc; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase C; LY5; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; membrane tyrosine phosphatase; protein tyrosine phosphatase lambda; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; Protein tyrosine phosphatase, receptor-type, c polypeptide; protein tyrosine phosphatase; alternatively spliced; Ptprc; Receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein; T200 leukocyte common antigen; T220 and B220
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国