产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD45 Monoclonal Antibody (HI30), Pacific Orange™
目录 :
MHCD4530TR
规格 :
25试验
价格 :
美国239
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
pacific orange
克隆名称 :
HI30
反应物种 :
人类, 小鼠
应用 :
免疫细胞化学, 流式细胞仪
更多信息或购买 :
文章摘录数: 33
出版应用/物种/样本/稀释 | 参考文献 |
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| Jasionowski T, Hartung L, Greenwood J, Perkins S, Bahler D. Analysis of CD10+ hairy cell leukemia. Am J Clin Pathol. 2003;120:228-35 pubmed
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| Manz M, Miyamoto T, Akashi K, Weissman I. Prospective isolation of human clonogenic common myeloid progenitors. Proc Natl Acad Sci U S A. 2002;99:11872-7 pubmed
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| Janossy G, Jani I, Kahan M, Barnett D, Mandy F, Shapiro H. Precise CD4 T-cell counting using red diode laser excitation: for richer, for poorer. Cytometry. 2002;50:78-85 pubmed
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| Capmany G, Querol S, Cancelas J, Garcia J. Short-term, serum-free, static culture of cord blood-derived CD34+ cells: effects of FLT3-L and MIP-1alpha on in vitro expansion of hematopoietic progenitor cells. Haematologica. 1999;84:675-82 pubmed
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| Negrier C, Vinciguerra C, Attali O, Grenier C, Larcher M, Dechavanne M. Illegitimate transcription: its use for studying genetic abnormalities in lymphoblastoid cells from patients with Glanzmann thrombasthenia. Br J Haematol. 1998;100:33-9 pubmed
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| Basch R, Quito F, Beh J, Hirst J. Growth of human hematopoietic cells in immunodeficient mice conditioned with cyclophosphamide and busulfan. Stem Cells. 1997;15:314-23 pubmed
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Leone A, Rutella S, Bonanno G, Abbate A, Rebuzzi A, Giovannini S, et al. Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function. Eur Heart J. 2005;26:1196-204 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
CD45 Monoclonal Antibody (HI30), Pacific Orange™
目录# :
MHCD4530TR
规格 :
25试验
价格 :
美国239
克隆性 :
单克隆
纯度 :
纯化
宿主 :
小鼠
反应物种 :
人类
应用 :
Flow Cytometry: Assay-Dependent
物种 :
人类
克隆 :
HI30
抗体亚型 :
IgG1
储存 :
4° C, store in dark
描述 :
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 is absent on non-hematopoietic cell lines, normal and malignant, non-hematopoietic tissues. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions.
免疫原 :
CD45抗原
格式 :
液体
应用w/稀释 :
Flow Cytometry: Assay-Dependent
别名 :
B220; cd45; CD45 antigen; CD45 antigen isoform 1 precursor; CD45 antigen isoform 2 precursor; CD45 antigen isoform 3 precursor; CD45 antigen isoform 4 precursor; CD45 antigen isoform 5 precursor; CD45 antigen isoform 6 precursor; CD45R; GP180; Lca; L-CA; leucocyte common antigen; leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; leukocyte common antigen, CD45; loc; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase C; LY5; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; membrane tyrosine phosphatase; protein tyrosine phosphatase lambda; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; Protein tyrosine phosphatase, receptor-type, c polypeptide; protein tyrosine phosphatase; alternatively spliced; Ptprc; Receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein; T200 leukocyte common antigen; T220 and B220
更多信息或购买 :
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赛默飞世尔
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