产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
IL-12 p70单克隆抗体(C17-8), 生物素
目录 :
MM121B
规格 :
250微克
价格 :
美国450.00
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
生物素
克隆名称 :
C17-8
反应物种 :
小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 流式细胞仪
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 22
出版应用/物种/样本/稀释参考文献
  • 酶联免疫吸附测定; 小鼠
Zhao X, Ross E, Wang Y, Horwitz B. Nfkb1 inhibits LPS-induced IFN-? and IL-12 p40 production in macrophages by distinct mechanisms. PLoS ONE. 2012;7:e32811 pubmed 出版商
  • 免疫印迹; 小鼠
Zwiers A, Fuss I, Seegers D, Konijn T, Garcia Vallejo J, Samsom J, et al. A polymorphism in the coding region of Il12b promotes IL-12p70 and IL-23 heterodimer formation. J Immunol. 2011;186:3572-80 pubmed 出版商
  • 酶联免疫吸附测定; 小鼠
Dewamitta S, Nomura T, Kawamura I, Hara H, Tsuchiya K, Kurenuma T, et al. Listeriolysin O-dependent bacterial entry into the cytoplasm is required for calpain activation and interleukin-1 alpha secretion in macrophages infected with Listeria monocytogenes. Infect Immun. 2010;78:1884-94 pubmed 出版商
  • 酶联免疫吸附测定; 小鼠
Biedroń R, Ciszek M, Tokarczyk M, Bobek M, Kurnyta M, Słomińska E, et al. 1-Methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages. Arch Immunol Ther Exp (Warsz). 2008;56:127-34 pubmed 出版商
  • 酶联免疫吸附测定; 小鼠
Setiawan T, Metwali A, Blum A, Ince M, Urban J, Elliott D, et al. Heligmosomoides polygyrus promotes regulatory T-cell cytokine production in the murine normal distal intestine. Infect Immun. 2007;75:4655-63 pubmed
  • 酶联免疫吸附测定; 小鼠
Bryniarski K, Szczepanik M, Ptak M, Ptak W. The influence of collagenase treatment on the production of TNF-alpha, IL-6 and IL-10 by testicular macrophages. J Immunol Methods. 2005;301:186-9 pubmed
  • 酶联免疫吸附测定; 小鼠
Bryniarski K, Szczepanik M, Ptak M, Ptak W. Modulation of testicular macrophage activity by collagenase. Folia Histochem Cytobiol. 2005;43:37-41 pubmed
  • 酶联免疫吸附测定; 小鼠; 0.5 ug/ml
Bryniarski K, Maresz K, Szczepanik M, Ptak M, Ptak W. Modulation of macrophage activity by proteolytic enzymes. Differential regulation of IL-6 and reactive oxygen intermediates (ROIs) synthesis as a possible homeostatic mechanism in the control of inflammation. Inflammation. 2003;27:333-40 pubmed
  • 流式细胞仪; 小鼠
  • 酶联免疫吸附测定; 小鼠
Fujimoto N, Ishida H, Nakamura I, Ogasawara K, Itoh Y. Quantities of interleukin-12p40 in mature CD8alpha negative dendritic cells correlate with strength of TCR signal and determine Th cell development. Microbiol Immunol. 2003;47:1017-24 pubmed
Conaway E, de Oliveira D, McInnis C, Snapper S, Horwitz B. Inhibition of Inflammatory Gene Transcription by IL-10 Is Associated with Rapid Suppression of Lipopolysaccharide-Induced Enhancer Activation. J Immunol. 2017;198:2906-2915 pubmed 出版商
Kim A, Noh Y, Kim K, Jang Y, Choe Y, Lim J. Activated natural killer cell-mediated immunity is required for the inhibition of tumor metastasis by dendritic cell vaccination. Exp Mol Med. 2004;36:428-43 pubmed
Kirby A, Sundquist M, Wick M. In vivo compartmentalization of functionally distinct, rapidly responsive antigen-specific T-cell populations in DNA-immunized or Salmonella enterica serovar Typhimurium-infected mice. Infect Immun. 2004;72:6390-400 pubmed
Elliott D, Setiawan T, Metwali A, Blum A, Urban J, Weinstock J. Heligmosomoides polygyrus inhibits established colitis in IL-10-deficient mice. Eur J Immunol. 2004;34:2690-8 pubmed
Tomczak M, Erdman S, Poutahidis T, Rogers A, Holcombe H, Plank B, et al. NF-kappa B is required within the innate immune system to inhibit microflora-induced colitis and expression of IL-12 p40. J Immunol. 2003;171:1484-92 pubmed
Das S, Khar A. Regulation of NK cell function in vivo by the dose of tumour transplanted in the peritoneum. Immunol Lett. 2002;83:133-42 pubmed
Blum A, Metwali A, Crawford C, Li J, Qadir K, Elliott D, et al. Interleukin 12 and antigen independently induce substance P receptor expression in T cells in murine schistosomiasis mansoni. FASEB J. 2001;15:950-7 pubmed
Yeung V, Gieni R, Umetsu D, DeKruyff R. Heat-killed Listeria monocytogenes as an adjuvant converts established murine Th2-dominated immune responses into Th1-dominated responses. J Immunol. 1998;161:4146-52 pubmed
Flamand V, Donckier V, Demoor F, Le Moine A, Matthys P, Vanderhaeghen M, et al. CD40 ligation prevents neonatal induction of transplantation tolerance. J Immunol. 1998;160:4666-9 pubmed
DeKruyff R, Fang Y, Umetsu D. Corticosteroids enhance the capacity of macrophages to induce Th2 cytokine synthesis in CD4+ lymphocytes by inhibiting IL-12 production. J Immunol. 1998;160:2231-7 pubmed
Taneichi M, Horino A, Naito S, Sakurai S, Komuro K, Uchida T. Differential stimulation requirements for IL-12 production among clones of macrophage hybridomas. J Interferon Cytokine Res. 1997;17:603-7 pubmed
Orange J, Biron C. Characterization of early IL-12, IFN-alphabeta, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection. J Immunol. 1996;156:4746-56 pubmed
Heufler C, Koch F, Stanzl U, Topar G, Wysocka M, Trinchieri G, et al. Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells. Eur J Immunol. 1996;26:659-68 pubmed
产品信息
产品类型 :
抗体
产品名称 :
IL-12 p70单克隆抗体(C17-8), 生物素
目录# :
MM121B
规格 :
250微克
价格 :
美国450.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
大鼠
反应物种 :
小鼠
应用 :
ELISA: Assay-dependent, Western Blot: Assay-dependent
物种 :
小鼠
克隆 :
C17-8
抗体亚型 :
IgG2a
储存 :
-20°C
描述 :
IL-12 p70, also known as interleukin-12, is a cytokine that plays a critical role in the immune system's response to infections and cancer. It is produced by immune cells, including dendritic cells, macrophages, and B cells, in response to certain pathogens and tumor cells. IL-12 p70 stimulates the production of interferon-gamma and other cytokines, which promote the activation and proliferation of T cells and natural killer cells. IL-12 p70 has been studied as a potential therapeutic target for various diseases and conditions, including infectious diseases, autoimmune disorders, and cancer. It has been shown to enhance immune responses against certain infections and tumors, and to modulate inflammatory responses in autoimmune diseases.
免疫原 :
重组小鼠IL-12
格式 :
液体
应用w/稀释 :
ELISA: Assay-dependent, Western Blot: Assay-dependent
别名 :
20C2; CLMF; CLMF p35; CLMF p40; CLMF2; cytokine; cytotoxic lymphocyte maturation factor 1, p35; cytotoxic lymphocyte maturation factor 35 kDa subunit; Cytotoxic lymphocyte maturation factor 40 kDa subunit; il 12; IL 12p70; Il12; IL-12; Il-12 p35; IL-12 p75; IL-12 subunit p35; IL-12 subunit p40; IL-12, subunit p35; IL12, subunit p40; Il-12; cytokine; IL12A; IL-12A; IL12A/B; IL12AB; IL12B; Il-12b; IL12P35; IL-12p35; Il12p40; Il-12p40; IL35 subunit; ILN; IMD28; IMD29; Interleukin; interleukin 12 35 kDa subunit; interleukin 12 35kDa subunit; interleukin 12 40 kDa subunit; interleukin 12 40kDa subunit; interleukin 12 p35 subunit; interleukin 12 p40 subunit precursor; interleukin 12 polypeptide 35; interleukin 12, p35; interleukin 12, p40; interleukin 12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); interleukin 12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin 12p35 subunit precursor; interleukin-12 alpha chain; interleukin-12 alpha p40 subunit; interleukin-12 beta chain; interleukin-12 beta p35 subunit; interleukin-12 p35 subunit; interleukin-12 p35 subunit precursor; interleukin-12 p40; interleukin-12 p40 subunit; interleukin-12 p40 subunit precursor; Interleukin-12 p70; interleukin-12 subunit alpha; Interleukin-12 subunit beta; interleukin-23 p40 subunit; Ll12a; MGC151228; MGC151232; natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35; natural killer cell stimulatory factor, 40 kD subunit; NF cell stimulatory factor chain 1; NFSK; NK cell stimulatory factor chain 1; NK cell stimulatory factor chain 2; NKSF; NKSF1; NKSF2; P35; p40
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国