产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
IL-1乙单克隆抗体(1400.24.17)
目录 :
MM425B
规格 :
500微克
价格 :
美国441
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
1400.24.17
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 抑制或激活实验
更多信息或购买 :
文章摘录数: 19
出版应用/物种/样本/稀释参考文献
  • 抑制或激活实验; 小鼠; 图 5a
Eyre R, Alferez D, Santiago Gómez A, Spence K, McConnell J, Hart C, et al. Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling. Nat Commun. 2019;10:5016 pubmed 出版商
  • 抑制或激活实验; 小鼠; 图 9
Cohen T, Many G, Fleming B, Gnocchi V, Ghimbovschi S, Mosser D, et al. Upregulated IL-1β in dysferlin-deficient muscle attenuates regeneration by blunting the response to pro-inflammatory macrophages. Skelet Muscle. 2015;5:24 pubmed 出版商
  • 免疫印迹; 小鼠
Kim H, Jeong J, Kim S, Park S, Chae H, Lee Y. Inhibition of endoplasmic reticulum stress alleviates lipopolysaccharide-induced lung inflammation through modulation of NF-?B/HIF-1? signaling pathway. Sci Rep. 2013;3:1142 pubmed 出版商
  • 抑制或激活实验; 小鼠
Tanaka M, Mroz P, Dai T, Huang L, Morimoto Y, Kinoshita M, et al. Photodynamic therapy can induce a protective innate immune response against murine bacterial arthritis via neutrophil accumulation. PLoS ONE. 2012;7:e39823 pubmed 出版商
  • 免疫组化; 小鼠
Miller L, Pietras E, Uricchio L, Hirano K, Rao S, Lin H, et al. Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo. J Immunol. 2007;179:6933-42 pubmed
  • 酶联免疫吸附测定; 小鼠
Johnson D, O Connor J, Dantzer R, Freund G. Inhibition of vagally mediated immune-to-brain signaling by vanadyl sulfate speeds recovery from sickness. Proc Natl Acad Sci U S A. 2005;102:15184-9 pubmed
Tu H, Zhang D, Barksdale A, Wadman M, Muelleman R, Li Y. Dexamethasone Improves Wound Healing by Decreased Inflammation and Increased Vasculogenesis in Mouse Skin Frostbite Model. Wilderness Environ Med. 2020;31:407-417 pubmed 出版商
Zhang K, Fang Y, He Y, Yin H, Guan X, Pu Y, et al. Extravascular gelation shrinkage-derived internal stress enables tumor starvation therapy with suppressed metastasis and recurrence. Nat Commun. 2019;10:5380 pubmed 出版商
Liang Z, Han L, Sun D, Chen Y, Wu Q, Zhang L, et al. Chemerin-induced macrophages pyroptosis in fetal brain tissue leads to cognitive disorder in offspring of diabetic dams. J Neuroinflammation. 2019;16:226 pubmed 出版商
Incio J, Liu H, Suboj P, Chin S, Chen I, Pinter M, et al. Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy. Cancer Discov. 2016;6:852-69 pubmed 出版商
Joshi V, Kalvakolanu D, Hebel J, Hasday J, Cross A. Role of caspase 1 in murine antibacterial host defenses and lethal endotoxemia. Infect Immun. 2002;70:6896-903 pubmed
Edberg J, Qin H, Gibson A, Yee A, Redecha P, Indik Z, et al. The CY domain of the Fcgamma RIa alpha-chain (CD64) alters gamma-chain tyrosine-based signaling and phagocytosis. J Biol Chem. 2002;277:41287-93 pubmed
Joshi V, Kalvakolanu D, Hasday J, Hebel R, Cross A. IL-18 levels and the outcome of innate immune response to lipopolysaccharide: importance of a positive feedback loop with caspase-1 in IL-18 expression. J Immunol. 2002;169:2536-44 pubmed
Cecic I, Korbelik M. Mediators of peripheral blood neutrophilia induced by photodynamic therapy of solid tumors. Cancer Lett. 2002;183:43-51 pubmed
De Boer M, Hu J, Kalvakolanu D, Hasday J, Cross A. IFN-gamma inhibits lipopolysaccharide-induced interleukin-1 beta in primary murine macrophages via a Stat1-dependent pathway. J Interferon Cytokine Res. 2001;21:485-94 pubmed
Lubberts E, Joosten L, van den Bersselaar L, Helsen M, Bakker A, van Meurs J, et al. Adenoviral vector-mediated overexpression of IL-4 in the knee joint of mice with collagen-induced arthritis prevents cartilage destruction. J Immunol. 1999;163:4546-56 pubmed
Cardona A, Restrepo B, Jaramillo J, Teale J. Development of an animal model for neurocysticercosis: immune response in the central nervous system is characterized by a predominance of gamma delta T cells. J Immunol. 1999;162:995-1002 pubmed
Duong M, Ouellet N, Simard M, Bergeron Y, Olivier M, Bergeron M. Kinetic study of host defense and inflammatory response to Aspergillus fumigatus in steroid-induced immunosuppressed mice. J Infect Dis. 1998;178:1472-82 pubmed
Geiger T, Towbin H, Cosenti Vargas A, Zingel O, Arnold J, Rordorf C, et al. Neutralization of interleukin-1 beta activity in vivo with a monoclonal antibody alleviates collagen-induced arthritis in DBA/1 mice and prevents the associated acute-phase response. Clin Exp Rheumatol. 1993;11:515-22 pubmed
产品信息
产品类型 :
抗体
产品名称 :
IL-1乙单克隆抗体(1400.24.17)
目录# :
MM425B
规格 :
500微克
价格 :
美国441
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类, 小鼠
应用 :
ELISA: Assay-dependent, Western Blot: 1 µg/mL
物种 :
人类, 小鼠
克隆 :
1400.24.17
抗体亚型 :
IgG1, kappa
储存 :
-20°C
描述 :
Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.
免疫原 :
重组小鼠IL-1乙
格式 :
液体
应用w/稀释 :
ELISA: Assay-dependent, Western Blot: 1 µg/mL
别名 :
catabolin; cytokine; Hematopoietin 1 (H1); IFN beta inducing factor; il 1b; IL 1ß; IL-1; IL1 B; IL-1 beta; IL-1 precursor; IL1B; IL-1B; IL1B1; IL1beta; IL-1beta; IL1-BETA; IL1F2; IL1ß; ILN; Interleukin; interleukin 1 beta; Interleukin 1 beta precursor; interleukin 1, beta; interleukin 1, beta 1; interleukin 1-beta; interleukin*1*beta; Interleukin1 beta; interleukin-1 beta; interleukin-1 beta precursor; interleukin-1 beta precursor (AA -113 to 153); interleukin-1 beta proprotein; interleukin-1b; interleukin-1beta; interleukin-beta; LAF; lymphocyte proliferation-potentiating factor; Osteoclast activating factor (OAF); preinterleukin 1 beta; Pro interleukin 1 beta; prointerleukin-1 beta; pro-interleukin-1-beta
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国