产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
IFN丙单克隆抗体(XMG1.2), 生物素
目录 :
MM700B
规格 :
250微克
价格 :
美国412
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
生物素
克隆名称 :
XMG1.2
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 中和反应, 免疫组化-冰冻切片, 抑制或激活实验
更多信息或购买 :
文章摘录数: 83
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| Newton M, Askeland E, Andresen E, Chehval V, Wang X, Askeland R, et al. Anti-interleukin-10R1 monoclonal antibody in combination with bacillus Calmette--Guérin is protective against bladder cancer metastasis in a murine orthotopic tumour model and demonstrates systemic specific anti-tumour immunity. Clin Exp Immunol. 2014;177:261-8 pubmed 出版商
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| Hara H, Kawamura I, Nomura T, Tominaga T, Tsuchiya K, Mitsuyama M. Cytolysin-dependent escape of the bacterium from the phagosome is required but not sufficient for induction of the Th1 immune response against Listeria monocytogenes infection: distinct role of Listeriolysin O determined by cytolysin gene replacement. Infect Immun. 2007;75:3791-801 pubmed
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| Mascolo D, Barba P, De Berardinis P, Di Rosa F, Del Pozzo G. Phage display of a CTL epitope elicits a long-term in vivo cytotoxic response. FEMS Immunol Med Microbiol. 2007;50:59-66 pubmed
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| Tsunetsugu Yokota Y, Ishige M, Murakami M. Oral attenuated Salmonella enterica serovar Typhimurium vaccine expressing codon-optimized HIV type 1 Gag enhanced intestinal immunity in mice. AIDS Res Hum Retroviruses. 2007;23:278-86 pubmed
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| Parent M, Wilhelm L, Kummer L, Szaba F, Mullarky I, Smiley S. Gamma interferon, tumor necrosis factor alpha, and nitric oxide synthase 2, key elements of cellular immunity, perform critical protective functions during humoral defense against lethal pulmonary Yersinia pestis infection. Infect Immun. 2006;74:3381-6 pubmed
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| Yamamoto K, Kawamura I, Tominaga T, Nomura T, Kohda C, Ito J, et al. Listeriolysin O, a cytolysin derived from Listeria monocytogenes, inhibits generation of ovalbumin-specific Th2 immune response by skewing maturation of antigen-specific T cells into Th1 cells. Clin Exp Immunol. 2005;142:268-74 pubmed
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| Roach D, Briscoe H, Saunders B, Britton W. Independent protective effects for tumor necrosis factor and lymphotoxin alpha in the host response to Listeria monocytogenes infection. Infect Immun. 2005;73:4787-92 pubmed
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| Puddu P, Carollo M, Pietraforte I, Spadaro F, Tombesi M, Ramoni C, et al. IL-2 induces expression and secretion of IFN-gamma in murine peritoneal macrophages. J Leukoc Biol. 2005;78:686-95 pubmed
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| Roach D, Bean A, Demangel C, France M, Briscoe H, Britton W. TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection. J Immunol. 2002;168:4620-7 pubmed
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Saunders B, Briscoe H, Britton W. T cell-derived tumour necrosis factor is essential, but not sufficient, for protection against Mycobacterium tuberculosis infection. Clin Exp Immunol. 2004;137:279-87 pubmed
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Antúnez M, Cardoni R. Trypanosoma cruzi: the expansion of NK, T, and NKT cells in the experimental infection. Exp Parasitol. 2004;106:85-94 pubmed
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Yoshizawa I, Mizuochi T, Ogata A, Murakami M, Yagita H, Takahashi Y, et al. Studies on the generation and maintenance of mucosal cytotoxic T lymphocytes against human immunodeficiency virus type 1 Gag in mice. AIDS Res Hum Retroviruses. 2003;19:469-79 pubmed
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Hufnagl K, Wagner B, Winkler B, Baier K, Hochreiter R, Thalhamer J, et al. Induction of mucosal tolerance with recombinant Hev b 1 and recombinant Hev b 3 for prevention of latex allergy in BALB/c mice. Clin Exp Immunol. 2003;133:170-6 pubmed
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Martin E, Kamath A, Briscoe H, Britton W. The combination of plasmid interleukin-12 with a single DNA vaccine is more effective than Mycobacterium bovis (bacille Calmette-Guèrin) in protecting against systemic Mycobacterim avium infection. Immunology. 2003;109:308-14 pubmed
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Hill H, Conway T, Sabel M, Jong Y, Mathiowitz E, Bankert R, et al. Cancer immunotherapy with interleukin 12 and granulocyte-macrophage colony-stimulating factor-encapsulated microspheres: coinduction of innate and adaptive antitumor immunity and cure of disseminated disease. Cancer Res. 2002;62:7254-63 pubmed
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Angulo I, Jiménez Díaz M, García Bustos J, Gargallo D, de las Heras F, Muñoz Fernández M, et al. Candida albicans infection enhances immunosuppression induced by cyclophosphamide by selective priming of suppressive myeloid progenitors for NO production. Cell Immunol. 2002;218:46-58 pubmed
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Goñi O, Alcaide P, Fresno M. Immunosuppression during acute Trypanosoma cruzi infection: involvement of Ly6G (Gr1(+))CD11b(+ )immature myeloid suppressor cells. Int Immunol. 2002;14:1125-34 pubmed
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Chen M, Hu K, Rozell B, Orvell C, Morein B, Liljestrom P. Vaccination with recombinant alphavirus or immune-stimulating complex antigen against respiratory syncytial virus. J Immunol. 2002;169:3208-16 pubmed
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Das S, Khar A. Regulation of NK cell function in vivo by the dose of tumour transplanted in the peritoneum. Immunol Lett. 2002;83:133-42 pubmed
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Palendira U, Kamath A, Feng C, Martin E, Chaplin P, Triccas J, et al. Coexpression of interleukin-12 chains by a self-splicing vector increases the protective cellular immune response of DNA and Mycobacterium bovis BCG vaccines against Mycobacterium tuberculosis. Infect Immun. 2002;70:1949-56 pubmed
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Kohda C, Kawamura I, Baba H, Nomura T, Ito Y, Kimoto T, et al. Dissociated linkage of cytokine-inducing activity and cytotoxicity to different domains of listeriolysin O from Listeria monocytogenes. Infect Immun. 2002;70:1334-41 pubmed
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Nomura T, Kawamura I, Tsuchiya K, Kohda C, Baba H, Ito Y, et al. Essential role of interleukin-12 (IL-12) and IL-18 for gamma interferon production induced by listeriolysin O in mouse spleen cells. Infect Immun. 2002;70:1049-55 pubmed
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Smith R, Harris S, Phipps R, Iglewski B. The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)homoserine lactone contributes to virulence and induces inflammation in vivo. J Bacteriol. 2002;184:1132-9 pubmed
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Das S, Varalakshmi C, Kumari A, Patel M, Khar A. Target cell induced activation of NK cells in vitro: cytokine production and enhancement of cytotoxic function. Cancer Immunol Immunother. 2001;50:428-36 pubmed
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Chitnis T, Najafian N, Benou C, Salama A, Grusby M, Sayegh M, et al. Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J Clin Invest. 2001;108:739-47 pubmed
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Park W, Park C, Tomura M, Ahn H, Nakahira Y, Iwasaki M, et al. CD28 costimulation is required not only to induce IL-12 receptor but also to render janus kinases/STAT4 responsive to IL-12 stimulation in TCR-triggered T cells. Eur J Immunol. 2001;31:1456-64 pubmed
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Grohmann U, Belladonna M, Vacca C, Bianchi R, Fallarino F, Orabona C, et al. Positive regulatory role of IL-12 in macrophages and modulation by IFN-gamma. J Immunol. 2001;167:221-7 pubmed
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Cifaldi L, Quaglino E, Di Carlo E, Musiani P, Spadaro M, Lollini P, et al. A light, nontoxic interleukin 12 protocol inhibits HER-2/neu mammary carcinogenesis in BALB/c transgenic mice with established hyperplasia. Cancer Res. 2001;61:2809-12 pubmed
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Jyonouchi H, Sun S, Winship T, Kuchan M. Dietary ribonucleotides modulate type 1 and type 2 T-helper cell responses against ovalbumin in young BALB/cJ mice. J Nutr. 2001;131:1165-70 pubmed
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Chitnis T, Najafian N, Abdallah K, Dong V, Yagita H, Sayegh M, et al. CD28-independent induction of experimental autoimmune encephalomyelitis. J Clin Invest. 2001;107:575-83 pubmed
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Gao P, Uekusa Y, Nakajima C, Iwasaki M, Nakahira M, Yang Y, et al. Tumor vaccination that enhances antitumor T-cell responses does not inhibit the growth of established tumors even in combination with interleukin-12 treatment: the importance of inducing intratumoral T-cell migration. J Immunother. 2000;23:643-53 pubmed
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Martin E, Roche P, Triccas J, Britton W. DNA encoding a single mycobacterial antigen protects against leprosy infection. Vaccine. 2001;19:1391-6 pubmed
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Yamamoto N, Suzuki S, Suzuki Y, Shirai A, Nakazawa M, Suzuki M, et al. Immune response induced by airway sensitization after influenza A virus infection depends on timing of antigen exposure in mice. J Virol. 2001;75:499-505 pubmed
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Matsumoto S, Yukitake H, Kanbara H, Yamada H, Kitamura A, Yamada T. Mycobacterium bovis bacillus calmette-guérin induces protective immunity against infection by Plasmodium yoelii at blood-stage depending on shifting immunity toward Th1 type and inducing protective IgG2a after the parasite infection. Vaccine. 2000;19:779-87 pubmed
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Rolph M, Kaufmann S. Partially TAP-independent protection against Listeria monocytogenes by H2-M3-restricted CD8+ T cells. J Immunol. 2000;165:4575-80 pubmed
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Martin E, Kamath A, Triccas J, Britton W. Protection against virulent Mycobacterium avium infection following DNA vaccination with the 35-kilodalton antigen is accompanied by induction of gamma interferon-secreting CD4(+) T cells. Infect Immun. 2000;68:3090-6 pubmed
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Iwasaki M, Yu W, Uekusa Y, Nakajima C, Yang Y, Gao P, et al. Differential IL-12 responsiveness of T cells but not of NK cells from tumor-bearing mice in IL-12-responsive versus -unresponsive tumor models. Int Immunol. 2000;12:701-9 pubmed
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Issazadeh S, Abdallah K, Chitnis T, Chandraker A, Wells A, Turka L, et al. Role of passive T-cell death in chronic experimental autoimmune encephalomyelitis. J Clin Invest. 2000;105:1109-16 pubmed
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Angulo I, de las Heras F, Garcia Bustos J, Gargallo D, Munoz Fernandez M, Fresno M. Nitric oxide-producing CD11b(+)Ly-6G(Gr-1)(+)CD31(ER-MP12)(+) cells in the spleen of cyclophosphamide-treated mice: implications for T-cell responses in immunosuppressed mice. Blood. 2000;95:212-20 pubmed
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Hoshino K, Kashiwamura S, Kuribayashi K, Kodama T, Tsujimura T, Nakanishi K, et al. The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function. J Exp Med. 1999;190:1541-8 pubmed
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Lamouse Smith E, Dougall D, McCarthy S. Cytokine requirements for production of a novel anti-CD8-resistant CTL population. J Immunol. 1999;163:4160-7 pubmed
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Gonzalo J, Pan Y, Lloyd C, Jia G, Yu G, Dussault B, et al. Mouse monocyte-derived chemokine is involved in airway hyperreactivity and lung inflammation. J Immunol. 1999;163:403-11 pubmed
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Tomura M, Yu W, Ahn H, Yamashita M, Yang Y, Ono S, et al. A novel function of Valpha14+CD4+NKT cells: stimulation of IL-12 production by antigen-presenting cells in the innate immune system. J Immunol. 1999;163:93-101 pubmed
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Kamath A, Hanke T, Briscoe H, Britton W. Co-immunization with DNA vaccines expressing granulocyte-macrophage colony-stimulating factor and mycobacterial secreted proteins enhances T-cell immunity, but not protective efficacy against Mycobacterium tuberculosis. Immunology. 1999;96:511-6 pubmed
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Bean A, Roach D, Briscoe H, France M, Korner H, Sedgwick J, et al. Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin. J Immunol. 1999;162:3504-11 pubmed
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Kamath A, Feng C, Macdonald M, Briscoe H, Britton W. Differential protective efficacy of DNA vaccines expressing secreted proteins of Mycobacterium tuberculosis. Infect Immun. 1999;67:1702-7 pubmed
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Ahn H, Tomura M, Yu W, Iwasaki M, Park W, Hamaoka T, et al. Requirement for distinct Janus kinases and STAT proteins in T cell proliferation versus IFN-gamma production following IL-12 stimulation. J Immunol. 1998;161:5893-900 pubmed
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Cohn L, Tepper J, Bottomly K. IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells. J Immunol. 1998;161:3813-6 pubmed
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Wijesuriya R, Maruo S, Zou J, Ogawa M, Umehara K, Yamashita M, et al. B cell-mediated down-regulation of IFN-gamma and IL-12 production induced during anti-tumor immune responses in the tumor-bearing state. Int Immunol. 1998;10:1057-65 pubmed
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Bordmann G, Rudin W, Favre N. Immunization of mice with phosphatidylcholine drastically reduces the parasitaemia of subsequent Plasmodium chabaudi chabaudi blood-stage infections. Immunology. 1998;94:35-40 pubmed
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Jiao Y, Fujimoto S. Sequential T cell response involved in tumor rejection of sarcoma, Meth A, in syngeneic mice. Jpn J Cancer Res. 1998;89:657-65 pubmed
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Mottram P, Raisanen Sokolowski A, Glysing Jensen T, Stein Oakley A, Russell M. Cardiac allografts from IL-4 knockout recipients: assessment of transplant arteriosclerosis and peripheral tolerance. J Immunol. 1998;161:602-9 pubmed
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Targoni O, Lehmann P. Endogenous myelin basic protein inactivates the high avidity T cell repertoire. J Exp Med. 1998;187:2055-63 pubmed
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Homey B, Assmann T, Vohr H, Ulrich P, Lauerma A, Ruzicka T, et al. Topical FK506 suppresses cytokine and costimulatory molecule expression in epidermal and local draining lymph node cells during primary skin immune responses. J Immunol. 1998;160:5331-40 pubmed
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Rosendahl A, Kristensson K, Hansson J, Riesbeck K, Kalland T, Dohlsten M. Perforin and IFN-gamma are involved in the antitumor effects of antibody-targeted superantigens. J Immunol. 1998;160:5309-13 pubmed
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Tomura M, Zhou X, Maruo S, Ahn H, Hamaoka T, Okamura H, et al. A critical role for IL-18 in the proliferation and activation of NK1.1+ CD3- cells. J Immunol. 1998;160:4738-46 pubmed
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Tomura M, Maruo S, Mu J, Zhou X, Ahn H, Hamaoka T, et al. Differential capacities of CD4+, CD8+, and CD4-CD8- T cell subsets to express IL-18 receptor and produce IFN-gamma in response to IL-18. J Immunol. 1998;160:3759-65 pubmed
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Ahn H, Maruo S, Tomura M, Mu J, Hamaoka T, Nakanishi K, et al. A mechanism underlying synergy between IL-12 and IFN-gamma-inducing factor in enhanced production of IFN-gamma. J Immunol. 1997;159:2125-31 pubmed
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Williams D, Grubbs B, Pack E, Kelly K, Rank R. Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis. Infect Immun. 1997;65:2876-82 pubmed
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Bogen S, Fogelman I, Abbas A. Analysis of IL-2, IL-4, and IFN-gamma-producing cells in situ during immune responses to protein antigens. J Immunol. 1993;150:4197-205 pubmed
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Kohler J, Heumann D, Garotta G, Leroy D, Bailat S, Barras C, et al. IFN-gamma involvement in the severity of gram-negative infections in mice. J Immunol. 1993;151:916-21 pubmed
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Tobin J, Reiner S, Hatam F, Zheng S, Leptak C, Wirth D, et al. Transfected Leishmania expressing biologically active IFN-gamma. J Immunol. 1993;150:5059-69 pubmed
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Gorczynski R, Wojcik D. A role for nonspecific (cyclosporin A) or specific (monoclonal antibodies to ICAM-1, LFA-1, and IL-10) immunomodulation in the prolongation of skin allografts after antigen-specific pretransplant immunization or transfusion. J Immunol. 1994;152:2011-9 pubmed
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Morris S, Madden K, Adamovicz J, Gause W, Hubbard B, Gately M, et al. Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection. J Immunol. 1994;152:1047-56 pubmed
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Bradley L, Yoshimoto K, Swain S. The cytokines IL-4, IFN-gamma, and IL-12 regulate the development of subsets of memory effector helper T cells in vitro. J Immunol. 1995;155:1713-24 pubmed
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Taguchi T, McGhee J, Coffman R, Beagley K, Eldridge J, Takatsu K, et al. Analysis of Th1 and Th2 cells in murine gut-associated tissues. Frequencies of CD4+ and CD8+ T cells that secrete IFN-gamma and IL-5. J Immunol. 1990;145:68-77 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
IFN丙单克隆抗体(XMG1.2), 生物素
目录# :
MM700B
规格 :
250微克
价格 :
美国412
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
大鼠
反应物种 :
人类, 小鼠
应用 :
ELISA: 0.125-1.0 µg/mL, Immunohistochemistry (Frozen): Assay-dependent, Neutralization: Assay-dependent, Western Blot: 2 µg/mL
物种 :
人类, 小鼠
克隆 :
XMG1.2
抗体亚型 :
IgG1
储存 :
-20°C
描述 :
IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor, and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists, functionally, as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. Activation of IFN gamma takes place through binding of IFN gamma receptor I and II, and activating the JAK-STAT pathway. IFN gamma does not show any homology with IFN alpha or IFN beta but human IFN gamma shows about 40% sequence homology with mouse IFN gamma. IFN gamma is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. IFN gamma gene mutations are associated with aplastic anemia.
免疫原 :
重组小鼠IFN丙
格式 :
液体
应用w/稀释 :
ELISA: 0.125-1.0 µg/mL, Immunohistochemistry (Frozen): Assay-dependent, Neutralization: Assay-dependent, Western Blot: 2 µg/mL
别名 :
BoIFNG; cytokine; EGK_03901; gamma interferon; gamma interferon precursor; gamma-interferon; gamma-interferon precursor (AA -23 to 143); H-IFN-g; IFG; IFI; IFN gamma; IFN ?; Ifng; IFN-g; IFNG2; IFN-gamma; IFN-gamma precursor; IFN-y; IFN?; Immune interferon; interferon gamma; interferon gamma precursor; interferon gamma type 2; Interferon y; Interferon ?; interferon, gamma; interferon-gama; interferon-gamma; Interferon-gamma level; interferon-gamma precursor; Interferon?; M-IFN-g; R-IFN-g
更多信息或购买 :
公司信息
赛默飞世尔