产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
IFN丙单克隆抗体(R4-6A2)
目录 :
MM701
规格 :
500微克
价格 :
美国391
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
R4-6A2
反应物种 :
小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 中和反应, 流式细胞仪, 免疫组化-冰冻切片, 抑制或激活实验
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文章摘录数: 72
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| Newton M, Askeland E, Andresen E, Chehval V, Wang X, Askeland R, et al. Anti-interleukin-10R1 monoclonal antibody in combination with bacillus Calmette--Guérin is protective against bladder cancer metastasis in a murine orthotopic tumour model and demonstrates systemic specific anti-tumour immunity. Clin Exp Immunol. 2014;177:261-8 pubmed 出版商
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| Akbari O, Stock P, Meyer E, Freeman G, Sharpe A, Umetsu D, et al. ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival. J Immunol. 2008;180:5448-56 pubmed
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| Tian C, Ansari M, Paez Cortez J, Bagley J, Godwin J, Donnarumma M, et al. Induction of robust diabetes resistance and prevention of recurrent type 1 diabetes following islet transplantation by gene therapy. J Immunol. 2007;179:6762-9 pubmed
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| Hara H, Kawamura I, Nomura T, Tominaga T, Tsuchiya K, Mitsuyama M. Cytolysin-dependent escape of the bacterium from the phagosome is required but not sufficient for induction of the Th1 immune response against Listeria monocytogenes infection: distinct role of Listeriolysin O determined by cytolysin gene replacement. Infect Immun. 2007;75:3791-801 pubmed
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| Tsunetsugu Yokota Y, Ishige M, Murakami M. Oral attenuated Salmonella enterica serovar Typhimurium vaccine expressing codon-optimized HIV type 1 Gag enhanced intestinal immunity in mice. AIDS Res Hum Retroviruses. 2007;23:278-86 pubmed
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| Roach D, Briscoe H, Saunders B, Britton W. Independent protective effects for tumor necrosis factor and lymphotoxin alpha in the host response to Listeria monocytogenes infection. Infect Immun. 2005;73:4787-92 pubmed
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| Puddu P, Carollo M, Pietraforte I, Spadaro F, Tombesi M, Ramoni C, et al. IL-2 induces expression and secretion of IFN-gamma in murine peritoneal macrophages. J Leukoc Biol. 2005;78:686-95 pubmed
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| Aramaki O, Shirasugi N, Takayama T, Shimazu M, Kitajima M, Ikeda Y, et al. Programmed death-1-programmed death-L1 interaction is essential for induction of regulatory cells by intratracheal delivery of alloantigen. Transplantation. 2004;77:6-12 pubmed
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| Roach D, Bean A, Demangel C, France M, Briscoe H, Britton W. TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection. J Immunol. 2002;168:4620-7 pubmed
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Guzik T, Hoch N, Brown K, McCann L, Rahman A, Dikalov S, et al. Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. J Exp Med. 2007;204:2449-60 pubmed
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Michel M, Keller A, Paget C, Fujio M, Trottein F, Savage P, et al. Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia. J Exp Med. 2007;204:995-1001 pubmed
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Liang S, Tan X, Luxenberg D, Karim R, Dunussi Joannopoulos K, Collins M, et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med. 2006;203:2271-9 pubmed
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Boyman O, Cho J, Tan J, Surh C, Sprent J. A major histocompatibility complex class I-dependent subset of memory phenotype CD8+ cells. J Exp Med. 2006;203:1817-25 pubmed
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Saunders B, Briscoe H, Britton W. T cell-derived tumour necrosis factor is essential, but not sufficient, for protection against Mycobacterium tuberculosis infection. Clin Exp Immunol. 2004;137:279-87 pubmed
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Luo Y, Yamada H, Chen X, Ryan A, Evanoff D, Triccas J, et al. Recombinant Mycobacterium bovis bacillus Calmette-Guérin (BCG) expressing mouse IL-18 augments Th1 immunity and macrophage cytotoxicity. Clin Exp Immunol. 2004;137:24-34 pubmed
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Chaudhri G, Panchanathan V, Buller R, van den Eertwegh A, Claassen E, Zhou J, et al. Polarized type 1 cytokine response and cell-mediated immunity determine genetic resistance to mousepox. Proc Natl Acad Sci U S A. 2004;101:9057-62 pubmed
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Antúnez M, Cardoni R. Trypanosoma cruzi: the expansion of NK, T, and NKT cells in the experimental infection. Exp Parasitol. 2004;106:85-94 pubmed
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Tokoyoda K, Tsujikawa K, Matsushita H, Ono Y, Hayashi T, Harada Y, et al. Up-regulation of IL-4 production by the activated cAMP/cAMP-dependent protein kinase (protein kinase A) pathway in CD3/CD28-stimulated naive T cells. Int Immunol. 2004;16:643-53 pubmed
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Matsuura M, Saito S, Hirai Y, Okamura H. A pathway through interferon-gamma is the main pathway for induction of nitric oxide upon stimulation with bacterial lipopolysaccharide in mouse peritoneal cells. Eur J Biochem. 2003;270:4016-25 pubmed
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Yoshizawa I, Mizuochi T, Ogata A, Murakami M, Yagita H, Takahashi Y, et al. Studies on the generation and maintenance of mucosal cytotoxic T lymphocytes against human immunodeficiency virus type 1 Gag in mice. AIDS Res Hum Retroviruses. 2003;19:469-79 pubmed
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Hufnagl K, Wagner B, Winkler B, Baier K, Hochreiter R, Thalhamer J, et al. Induction of mucosal tolerance with recombinant Hev b 1 and recombinant Hev b 3 for prevention of latex allergy in BALB/c mice. Clin Exp Immunol. 2003;133:170-6 pubmed
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Lang T, Courret N, Colle J, Milon G, Antoine J. The levels and patterns of cytokines produced by CD4 T lymphocytes of BALB/c mice infected with Leishmania major by inoculation into the ear dermis depend on the infectiousness and size of the inoculum. Infect Immun. 2003;71:2674-83 pubmed
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Hill H, Conway T, Sabel M, Jong Y, Mathiowitz E, Bankert R, et al. Cancer immunotherapy with interleukin 12 and granulocyte-macrophage colony-stimulating factor-encapsulated microspheres: coinduction of innate and adaptive antitumor immunity and cure of disseminated disease. Cancer Res. 2002;62:7254-63 pubmed
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Hess S, Egilmez N, Bailey N, Anderson T, Mathiowitz E, Bernstein S, et al. Human CD4+ T cells present within the microenvironment of human lung tumors are mobilized by the local and sustained release of IL-12 to kill tumors in situ by indirect effects of IFN-gamma. J Immunol. 2003;170:400-12 pubmed
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Kohda C, Kawamura I, Baba H, Nomura T, Ito Y, Kimoto T, et al. Dissociated linkage of cytokine-inducing activity and cytotoxicity to different domains of listeriolysin O from Listeria monocytogenes. Infect Immun. 2002;70:1334-41 pubmed
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Smith R, Harris S, Phipps R, Iglewski B. The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)homoserine lactone contributes to virulence and induces inflammation in vivo. J Bacteriol. 2002;184:1132-9 pubmed
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Chitnis T, Najafian N, Benou C, Salama A, Grusby M, Sayegh M, et al. Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J Clin Invest. 2001;108:739-47 pubmed
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Jyonouchi H, Sun S, Winship T, Kuchan M. Dietary ribonucleotides modulate type 1 and type 2 T-helper cell responses against ovalbumin in young BALB/cJ mice. J Nutr. 2001;131:1165-70 pubmed
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Chitnis T, Najafian N, Abdallah K, Dong V, Yagita H, Sayegh M, et al. CD28-independent induction of experimental autoimmune encephalomyelitis. J Clin Invest. 2001;107:575-83 pubmed
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Martin E, Roche P, Triccas J, Britton W. DNA encoding a single mycobacterial antigen protects against leprosy infection. Vaccine. 2001;19:1391-6 pubmed
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Yamamoto N, Suzuki S, Suzuki Y, Shirai A, Nakazawa M, Suzuki M, et al. Immune response induced by airway sensitization after influenza A virus infection depends on timing of antigen exposure in mice. J Virol. 2001;75:499-505 pubmed
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Rolph M, Kaufmann S. Partially TAP-independent protection against Listeria monocytogenes by H2-M3-restricted CD8+ T cells. J Immunol. 2000;165:4575-80 pubmed
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Martin E, Kamath A, Triccas J, Britton W. Protection against virulent Mycobacterium avium infection following DNA vaccination with the 35-kilodalton antigen is accompanied by induction of gamma interferon-secreting CD4(+) T cells. Infect Immun. 2000;68:3090-6 pubmed
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Kamath A, Hanke T, Briscoe H, Britton W. Co-immunization with DNA vaccines expressing granulocyte-macrophage colony-stimulating factor and mycobacterial secreted proteins enhances T-cell immunity, but not protective efficacy against Mycobacterium tuberculosis. Immunology. 1999;96:511-6 pubmed
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Bean A, Roach D, Briscoe H, France M, Korner H, Sedgwick J, et al. Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin. J Immunol. 1999;162:3504-11 pubmed
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Kamath A, Feng C, Macdonald M, Briscoe H, Britton W. Differential protective efficacy of DNA vaccines expressing secreted proteins of Mycobacterium tuberculosis. Infect Immun. 1999;67:1702-7 pubmed
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Assenmacher M, Lohning M, Scheffold A, Richter A, Miltenyi S, Schmitz J, et al. Commitment of individual Th1-like lymphocytes to expression of IFN-gamma versus IL-4 and IL-10: selective induction of IL-10 by sequential stimulation of naive Th cells with IL-12 and IL-4. J Immunol. 1998;161:2825-32 pubmed
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Bordmann G, Rudin W, Favre N. Immunization of mice with phosphatidylcholine drastically reduces the parasitaemia of subsequent Plasmodium chabaudi chabaudi blood-stage infections. Immunology. 1998;94:35-40 pubmed
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Targoni O, Lehmann P. Endogenous myelin basic protein inactivates the high avidity T cell repertoire. J Exp Med. 1998;187:2055-63 pubmed
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Miner K, Croft M. Generation, persistence, and modulation of Th0 effector cells: role of autocrine IL-4 and IFN-gamma. J Immunol. 1998;160:5280-7 pubmed
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Flamand V, Donckier V, Demoor F, Le Moine A, Matthys P, Vanderhaeghen M, et al. CD40 ligation prevents neonatal induction of transplantation tolerance. J Immunol. 1998;160:4666-9 pubmed
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Tsung K, Meko J, Tsung Y, Peplinski G, Norton J. Immune response against large tumors eradicated by treatment with cyclophosphamide and IL-12. J Immunol. 1998;160:1369-77 pubmed
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Chu R, Targoni O, Krieg A, Lehmann P, Harding C. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J Exp Med. 1997;186:1623-31 pubmed
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Williams D, Grubbs B, Pack E, Kelly K, Rank R. Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis. Infect Immun. 1997;65:2876-82 pubmed
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Pearlman E, Kazura J, Hazlett F, Boom W. Modulation of murine cytokine responses to mycobacterial antigens by helminth-induced T helper 2 cell responses. J Immunol. 1993;151:4857-64 pubmed
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Morris S, Madden K, Adamovicz J, Gause W, Hubbard B, Gately M, et al. Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection. J Immunol. 1994;152:1047-56 pubmed
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Taguchi T, McGhee J, Coffman R, Beagley K, Eldridge J, Takatsu K, et al. Analysis of Th1 and Th2 cells in murine gut-associated tissues. Frequencies of CD4+ and CD8+ T cells that secrete IFN-gamma and IL-5. J Immunol. 1990;145:68-77 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
IFN丙单克隆抗体(R4-6A2)
目录# :
MM701
规格 :
500微克
价格 :
美国391
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
大鼠
反应物种 :
小鼠
应用 :
ELISA: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Neutralization: Assay-dependent, Western Blot: Assay-dependent
物种 :
小鼠
克隆 :
R4-6A2
抗体亚型 :
IgG1
储存 :
-20°C
描述 :
IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor, and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists, functionally, as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. Activation of IFN gamma takes place through binding of IFN gamma receptor I and II, and activating the JAK-STAT pathway. IFN gamma does not show any homology with IFN alpha or IFN beta but human IFN gamma shows about 40% sequence homology with mouse IFN gamma. IFN gamma is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. IFN gamma gene mutations are associated with aplastic anemia.
免疫原 :
重组小鼠IFN丙
格式 :
液体
应用w/稀释 :
ELISA: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Neutralization: Assay-dependent, Western Blot: Assay-dependent
别名 :
BoIFNG; cytokine; EGK_03901; gamma interferon; gamma interferon precursor; gamma-interferon; gamma-interferon precursor (AA -23 to 143); H-IFN-g; IFG; IFI; IFN gamma; IFN ?; Ifng; IFN-g; IFNG2; IFN-gamma; IFN-gamma precursor; IFN-y; IFN?; Immune interferon; interferon gamma; interferon gamma precursor; interferon gamma type 2; Interferon y; Interferon ?; interferon, gamma; interferon-gama; interferon-gamma; Interferon-gamma level; interferon-gamma precursor; Interferon?; M-IFN-g; R-IFN-g
更多信息或购买 :
公司信息
赛默飞世尔