产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Tau Monoclonal Antibody (HT7)
目录 :
MN1000
规格 :
100µg
价格 :
美国330.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
HT7
反应物种 :
African green monkey, 人类, 小鼠, 大鼠,
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, immunohistochemistry - free floating section, 抑制或激活实验, 免疫印迹基因敲除验证, 免疫组化基因敲除验证
更多信息或购买 :
文章摘录数: 140
出版应用/物种/样品/稀释参考文献
  • immunohistochemistry - free floating section; 小鼠; 1:1000; 图 1a
  • 免疫印迹; 小鼠; 1:1000; 图 5g
Baglietto Vargas D, Prieto G, Limon A, Forner S, Rodriguez Ortiz C, Ikemura K, et al. Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease. Aging Cell. 2018;:e12791 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 1:1000; 表 1
  • 免疫细胞化学; 人类; 1:100; 表 2
  • 免疫印迹; 小鼠
Ercan E, Eid S, Weber C, Kowalski A, Bichmann M, Behrendt A, et al. A validated antibody panel for the characterization of tau post-translational modifications. Mol Neurodegener. 2017;12:87 pubmed 出版商
  • 酶联免疫吸附测定; 小鼠; 图 2a
Nobuhara C, DeVos S, Commins C, Wegmann S, Moore B, Roe A, et al. Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro. Am J Pathol. 2017;187:1399-1412 pubmed 出版商
  • 免疫组化; 小鼠; 图 4c
  • 免疫印迹; 小鼠; 图 4a
Li J, Barrero C, Merali S, Pratico D. Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype. Sci Rep. 2017;7:46002 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3i
Zhang Z, Obianyo O, Dall E, Du Y, Fu H, Liu X, et al. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun. 2017;8:14740 pubmed 出版商
  • 免疫印迹; 人类; 0.2 ug/ml; 图 1b
Bodea L, Evans H, Van der Jeugd A, Ittner L, Delerue F, Kril J, et al. Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model. Aging Cell. 2017;16:377-386 pubmed 出版商
  • 免疫细胞化学; 人类; 图 s2a
  • 免疫印迹; 人类; 图 s1
McEwan W, Falcon B, Vaysburd M, Clift D, Oblak A, Ghetti B, et al. Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation. Proc Natl Acad Sci U S A. 2017;114:574-579 pubmed 出版商
  • 免疫印迹; 小鼠
Laurent C, Dorothee G, Hunot S, Martin E, Monnet Y, Duchamp M, et al. Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy. Brain. 2017;140:184-200 pubmed 出版商
  • 免疫组化; 小鼠; 1:300; 图 3c
  • 免疫印迹; 小鼠; 1:200; 图 3a
di Meco A, Li J, Blass B, Abou Gharbia M, Lauretti E, Praticò D. 12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice. Biol Psychiatry. 2017;81:92-100 pubmed 出版商
  • 免疫组化基因敲除验证; 人类; 图 2
  • 免疫组化-石蜡切片; 人类; 图 2
Fernández Nogales M, Santos Galindo M, Merchán Rubira J, Hoozemans J, Rábano A, Ferrer I, et al. Tau-positive nuclear indentations in P301S tauopathy mice. Brain Pathol. 2017;27:314-322 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 5
Cabrera J, Lucas J. MAP2 Splicing is Altered in Huntington's Disease. Brain Pathol. 2017;27:181-189 pubmed 出版商
  • 免疫印迹; 人类; 图 s2
García Ayllón M, Botella López A, Cuchillo Ibañez I, Rábano A, Andreasen N, Blennow K, et al. HNK-1 Carrier Glycoproteins Are Decreased in the Alzheimer's Disease Brain. Mol Neurobiol. 2017;54:188-199 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000; 图 3d
Kuan W, Bennett N, He X, Skepper J, Martynyuk N, Wijeyekoon R, et al. ?-Synuclein pre-formed fibrils impair tight junction protein expression without affecting cerebral endothelial cell function. Exp Neurol. 2016;285:72-81 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Yoshitake J, Soeda Y, Ida T, Sumioka A, Yoshikawa M, Matsushita K, et al. Modification of Tau by 8-Nitroguanosine 3',5'-Cyclic Monophosphate (8-Nitro-cGMP): EFFECTS OF NITRIC OXIDE-LINKED CHEMICAL MODIFICATION ON TAU AGGREGATION. J Biol Chem. 2016;291:22714-22720 pubmed
  • 免疫印迹; 大鼠; 1:1000; 图 7
Steffen J, Krohn M, Paarmann K, Schwitlick C, Brüning T, Marreiros R, et al. Revisiting rodent models: Octodon degus as Alzheimer's disease model?. Acta Neuropathol Commun. 2016;4:91 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3
Kim H, Lee K, Kim A, Choi M, Choi K, Kang M, et al. A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition. Dis Model Mech. 2016;9:839-48 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:1000; 图 1a
  • 免疫细胞化学; 人类; 图 4b
  • 免疫印迹; 人类; 图 1c
Lee S, Le Pichon C, Adolfsson O, Gafner V, Pihlgren M, Lin H, et al. Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement. Cell Rep. 2016;16:1690-1700 pubmed 出版商
  • 免疫印迹; 小鼠; 1:3000; 图 6
Velázquez R, Shaw D, Caccamo A, Oddo S. Pim1 inhibition as a novel therapeutic strategy for Alzheimer's disease. Mol Neurodegener. 2016;11:52 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Sohn P, Tracy T, Son H, Zhou Y, Leite R, Miller B, et al. Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment. Mol Neurodegener. 2016;11:47 pubmed 出版商
  • 抑制或激活实验; 人类; 图 3
Takeda S, Commins C, DeVos S, Nobuhara C, Wegmann S, Roe A, et al. Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients. Ann Neurol. 2016;80:355-67 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1
Yin Y, Gao D, Wang Y, Wang Z, Wang X, Ye J, et al. Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling. Proc Natl Acad Sci U S A. 2016;113:E3773-81 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 1
Yin Y, Wang Y, Gao D, Ye J, Wang X, Fang L, et al. Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2. Sci Rep. 2016;6:27283 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 4
Gorsky M, Burnouf S, Dols J, Mandelkow E, Partridge L. Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo. Sci Rep. 2016;6:22685 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 1
Gurdziel K, Vogt K, Walton K, Schneider G, Gumucio D. Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016;245:614-26 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:500; 图 1
Van der Jeugd A, Vermaercke B, Halliday G, Staufenbiel M, Götz J. Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia. Neurobiol Learn Mem. 2016;130:34-43 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 1
Platt T, Beckett T, Kohler K, Niedowicz D, Murphy M. Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease. Neuroscience. 2016;315:162-74 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3
Müller Schiffmann A, Herring A, Abdel Hafiz L, Chepkova A, Schäble S, Wedel D, et al. Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity. Brain. 2016;139:509-25 pubmed 出版商
  • 免疫印迹; 小鼠; 1:200; 图 3
Di Meco A, Joshi Y, Lauretti E, Praticò D. Maternal dexamethasone exposure ameliorates cognition and tau pathology in the offspring of triple transgenic AD mice. Mol Psychiatry. 2016;21:403-10 pubmed 出版商
  • 免疫印迹; 人类; 1:3000
Guerreiro P, Gerhardt E, Lopes da Fonseca T, Bähr M, Outeiro T, Eckermann K. LRRK2 Promotes Tau Accumulation, Aggregation and Release. Mol Neurobiol. 2016;53:3124-3135 pubmed 出版商
  • 免疫印迹; 人类; 1:3000; 图 5
Caccamo A, Branca C, Talboom J, Shaw D, Turner D, Ma L, et al. Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease. J Neurosci. 2015;35:14042-56 pubmed 出版商
  • 免疫印迹; 人类; 1:5000; 图 3
Wagner J, Krauss S, Shi S, Ryazanov S, Steffen J, Miklitz C, et al. Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies. Acta Neuropathol. 2015;130:619-31 pubmed 出版商
  • 免疫组化; 小鼠; 1:500; 图 1
  • 免疫印迹; 小鼠; 1:500; 图 5
Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, et al. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015;18:1584-93 pubmed 出版商
  • immunohistochemistry - free floating section; 小鼠; 图 2
Min S, Chen X, Tracy T, Li Y, Zhou Y, Wang C, et al. Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. Nat Med. 2015;21:1154-62 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:500; 图 1,2,3
Brelstaff J, Ossola B, Neher J, Klingstedt T, Nilsson K, Goedert M, et al. The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice. Front Neurosci. 2015;9:184 pubmed 出版商
  • 酶联免疫吸附测定; 人类; 1-2.5 ug/ml
Sankaranarayanan S, Barten D, Vana L, Devidze N, Yang L, Cadelina G, et al. Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models. PLoS ONE. 2015;10:e0125614 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Song L, Lu S, Ouyang X, Melchor J, Lee J, Terracina G, et al. Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology. Mol Neurodegener. 2015;10:14 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:100
  • 免疫印迹; 小鼠; 1:200
Lauretti E, di Meco A, Chu J, Praticò D. Modulation of AD neuropathology and memory impairments by the isoprostane F2α is mediated by the thromboxane receptor. Neurobiol Aging. 2015;36:812-20 pubmed 出版商
  • 免疫细胞化学; 人类; 1:500; 图 6
  • 免疫印迹; 人类; 1:2500; 图 4
Falcon B, Cavallini A, Angers R, Glover S, Murray T, Barnham L, et al. Conformation determines the seeding potencies of native and recombinant Tau aggregates. J Biol Chem. 2015;290:1049-65 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000
  • 免疫印迹; 人类; 1:5000
Saidi L, Polydoro M, Kay K, Sanchez L, Mandelkow E, Hyman B, et al. Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes. J Alzheimers Dis. 2015;44:937-47 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Dunn H, Ager R, Baglietto Vargas D, Cheng D, Kitazawa M, Cribbs D, et al. Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model. J Alzheimers Dis. 2015;43:893-903 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Xu H, Rösler T, Carlsson T, de Andrade A, Fiala O, Höllerhage M, et al. Tau silencing by siRNA in the P301S mouse model of tauopathy. Curr Gene Ther. 2014;14:343-51 pubmed
  • 免疫印迹; 小鼠; 1:1000
Höllerhage M, Deck R, de Andrade A, Respondek G, Xu H, Rösler T, et al. Piericidin A aggravates Tau pathology in P301S transgenic mice. PLoS ONE. 2014;9:e113557 pubmed 出版商
  • 免疫印迹; 小鼠
Hu X, Li X, Zhao M, Gottesdiener A, Luo W, Paul S. Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40. Mol Neurodegener. 2014;9:52 pubmed 出版商
  • 免疫印迹; 人类
Zhou Y, Hayashi I, Wong J, Tugusheva K, Renger J, Zerbinatti C. Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease. PLoS ONE. 2014;9:e103187 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200
Fernández Nogales M, Cabrera J, Santos Galindo M, Hoozemans J, Ferrer I, Rozemuller A, et al. Huntington's disease is a four-repeat tauopathy with tau nuclear rods. Nat Med. 2014;20:881-5 pubmed 出版商
  • 免疫印迹; 人类; 1:2000
Xia D, Götz J. Premature lethality, hyperactivity, and aberrant phosphorylation in transgenic mice expressing a constitutively active form of Fyn. Front Mol Neurosci. 2014;7:40 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500
Shilling D, Müller M, Takano H, Mak D, Abel T, Coulter D, et al. Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis. J Neurosci. 2014;34:6910-23 pubmed 出版商
  • 免疫印迹; 人类
Maurin H, Lechat B, Borghgraef P, Devijver H, Jaworski T, Van Leuven F. Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3?/?. Eur J Neurosci. 2014;40:2442-53 pubmed 出版商
  • 免疫组化; 小鼠; 1:400
  • 酶联免疫吸附测定; 小鼠; 1:1000
Castillo Carranza D, Sengupta U, Guerrero Muñoz M, Lasagna Reeves C, Gerson J, Singh G, et al. Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles. J Neurosci. 2014;34:4260-72 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类
Li J, Chu J, Barrero C, Merali S, Pratico D. Homocysteine exacerbates ?-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles. Ann Neurol. 2014;75:851-63 pubmed 出版商
  • 免疫印迹; 小鼠; 1:200
di Meco A, Joshi Y, Pratico D. Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles. Neurobiol Aging. 2014;35:1813-20 pubmed 出版商
  • 免疫组化; 小鼠; 1:200
Choi B, Cho W, Kim J, Lee H, Chung C, Jeon W, et al. Increased expression of the receptor for advanced glycation end products in neurons and astrocytes in a triple transgenic mouse model of Alzheimer's disease. Exp Mol Med. 2014;46:e75 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类
Chabrier M, Cheng D, Castello N, Green K, LaFerla F. Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease. Neurobiol Dis. 2014;64:107-17 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Orr M, Salinas A, Buffenstein R, Oddo S. Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology. Neurobiol Aging. 2014;35:1233-42 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Yamada E, Respondek G, Müssner S, de Andrade A, Höllerhage M, Depienne C, et al. Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice. Exp Neurol. 2014;253:113-25 pubmed 出版商
  • 免疫沉淀; 小鼠
  • 免疫组化; 小鼠
  • 免疫印迹; 小鼠
Borghgraef P, Menuet C, Theunis C, Louis J, Devijver H, Maurin H, et al. Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice. PLoS ONE. 2013;8:e84442 pubmed 出版商
  • 免疫沉淀; 小鼠
Graham D, Gray A, Joyce J, Yu D, O Moore J, Carlson G, et al. Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy. Neuropharmacology. 2014;79:307-13 pubmed 出版商
  • immunohistochemistry - free floating section; 小鼠
  • 免疫印迹; 小鼠
Medeiros R, Castello N, Cheng D, Kitazawa M, Baglietto Vargas D, Green K, et al. ?7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles. Am J Pathol. 2014;184:520-9 pubmed 出版商
  • 免疫组化; 小鼠; 1:1000
  • 免疫印迹; 小鼠; 1:1000
Rice R, Berchtold N, Cotman C, Green K. Age-related downregulation of the CaV3.1 T-type calcium channel as a mediator of amyloid beta production. Neurobiol Aging. 2014;35:1002-11 pubmed 出版商
  • 免疫印迹; 人类; 1:5000
Baglietto Vargas D, Kitazawa M, Le E, Estrada Hernandez T, Rodriguez Ortiz C, Medeiros R, et al. Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition. Neurobiol Dis. 2014;62:407-15 pubmed 出版商
  • 酶联免疫吸附测定; 人类; 2.5 ug/ml
Meredith J, Sankaranarayanan S, Guss V, Lanzetti A, Berisha F, Neely R, et al. Characterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease. PLoS ONE. 2013;8:e76523 pubmed 出版商
  • 免疫印迹; 人类; 1:50000
Cameron A, Giacomozzi B, Joyce J, Gray A, Graham D, Ousson S, et al. Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400. FEBS Lett. 2013;587:3722-8 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:300
  • 免疫细胞化学; 小鼠; 1:300
  • 免疫组化; 小鼠; 1:300
Pristerà A, Saraulli D, Farioli Vecchioli S, Strimpakos G, Costanzi M, Di Certo M, et al. Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory. Neurobiol Aging. 2013;34:2551-63 pubmed 出版商
  • 免疫组化; 小鼠
Maurin H, Seymour C, Lechat B, Borghgraef P, Devijver H, Jaworski T, et al. Tauopathy differentially affects cell adhesion molecules in mouse brain: early down-regulation of nectin-3 in stratum lacunosum moleculare. PLoS ONE. 2013;8:e63589 pubmed 出版商
  • 免疫印迹; 人类
Roher A, Cribbs D, Kim R, Maarouf C, Whiteside C, Kokjohn T, et al. Bapineuzumab alters a? composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapy. PLoS ONE. 2013;8:e59735 pubmed 出版商
  • 免疫印迹; 人类
Ozdemir A, Rom I, Kovalevich J, Yen W, Adiga R, Dave R, et al. PINCH in the cellular stress response to tau-hyperphosphorylation. PLoS ONE. 2013;8:e58232 pubmed 出版商
  • 免疫印迹; 小鼠
Nash K, Lee D, Hunt J, Morganti J, Selenica M, Moran P, et al. Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy. Neurobiol Aging. 2013;34:1540-8 pubmed 出版商
  • 免疫印迹; 小鼠; 1:5000
Baglietto Vargas D, Medeiros R, Martinez Coria H, LaFerla F, Green K. Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology. Biol Psychiatry. 2013;74:357-66 pubmed 出版商
  • 免疫印迹; 小鼠; 1:40,000; 表 1
  • 免疫印迹; 人类; 1:40000
Kohler C, Dinekov M, Götz J. Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice. Neurobiol Aging. 2013;34:1369-79 pubmed 出版商
  • 免疫印迹; 人类
Kokjohn T, Maarouf C, Daugs I, Hunter J, Whiteside C, Malek Ahmadi M, et al. Neurochemical profile of dementia pugilistica. J Neurotrauma. 2013;30:981-97 pubmed 出版商
  • 免疫组化; 小鼠; 1:400
Morcinek K, Kohler C, Götz J, Schröder H. Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice. Brain Res. 2013;1497:73-84 pubmed 出版商
  • 免疫组化; 小鼠; 1:1000
ATTAR A, Ripoli C, Riccardi E, Maiti P, Li Puma D, Liu T, et al. Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers. Brain. 2012;135:3735-48 pubmed 出版商
  • 酶联免疫吸附测定; 人类
Lund H, Cowburn R, Gustafsson E, Strömberg K, Svensson A, Dahllund L, et al. Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brain. Brain Pathol. 2013;23:378-89 pubmed 出版商
  • 免疫组化; 小鼠
  • 免疫印迹; 小鼠
Kopeikina K, Polydoro M, Tai H, Yaeger E, Carlson G, Pitstick R, et al. Synaptic alterations in the rTg4510 mouse model of tauopathy. J Comp Neurol. 2013;521:1334-53 pubmed 出版商
  • 免疫组化; 人类; 1:1000
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产品信息
产品类型 :
抗体
产品名称 :
Tau Monoclonal Antibody (HT7)
目录# :
MN1000
规格 :
100µg
价格 :
美国330.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
牛, 人类
应用 :
ELISA: Assay Dependent, Immunocytochemistry: 1:500-1:2000, Immunofluorescence: 1:500-1:2000, Immunohistochemistry (Paraffin): 1:500-1:2000, Western Blot: 1:200-1:2000
物种 :
牛, 人类
克隆 :
HT7
抗体亚型 :
IgG1, kappa
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclindependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
免疫原 :
Purified human Tau, epitope human Tau between residue 159 and 163 (numbering according to human Tau40), corresponding to the amino acid sequence PPGQK.
格式 :
Liquid
应用w/稀释 :
ELISA: Assay Dependent, Immunocytochemistry: 1:500-1:2000, Immunofluorescence: 1:500-1:2000, Immunohistochemistry (Paraffin): 1:500-1:2000, Western Blot: 1:200-1:2000
别名 :
G protein beta1/gamma2 subunit-interacting factor 1; PHF-tau; neurofibrillary tangle protein; paired helical filament-tau
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
www.thermo.com.cn
1084193588
公司总部: 美国