| 出版应用/物种/样本/稀释 | 参考文献 |
|---|
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- 免疫组化-自由浮动切片; 小鼠; 1:250; 图 5a
- 免疫组化-石蜡切片; 小鼠; 1:250; 图 5a
- 免疫印迹; 小鼠; 1:2000; 图 5b
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- 免疫组化; 小鼠; 1:400
- 酶联免疫吸附测定; 小鼠; 1:1000
| Castillo Carranza D, Sengupta U, Guerrero Muñoz M, Lasagna Reeves C, Gerson J, Singh G, et al. Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles. J Neurosci. 2014;34:4260-72 pubmed 出版商 |
| di Meco A, Joshi Y, Pratico D. Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles. Neurobiol Aging. 2014;35:1813-20 pubmed 出版商 |
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| Orr M, Salinas A, Buffenstein R, Oddo S. Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology. Neurobiol Aging. 2014;35:1233-42 pubmed 出版商 |
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| Borghgraef P, Menuet C, Theunis C, Louis J, Devijver H, Maurin H, et al. Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice. PLoS ONE. 2013;8:e84442 pubmed 出版商 |
| Hoffmann N, Dorostkar M, Blumenstock S, Goedert M, Herms J. Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice. Acta Neuropathol Commun. 2013;1:82 pubmed 出版商 |
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- 免疫印迹; 小鼠; 1:1000
| Rice R, Berchtold N, Cotman C, Green K. Age-related downregulation of the CaV3.1 T-type calcium channel as a mediator of amyloid beta production. Neurobiol Aging. 2014;35:1002-11 pubmed 出版商 |
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- 免疫组化; 小鼠; 1:300
| Pristerà A, Saraulli D, Farioli Vecchioli S, Strimpakos G, Costanzi M, Di Certo M, et al. Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory. Neurobiol Aging. 2013;34:2551-63 pubmed 出版商 |
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| Nash K, Lee D, Hunt J, Morganti J, Selenica M, Moran P, et al. Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy. Neurobiol Aging. 2013;34:1540-8 pubmed 出版商 |
| Baglietto Vargas D, Medeiros R, Martinez Coria H, LaFerla F, Green K. Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology. Biol Psychiatry. 2013;74:357-66 pubmed 出版商 |
| Kohler C, Dinekov M, Götz J. Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice. Neurobiol Aging. 2013;34:1369-79 pubmed 出版商 |
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| Harris J, Koyama A, Maeda S, Ho K, Devidze N, Dubal D, et al. Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits. PLoS ONE. 2012;7:e45881 pubmed 出版商 |
| Flunkert S, Hierzer M, Löffler T, Rabl R, Neddens J, Duller S, et al. Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model. Neurodegener Dis. 2013;11:194-205 pubmed 出版商 |
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| Medeiros R, Kitazawa M, Chabrier M, Cheng D, Baglietto Vargas D, Kling A, et al. Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice. Am J Pathol. 2012;181:616-25 pubmed 出版商 |
- 免疫印迹; African green monkey
| Matsushima T, Saito Y, Elliott J, Iijima Ando K, Nishimura M, Kimura N, et al. Membrane-microdomain localization of amyloid ?-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue. J Biol Chem. 2012;287:19715-24 pubmed 出版商 |
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| Clausen A, Xu X, Bi X, Baudry M. Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline. J Alzheimers Dis. 2012;30:183-208 pubmed 出版商 |
- 免疫组化; 小鼠; 1:1000
- 免疫印迹; 小鼠; 1:5000
| de Calignon A, Polydoro M, Suarez Calvet M, William C, Adamowicz D, Kopeikina K, et al. Propagation of tau pathology in a model of early Alzheimer's disease. Neuron. 2012;73:685-97 pubmed 出版商 |
| Kawakami F, Yabata T, Ohta E, Maekawa T, Shimada N, Suzuki M, et al. LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth. PLoS ONE. 2012;7:e30834 pubmed 出版商 |
| Burnouf S, Belarbi K, Troquier L, Derisbourg M, Demeyer D, Leboucher A, et al. Hippocampal BDNF expression in a tau transgenic mouse model. Curr Alzheimer Res. 2012;9:406-10 pubmed |
| Takahashi M, Chin Y, Nonaka T, Hasegawa M, Watanabe N, Arai T. Prolonged nitric oxide treatment induces tau aggregation in SH-SY5Y cells. Neurosci Lett. 2012;510:48-52 pubmed 出版商 |
| Kitazawa M, Cheng D, Tsukamoto M, Koike M, Wes P, Vasilevko V, et al. Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal ?-catenin pathway function in an Alzheimer's disease model. J Immunol. 2011;187:6539-49 pubmed 出版商 |
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| Khandelwal P, Dumanis S, Herman A, Rebeck G, Moussa C. Wild type and P301L mutant Tau promote neuro-inflammation and ?-Synuclein accumulation in lentiviral gene delivery models. Mol Cell Neurosci. 2012;49:44-53 pubmed 出版商 |
| Gong E, Park H, Kim M, Piao S, Lee E, Jo D, et al. Morin attenuates tau hyperphosphorylation by inhibiting GSK3β. Neurobiol Dis. 2011;44:223-30 pubmed 出版商 |
- 免疫组化; 小鼠; 1:3000
- 免疫印迹; 小鼠; 1:3000
| Tang J, Mardini F, Caltagarone B, Garrity S, Li R, Bianchi S, et al. Anesthesia in presymptomatic Alzheimer's disease: a study using the triple-transgenic mouse model. Alzheimers Dement. 2011;7:521-531.e1 pubmed 出版商 |
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| Medeiros R, Kitazawa M, Caccamo A, Baglietto Vargas D, Estrada Hernandez T, Cribbs D, et al. Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline. Am J Pathol. 2011;179:980-91 pubmed 出版商 |
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| Coffman K, Brodney M, Cook J, Lanyon L, Pandit J, Sakya S, et al. 6-amino-4-(pyrimidin-4-yl)pyridones: novel glycogen synthase kinase-3? inhibitors. Bioorg Med Chem Lett. 2011;21:1429-33 pubmed 出版商 |
| Ksiezak Reding H, Ho L, Santa Maria I, Díaz Ruiz C, Wang J, Pasinetti G. Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols. Neurobiol Aging. 2012;33:1427-39 pubmed 出版商 |
| Van der Jeugd A, Ahmed T, Burnouf S, Belarbi K, Hamdame M, Grosjean M, et al. Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission. Neurobiol Learn Mem. 2011;95:296-304 pubmed 出版商 |
| Sultan A, Nesslany F, Violet M, Bégard S, Loyens A, Talahari S, et al. Nuclear tau, a key player in neuronal DNA protection. J Biol Chem. 2011;286:4566-75 pubmed 出版商 |
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- 免疫组化; 人类; 1:3000
- 免疫印迹; 人类; 1:3000
| Medina D, Caccamo A, Oddo S. Methylene blue reduces a? levels and rescues early cognitive deficit by increasing proteasome activity. Brain Pathol. 2011;21:140-9 pubmed 出版商 |
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- 免疫印迹; 人类; 1:1000
| Hamilton L, Aumont A, Julien C, Vadnais A, Calon F, Fernandes K. Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer's disease. Eur J Neurosci. 2010;32:905-20 pubmed 出版商 |
| Desai M, Mastrangelo M, Ryan D, Sudol K, Narrow W, Bowers W. Early oligodendrocyte/myelin pathology in Alzheimer's disease mice constitutes a novel therapeutic target. Am J Pathol. 2010;177:1422-35 pubmed 出版商 |
| Larionov S, Wielgat P, Wang Y, Thal D, Neumann H. Spatially pathogenic forms of tau detected in Alzheimer's disease brain tissue by fluorescence lifetime-based Förster resonance energy transfer. J Neurosci Methods. 2010;192:127-37 pubmed 出版商 |
| Ittner L, Ke Y, Delerue F, Bi M, Gladbach A, van Eersel J, et al. Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell. 2010;142:387-97 pubmed 出版商 |
- 流式细胞仪; 人类
- 免疫细胞化学; 人类
- 免疫印迹; 人类
| van Eersel J, Ke Y, Liu X, Delerue F, Kril J, Götz J, et al. Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proc Natl Acad Sci U S A. 2010;107:13888-93 pubmed 出版商 |
| Li Y, Duffy K, Ottinger M, Ray B, Bailey J, Holloway H, et al. GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease. J Alzheimers Dis. 2010;19:1205-19 pubmed 出版商 |
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- 免疫细胞化学; 人类; 1:200
- 免疫印迹; 人类
- 免疫细胞化学; 小鼠; 1:200
- 免疫印迹; 小鼠
| Vale C, Alonso E, Rubiolo J, Vieytes M, LaFerla F, Gimenez Llort L, et al. Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice. Cell Mol Neurobiol. 2010;30:577-90 pubmed 出版商 |
| Campos Peña V, Tapia Ramírez J, Sanchez Torres C, Meraz Rios M. Pathological-like assembly of tau induced by a paired helical filament core expressed at the plasma membrane. J Alzheimers Dis. 2009;18:919-33 pubmed 出版商 |
| Nonaka T, Hasegawa M. A cellular model to monitor proteasome dysfunction by alpha-synuclein. Biochemistry. 2009;48:8014-22 pubmed 出版商 |
- 免疫印迹; 小鼠; 1:100
- 免疫印迹; 人类; 1:100
| Perreault S, Bousquet O, Lauzon M, Paiement J, Leclerc N. Increased association between rough endoplasmic reticulum membranes and mitochondria in transgenic mice that express P301L tau. J Neuropathol Exp Neurol. 2009;68:503-14 pubmed 出版商 |
- 抑制或激活实验; 人类
- 免疫印迹; 人类; 1:1000
| Clavaguera F, Bolmont T, Crowther R, Abramowski D, Frank S, Probst A, et al. Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol. 2009;11:909-13 pubmed 出版商 |
| Mastrangelo M, Bowers W. Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice. BMC Neurosci. 2008;9:81 pubmed 出版商 |
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| Yamamori H, Khatoon S, Grundke Iqbal I, Blennow K, Ewers M, Hampel H, et al. Tau in cerebrospinal fluid: a sensitive sandwich enzyme-linked immunosorbent assay using tyramide signal amplification. Neurosci Lett. 2007;418:186-9 pubmed |
| Kashyap R, Balzano M, Lechat B, Lambaerts K, Egea Jimenez A, Lembo F, et al. Syntenin-knock out reduces exosome turnover and viral transduction. Sci Rep. 2021;11:4083 pubmed 出版商 |
| Sandusky Beltran L, Kovalenko A, Placides D, Ratnasamy K, Ma C, Hunt J, et al. Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology. J Clin Invest. 2021;131: pubmed 出版商 |
| Laversenne V, Nazeeruddin S, Källstig E, Colin P, Voize C, Schneider B. Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology. Acta Neuropathol Commun. 2020;8:198 pubmed 出版商 |
| Gratuze M, Leyns C, Sauerbeck A, St Pierre M, Xiong M, Kim N, et al. Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration. J Clin Invest. 2020;130:4954-4968 pubmed 出版商 |
| Sola M, Magrin C, Pedrioli G, Pinton S, Salvade A, Papin S, et al. Tau affects P53 function and cell fate during the DNA damage response. Commun Biol. 2020;3:245 pubmed 出版商 |
| Lin Y, Rajamohamedsait H, Sandusky Beltran L, Gamallo Lana B, Mar A, Sigurdsson E. Chronic PD-1 Checkpoint Blockade Does Not Affect Cognition or Promote Tau Clearance in a Tauopathy Mouse Model. Front Aging Neurosci. 2019;11:377 pubmed 出版商 |
| Gallardo G, Wong C, Ricardez S, Mann C, Lin K, Leyns C, et al. Targeting tauopathy with engineered tau-degrading intrabodies. Mol Neurodegener. 2019;14:38 pubmed 出版商 |
| Shi Y, Manis M, Long J, Wang K, Sullivan P, Remolina Serrano J, et al. Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model. J Exp Med. 2019;216:2546-2561 pubmed 出版商 |
| Carlomagno Y, Chung D, Yue M, Kurti A, Avendano N, Castanedes Casey M, et al. Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant. Acta Neuropathol Commun. 2019;7:10 pubmed 出版商 |
| Zhao N, Liu C, Van Ingelgom A, Linares C, Kurti A, Knight J, et al. APOE ε2 is associated with increased tau pathology in primary tauopathy. Nat Commun. 2018;9:4388 pubmed 出版商 |
| Eftekharzadeh B, Daigle J, Kapinos L, Coyne A, Schiantarelli J, Carlomagno Y, et al. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 2018;99:925-940.e7 pubmed 出版商 |
| Wegmann S, Eftekharzadeh B, Tepper K, Zoltowska K, Bennett R, Dujardin S, et al. Tau protein liquid-liquid phase separation can initiate tau aggregation. EMBO J. 2018;37: pubmed 出版商 |
| Gibbons G, Banks R, Kim B, Changolkar L, Riddle D, Leight S, et al. Detection of Alzheimer Disease (AD)-Specific Tau Pathology in AD and NonAD Tauopathies by Immunohistochemistry With Novel Conformation-Selective Tau Antibodies. J Neuropathol Exp Neurol. 2018;77:216-228 pubmed 出版商 |
| Cuadrado A, Kügler S, Lastres Becker I. Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy. Redox Biol. 2018;14:522-534 pubmed 出版商 |
| Leyns C, ULRICH J, Finn M, Stewart F, Koscal L, Remolina Serrano J, et al. TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy. Proc Natl Acad Sci U S A. 2017;114:11524-11529 pubmed 出版商 |
| Shi Y, Yamada K, Liddelow S, Smith S, Zhao L, Luo W, et al. ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. Nature. 2017;549:523-527 pubmed 出版商 |
| Narasimhan S, Lee V. The use of mouse models to study cell-to-cell transmission of pathological tau. Methods Cell Biol. 2017;141:287-305 pubmed 出版商 |
| Nobuhara C, DeVos S, Commins C, Wegmann S, Moore B, Roe A, et al. Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro. Am J Pathol. 2017;187:1399-1412 pubmed 出版商 |
| Schoch K, DeVos S, Miller R, Chun S, Norrbom M, Wozniak D, et al. Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model. Neuron. 2016;90:941-7 pubmed 出版商 |
| Luo W, Liu W, Hu X, Hanna M, Caravaca A, Paul S. Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody. Sci Rep. 2015;5:11161 pubmed 出版商 |
| Santa Maria I, Díaz Ruiz C, Ksiezak Reding H, Chen A, Ho L, Wang J, et al. GSPE interferes with tau aggregation in vivo: implication for treating tauopathy. Neurobiol Aging. 2012;33:2072-81 pubmed 出版商 |
