产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Tau Monoclonal Antibody (BT2)
目录 :
MN1010
规格 :
100微克
价格 :
美国412
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
BT2
反应物种 :
人类, 小鼠, 大鼠, 牛
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫印迹基因敲除验证
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 24
出版应用/物种/样本/稀释参考文献
  • 酶联免疫吸附测定; 人类; 图 5a
Ercan Herbst E, Ehrig J, Schöndorf D, Behrendt A, Klaus B, Gomez Ramos B, et al. A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer's disease brain. Acta Neuropathol Commun. 2019;7:192 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 1:1000; 表 1
  • 免疫细胞化学; 人类; 1:100; 表 2
  • 免疫印迹; 小鼠
Ercan E, Eid S, Weber C, Kowalski A, Bichmann M, Behrendt A, et al. A validated antibody panel for the characterization of tau post-translational modifications. Mol Neurodegener. 2017;12:87 pubmed 出版商
  • 酶联免疫吸附测定; 小鼠; 图 4a
Croft C, Wade M, Kurbatskaya K, Mastrandreas P, Hughes M, Phillips E, et al. Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures. Cell Death Dis. 2017;8:e2671 pubmed 出版商
  • 酶联免疫吸附测定; 人类
Sankaranarayanan S, Barten D, Vana L, Devidze N, Yang L, Cadelina G, et al. Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models. PLoS ONE. 2015;10:e0125614 pubmed 出版商
  • 酶联免疫吸附测定; 人类; 图 7
Song L, Lu S, Ouyang X, Melchor J, Lee J, Terracina G, et al. Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology. Mol Neurodegener. 2015;10:14 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Santos R, Correia S, Alves M, Oliveira P, Cardoso S, Carvalho C, et al. Insulin therapy modulates mitochondrial dynamics and biogenesis, autophagy and tau protein phosphorylation in the brain of type 1 diabetic rats. Biochim Biophys Acta. 2014;1842:1154-66 pubmed 出版商
  • 免疫印迹; 大鼠; 1:2000
Rahman A, Khan K, Al Khaledi G, Khan I, Attur S. Early postnatal lead exposure induces tau phosphorylation in the brain of young rats. Acta Biol Hung. 2012;63:411-25 pubmed 出版商
  • 免疫印迹; 人类
Karch C, Jeng A, Goate A. Calcium phosphatase calcineurin influences tau metabolism. Neurobiol Aging. 2013;34:374-86 pubmed 出版商
  • 免疫印迹; 大鼠; 1:2000
Rahman A, Khan K, Al Khaledi G, Khan I, Al Shemary T. Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats. Neurotoxicology. 2012;33:370-83 pubmed 出版商
  • 免疫印迹; 小鼠
  • 免疫印迹; 人类
Yamada K, Cirrito J, Stewart F, Jiang H, Finn M, Holmes B, et al. In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. J Neurosci. 2011;31:13110-7 pubmed 出版商
  • 酶联免疫吸附测定; 人类; 0.1 ug/ml
Wu G, Sankaranarayanan S, Hsieh S, Simon A, Savage M. Decrease in brain soluble amyloid precursor protein ? (sAPP?) in Alzheimer's disease cortex. J Neurosci Res. 2011;89:822-32 pubmed 出版商
  • 免疫印迹; 小鼠; 1:3,000
Koike M, Garcia F, Kitazawa M, Green K, LaFerla F. Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia. Neurosci Lett. 2011;495:55-9 pubmed 出版商
  • 免疫印迹; 小鼠; 1:100
  • 免疫印迹; 人类; 1:100
Perreault S, Bousquet O, Lauzon M, Paiement J, Leclerc N. Increased association between rough endoplasmic reticulum membranes and mitochondria in transgenic mice that express P301L tau. J Neuropathol Exp Neurol. 2009;68:503-14 pubmed 出版商
  • 免疫组化; 小鼠; 1:200
Mastrangelo M, Bowers W. Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice. BMC Neurosci. 2008;9:81 pubmed 出版商
  • 免疫组化; 小鼠; 1:500
Menendez J, Rodriguez Navarro J, Solano R, Casarejos M, Rodal I, Guerrero R, et al. Suppression of Parkin enhances nigrostriatal and motor neuron lesion in mice over-expressing human-mutated tau protein. Hum Mol Genet. 2006;15:2045-58 pubmed
Latina V, Giacovazzo G, Cordella F, Balzamino B, Micera A, Varano M, et al. Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer's Disease. Acta Neuropathol Commun. 2021;9:38 pubmed 出版商
Triana Baltzer G, Van Kolen K, Theunis C, Moughadam S, Slemmon R, Mercken M, et al. Development and Validation of a High Sensitivity Assay for Measuring p217 + tau in Cerebrospinal Fluid. J Alzheimers Dis. 2020;77:1417-1430 pubmed 出版商
Lin Y, Rajamohamedsait H, Sandusky Beltran L, Gamallo Lana B, Mar A, Sigurdsson E. Chronic PD-1 Checkpoint Blockade Does Not Affect Cognition or Promote Tau Clearance in a Tauopathy Mouse Model. Front Aging Neurosci. 2019;11:377 pubmed 出版商
Chan H, Xu D, Ho S, He D, Wong M, Li H. Highly sensitive quantification of Alzheimer's disease biomarkers by aptamer-assisted amplification. Theranostics. 2019;9:2939-2949 pubmed 出版商
Guix F, Corbett G, Cha D, Mustapic M, Liu W, Mengel D, et al. Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles. Int J Mol Sci. 2018;19: pubmed 出版商
Piccardo P, King D, Brown D, Barron R. Variable tau accumulation in murine models with abnormal prion protein deposits. J Neurol Sci. 2017;383:142-150 pubmed 出版商
Huang R, Iacob R, Sankaranarayanan S, Yang L, Ahlijanian M, Tao L, et al. Probing Conformational Dynamics of Tau Protein by Hydrogen/Deuterium Exchange Mass Spectrometry. J Am Soc Mass Spectrom. 2018;29:174-182 pubmed 出版商
Meredith J, Sankaranarayanan S, Guss V, Lanzetti A, Berisha F, Neely R, et al. Characterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease. PLoS ONE. 2013;8:e76523 pubmed 出版商
Nashmi R, Dickinson M, McKinney S, Jareb M, Labarca C, Fraser S, et al. Assembly of alpha4beta2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: effects of localization, trafficking, and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons. J Neurosci. 2003;23:11554-67 pubmed
产品信息
产品类型 :
抗体
产品名称 :
Tau Monoclonal Antibody (BT2)
目录# :
MN1010
规格 :
100微克
价格 :
美国412
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
Bovine, Human, Non-human primate, Rat
应用 :
ELISA: 2-10 µg/mL, Western Blot: 1:500
物种 :
Bovine, Human, Non-human primate, Rat
克隆 :
BT2
抗体亚型 :
IgG1, kappa
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
免疫原 :
Purified bovine Tau
格式 :
液体
应用w/稀释 :
ELISA: 2-10 µg/mL, Western Blot: 1:500
别名 :
AI413597; AW045860; DDPAC; FLJ31424; FTDP17; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; map tau; Mapt; MAPTL; MGC138549; microtubule associated protein tau; microtubule-associated protein tau; microtubule-associated protein tau, isoform 4; microtubules; MSTD; Mtapt; MTBT1; MTBT2; Neurofibrillary tangle protein; neurofibrillary tangles; Neuronal Marker; paired helical filament-tau; PHFtau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; pTau; RNPTAU; Tau; Tau microtubule-associated protein; tau protein; Tau-4; Tau5; Unknown (protein for MGC:134287)
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国