产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8)
目录 :
MN1020
规格 :
100µg
价格 :
美国506
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
AT8
反应物种 :
leopard cat, African green monkey, 仓鼠, degu, lowland gorilla, baboons, 人类, 小鼠, 大鼠, , , 黑猩猩, , 果蝇, , 猕猴
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫组化-自由浮动切片, 抑制或激活实验, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 671
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 小鼠; 1:1000; 图 6a
  • 免疫印迹; 小鼠; 1:1000; 图 s9a
Gamache J, Benzow K, Forster C, Kemper L, Hlynialuk C, Furrow E, et al. Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice. Nat Commun. 2019;10:2479 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2c
Chang H, Di T, Wang Y, Zeng X, Li G, Wan Q, et al. Seipin deletion in mice enhances phosphorylation and aggregation of tau protein through reduced neuronal PPARγ and insulin resistance. Neurobiol Dis. 2019;127:350-361 pubmed 出版商
  • 免疫组化; 小鼠; 图 1e
Merezhko M, Brunello C, Yan X, Vihinen H, Jokitalo E, Uronen R, et al. Secretion of Tau via an Unconventional Non-vesicular Mechanism. Cell Rep. 2018;25:2027-2035.e4 pubmed 出版商
  • 免疫组化; 人类; 图 s4a
Thygesen C, Ilkjær L, Kempf S, Hemdrup A, von Linstow C, Babcock A, et al. Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APPSWE/PS1ΔE9 Transgenic Mice Implicate Cathepsin Z in Alzheimer's Disease. Front Cell Neurosci. 2018;12:397 pubmed 出版商
  • 免疫细胞化学; 人类; 图 s10b
  • 免疫印迹; 人类; 图 s10a
Wang C, Najm R, Xu Q, Jeong D, Walker D, Balestra M, et al. Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. Nat Med. 2018;24:647-657 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4
Hou Y, Lautrup S, Cordonnier S, Wang Y, Croteau D, Zavala E, et al. NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency. Proc Natl Acad Sci U S A. 2018;115:E1876-E1885 pubmed 出版商
  • 免疫组化-冰冻切片; African green monkey; 1:500; 图 6a
Cramer P, Gentzel R, Tanis K, Vardigan J, Wang Y, Connolly B, et al. Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease. Neurobiol Aging. 2018;64:92-106 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:1000; 图 2c
Brici D, G tz J, Nisbet R. A Novel Antibody Targeting Tau Phosphorylated at Serine 235 Detects Neurofibrillary Tangles. J Alzheimers Dis. 2018;61:899-905 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 8b
Qu X, Yuan F, Corona C, Pasini S, Pero M, Gundersen G, et al. Stabilization of dynamic microtubules by mDia1 drives Tau-dependent Aβ1-42 synaptotoxicity. J Cell Biol. 2017;216:3161-3178 pubmed 出版商
  • 免疫组化; 人类; 1:500; 图 1a
Tseng J, Xie L, Song S, Xie Y, Allen L, Ajit D, et al. The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology. Cell Rep. 2017;20:2169-2183 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 2a
Siedlak S, Jiang Y, Huntley M, Wang L, Gao J, Xie F, et al. TMEM230 Accumulation in Granulovacuolar Degeneration Bodies and Dystrophic Neurites of Alzheimer's Disease. J Alzheimers Dis. 2017;58:1027-1033 pubmed 出版商
  • 免疫组化; 小鼠; 图 4c
  • 免疫印迹; 小鼠; 图 4a
Li J, Barrero C, Merali S, Pratico D. Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype. Sci Rep. 2017;7:46002 pubmed 出版商
  • 免疫细胞化学; 人类; 图 5
  • 免疫印迹; 人类; 图 4a
Wu X, Kosaraju J, Tam K. SLM, a novel carbazole-based fluorophore attenuates okadaic acid-induced tau hyperphosphorylation via down-regulating GSK-3? activity in SH-SY5Y cells. Eur J Pharm Sci. 2017;110:101-108 pubmed 出版商
  • 免疫组化; 小鼠; 图 4
Zhang Z, Obianyo O, Dall E, Du Y, Fu H, Liu X, et al. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun. 2017;8:14740 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:1000; 图 1d
  • 免疫印迹; 人类; 1:1000; 图 1a
Trzeciakiewicz H, Tseng J, Wander C, Madden V, Tripathy A, Yuan C, et al. A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy. Sci Rep. 2017;7:44102 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 3a
  • 免疫印迹; 小鼠; 0.2 ug/ml; 图 2a
Bodea L, Evans H, Van der Jeugd A, Ittner L, Delerue F, Kril J, et al. Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model. Aging Cell. 2017;16:377-386 pubmed 出版商
  • 免疫组化-自由浮动切片; 小鼠; 1:500; 图 1a
Fu H, Rodriguez G, Herman M, Emrani S, Nahmani E, Barrett G, et al. Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease. Neuron. 2017;93:533-541.e5 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 3a
  • 免疫印迹; 小鼠; 图 3b
Wang P, Joberty G, Buist A, Vanoosthuyse A, Stancu I, Vasconcelos B, et al. Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo. Acta Neuropathol. 2017;133:731-749 pubmed 出版商
  • 免疫组化; 人类; 1:500; 图 7c
Takahashi H, Klein Z, Bhagat S, Kaufman A, Kostylev M, Ikezu T, et al. Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network. Acta Neuropathol. 2017;133:785-807 pubmed 出版商
  • 免疫组化; 人类; 1:1000; 图 3d
Yoshida K, Hata Y, Kinoshita K, Takashima S, Tanaka K, Nishida N. Incipient progressive supranuclear palsy is more common than expected and may comprise clinicopathological subtypes: a forensic autopsy series. Acta Neuropathol. 2017;133:809-823 pubmed 出版商
  • 免疫组化-冰冻切片; 人类
Stepanov V, Svedberg M, Jia Z, Krasikova R, Lemoine L, Okamura N, et al. Development of [11C]/[3H]THK-5351 - A potential novel carbon-11 tau imaging PET radioligand. Nucl Med Biol. 2017;46:50-53 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200; 图 3m
van der Zee J, Gijselinck I, Van Mossevelde S, Perrone F, Dillen L, Heeman B, et al. TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. Hum Mutat. 2017;38:297-309 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Shively S, Edgerton S, Iacono D, Purohit D, Qu B, Haroutunian V, et al. Localized cortical chronic traumatic encephalopathy pathology after single, severe axonal injury in human brain. Acta Neuropathol. 2017;133:353-366 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 3a
Jan A, Jansonius B, Delaidelli A, Somasekharan S, Bhanshali F, Vandal M, et al. eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response. Acta Neuropathol. 2017;133:101-119 pubmed 出版商
  • 免疫组化-自由浮动切片; 人类; 图 2
Fernández Nogales M, Santos Galindo M, Merchán Rubira J, Hoozemans J, Rábano A, Ferrer I, et al. Tau-positive nuclear indentations in P301S tauopathy mice. Brain Pathol. 2017;27:314-322 pubmed 出版商
  • 免疫组化-自由浮动切片; 小鼠; 图 4
  • 免疫组化-自由浮动切片; 人类; 图 4
  • 免疫印迹; 果蝇; 图 3
Dourlen P, Fernandez Gomez F, Dupont C, Grenier Boley B, Bellenguez C, Obriot H, et al. Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology. Mol Psychiatry. 2017;22:874-883 pubmed 出版商
  • 免疫组化-石蜡切片; 果蝇; 1:1000; 图 4
  • 免疫印迹; 果蝇; 1:2000; 图 4
Chanu S, Sarkar S. Targeted Downregulation of dMyc Suppresses Pathogenesis of Human Neuronal Tauopathies in Drosophila by Limiting Heterochromatin Relaxation and Tau Hyperphosphorylation. Mol Neurobiol. 2017;54:2706-2719 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5c
Wang A, Jensen E, Rexach J, Vinters H, Hsieh Wilson L. Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration. Proc Natl Acad Sci U S A. 2016;113:15120-15125 pubmed 出版商
  • 免疫组化; 小鼠; 1:500; 图 5
Lipton S, Rezaie T, Nutter A, Lopez K, Parker J, Kosaka K, et al. Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease models. Cell Death Dis. 2016;7:e2499 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:3000; 图 1
Noy S, Krawitz S, Del Bigio M. Chronic Traumatic Encephalopathy-Like Abnormalities in a Routine Neuropathology Service. J Neuropathol Exp Neurol. 2016;75:1145-1154 pubmed 出版商
  • 免疫组化; 人类; 1:600; 图 3
Ling H, Kovacs G, Vonsattel J, DAVEY K, Mok K, Hardy J, et al. Astrogliopathy predominates the earliest stage of corticobasal degeneration pathology. Brain. 2016;139:3237-3252 pubmed
  • 免疫组化; 人类; 图 4
Mansuroglu Z, Benhelli Mokrani H, Marcato V, Sultan A, Violet M, Chauderlier A, et al. Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin. Sci Rep. 2016;6:33047 pubmed 出版商
  • 免疫组化; 小鼠; 图 7d
Qin Y, Liu Y, Hao W, Decker Y, Tomic I, Menger M, et al. Stimulation of TLR4 Attenuates Alzheimer's Disease-Related Symptoms and Pathology in Tau-Transgenic Mice. J Immunol. 2016;197:3281-3292 pubmed
  • 免疫组化-石蜡切片; 小鼠; 图 6g
Zimova I, Brezovakova V, Hromádka T, Weisová P, Cubinkova V, Valachova B, et al. Human Truncated Tau Induces Mature Neurofibrillary Pathology in a Mouse Model of Human Tauopathy. J Alzheimers Dis. 2016;54:831-43 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠; 1:50; 图 6
  • 免疫印迹; 大鼠; 1:1000
Steffen J, Krohn M, Paarmann K, Schwitlick C, Brüning T, Marreiros R, et al. Revisiting rodent models: Octodon degus as Alzheimer's disease model?. Acta Neuropathol Commun. 2016;4:91 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 8
  • 免疫印迹; 小鼠; 1:500; 图 3a
Salta E, Sierksma A, Vanden Eynden E, De Strooper B. miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain. EMBO Mol Med. 2016;8:1005-18 pubmed 出版商
  • 免疫印迹; 人类; 图 1c
Lee S, Le Pichon C, Adolfsson O, Gafner V, Pihlgren M, Lin H, et al. Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement. Cell Rep. 2016;16:1690-1700 pubmed 出版商
  • 免疫组化-自由浮动切片; 小鼠; 1:1000; 图 5a
Pajares M, Jiménez Moreno N, García Yagüe A, Escoll M, De Ceballos M, Van Leuven F, et al. Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes. Autophagy. 2016;12:1902-1916 pubmed
  • 免疫组化-石蜡切片; 小鼠; 1:25; 图 2
Manassero G, Guglielmotto M, Zamfir R, Borghi R, Colombo L, Salmona M, et al. Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein. Aging Cell. 2016;15:914-23 pubmed 出版商
  • 免疫印迹; 兔; 1:1000; 图 3
Chen X, Wagener J, Ghribi O, Geiger J. Role of Endolysosomes in Skeletal Muscle Pathology Observed in a Cholesterol-Fed Rabbit Model of Alzheimer's Disease. Front Aging Neurosci. 2016;8:129 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200; 图 2a
Gelpi E, Hoftberger R, Graus F, Ling H, Holton J, Dawson T, et al. Neuropathological criteria of anti-IgLON5-related tauopathy. Acta Neuropathol. 2016;132:531-43 pubmed 出版商
  • 免疫印迹; 人类; 图 s3
  • 免疫印迹; 小鼠; 图 s3
Sohn P, Tracy T, Son H, Zhou Y, Leite R, Miller B, et al. Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment. Mol Neurodegener. 2016;11:47 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:2000; 图 7
Adams S, Tilton K, Kozubek J, Seshadri S, Delalle I. Subcellular Changes in Bridging Integrator 1 Protein Expression in the Cerebral Cortex During the Progression of Alzheimer Disease Pathology. J Neuropathol Exp Neurol. 2016;75:779-790 pubmed
  • 免疫印迹; 小鼠; 1:500; 图 6
Herring A, Münster Y, Akkaya T, Moghaddam S, Deinsberger K, Meyer J, et al. Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice. Alzheimers Dement. 2016;12:1273-1287 pubmed 出版商
  • 免疫组化; 小鼠; 1:80
  • 免疫印迹; 小鼠; 1:500
Herring A, Münster Y, Metzdorf J, Bolczek B, Krüssel S, Krieter D, et al. Late running is not too late against Alzheimer's pathology. Neurobiol Dis. 2016;94:44-54 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:2000; 图 1
Shively S, Horkayne Szakaly I, Jones R, Kelly J, Armstrong R, Perl D. Characterisation of interface astroglial scarring in the human brain after blast exposure: a post-mortem case series. Lancet Neurol. 2016;15:944-953 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 2
Ando K, Tomimura K, Sazdovitch V, Suain V, Yilmaz Z, Authelet M, et al. Level of PICALM, a key component of clathrin-mediated endocytosis, is correlated with levels of phosphotau and autophagy-related proteins and is associated with tau inclusions in AD, PSP and Pick disease. Neurobiol Dis. 2016;94:32-43 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6
Wang H, Wang R, Carrera I, Xu S, Lakshmana M. TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory Deficits. Eneuro. 2016;3: pubmed 出版商
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Makioka K, Yamazaki T, Takatama M, Ikeda M, Murayama S, Okamoto K, et al. Immunolocalization of Tom1 in relation to protein degradation systems in Alzheimer's disease. J Neurol Sci. 2016;365:101-7 pubmed 出版商
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Bouvier D, Jones E, Quesseveur G, Davoli M, A Ferreira T, Quirion R, et al. High Resolution Dissection of Reactive Glial Nets in Alzheimer's Disease. Sci Rep. 2016;6:24544 pubmed 出版商
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  • 免疫印迹; 人类; 1:2500; 图 5
Yetman M, Fowler S, Jankowsky J. Humanized Tau Mice with Regionalized Amyloid Exhibit Behavioral Deficits but No Pathological Interaction. PLoS ONE. 2016;11:e0153724 pubmed 出版商
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Kawakami I, Kobayashi Z, Arai T, Yokota O, Nonaka T, Aoki N, et al. Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration. Acta Neuropathol Commun. 2016;4:36 pubmed 出版商
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Polanco J, Scicluna B, Hill A, Götz J. Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner. J Biol Chem. 2016;291:12445-66 pubmed 出版商
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Merlini M, Wanner D, Nitsch R. Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer's disease-related microvascular cerebral amyloid angiopathy. Acta Neuropathol. 2016;131:737-52 pubmed 出版商
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Gorsky M, Burnouf S, Dols J, Mandelkow E, Partridge L. Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo. Sci Rep. 2016;6:22685 pubmed 出版商
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Piras A, Collin L, Grüninger F, Graff C, Rönnbäck A. Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy. Acta Neuropathol Commun. 2016;4:22 pubmed 出版商
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Maeda S, Djukic B, Taneja P, Yu G, Lo I, Davis A, et al. Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice. EMBO Rep. 2016;17:530-51 pubmed 出版商
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Perez S, Sherwood C, Cranfield M, Erwin J, Mudakikwa A, Hof P, et al. Early Alzheimer's disease-type pathology in the frontal cortex of wild mountain gorillas (Gorilla beringei beringei). Neurobiol Aging. 2016;39:195-201 pubmed 出版商
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Guillot F, Kemppainen S, Lavasseur G, Miettinen P, Laroche S, Tanila H, et al. Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AβPP/PS1 Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016;51:1157-73 pubmed 出版商
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Garcia Ratés S, Morrill P, Tu H, Pottiez G, Badin A, Tormo Garcia C, et al. (I) Pharmacological profiling of a novel modulator of the α7 nicotinic receptor: Blockade of a toxic acetylcholinesterase-derived peptide increased in Alzheimer brains. Neuropharmacology. 2016;105:487-499 pubmed 出版商
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Winston C, Noël A, Neustadtl A, Parsadanian M, Barton D, Chellappa D, et al. Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma. Am J Pathol. 2016;186:552-67 pubmed 出版商
  • 免疫组化; 人类; 1:100; 图 5
Ahn M, Kalume F, Pitstick R, Oehler A, Carlson G, Dearmond S. Brain Aggregates: An Effective In Vitro Cell Culture System Modeling Neurodegenerative Diseases. J Neuropathol Exp Neurol. 2016;75:256-62 pubmed 出版商
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Van der Jeugd A, Vermaercke B, Halliday G, Staufenbiel M, Götz J. Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia. Neurobiol Learn Mem. 2016;130:34-43 pubmed 出版商
  • 免疫组化; 人类; 图 3
  • 免疫印迹; 人类; 1:1000; 图 3
  • 免疫组化; 小鼠; 图 3
  • 免疫印迹; 小鼠; 1:1000; 图 3
Jiang T, Zhang Y, Chen Q, Gao Q, Zhu X, Zhou J, et al. TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice. Neuropharmacology. 2016;105:196-206 pubmed 出版商
  • 免疫组化; 小鼠; 1:100; 图 7
  • 免疫印迹; 小鼠; 1:750; 图 7
Peng Y, Kim M, Hullinger R, O Riordan K, Burger C, Pehar M, et al. Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse. Brain. 2016;139:937-52 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3
El Khoury N, Gratuze M, Petry F, Papon M, Julien C, Marcouiller F, et al. Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice. Neurobiol Dis. 2016;88:55-65 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3e
Liu H, Shi H, Huang F, Peterson K, Wu H, Lan Y, et al. Astragaloside IV inhibits microglia activation via glucocorticoid receptor mediated signaling pathway. Sci Rep. 2016;6:19137 pubmed 出版商
  • 免疫组化; 人类; 1:800; 表 2
Rosenberger A, Morrema T, Gerritsen W, van Haastert E, Snkhchyan H, Hilhorst R, et al. Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer's disease pathology. J Neuroinflammation. 2016;13:4 pubmed 出版商
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Platt T, Beckett T, Kohler K, Niedowicz D, Murphy M. Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease. Neuroscience. 2016;315:162-74 pubmed 出版商
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Boländer A, Kieser D, Voss C, Bauer S, Schön C, Burgold S, et al. Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils and ?-amyloid plaques in Alzheimer's disease models. J Med Chem. 2012;55:9170-80 pubmed 出版商
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Castello N, Green K, LaFerla F. Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter A? or tau pathology. PLoS ONE. 2012;7:e39566 pubmed 出版商
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Colom Cadena M, Gelpi E, Marti M, Charif S, Dols Icardo O, Blesa R, et al. MAPT H1 haplotype is associated with enhanced ?-synuclein deposition in dementia with Lewy bodies. Neurobiol Aging. 2013;34:936-42 pubmed 出版商
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Medeiros R, Kitazawa M, Chabrier M, Cheng D, Baglietto Vargas D, Kling A, et al. Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice. Am J Pathol. 2012;181:616-25 pubmed 出版商
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Barten D, Fanara P, Andorfer C, Hoque N, Wong P, Husted K, et al. Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027. J Neurosci. 2012;32:7137-45 pubmed 出版商
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Herzig M, Bidinosti M, Schweizer T, Hafner T, Stemmelen C, Weiss A, et al. High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain. PLoS ONE. 2012;7:e36581 pubmed 出版商
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Cancino G, Miller F, Kaplan D. p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease. Neurobiol Aging. 2013;34:387-99 pubmed 出版商
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Mustroph M, King M, Klein R, Ramirez J. Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats. Behav Brain Res. 2012;233:141-8 pubmed 出版商
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Fine J, Baillargeon A, Renner D, Hoerster N, Tokarev J, Colton S, et al. Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1?, and phosphorylates GSK3? in P301L tau transgenic mice. Exp Brain Res. 2012;219:381-90 pubmed 出版商
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Petratos S, Ozturk E, Azari M, Kenny R, Lee J, Magee K, et al. Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation. Brain. 2012;135:1794-818 pubmed 出版商
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Chen C, Weng Y, Chien K, Lin K, Yeh T, Cheng Y, et al. (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD. Cell Death Differ. 2012;19:1623-33 pubmed 出版商
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Kapás I, Majtenyi K, Töro K, Keller E, Voigtlander T, Kovacs G. Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease. Metab Brain Dis. 2012;27:231-5 pubmed 出版商
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Van der Jeugd A, Hochgräfe K, Ahmed T, Decker J, Sydow A, Hofmann A, et al. Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau. Acta Neuropathol. 2012;123:787-805 pubmed 出版商
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Joshi Y, Chu J, Pratico D. Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease. J Alzheimers Dis. 2012;31:167-76 pubmed 出版商
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Matsushima T, Saito Y, Elliott J, Iijima Ando K, Nishimura M, Kimura N, et al. Membrane-microdomain localization of amyloid ?-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue. J Biol Chem. 2012;287:19715-24 pubmed 出版商
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Fodero Tavoletti M, Brockschnieder D, Villemagne V, Martin L, Connor A, Thiele A, et al. In vitro characterization of [18F]-florbetaben, an Aβ imaging radiotracer. Nucl Med Biol. 2012;39:1042-8 pubmed 出版商
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Talbot K, Wang H, Kazi H, Han L, Bakshi K, Stucky A, et al. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest. 2012;122:1316-38 pubmed 出版商
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Zhang Q, Gao T, Luo Y, Chen X, Gao G, Gao X, et al. Transient focal cerebral ischemia/reperfusion induces early and chronic axonal changes in rats: its importance for the risk of Alzheimer's disease. PLoS ONE. 2012;7:e33722 pubmed 出版商
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Soontornniyomkij V, Soontornniyomkij B, Moore D, Gouaux B, Masliah E, Tung S, et al. Antioxidant sestrin-2 redistribution to neuronal soma in human immunodeficiency virus-associated neurocognitive disorders. J Neuroimmune Pharmacol. 2012;7:579-90 pubmed 出版商
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Carvalho C, Cardoso S, Correia S, Santos R, Santos M, Baldeiras I, et al. Metabolic alterations induced by sucrose intake and Alzheimer's disease promote similar brain mitochondrial abnormalities. Diabetes. 2012;61:1234-42 pubmed 出版商
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Clausen A, Xu X, Bi X, Baudry M. Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline. J Alzheimers Dis. 2012;30:183-208 pubmed 出版商
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Woehrer A, Laszlo L, Finsterer J, Stollberger C, Furtner J, Rinner W, et al. Novel crystalloid oligodendrogliopathy in hereditary spastic paraplegia. Acta Neuropathol. 2012;124:583-91 pubmed 出版商
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Rahman A, Khan K, Al Khaledi G, Khan I, Al Shemary T. Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats. Neurotoxicology. 2012;33:370-83 pubmed 出版商
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Zago W, Buttini M, Comery T, Nishioka C, Gardai S, Seubert P, et al. Neutralization of soluble, synaptotoxic amyloid ? species by antibodies is epitope specific. J Neurosci. 2012;32:2696-702 pubmed 出版商
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Matsuki T, Zaka M, Guerreiro R, van der Brug M, Cooper J, Cookson M, et al. Identification of Stk25 as a genetic modifier of Tau phosphorylation in Dab1-mutant mice. PLoS ONE. 2012;7:e31152 pubmed 出版商
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Löffler T, Flunkert S, Taub N, Schofield E, Ward M, Windisch M, et al. Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates. J Mol Neurosci. 2012;47:192-203 pubmed 出版商
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Caesar I, Jonson M, Nilsson K, Thor S, Hammarstrom P. Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila. PLoS ONE. 2012;7:e31424 pubmed 出版商
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Sudduth T, Wilson J, Everhart A, Colton C, Wilcock D. Lithium treatment of APPSwDI/NOS2-/- mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype. PLoS ONE. 2012;7:e31993 pubmed 出版商
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Kawakami F, Yabata T, Ohta E, Maekawa T, Shimada N, Suzuki M, et al. LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth. PLoS ONE. 2012;7:e30834 pubmed 出版商
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Troquier L, Caillierez R, Burnouf S, Fernandez Gomez F, Grosjean M, Zommer N, et al. Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach. Curr Alzheimer Res. 2012;9:397-405 pubmed
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Sundaram J, Chan E, Poore C, Pareek T, Cheong W, Shui G, et al. Cdk5/p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration. J Neurosci. 2012;32:1020-34 pubmed 出版商
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Lasagna Reeves C, Castillo Carranza D, Sengupta U, Sarmiento J, Troncoso J, Jackson G, et al. Identification of oligomers at early stages of tau aggregation in Alzheimer's disease. FASEB J. 2012;26:1946-59 pubmed 出版商
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Giustiniani J, Sineus M, Sardin E, Dounane O, Panchal M, Sazdovitch V, et al. Decrease of the immunophilin FKBP52 accumulation in human brains of Alzheimer's disease and FTDP-17. J Alzheimers Dis. 2012;29:471-83 pubmed 出版商
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产品信息
产品类型 :
抗体
产品名称 :
Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8)
目录# :
MN1020
规格 :
100µg
价格 :
美国506
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类
应用 :
ELISA: Assay Dependent, Immunocytochemistry: 1:50-1:1000, Immunofluorescence: 1:50-1:1000, Immunohistochemistry (Paraffin): Assay Dependent, Western Blot: 1:250-1:2000
物种 :
人类
克隆 :
AT8
抗体亚型 :
IgG1
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclindependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
免疫原 :
Partially purified human PHF-Tau
格式 :
液体
应用w/稀释 :
ELISA: Assay Dependent, Immunocytochemistry: 1:50-1:1000, Immunofluorescence: 1:50-1:1000, Immunohistochemistry (Paraffin): Assay Dependent, Western Blot: 1:250-1:2000
别名 :
G protein beta1/gamma2 subunit-interacting factor 1; PHF-tau; neurofibrillary tangle protein; paired helical filament-tau
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国