产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8)
目录 :
MN1020
规格 :
100微克
价格 :
美国536
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
AT8
反应物种 :
African green monkey, leopard cat, lowland gorilla, baboons, degu, 仓鼠, 人类, 小鼠, 大鼠, , , 黑猩猩, , fruit fly , domestic rabbit, 猕猴
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫组化-自由浮动切片, 抑制或激活实验, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 897
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 小鼠; 图 s9b
Barker S, Raju R, Milman N, Wang J, Davila Velderrain J, Gunter Rahman F, et al. MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration. Sci Transl Med. 2021;13:eabd7695 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100; 图 2e
  • 免疫印迹; 人类; 图 2f
Yuste Checa P, Trinkaus V, Riera Tur I, Imamoglu R, Schaller T, Wang H, et al. The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model. Nat Commun. 2021;12:4863 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:500; 图 1c
Bampton A, Gatt A, Humphrey J, Cappelli S, Bhattacharya D, Foti S, et al. HnRNP K mislocalisation is a novel protein pathology of frontotemporal lobar degeneration and ageing and leads to cryptic splicing. Acta Neuropathol. 2021;142:609-627 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 6c
  • 免疫印迹; 小鼠; 1:1000; 图 6d
Valencia A, Bieber V, Bajrami B, Marsh G, Hamann S, Wei R, et al. Antisense Oligonucleotide-Mediated Reduction of HDAC6 Does Not Reduce Tau Pathology in P301S Tau Transgenic Mice. Front Neurol. 2021;12:624051 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 2a
Zheng J, Tian N, Liu F, Zhang Y, Su J, Gao Y, et al. A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies. Signal Transduct Target Ther. 2021;6:269 pubmed 出版商
  • 免疫细胞化学; 人类; 1:400; 图 7f
Cores A, Abril S, Michalska P, Duarte P, Olives A, Martín M, et al. Bisavenathramide Analogues as Nrf2 Inductors and Neuroprotectors in In Vitro Models of Oxidative Stress and Hyperphosphorylation. Antioxidants (Basel). 2021;10: pubmed 出版商
  • 免疫印迹; 小鼠; 图 1a
Wu D, Gao D, Yu H, Pi G, Xiong R, Lei H, et al. Medial septum tau accumulation induces spatial memory deficit via disrupting medial septum-hippocampus cholinergic pathway. Clin Transl Med. 2021;11:e428 pubmed 出版商
  • 免疫组化; 小鼠; 1:500; 图 3a
Sakakibara Y, Hirota Y, Ibaraki K, Takei K, Chikamatsu S, Tsubokawa Y, et al. Widespread Reduced Density of Noradrenergic Locus Coeruleus Axons in the App Knock-In Mouse Model of Amyloid-β Amyloidosis. J Alzheimers Dis. 2021;82:1513-1530 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:200; 图 s1a
Zhang J, Wu N, Wang S, Yao Z, Xiao F, Lu J, et al. Neuronal loss and microgliosis are restricted to the core of Aβ deposits in mouse models of Alzheimer's disease. Aging Cell. 2021;20:e13380 pubmed 出版商
  • 免疫印迹; fruit fly ; 1:1000; 图 3g
  • 免疫组化; 小鼠; 1:200; 图 s6d
Subramanian M, Hyeon S, Das T, Suh Y, Kim Y, Lee J, et al. UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation. Nat Commun. 2021;12:3291 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 2n
López Gambero A, Rosell Valle C, Medina Vera D, Navarro J, Vargas A, Rivera P, et al. A Negative Energy Balance Is Associated with Metabolic Dysfunctions in the Hypothalamus of a Humanized Preclinical Model of Alzheimer's Disease, the 5XFAD Mouse. Int J Mol Sci. 2021;22: pubmed 出版商
  • 免疫组化; 小鼠; 1:1000; 图 4d
Zhang X, Zou L, Meng L, Xiong M, Pan L, Chen G, et al. Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction. elife. 2021;10: pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 5b
Galán Ganga M, Rodríguez Cueto C, Merchán Rubira J, Hernandez F, Avila J, Posada Ayala M, et al. Cannabinoid receptor CB2 ablation protects against TAU induced neurodegeneration. Acta Neuropathol Commun. 2021;9:90 pubmed 出版商
  • 免疫印迹; 小鼠; 1:200; 图 2b
Dong Y, Liang F, Huang L, Fang F, Yang G, Tanzi R, et al. The anesthetic sevoflurane induces tau trafficking from neurons to microglia. Commun Biol. 2021;4:560 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
Tseng J, Ajit A, Tabassum Z, Patel N, Tian X, Chen Y, et al. Tau seeds are subject to aberrant modifications resulting in distinct signatures. Cell Rep. 2021;35:109037 pubmed 出版商
  • 免疫组化; 人类
Miguel J, Perez S, Malek Ahmadi M, Mufson E. Cerebellar Calcium-Binding Protein and Neurotrophin Receptor Defects in Down Syndrome and Alzheimer's Disease. Front Aging Neurosci. 2021;13:645334 pubmed 出版商
  • 免疫印迹; 大鼠; 1:600
Shili C, Habibi M, Sutton J, Barnes J, Burch Konda J, Pezeshki A. Effect of a Phytogenic Water Additive on Growth Performance, Blood Metabolites and Gene Expression of Amino Acid Transporters in Nursery Pigs Fed with Low-Protein/High-Carbohydrate Diets. Animals (Basel). 2021;11: pubmed 出版商
  • 免疫印迹; 大鼠; 1:600
Wang X, Kuang N, Chen Y, Liu G, Wang N, Kong F, et al. Transplantation of olfactory ensheathing cells promotes the therapeutic effect of neural stem cells on spinal cord injury by inhibiting necrioptosis. Aging (Albany NY). 2021;13:9056-9070 pubmed 出版商
  • 免疫印迹; 大鼠; 1:600
Perez Garcia G, De Gasperi R, Gama Sosa M, Perez G, Otero Pagan A, Pryor D, et al. Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast. Acta Neuropathol Commun. 2021;9:33 pubmed 出版商
  • 免疫组化; 小鼠; 图 4a
  • 免疫印迹; 小鼠; 1:300; 图 4c
Choi Y, Dunn Meynell A, Marchese M, Blumberg B, Gaindh D, Dowling P, et al. Erythropoietin-derived peptide treatment reduced neurological deficit and neuropathological changes in a mouse model of tauopathy. Alzheimers Res Ther. 2021;13:32 pubmed 出版商
  • 免疫组化; 人类; 1:800
Hondius D, Koopmans F, Leistner C, Pita Illobre D, Peferoen Baert R, Marbus F, et al. The proteome of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer's disease. Acta Neuropathol. 2021;141:341-358 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:500; 图 2f
Sobue A, Komine O, Hara Y, Endo F, Mizoguchi H, Watanabe S, et al. Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease. Acta Neuropathol Commun. 2021;9:1 pubmed 出版商
  • 免疫组化; 小鼠; 1:500
Biechele G, Franzmeier N, Blume T, Ewers M, Luque J, Eckenweber F, et al. Glial activation is moderated by sex in response to amyloidosis but not to tau pathology in mouse models of neurodegenerative diseases. J Neuroinflammation. 2020;17:374 pubmed 出版商
  • 免疫组化; 小鼠; 1:500; 图 4d
  • 免疫印迹; 小鼠; 图 4a
Chiu C, Weng Y, Huang Y, Chen R, Liu Y, Yeh T, et al. (D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model. Cell Death Dis. 2020;11:1018 pubmed 出版商
  • 免疫组化; 小鼠; 1:500; 图 2a
Tang S, Fesharaki Zadeh A, Takahashi H, Nies S, Smith L, Luo A, et al. Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy. Acta Neuropathol Commun. 2020;8:96 pubmed 出版商
  • 免疫组化; 小鼠; 1:100; 图 2a
LeBlang C, Medalla M, Nicoletti N, Hays E, Zhao J, Shattuck J, et al. Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in Tauopathy. Front Neurosci. 2020;14:285 pubmed 出版商
  • 免疫组化; fruit fly ; 1:250; 图 4a
Ma X, Zhu Y, Lu J, Xie J, Li C, Shin W, et al. Nicotinamide mononucleotide adenylyltransferase uses its NAD+ substrate-binding site to chaperone phosphorylated Tau. elife. 2020;9: pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 3a
  • 免疫组化-石蜡切片; 小鼠; 图 2d
  • 免疫印迹; 小鼠; 图 1a, 1b
Hu S, Hu M, Liu J, Zhang B, Zhang Z, Zhou F, et al. Phosphorylation of Tau and α-Synuclein Induced Neurodegeneration in MPTP Mouse Model of Parkinson's Disease. Neuropsychiatr Dis Treat. 2020;16:651-663 pubmed 出版商
  • 免疫组化; 人类; 1:2000; 表 1
Yilmazer Hanke D, Mayer T, Müller H, Neugebauer H, Abaei A, Scheuerle A, et al. Histological correlates of postmortem ultra-high-resolution single-section MRI in cortical cerebral microinfarcts. Acta Neuropathol Commun. 2020;8:33 pubmed 出版商
  • 免疫组化; 人类; 1:2000; 图 1g
Liao X, Cai F, Sun Z, Zhang Y, Wang J, Jiao B, et al. Identification of Alzheimer's disease-associated rare coding variants in the ECE2 gene. JCI Insight. 2020;5: pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:50; 图 5a
  • 免疫印迹; 小鼠; 1:2000; 图 4a
Sun Y, Guo Y, Feng X, Jia M, Ai N, Dong Y, et al. The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer's disease. J Neuroinflammation. 2020;17:72 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4k
Rodriguez Ortiz C, Prieto G, Martini A, Forner S, Trujillo Estrada L, LaFerla F, et al. miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's disease. Aging Cell. 2020;19:e13118 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000; 图 2a
Schrank S, McDaid J, Briggs C, Mustaly Kalimi S, Brinks D, Houcek A, et al. Human-Induced Neurons from Presenilin 1 Mutant Patients Model Aspects of Alzheimer's Disease Pathology. Int J Mol Sci. 2020;21: pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:500; 图 1c
Kaalund S, Passamonti L, Allinson K, Murley A, Robbins T, Spillantini M, et al. Locus coeruleus pathology in progressive supranuclear palsy, and its relation to disease severity. Acta Neuropathol Commun. 2020;8:11 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:500; 图 3e
Bencze J, Szarka M, Bencs V, Szabó R, Módis L, Aarsland D, et al. Lemur Tyrosine Kinase 2 (LMTK2) Level Inversely Correlates with Phospho-Tau in Neuropathological Stages of Alzheimer's Disease. Brain Sci. 2020;10: pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:3000; 图 5d
Walker D, Tang T, Mendsaikhan A, Tooyama I, Serrano G, Sue L, et al. Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains. Int J Mol Sci. 2020;21: pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 4c
  • 免疫印迹; 小鼠; 图 4a
Li J, Chiu J, Ramanjulu M, Blass B, Pratico D. A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles. Mol Neurodegener. 2020;15:1 pubmed 出版商
  • 免疫组化; 人类; 1:200; 图 1, s2b
  • 免疫印迹; 人类; 1:250-1:2000; 图 5, 6
Inda M, Joshi S, Wang T, Bolaender A, Gandu S, Koren Iii J, et al. The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction. Nat Commun. 2020;11:319 pubmed 出版商
  • 免疫印迹; 小鼠; 1:100; 图 4s2a
Bowie E, Goetz S. TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons. elife. 2020;9: pubmed 出版商
  • 免疫组化-自由浮动切片; 人类; 1:2000; 图 3a
Braak H, Del Tredici K. From the Entorhinal Region via the Prosubiculum to the Dentate Fascia: Alzheimer Disease-Related Neurofibrillary Changes in the Temporal Allocortex. J Neuropathol Exp Neurol. 2020;79:163-175 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2f
He Z, McBride J, Xu H, Changolkar L, Kim S, Zhang B, et al. Transmission of tauopathy strains is independent of their isoform composition. Nat Commun. 2020;11:7 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200; 图 2a
Arenas F, Castro F, Núñez S, Gay G, Garcia Ruiz C, Fernandez Checa J. STARD1 and NPC1 expression as pathological markers associated with astrogliosis in post-mortem brains from patients with Alzheimer's disease and Down syndrome. Aging (Albany NY). 2020;12:571-592 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:600; 图 2a13
Shafei R, Woollacott I, Mummery C, Bocchetta M, Guerreiro R, Bras J, et al. Two pathologically confirmed cases of novel mutations in the MAPT gene causing frontotemporal dementia. Neurobiol Aging. 2020;87:141.e15-141.e20 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:1000; 图 5s1b
  • 免疫印迹; 小鼠; 图 5a
Fan Q, He W, Gayen M, Benoit M, Luo X, Hu X, et al. Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction. J Neurosci. 2020;40:1133-1144 pubmed 出版商
  • 免疫组化; 人类; 1:2000; 表 2
Yu L, Boyle P, Dawe R, Bennett D, Arfanakis K, Schneider J. Contribution of TDP and hippocampal sclerosis to hippocampal volume loss in older-old persons. Neurology. 2020;94:e142-e152 pubmed 出版商
  • 免疫组化-石蜡切片; 猫; 1:2000; 图 1
Fiock K, Smith J, Crary J, Hefti M. β-amyloid and tau pathology in the aging feline brain. J Comp Neurol. 2020;528:108-113 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:500; 图 1f
Kirabali T, Rigotti S, Siccoli A, Liebsch F, Shobo A, Hock C, et al. The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer's disease. Acta Neuropathol Commun. 2019;7:194 pubmed 出版商
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Pires G, McElligott S, Drusinsky S, Halliday G, Potier M, Wisniewski T, et al. Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer's disease and not in other tauopathies. Acta Neuropathol Commun. 2019;7:195 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1a
Faraco G, Hochrainer K, Segarra S, Schaeffer S, Santisteban M, Menon A, et al. Dietary salt promotes cognitive impairment through tau phosphorylation. Nature. 2019;: pubmed 出版商
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di Meco A, Pratico D. Early-life exposure to high-fat diet influences brain health in aging mice. Aging Cell. 2019;18:e13040 pubmed 出版商
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Kroth H, Oden F, Molette J, Schieferstein H, Capotosti F, Mueller A, et al. Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and other tauopathies. Eur J Nucl Med Mol Imaging. 2019;46:2178-2189 pubmed 出版商
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Latimer C, Burke B, Liachko N, Currey H, Kilgore M, Gibbons L, et al. Resistance and resilience to Alzheimer's disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort. Acta Neuropathol Commun. 2019;7:9 pubmed 出版商
  • 免疫组化; 小鼠; 1:1000; 图 6a
  • 免疫印迹; 小鼠; 1:1000; 图 s9a
Gamache J, Benzow K, Forster C, Kemper L, Hlynialuk C, Furrow E, et al. Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice. Nat Commun. 2019;10:2479 pubmed 出版商
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Zhang J, Chen B, Lu J, Wu Y, Wang S, Yao Z, et al. Brains of rhesus monkeys display Aβ deposits and glial pathology while lacking Aβ dimers and other Alzheimer's pathologies. Aging Cell. 2019;18:e12978 pubmed 出版商
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Libard S, Alafuzoff I. Alzheimer's disease neuropathological change and loss of matrix/neuropil in patients with idiopathic Normal Pressure Hydrocephalus, a model of Alzheimer's disease. Acta Neuropathol Commun. 2019;7:3 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 2a
  • 免疫印迹; 小鼠; 图 s15a
Sartori M, Mendes T, Desai S, Lasorsa A, Herledan A, Malmanche N, et al. BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation. Acta Neuropathol. 2019;: pubmed 出版商
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Chang H, Di T, Wang Y, Zeng X, Li G, Wan Q, et al. Seipin deletion in mice enhances phosphorylation and aggregation of tau protein through reduced neuronal PPARγ and insulin resistance. Neurobiol Dis. 2019;127:350-361 pubmed 出版商
  • 免疫组化; 人类; 1:300; 图 1a
Falcon B, Zivanov J, Zhang W, Murzin A, Garringer H, Vidal R, et al. Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules. Nature. 2019;568:420-423 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:500; 图 1c, 1f
Stejskalova Z, Rohan Z, Rusina R, Tesar A, Kukal J, Kovacs G, et al. Pyramidal system involvement in progressive supranuclear palsy - a clinicopathological correlation. BMC Neurol. 2019;19:42 pubmed 出版商
  • 免疫组化; 小鼠; 图 1e
Merezhko M, Brunello C, Yan X, Vihinen H, Jokitalo E, Uronen R, et al. Secretion of Tau via an Unconventional Non-vesicular Mechanism. Cell Rep. 2018;25:2027-2035.e4 pubmed 出版商
  • 免疫组化; 人类; 图 s4a
Thygesen C, Ilkjær L, Kempf S, Hemdrup A, von Linstow C, Babcock A, et al. Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APPSWE/PS1ΔE9 Transgenic Mice Implicate Cathepsin Z in Alzheimer's Disease. Front Cell Neurosci. 2018;12:397 pubmed 出版商
  • 免疫细胞化学; 人类; 图 s10b
  • 免疫印迹; 人类; 图 s10a
Wang C, Najm R, Xu Q, Jeong D, Walker D, Balestra M, et al. Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. Nat Med. 2018;24:647-657 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4
Hou Y, Lautrup S, Cordonnier S, Wang Y, Croteau D, Zavala E, et al. NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency. Proc Natl Acad Sci U S A. 2018;115:E1876-E1885 pubmed 出版商
  • 免疫组化-冰冻切片; African green monkey; 1:500; 图 6a
Cramer P, Gentzel R, Tanis K, Vardigan J, Wang Y, Connolly B, et al. Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease. Neurobiol Aging. 2018;64:92-106 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:1000; 图 2c
Brici D, G tz J, Nisbet R. A Novel Antibody Targeting Tau Phosphorylated at Serine 235 Detects Neurofibrillary Tangles. J Alzheimers Dis. 2018;61:899-905 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 8b
Qu X, Yuan F, Corona C, Pasini S, Pero M, Gundersen G, et al. Stabilization of dynamic microtubules by mDia1 drives Tau-dependent Aβ1-42 synaptotoxicity. J Cell Biol. 2017;216:3161-3178 pubmed 出版商
  • 免疫组化; 人类; 1:500; 图 1a
Tseng J, Xie L, Song S, Xie Y, Allen L, Ajit D, et al. The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology. Cell Rep. 2017;20:2169-2183 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 2a
Siedlak S, Jiang Y, Huntley M, Wang L, Gao J, Xie F, et al. TMEM230 Accumulation in Granulovacuolar Degeneration Bodies and Dystrophic Neurites of Alzheimer's Disease. J Alzheimers Dis. 2017;58:1027-1033 pubmed 出版商
  • 免疫组化; 小鼠; 图 4c
  • 免疫印迹; 小鼠; 图 4a
Li J, Barrero C, Merali S, Pratico D. Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype. Sci Rep. 2017;7:46002 pubmed 出版商
  • 免疫细胞化学; 人类; 图 5
  • 免疫印迹; 人类; 图 4a
Wu X, Kosaraju J, Tam K. SLM, a novel carbazole-based fluorophore attenuates okadaic acid-induced tau hyperphosphorylation via down-regulating GSK-3? activity in SH-SY5Y cells. Eur J Pharm Sci. 2017;110:101-108 pubmed 出版商
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Wang H, Wang R, Carrera I, Xu S, Lakshmana M. TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory Deficits. Eneuro. 2016;3: pubmed 出版商
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Polanco J, Scicluna B, Hill A, Götz J. Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner. J Biol Chem. 2016;291:12445-66 pubmed 出版商
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Chanu S, Sarkar S. Targeted Downregulation of dMyc Suppresses Pathogenesis of Human Neuronal Tauopathies in Drosophila by Limiting Heterochromatin Relaxation and Tau Hyperphosphorylation. Mol Neurobiol. 2017;54:2706-2719 pubmed 出版商
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Garcia Ratés S, Morrill P, Tu H, Pottiez G, Badin A, Tormo Garcia C, et al. (I) Pharmacological profiling of a novel modulator of the α7 nicotinic receptor: Blockade of a toxic acetylcholinesterase-derived peptide increased in Alzheimer brains. Neuropharmacology. 2016;105:487-499 pubmed 出版商
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Winston C, Noël A, Neustadtl A, Parsadanian M, Barton D, Chellappa D, et al. Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma. Am J Pathol. 2016;186:552-67 pubmed 出版商
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产品信息
产品类型 :
抗体
产品名称 :
Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8)
目录# :
MN1020
规格 :
100微克
价格 :
美国536
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类, 小鼠, 大鼠
应用 :
Immunocytochemistry: 1:50-1:1,000, Immunohistochemistry (Paraffin): 5-10 µg/mL, Western Blot: 1:250-1:2,000
物种 :
人类, 小鼠, 大鼠
克隆 :
AT8
抗体亚型 :
IgG1, kappa
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
免疫原 :
Partially purified human PHF-Tau
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:50-1:1,000, Immunohistochemistry (Paraffin): 5-10 µg/mL, Western Blot: 1:250-1:2,000
别名 :
AI413597; AW045860; DDPAC; FLJ31424; FTDP17; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; map tau; Mapt; MAPTL; MGC138549; microtubule associated protein tau; microtubule-associated protein tau; microtubule-associated protein tau, isoform 4; microtubules; MSTD; Mtapt; MTBT1; MTBT2; Neurofibrillary tangle protein; neurofibrillary tangles; Neuronal Marker; paired helical filament-tau; PHFtau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; pTau; RNPTAU; Tau; Tau microtubule-associated protein; tau protein; Tau-4; Tau5; Unknown (protein for MGC:134287)
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国