出版应用/物种/样本/稀释 | 参考文献 |
---|
- 免疫组化-自由浮动切片; 小鼠; 1:500; 图 1j
| Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt S, Vieira Saecker A, et al. NLRP3 inflammasome activation drives tau pathology. Nature. 2019;: pubmed 出版商
|
| Gary C, Lam S, Herard A, Koch J, Petit F, Gipchtein P, et al. Encephalopathy induced by Alzheimer brain inoculation in a non-human primate. Acta Neuropathol Commun. 2019;7:126 pubmed 出版商
|
| Kubo A, Misonou H, Matsuyama M, Nomori A, Wada Kakuda S, Takashima A, et al. Distribution of endogenous normal tau in the mouse brain. J Comp Neurol. 2019;527:985-998 pubmed 出版商
|
| Lang S, Harre U, Purohit P, Dietel K, Kienhöfer D, Hahn J, et al. Neurodegeneration Enhances the Development of Arthritis. J Immunol. 2017;198:2394-2402 pubmed 出版商
|
| Foxton R, Osborne A, Martin K, Ng Y, Shima D. Distal retinal ganglion cell axon transport loss and activation of p38 MAPK stress pathway following VEGF-A antagonism. Cell Death Dis. 2016;7:e2212 pubmed 出版商
|
| Makani V, Jang Y, Christopher K, Judy W, Eckstein J, Hensley K, et al. BBB-Permeable, Neuroprotective, and Neurotrophic Polysaccharide, Midi-GAGR. PLoS ONE. 2016;11:e0149715 pubmed 出版商
|
| Puvenna V, Engeler M, Banjara M, Brennan C, Schreiber P, Dadas A, et al. Is phosphorylated tau unique to chronic traumatic encephalopathy? Phosphorylated tau in epileptic brain and chronic traumatic encephalopathy. Brain Res. 2016;1630:225-40 pubmed 出版商
|
| Tousseyn T, Bajsarowicz K, Sánchez H, Gheyara A, Oehler A, Geschwind M, et al. Prion Disease Induces Alzheimer Disease-Like Neuropathologic Changes. J Neuropathol Exp Neurol. 2015;74:873-88 pubmed 出版商
|
| Liu P, Paulson J, Forster C, Shapiro S, Ashe K, Zahs K. Characterization of a Novel Mouse Model of Alzheimer's Disease--Amyloid Pathology and Unique β-Amyloid Oligomer Profile. PLoS ONE. 2015;10:e0126317 pubmed 出版商
|
| Blum D, Herrera F, Francelle L, Mendes T, Basquin M, Obriot H, et al. Mutant huntingtin alters Tau phosphorylation and subcellular distribution. Hum Mol Genet. 2015;24:76-85 pubmed 出版商
|
| Lasagna Reeves C, Sengupta U, Castillo Carranza D, Gerson J, Guerrero Munoz M, Troncoso J, et al. The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes. Acta Neuropathol Commun. 2014;2:56 pubmed 出版商
|
- 免疫印迹; 人类; 1:1000
- 免疫组化; 小鼠; 1:400
| Jiang T, Yu J, Zhu X, Zhang Q, Cao L, Wang H, et al. Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance. Neuropharmacology. 2014;85:121-30 pubmed 出版商
|
| Garcia Mesa Y, Pareja Galeano H, Bonet Costa V, Revilla S, Gómez Cabrera M, Gambini J, et al. Physical exercise neuroprotects ovariectomized 3xTg-AD mice through BDNF mechanisms. Psychoneuroendocrinology. 2014;45:154-66 pubmed 出版商
|
- 免疫组化; 小鼠; 1:100
- 免疫印迹; 小鼠; 1:500
| Shilling D, Müller M, Takano H, Mak D, Abel T, Coulter D, et al. Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis. J Neurosci. 2014;34:6910-23 pubmed 出版商
|
| Lin L, Yang S, Chu J, Wang L, Ning L, Zhang T, et al. Region-specific expression of tau, amyloid-? protein precursor, and synaptic proteins at physiological condition or under endoplasmic reticulum stress in rats. J Alzheimers Dis. 2014;41:1149-63 pubmed 出版商
|
| Inoue H, Hiradate Y, Shirakata Y, Kanai K, Kosaka K, Gotoh A, et al. Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis. FEBS Lett. 2014;588:2003-8 pubmed 出版商
|
| Kondadi A, Wang S, Montagner S, Kladt N, Korwitz A, Martinelli P, et al. Loss of the m-AAA protease subunit AFG?L? causes mitochondrial transport defects and tau hyperphosphorylation. EMBO J. 2014;33:1011-26 pubmed 出版商
|
| Pan J, Lee M, Honig L, Vonsattel J, Faust P, Louis E. Alzheimer's-related changes in non-demented essential tremor patients vs. controls: links between tau and tremor?. Parkinsonism Relat Disord. 2014;20:655-8 pubmed 出版商
|
- 免疫组化; 小鼠; 1:100
- 酶联免疫吸附测定; 小鼠; 1:250
- 免疫印迹; 小鼠; 1:1000
| Castillo Carranza D, Sengupta U, Guerrero Muñoz M, Lasagna Reeves C, Gerson J, Singh G, et al. Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles. J Neurosci. 2014;34:4260-72 pubmed 出版商
|
| Lu J, Li T, He R, Bartlett P, Götz J. Visualizing the microtubule-associated protein tau in the nucleus. Sci China Life Sci. 2014;57:422-31 pubmed 出版商
|
| Palm R, Chang J, Blair J, Garcia Mesa Y, Lee H, Castellani R, et al. Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice. J Neurochem. 2014;130:115-25 pubmed 出版商
|
| Kim H, Chang K, Ha T, Kim J, Ha S, Shin K, et al. S100A9 knockout decreases the memory impairment and neuropathology in crossbreed mice of Tg2576 and S100A9 knockout mice model. PLoS ONE. 2014;9:e88924 pubmed 出版商
|
| Dalby N, Volbracht C, Helboe L, Larsen P, Jensen H, Egebjerg J, et al. Altered function of hippocampal CA1 pyramidal neurons in the rTg4510 mouse model of tauopathy. J Alzheimers Dis. 2014;40:429-42 pubmed 出版商
|
| Abbondante S, Baglietto Vargas D, Rodriguez Ortiz C, Estrada Hernandez T, Medeiros R, LaFerla F. Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes. Am J Pathol. 2014;184:819-26 pubmed 出版商
|
| Orr M, Salinas A, Buffenstein R, Oddo S. Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology. Neurobiol Aging. 2014;35:1233-42 pubmed 出版商
|
- 免疫组化; 小鼠; 1:100
- 免疫印迹; 小鼠; 1:1000
| Yamada E, Respondek G, Müssner S, de Andrade A, Höllerhage M, Depienne C, et al. Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice. Exp Neurol. 2014;253:113-25 pubmed 出版商
|
| Torres M, Price S, Fiol deRoque M, Marcilla Etxenike A, Ahyayauch H, Barcelo Coblijn G, et al. Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease. Biochim Biophys Acta. 2014;1838:1680-92 pubmed 出版商
|
| Hoffmann N, Dorostkar M, Blumenstock S, Goedert M, Herms J. Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice. Acta Neuropathol Commun. 2013;1:82 pubmed 出版商
|
| Pehar M, Ko M, Li M, Scrable H, Puglielli L. P44, the 'longevity-assurance' isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion. Aging Cell. 2014;13:449-56 pubmed 出版商
|
| Huang X, Qian Z, He X, Gong Q, Wu K, Jiang L, et al. Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease. Neurobiol Aging. 2014;35:1045-54 pubmed 出版商
|
- 免疫组化; 小鼠; 1:500
- 免疫印迹; 小鼠; 1:500
| Graham D, Gray A, Joyce J, Yu D, O Moore J, Carlson G, et al. Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy. Neuropharmacology. 2014;79:307-13 pubmed 出版商
|
| Trujillo Estrada L, Jimenez S, De Castro V, Torres M, Baglietto Vargas D, Moreno Gonzalez I, et al. In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology. Acta Neuropathol Commun. 2013;1:73 pubmed 出版商
|
| Yanagisawa D, Taguchi H, Ibrahim N, Morikawa S, Shiino A, Inubushi T, et al. Preferred features of a fluorine-19 MRI probe for amyloid detection in the brain. J Alzheimers Dis. 2014;39:617-31 pubmed 出版商
|
| Baglietto Vargas D, Kitazawa M, Le E, Estrada Hernandez T, Rodriguez Ortiz C, Medeiros R, et al. Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition. Neurobiol Dis. 2014;62:407-15 pubmed 出版商
|
| Blennerhassett R, Lillo P, Halliday G, Hodges J, Kril J. Distribution of pathology in frontal variant Alzheimer's disease. J Alzheimers Dis. 2014;39:63-70 pubmed 出版商
|
| Nölle A, van Haastert E, Zwart R, Hoozemans J, Scheper W. Ubiquilin 2 is not associated with tau pathology. PLoS ONE. 2013;8:e76598 pubmed 出版商
|
| Hensley K, Gabbita S, Venkova K, Hristov A, Johnson M, Eslami P, et al. A derivative of the brain metabolite lanthionine ketimine improves cognition and diminishes pathology in the 3 × Tg-AD mouse model of Alzheimer disease. J Neuropathol Exp Neurol. 2013;72:955-69 pubmed 出版商
|
| Natunen T, Parrado A, Helisalmi S, Pursiheimo J, Sarajärvi T, Mäkinen P, et al. Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease. J Alzheimers Dis. 2013;37:217-32 pubmed 出版商
|
| Levarska L, Zilka N, Jadhav S, Neradil P, Novak M. Of rodents and men: the mysterious interneuronal pilgrimage of misfolded protein tau in Alzheimer’s disease. J Alzheimers Dis. 2013;37:569-77 pubmed 出版商
|
| Mannix R, Meehan W, MANDEVILLE J, Grant P, Gray T, Berglass J, et al. Clinical correlates in an experimental model of repetitive mild brain injury. Ann Neurol. 2013;74:65-75 pubmed 出版商
|
| Bonda D, Stone J, Torres S, Siedlak S, Perry G, Kryscio R, et al. Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance. J Neurochem. 2014;128:162-72 pubmed 出版商
|
| Anumala U, Gu J, Lo Monte F, Kramer T, Heyny von Haußen R, Hölzer J, et al. Fluorescent rhodanine-3-acetic acids visualize neurofibrillary tangles in Alzheimer's disease brains. Bioorg Med Chem. 2013;21:5139-44 pubmed 出版商
|
| Rantamäki T, Kemppainen S, Autio H, Stavén S, Koivisto H, Kojima M, et al. The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease. PLoS ONE. 2013;8:e68722 pubmed 出版商
|
| Chen R, Chang W, Lin Y, Cheng P, Chen Y. Alzheimer's amyloid-? oligomers rescue cellular prion protein induced tau reduction via the Fyn pathway. ACS Chem Neurosci. 2013;4:1287-96 pubmed 出版商
|
| Barron A, Garcia Segura L, Caruso D, Jayaraman A, Lee J, Melcangi R, et al. Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease. J Neurosci. 2013;33:8891-7 pubmed 出版商
|
| Ozcelik S, Fraser G, Castets P, Schaeffer V, Skachokova Z, Breu K, et al. Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice. PLoS ONE. 2013;8:e62459 pubmed 出版商
|
- 免疫组化; 大鼠; 1:100
- 酶联免疫吸附测定; 大鼠; 1:1000
- 免疫印迹; 大鼠; 1:1000
| Hawkins B, Krishnamurthy S, Castillo Carranza D, Sengupta U, Prough D, Jackson G, et al. Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies. J Biol Chem. 2013;288:17042-50 pubmed 出版商
|
| Tackenberg C, Grinschgl S, Trutzel A, Santuccione A, Frey M, Konietzko U, et al. NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss. Cell Death Dis. 2013;4:e608 pubmed 出版商
|
| Manczak M, Reddy P. Abnormal interaction of oligomeric amyloid-? with phosphorylated tau: implications to synaptic dysfunction and neuronal damage. J Alzheimers Dis. 2013;36:285-95 pubmed 出版商
|
| Gu J, Anumala U, Heyny von Haußen R, Hölzer J, Goetschy Meyer V, Mall G, et al. Design, synthesis and biological evaluation of trimethine cyanine dyes as fluorescent probes for the detection of tau fibrils in Alzheimer's disease brain and olfactory epithelium. ChemMedChem. 2013;8:891-7 pubmed 出版商
|
- 免疫组化; 人类; 1:50
- 免疫印迹; 人类; 1:2000
| Ando K, Brion J, Stygelbout V, Suain V, Authelet M, Dedecker R, et al. Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains. Acta Neuropathol. 2013;125:861-78 pubmed 出版商
|
| Iranzo A, Tolosa E, Gelpi E, Molinuevo J, Valldeoriola F, Serradell M, et al. Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study. Lancet Neurol. 2013;12:443-53 pubmed 出版商
|
| Ozdemir A, Rom I, Kovalevich J, Yen W, Adiga R, Dave R, et al. PINCH in the cellular stress response to tau-hyperphosphorylation. PLoS ONE. 2013;8:e58232 pubmed 出版商
|
| Varges D, Schulz Schaeffer W, Wemheuer W, Damman I, Schmitz M, Cramm M, et al. Spongiform encephalopathy in siblings with no evidence of protease-resistant prion protein or a mutation in the prion protein gene. J Neurol. 2013;260:1871-9 pubmed 出版商
|
| Josephs K, Dickson D, Murray M, Senjem M, Parisi J, Petersen R, et al. Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer's disease presenting as logopenic progressive aphasia. Brain Lang. 2013;127:127-34 pubmed 出版商
|
| Feldengut S, Del Tredici K, Braak H. Paraffin sections of 70-100 ?m: a novel technique and its benefits for studying the nervous system. J Neurosci Methods. 2013;215:241-4 pubmed 出版商
|
| Geekiyanage H, Upadhye A, Chan C. Inhibition of serine palmitoyltransferase reduces A? and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease. Neurobiol Aging. 2013;34:2037-51 pubmed 出版商
|
| Alonso E, Vale C, Vieytes M, Botana L. Translocation of PKC by yessotoxin in an in vitro model of Alzheimer's disease with improvement of tau and ?-amyloid pathology. ACS Chem Neurosci. 2013;4:1062-70 pubmed 出版商
|
| Bigio E. Making the diagnosis of frontotemporal lobar degeneration. Arch Pathol Lab Med. 2013;137:314-25 pubmed 出版商
|
| Garringer H, Murrell J, Sammeta N, Gnezda A, Ghetti B, Vidal R. Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice. PLoS ONE. 2013;8:e56426 pubmed 出版商
|
| Zufferey V, Vallet P, Moeri M, Moulin Sallanon M, Piotton F, Marin P, et al. Maladaptive exploratory behavior and neuropathology of the PS-1 P117L Alzheimer transgenic mice. Brain Res Bull. 2013;94:17-22 pubmed 出版商
|
| Parrella E, Maxim T, Maialetti F, Zhang L, Wan J, Wei M, et al. Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model. Aging Cell. 2013;12:257-68 pubmed 出版商
|
| Nash K, Lee D, Hunt J, Morganti J, Selenica M, Moran P, et al. Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy. Neurobiol Aging. 2013;34:1540-8 pubmed 出版商
|
| Baglietto Vargas D, Medeiros R, Martinez Coria H, LaFerla F, Green K. Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology. Biol Psychiatry. 2013;74:357-66 pubmed 出版商
|
| Schön C, Hoffmann N, Ochs S, Burgold S, Filser S, Steinbach S, et al. Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice. PLoS ONE. 2012;7:e53547 pubmed 出版商
|
| Kohler C, Dinekov M, Götz J. Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice. Neurobiol Aging. 2013;34:1369-79 pubmed 出版商
|
| Liu D, Pitta M, Jiang H, Lee J, Zhang G, Chen X, et al. Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession. Neurobiol Aging. 2013;34:1564-80 pubmed 出版商
|
| Yao J, Ho D, Calingasan N, Pipalia N, Lin M, Beal M. Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease. J Exp Med. 2012;209:2501-13 pubmed 出版商
|
| Hong Y, Chan C, Kwon I, Li X, Song M, Lee H, et al. SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease. J Neurosci. 2012;32:17262-72 pubmed 出版商
|
| ATTAR A, Ripoli C, Riccardi E, Maiti P, Li Puma D, Liu T, et al. Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers. Brain. 2012;135:3735-48 pubmed 出版商
|
| Borlikova G, Trejo M, Mably A, Mc Donald J, Sala Frigerio C, Regan C, et al. Alzheimer brain-derived amyloid ?-protein impairs synaptic remodeling and memory consolidation. Neurobiol Aging. 2013;34:1315-27 pubmed 出版商
|
- 免疫组化; 小鼠; 1:500
- 免疫印迹; 小鼠; 1:1000
| Torres M, Jimenez S, Sanchez Varo R, Navarro V, Trujillo Estrada L, Sanchez Mejias E, et al. Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus. Mol Neurodegener. 2012;7:59 pubmed 出版商
|
| Kovari E, Herrmann F, Hof P, Bouras C. The relationship between cerebral amyloid angiopathy and cortical microinfarcts in brain ageing and Alzheimer's disease. Neuropathol Appl Neurobiol. 2013;39:498-509 pubmed 出版商
|
| Yokota T, Akatsu H, Miyauchi T, Heese K. Characterization of the novel protein P9TLDR (temporal lobe down-regulated) with a brain-site-specific gene expression modality in Alzheimer's disease brain. FEBS Lett. 2012;586:4357-61 pubmed 出版商
|
| Merkwirth C, Martinelli P, Korwitz A, Morbin M, Brönneke H, Jordan S, et al. Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration. PLoS Genet. 2012;8:e1003021 pubmed 出版商
|
| Rahman A, Khan K, Al Khaledi G, Khan I, Attur S. Early postnatal lead exposure induces tau phosphorylation in the brain of young rats. Acta Biol Hung. 2012;63:411-25 pubmed 出版商
|
| Pirker S, Perju Dumbrava L, Kovacs G, Traub Weidinger T, Asenbaum S, Pirker W. Dopamine D2 receptor SPECT in corticobasal syndrome and autopsy-confirmed corticobasal degeneration. Parkinsonism Relat Disord. 2013;19:222-6 pubmed 出版商
|
- 免疫沉淀; 人类
- 免疫细胞化学; 人类
- 免疫印迹; 人类
| López Menéndez C, Gamir Morralla A, Jurado Arjona J, Higuero A, Campanero M, Ferrer I, et al. Kidins220 accumulates with tau in human Alzheimer's disease and related models: modulation of its calpain-processing by GSK3?/PP1 imbalance. Hum Mol Genet. 2013;22:466-82 pubmed 出版商
|
- 免疫组化; 人类; 1:200
- 免疫印迹; 人类; 1:500
| Choi S, Aid S, Caracciolo L, Minami S, Niikura T, Matsuoka Y, et al. Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease. J Neurochem. 2013;124:59-68 pubmed 出版商
|
| Harris J, Koyama A, Maeda S, Ho K, Devidze N, Dubal D, et al. Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits. PLoS ONE. 2012;7:e45881 pubmed 出版商
|
| Inoue K, Rispoli J, Kaphzan H, Klann E, Chen E, Kim J, et al. Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway. Mol Neurodegener. 2012;7:48 pubmed 出版商
|
| Vepsäläinen S, Koivisto H, Pekkarinen E, Mäkinen P, Dobson G, McDougall G, et al. Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease. J Nutr Biochem. 2013;24:360-70 pubmed 出版商
|
| van Abel D, Abdulhamid O, Scheper W, van Dijk M, Oudejans C. STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease. Neurosci Lett. 2012;528:104-9 pubmed 出版商
|
| Britschgi M, Takeda Uchimura Y, Rockenstein E, Johns H, Masliah E, Wyss Coray T. Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice. J Neuroinflammation. 2012;9:220 pubmed 出版商
|
| Capsoni S, Carlo A, Vignone D, Amato G, Criscuolo C, Willnow T, et al. SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2013;33:357-71 pubmed 出版商
|
| Mewes A, Franke H, Singer D. Organotypic brain slice cultures of adult transgenic P301S mice--a model for tauopathy studies. PLoS ONE. 2012;7:e45017 pubmed 出版商
|
| Tang J, Mardini F, Janik L, Garrity S, Li R, Bachlani G, et al. Modulation of murine Alzheimer pathogenesis and behavior by surgery. Ann Surg. 2013;257:439-48 pubmed 出版商
|
| Dumont M, Stack C, Elipenahli C, Jainuddin S, Gerges M, Starkova N, et al. Bezafibrate administration improves behavioral deficits and tau pathology in P301S mice. Hum Mol Genet. 2012;21:5091-105 pubmed 出版商
|
| Boländer A, Kieser D, Voss C, Bauer S, Schön C, Burgold S, et al. Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils and ?-amyloid plaques in Alzheimer's disease models. J Med Chem. 2012;55:9170-80 pubmed 出版商
|
| Tokutake T, Kasuga K, Yajima R, Sekine Y, Tezuka T, Nishizawa M, et al. Hyperphosphorylation of Tau induced by naturally secreted amyloid-? at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3? signaling pathway. J Biol Chem. 2012;287:35222-33 pubmed 出版商
|
| Gelpi E, Lladó A, Clarimon J, Rey M, Rivera R, Ezquerra M, et al. Phenotypic variability within the inclusion body spectrum of basophilic inclusion body disease and neuronal intermediate filament inclusion disease in frontotemporal lobar degenerations with FUS-positive inclusions. J Neuropathol Exp Neurol. 2012;71:795-805 pubmed 出版商
|
| Castello N, Green K, LaFerla F. Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter A? or tau pathology. PLoS ONE. 2012;7:e39566 pubmed 出版商
|
| Gelpi E, Soler Insa J, Parchi P, Saverioni D, Yague J, Nos C, et al. Atypical neuropathological sCJD-MM phenotype with abundant white matter Kuru-type plaques sparing the cerebellar cortex. Neuropathology. 2013;33:204-8 pubmed 出版商
|
| Mondragón Rodríguez S, Trillaud Doppia E, Dudilot A, Bourgeois C, Lauzon M, Leclerc N, et al. Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation. J Biol Chem. 2012;287:32040-53 pubmed 出版商
|
| Colom Cadena M, Gelpi E, Marti M, Charif S, Dols Icardo O, Blesa R, et al. MAPT H1 haplotype is associated with enhanced ?-synuclein deposition in dementia with Lewy bodies. Neurobiol Aging. 2013;34:936-42 pubmed 出版商
|
| Wang H, Bakshi K, Frankfurt M, Stucky A, Goberdhan M, Shah S, et al. Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A. J Neurosci. 2012;32:9773-84 pubmed 出版商
|
| Flunkert S, Hierzer M, Löffler T, Rabl R, Neddens J, Duller S, et al. Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model. Neurodegener Dis. 2013;11:194-205 pubmed 出版商
|
| Julien C, Marcouiller F, Bretteville A, El Khoury N, Baillargeon J, Hébert S, et al. Dimethyl sulfoxide induces both direct and indirect tau hyperphosphorylation. PLoS ONE. 2012;7:e40020 pubmed 出版商
|
| Medeiros R, Kitazawa M, Chabrier M, Cheng D, Baglietto Vargas D, Kling A, et al. Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice. Am J Pathol. 2012;181:616-25 pubmed 出版商
|
| Capsoni S, Marinelli S, Ceci M, Vignone D, Amato G, Malerba F, et al. Intranasal "painless" human Nerve Growth Factor [corrected] slows amyloid neurodegeneration and prevents memory deficits in App X PS1 mice. PLoS ONE. 2012;7:e37555 pubmed 出版商
|
| Schauer T, Lochner M, Kovacs G. Nigral Tau pathology and striatal amyloid-? deposition does not correlate with striatal dopamine deficit in Alzheimer's disease. J Neural Transm (Vienna). 2012;119:1545-9 pubmed 出版商
|
| Barten D, Fanara P, Andorfer C, Hoque N, Wong P, Husted K, et al. Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027. J Neurosci. 2012;32:7137-45 pubmed 出版商
|
| Herzig M, Bidinosti M, Schweizer T, Hafner T, Stemmelen C, Weiss A, et al. High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain. PLoS ONE. 2012;7:e36581 pubmed 出版商
|
| Cancino G, Miller F, Kaplan D. p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease. Neurobiol Aging. 2013;34:387-99 pubmed 出版商
|
| Mustroph M, King M, Klein R, Ramirez J. Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats. Behav Brain Res. 2012;233:141-8 pubmed 出版商
|
| Petratos S, Ozturk E, Azari M, Kenny R, Lee J, Magee K, et al. Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation. Brain. 2012;135:1794-818 pubmed 出版商
|
| Chen C, Weng Y, Chien K, Lin K, Yeh T, Cheng Y, et al. (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD. Cell Death Differ. 2012;19:1623-33 pubmed 出版商
|
| Kapás I, Majtenyi K, Töro K, Keller E, Voigtlander T, Kovacs G. Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease. Metab Brain Dis. 2012;27:231-5 pubmed 出版商
|
| Van der Jeugd A, Hochgräfe K, Ahmed T, Decker J, Sydow A, Hofmann A, et al. Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau. Acta Neuropathol. 2012;123:787-805 pubmed 出版商
|
- 免疫组化; 小鼠; 1:100
- 免疫印迹; 小鼠; 1:200
| Joshi Y, Chu J, Pratico D. Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease. J Alzheimers Dis. 2012;31:167-76 pubmed 出版商
|
- 免疫印迹; African green monkey
| Matsushima T, Saito Y, Elliott J, Iijima Ando K, Nishimura M, Kimura N, et al. Membrane-microdomain localization of amyloid ?-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue. J Biol Chem. 2012;287:19715-24 pubmed 出版商
|
| Fodero Tavoletti M, Brockschnieder D, Villemagne V, Martin L, Connor A, Thiele A, et al. In vitro characterization of [18F]-florbetaben, an Aβ imaging radiotracer. Nucl Med Biol. 2012;39:1042-8 pubmed 出版商
|
| Braak H, Thal D, Matschke J, Ghebremedhin E, Del Tredici K. Age-related appearance of dendritic inclusions in catecholaminergic brainstem neurons. Neurobiol Aging. 2013;34:286-97 pubmed 出版商
|
| Talbot K, Wang H, Kazi H, Han L, Bakshi K, Stucky A, et al. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest. 2012;122:1316-38 pubmed 出版商
|
| Carvalho C, Cardoso S, Correia S, Santos R, Santos M, Baldeiras I, et al. Metabolic alterations induced by sucrose intake and Alzheimer's disease promote similar brain mitochondrial abnormalities. Diabetes. 2012;61:1234-42 pubmed 出版商
|
| Clausen A, Xu X, Bi X, Baudry M. Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline. J Alzheimers Dis. 2012;30:183-208 pubmed 出版商
|
| Woehrer A, Laszlo L, Finsterer J, Stollberger C, Furtner J, Rinner W, et al. Novel crystalloid oligodendrogliopathy in hereditary spastic paraplegia. Acta Neuropathol. 2012;124:583-91 pubmed 出版商
|
| Rahman A, Khan K, Al Khaledi G, Khan I, Al Shemary T. Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats. Neurotoxicology. 2012;33:370-83 pubmed 出版商
|
| Zago W, Buttini M, Comery T, Nishioka C, Gardai S, Seubert P, et al. Neutralization of soluble, synaptotoxic amyloid ? species by antibodies is epitope specific. J Neurosci. 2012;32:2696-702 pubmed 出版商
|
| Matsuki T, Zaka M, Guerreiro R, van der Brug M, Cooper J, Cookson M, et al. Identification of Stk25 as a genetic modifier of Tau phosphorylation in Dab1-mutant mice. PLoS ONE. 2012;7:e31152 pubmed 出版商
|
| Löffler T, Flunkert S, Taub N, Schofield E, Ward M, Windisch M, et al. Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates. J Mol Neurosci. 2012;47:192-203 pubmed 出版商
|
- 免疫组化; 小鼠; 1:300
- 免疫印迹; 小鼠; 1:500
| Sudduth T, Wilson J, Everhart A, Colton C, Wilcock D. Lithium treatment of APPSwDI/NOS2-/- mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype. PLoS ONE. 2012;7:e31993 pubmed 出版商
|
| Kawakami F, Yabata T, Ohta E, Maekawa T, Shimada N, Suzuki M, et al. LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth. PLoS ONE. 2012;7:e30834 pubmed 出版商
|
| Sundaram J, Chan E, Poore C, Pareek T, Cheong W, Shui G, et al. Cdk5/p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration. J Neurosci. 2012;32:1020-34 pubmed 出版商
|
| Lasagna Reeves C, Castillo Carranza D, Sengupta U, Sarmiento J, Troncoso J, Jackson G, et al. Identification of oligomers at early stages of tau aggregation in Alzheimer's disease. FASEB J. 2012;26:1946-59 pubmed 出版商
|
| Giustiniani J, Sineus M, Sardin E, Dounane O, Panchal M, Sazdovitch V, et al. Decrease of the immunophilin FKBP52 accumulation in human brains of Alzheimer's disease and FTDP-17. J Alzheimers Dis. 2012;29:471-83 pubmed 出版商
|
| Venkataramani V, Wirths O, Budka H, Hartig W, Kovacs G, Bayer T. Antibody 9D5 recognizes oligomeric pyroglutamate amyloid-? in a fraction of amyloid-? deposits in Alzheimer's disease without cross-reactivity with other protein aggregates. J Alzheimers Dis. 2012;29:361-71 pubmed 出版商
|
| Stefanits H, Budka H, Kovacs G. Asymmetry of neurodegenerative disease-related pathologies: a cautionary note. Acta Neuropathol. 2012;123:449-52 pubmed 出版商
|
| Garcia Mesa Y, Gimenez Llort L, Lopez L, Venegas C, Cristofol R, Escames G, et al. Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse. Neurobiol Aging. 2012;33:1124.e13-29 pubmed 出版商
|
| Okamoto Y, Yamamoto T, Kalaria R, Senzaki H, Maki T, Hase Y, et al. Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts. Acta Neuropathol. 2012;123:381-94 pubmed 出版商
|
| Krüger U, Wang Y, Kumar S, Mandelkow E. Autophagic degradation of tau in primary neurons and its enhancement by trehalose. Neurobiol Aging. 2012;33:2291-305 pubmed 出版商
|
| Perez S, Getova D, He B, Counts S, Geula C, Désiré L, et al. Rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in Alzheimer's disease. Am J Pathol. 2012;180:526-40 pubmed 出版商
|
| Manaye K, Mouton P, Xu G, Drew A, Lei D, Sharma Y, et al. Age-related loss of noradrenergic neurons in the brains of triple transgenic mice. Age (Dordr). 2013;35:139-47 pubmed 出版商
|
- 免疫组化; baboons; 1:1000
- 免疫组化; African green monkey; 1:1000
| Ndung u M, Hartig W, Wegner F, Mwenda J, Low R, Akinyemi R, et al. Cerebral amyloid ?(42) deposits and microvascular pathology in ageing baboons. Neuropathol Appl Neurobiol. 2012;38:487-99 pubmed 出版商
|
| Morawski M, Brückner G, Jäger C, Seeger G, Matthews R, Arendt T. Involvement of perineuronal and perisynaptic extracellular matrix in Alzheimer's disease neuropathology. Brain Pathol. 2012;22:547-61 pubmed 出版商
|
| Li L, Zhang Z, Holscher C, Gao C, Jiang Y, Liu Y. (Val?) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains. Eur J Pharmacol. 2012;674:280-6 pubmed 出版商
|
| Nijholt D, van Haastert E, Rozemuller A, Scheper W, Hoozemans J. The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies. J Pathol. 2012;226:693-702 pubmed 出版商
|
| Kitazawa M, Cheng D, Tsukamoto M, Koike M, Wes P, Vasilevko V, et al. Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal ?-catenin pathway function in an Alzheimer's disease model. J Immunol. 2011;187:6539-49 pubmed 出版商
|
| Cuadrado Tejedor M, Ricobaraza A, Frechilla D, Franco R, Pérez Mediavilla A, Garcia Osta A. Chronic mild stress accelerates the onset and progression of the Alzheimer's disease phenotype in Tg2576 mice. J Alzheimers Dis. 2012;28:567-78 pubmed 出版商
|
- 免疫组化; 人类; 1:500
- 免疫印迹; 人类; 1:500
| Sanchez Varo R, Trujillo Estrada L, Sanchez Mejias E, Torres M, Baglietto Vargas D, Moreno Gonzalez I, et al. Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus. Acta Neuropathol. 2012;123:53-70 pubmed 出版商
|
| Piccardo P, Cervenak J, Yakovleva O, Gregori L, Pomeroy K, Cook A, et al. Squirrel monkeys (Saimiri sciureus) infected with the agent of bovine spongiform encephalopathy develop tau pathology. J Comp Pathol. 2012;147:84-93 pubmed 出版商
|
| Saing T, Dick M, Nelson P, Kim R, Cribbs D, Head E. Frontal cortex neuropathology in dementia pugilistica. J Neurotrauma. 2012;29:1054-70 pubmed 出版商
|
- 免疫细胞化学; 人类; 1:1000
- 免疫组化; 人类; 1:1000
| Wilhelmus M, de Jager M, Rozemuller A, Brevé J, Bol J, Eckert R, et al. Transglutaminase 1 and its regulator tazarotene-induced gene 3 localize to neuronal tau inclusions in tauopathies. J Pathol. 2012;226:132-42 pubmed 出版商
|
| Li X, Kumar Y, Zempel H, Mandelkow E, Biernat J, Mandelkow E. Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration. EMBO J. 2011;30:4825-37 pubmed 出版商
|
| Antonell A, Gelpi E, Sanchez Valle R, Martinez R, Molinuevo J, Lladó A. Breakpoint sequence analysis of an A?PP locus duplication associated with autosomal dominant Alzheimer's disease and severe cerebral amyloid angiopathy. J Alzheimers Dis. 2012;28:303-8 pubmed 出版商
|
| McMillan P, Kraemer B, Robinson L, Leverenz J, Raskind M, Schellenberg G. Truncation of tau at E391 promotes early pathologic changes in transgenic mice. J Neuropathol Exp Neurol. 2011;70:1006-19 pubmed 出版商
|
| Braak H, Thal D, Ghebremedhin E, Del Tredici K. Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years. J Neuropathol Exp Neurol. 2011;70:960-9 pubmed 出版商
|
| Elipenahli C, Stack C, Jainuddin S, Gerges M, Yang L, Starkov A, et al. Behavioral improvement after chronic administration of coenzyme Q10 in P301S transgenic mice. J Alzheimers Dis. 2012;28:173-82 pubmed 出版商
|
| Castellani R, Gupta Y, Sheng B, Siedlak S, Harris P, Coller J, et al. A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules. Lab Invest. 2011;91:1777-86 pubmed 出版商
|
| Ambegaokar S, Jackson G. Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation. Hum Mol Genet. 2011;20:4947-77 pubmed 出版商
|
| Khandelwal P, Dumanis S, Herman A, Rebeck G, Moussa C. Wild type and P301L mutant Tau promote neuro-inflammation and ?-Synuclein accumulation in lentiviral gene delivery models. Mol Cell Neurosci. 2012;49:44-53 pubmed 出版商
|
| Li L, Cheung T, Chen J, Herrup K. A comparative study of five mouse models of Alzheimer's disease: cell cycle events reveal new insights into neurons at risk for death. Int J Alzheimers Dis. 2011;2011:171464 pubmed 出版商
|
| Alonso E, Vale C, Vieytes M, LaFerla F, Gimenez Llort L, Botana L. 13-Desmethyl spirolide-C is neuroprotective and reduces intracellular A? and hyperphosphorylated tau in vitro. Neurochem Int. 2011;59:1056-65 pubmed 出版商
|
| Wilhelmus M, Bol J, van Haastert E, Rozemuller A, Bu G, Drukarch B, et al. Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis. Am J Pathol. 2011;179:2152-6 pubmed 出版商
|
| Xue Q, Streit W. Microglial pathology in Down syndrome. Acta Neuropathol. 2011;122:455-66 pubmed 出版商
|
| Emmer K, Waxman E, Covy J, Giasson B. E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment. J Biol Chem. 2011;286:35104-18 pubmed 出版商
|
| Sheppard O, Plattner F, Rubin A, Slender A, Linehan J, Brandner S, et al. Altered regulation of tau phosphorylation in a mouse model of down syndrome aging. Neurobiol Aging. 2012;33:828.e31-44 pubmed 出版商
|
- 酶联免疫吸附测定; 小鼠
- 免疫印迹; 小鼠; 1:1000
| Chai X, Wu S, Murray T, Kinley R, Cella C, Sims H, et al. Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression. J Biol Chem. 2011;286:34457-67 pubmed 出版商
|
| Dumont M, Stack C, Elipenahli C, Jainuddin S, Gerges M, Starkova N, et al. Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice. FASEB J. 2011;25:4063-72 pubmed 出版商
|
| Cho S, Sun B, Zhou Y, Kauppinen T, Halabisky B, Wes P, et al. CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease. J Biol Chem. 2011;286:32713-22 pubmed 出版商
|
| Panaite P, Kielar M, Kraftsik R, Gourdon G, Kuntzer T, Barakat Walter I. Peripheral neuropathy is linked to a severe form of myotonic dystrophy in transgenic mice. J Neuropathol Exp Neurol. 2011;70:678-85 pubmed 出版商
|
| Gerhauser I, Wohlsein P, Ernst H, Germann P, Baumgartner W. Lack of detectable diffuse or neuritic plaques and neurofibrillary tangles in the brains of aged hamsters. Neurobiol Aging. 2012;33:1716-9 pubmed 出版商
|
| Minami S, Clifford T, HOE H, Matsuoka Y, Rebeck G. Fyn knock-down increases A?, decreases phospho-tau, and worsens spatial learning in 3×Tg-AD mice. Neurobiol Aging. 2012;33:825.e15-24 pubmed 出版商
|
| Whiteman I, Minamide L, Goh D, Bamburg J, Goldsbury C. Rapid changes in phospho-MAP/tau epitopes during neuronal stress: cofilin-actin rods primarily recruit microtubule binding domain epitopes. PLoS ONE. 2011;6:e20878 pubmed 出版商
|
| Kanaan N, Morfini G, LaPointe N, Pigino G, Patterson K, Song Y, et al. Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases. J Neurosci. 2011;31:9858-68 pubmed 出版商
|
| Martínez Sáez E, Gelpi E, Rey M, Ferrer I, Ribalta T, Botta Orfila T, et al. Hirano body-rich subtypes of Creutzfeldt-Jakob disease. Neuropathol Appl Neurobiol. 2012;38:153-61 pubmed 出版商
|
| Roe A, Staup M, Serrats J, Sawchenko P, Rissman R. Lipopolysaccharide-induced tau phosphorylation and kinase activity--modulation, but not mediation, by corticotropin-releasing factor receptors. Eur J Neurosci. 2011;34:448-56 pubmed 出版商
|
| Satoh J, Tabunoki H, Ishida T, Saito Y, Arima K. Immunohistochemical characterization of ?-secretase activating protein expression in Alzheimer's disease brains. Neuropathol Appl Neurobiol. 2012;38:132-41 pubmed 出版商
|
- 免疫组化; 人类; 1 ug/ml
- 免疫印迹; 人类; 1:1000
| Tran H, LaFerla F, Holtzman D, Brody D. Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-? accumulation and independently accelerates the development of tau abnormalities. J Neurosci. 2011;31:9513-25 pubmed 出版商
|
| Silva D, Esteves A, Arduino D, Oliveira C, Cardoso S. Amyloid-?-induced mitochondrial dysfunction impairs the autophagic lysosomal pathway in a tubulin dependent pathway. J Alzheimers Dis. 2011;26:565-81 pubmed 出版商
|
| Rodriguez Diehl R, Rey M, Gironell A, Martínez Sáez E, Ferrer I, Sanchez Valle R, et al. "Preclinical" MSA in definite Creutzfeldt-Jakob disease. Neuropathology. 2012;32:158-63 pubmed 出版商
|
| Stone J, Siedlak S, Tabaton M, Hirano A, Castellani R, Santocanale C, et al. The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies. J Neuropathol Exp Neurol. 2011;70:578-87 pubmed 出版商
|
| Goodwin J, Zhang J, Gonzalez D, Albinsson S, Geller D. Knockout of the vascular endothelial glucocorticoid receptor abrogates dexamethasone-induced hypertension. J Hypertens. 2011;29:1347-56 pubmed 出版商
|
| Cuadrado Tejedor M, Hervias I, Ricobaraza A, Puerta E, Pérez Roldán J, García Barroso C, et al. Sildenafil restores cognitive function without affecting ?-amyloid burden in a mouse model of Alzheimer's disease. Br J Pharmacol. 2011;164:2029-41 pubmed 出版商
|
| Engmann O, Hortobagyi T, Thompson A, Guadagno J, Troakes C, Soriano S, et al. Cyclin-dependent kinase 5 activator p25 is generated during memory formation and is reduced at an early stage in Alzheimer's disease. Biol Psychiatry. 2011;70:159-68 pubmed 出版商
|
| Waxman E, Giasson B. Induction of intracellular tau aggregation is promoted by ?-synuclein seeds and provides novel insights into the hyperphosphorylation of tau. J Neurosci. 2011;31:7604-18 pubmed 出版商
|
| Copenhaver P, Anekonda T, Musashe D, Robinson K, Ramaker J, Swanson T, et al. A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug. Dis Model Mech. 2011;4:634-48 pubmed 出版商
|
| Belarbi K, Burnouf S, Fernandez Gomez F, Laurent C, Lestavel S, Figeac M, et al. Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology. Neurobiol Dis. 2011;43:486-94 pubmed 出版商
|
| Rusina R, Kovacs G, Fiala J, Hort J, Ridzon P, Holmerová I, et al. FTLD-TDP with motor neuron disease, visuospatial impairment and a progressive supranuclear palsy-like syndrome: broadening the clinical phenotype of TDP-43 proteinopathies. A report of three cases. BMC Neurol. 2011;11:50 pubmed 出版商
|
- 免疫组化; domestic rabbit; 1:500
| Sparks D, Ziolkowski C, Lawmaster T, Martin T. Influence of water quality on cholesterol-induced tau pathology: preliminary data. Int J Alzheimers Dis. 2011;2011:987023 pubmed 出版商
|
| Orejana L, Barros Miñones L, Jordan J, Puerta E, Aguirre N. Sildenafil ameliorates cognitive deficits and tau pathology in a senescence-accelerated mouse model. Neurobiol Aging. 2012;33:625.e11-20 pubmed 出版商
|
| Seilhean D, Le Ber I, Sarazin M, Lacomblez L, Millecamps S, Salachas F, et al. Fronto-temporal lobar degeneration: neuropathology in 60 cases. J Neural Transm (Vienna). 2011;118:753-64 pubmed 出版商
|
- 免疫组化; 大鼠; 1:500
- 免疫印迹; 大鼠; 1:500
| Castro Álvarez J, Gutierrez Vargas J, Darnaudéry M, Cardona Gómez G. ROCK inhibition prevents tau hyperphosphorylation and p25/CDK5 increase after global cerebral ischemia. Behav Neurosci. 2011;125:465-72 pubmed 出版商
|
- 免疫组化; 人类; 1:200
- 免疫印迹; 人类; 1:1000
| Chen L, Xiong Y, Kong F, Qu M, Wang Q, Chen X, et al. Neuroglobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling. J Neurochem. 2012;120:157-64 pubmed 出版商
|
| Gaig C, Valldeoriola F, Gelpi E, Ezquerra M, Llufriu S, Buongiorno M, et al. Rapidly progressive diffuse Lewy body disease. Mov Disord. 2011;26:1316-23 pubmed 出版商
|
| Ferreira A, Bigio E. Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies. Mol Med. 2011;17:676-85 pubmed 出版商
|
- 免疫组化; 人类; 1:200
- 免疫印迹; 人类; 1:500
| Kovacs G, Molnár K, Laszlo L, Strobel T, Botond G, Hönigschnabl S, et al. A peculiar constellation of tau pathology defines a subset of dementia in the elderly. Acta Neuropathol. 2011;122:205-22 pubmed 出版商
|
| Hagen M, Murrell J, Delisle M, Andermann E, Andermann F, Guiot M, et al. Encephalopathy with neuroserpin inclusion bodies presenting as progressive myoclonus epilepsy and associated with a novel mutation in the Proteinase Inhibitor 12 gene. Brain Pathol. 2011;21:575-82 pubmed 出版商
|
| Maeda J, Zhang M, Okauchi T, Ji B, Ono M, Hattori S, et al. In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders. J Neurosci. 2011;31:4720-30 pubmed 出版商
|
- 免疫细胞化学; 大鼠; 1:200
- 免疫印迹; 大鼠
| Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe D. Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proc Natl Acad Sci U S A. 2011;108:5819-24 pubmed 出版商
|
| Koike M, Garcia F, Kitazawa M, Green K, LaFerla F. Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia. Neurosci Lett. 2011;495:55-9 pubmed 出版商
|
| Green K, Khashwji H, Estrada T, LaFerla F. ST101 induces a novel 17 kDa APP cleavage that precludes A? generation in vivo. Ann Neurol. 2011;69:831-44 pubmed 出版商
|
| Jayadev S, Nochlin D, Poorkaj P, Steinbart E, Mastrianni J, Montine T, et al. Familial prion disease with Alzheimer disease-like tau pathology and clinical phenotype. Ann Neurol. 2011;69:712-20 pubmed 出版商
|
| Glöckner F, Meske V, Lutjohann D, Ohm T. Dietary cholesterol and its effect on tau protein: a study in apolipoprotein E-deficient and P301L human tau mice. J Neuropathol Exp Neurol. 2011;70:292-301 pubmed 出版商
|
| Talbot K, Louneva N, Cohen J, Kazi H, Blake D, Arnold S. Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location. PLoS ONE. 2011;6:e16886 pubmed 出版商
|
- 免疫组化; 人类; 1:200
- 免疫印迹; 人类; 1:3000
| Himeno E, Ohyagi Y, Ma L, Nakamura N, Miyoshi K, Sakae N, et al. Apomorphine treatment in Alzheimer mice promoting amyloid-? degradation. Ann Neurol. 2011;69:248-56 pubmed 出版商
|
| Sydow A, Van der Jeugd A, Zheng F, Ahmed T, Balschun D, Petrova O, et al. Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant. J Neurosci. 2011;31:2511-25 pubmed 出版商
|
| Whittington R, Virag L, Marcouiller F, Papon M, El Khoury N, Julien C, et al. Propofol directly increases tau phosphorylation. PLoS ONE. 2011;6:e16648 pubmed 出版商
|
| Nunes A, Pressey S, Cooper J, Soriano S. Loss of amyloid precursor protein in a mouse model of Niemann-Pick type C disease exacerbates its phenotype and disrupts tau homeostasis. Neurobiol Dis. 2011;42:349-59 pubmed 出版商
|
| Shipton O, Leitz J, Dworzak J, Acton C, Tunbridge E, Denk F, et al. Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation. J Neurosci. 2011;31:1688-92 pubmed 出版商
|
- 免疫组化; 仓鼠; 1:2000
- 免疫印迹; 仓鼠; 1:500
| Stieler J, Bullmann T, Kohl F, Tøien Ø, Brückner M, Hartig W, et al. The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation. PLoS ONE. 2011;6:e14530 pubmed 出版商
|
| Niikura T, Sidahmed E, Hirata Fukae C, Aisen P, Matsuoka Y. A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice. PLoS ONE. 2011;6:e16259 pubmed 出版商
|
- 免疫组化; 小鼠; 1:50
- 免疫印迹; 小鼠; 1:1000
| Cuadrado Tejedor M, Ricobaraza A, Del Rio J, Frechilla D, Franco R, Pérez Mediavilla A, et al. Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation. Behav Brain Res. 2011;220:338-43 pubmed 出版商
|
| Fonseca M, Chu S, Berci A, Benoit M, Peters D, Kimura Y, et al. Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease. J Neuroinflammation. 2011;8:4 pubmed 出版商
|
| Ksiezak Reding H, Ho L, Santa Maria I, Díaz Ruiz C, Wang J, Pasinetti G. Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols. Neurobiol Aging. 2012;33:1427-39 pubmed 出版商
|
| Filipcik P, Zilka N, Bugos O, Kučerák J, Koson P, Novak P, et al. First transgenic rat model developing progressive cortical neurofibrillary tangles. Neurobiol Aging. 2012;33:1448-56 pubmed 出版商
|
| Ando K, Uemura K, Kuzuya A, Maesako M, Asada Utsugi M, Kubota M, et al. N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: implications for neurodegeneration in Alzheimer disease. J Biol Chem. 2011;286:7619-28 pubmed 出版商
|
| Chen J, Cohen M, Lerner A, Yang Y, Herrup K. DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's disease. Mol Neurodegener. 2010;5:60 pubmed 出版商
|
| Braak H, Del Tredici K. The pathological process underlying Alzheimer's disease in individuals under thirty. Acta Neuropathol. 2011;121:171-81 pubmed 出版商
|
| Van der Jeugd A, Ahmed T, Burnouf S, Belarbi K, Hamdame M, Grosjean M, et al. Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission. Neurobiol Learn Mem. 2011;95:296-304 pubmed 出版商
|
| Sepulveda Falla D, Matschke J, Bernreuther C, Hagel C, Puig B, Villegas A, et al. Deposition of hyperphosphorylated tau in cerebellum of PS1 E280A Alzheimer's disease. Brain Pathol. 2011;21:452-63 pubmed 出版商
|
| Leger F, Fernagut P, Canron M, Leoni S, Vital C, Tison F, et al. Protein aggregation in the aging retina. J Neuropathol Exp Neurol. 2011;70:63-8 pubmed 出版商
|
| Boutajangout A, Quartermain D, Sigurdsson E. Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model. J Neurosci. 2010;30:16559-66 pubmed 出版商
|
- 免疫细胞化学; 人类; 1:10
- 免疫组化; 人类; 1:1000
- 免疫印迹; 人类; 1:100000
| Colodner K, Feany M. Glial fibrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy. J Neurosci. 2010;30:16102-13 pubmed 出版商
|
| Bittner T, Fuhrmann M, Burgold S, Ochs S, Hoffmann N, Mitteregger G, et al. Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice. PLoS ONE. 2010;5:e15477 pubmed 出版商
|
| Ringman J, Gylys K, Medina L, Fox M, Kepe V, Flores D, et al. Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation. Neurosci Lett. 2011;487:287-92 pubmed 出版商
|
| Takahashi R, Tobiume M, Sato Y, Sata T, Gouras G, Takahashi H. Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain. Neuropathology. 2011;31:208-14 pubmed 出版商
|
| Braak H, Thal D, Del Tredici K. Nerve cells immunoreactive for p62 in select hypothalamic and brainstem nuclei of controls and Parkinson's disease cases. J Neural Transm (Vienna). 2011;118:809-19 pubmed 出版商
|
| Tamayev R, Giliberto L, Li W, d Abramo C, Arancio O, Vidal R, et al. Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis. J Neurosci. 2010;30:14915-24 pubmed 出版商
|
| Yang D, Xie Z, Stephenson D, Morton D, Hicks C, Brown T, et al. Volumetric MRI and MRS provide sensitive measures of Alzheimer's disease neuropathology in inducible Tau transgenic mice (rTg4510). Neuroimage. 2011;54:2652-8 pubmed 出版商
|
| Bose A, Mouton Liger F, Paquet C, Mazot P, Vigny M, Gray F, et al. Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease. Brain Pathol. 2011;21:189-200 pubmed 出版商
|
| Kakefuda K, Oyagi A, Ishisaka M, Tsuruma K, Shimazawa M, Yokota K, et al. Diacylglycerol kinase ? knockout mice exhibit lithium-sensitive behavioral abnormalities. PLoS ONE. 2010;5:e13447 pubmed 出版商
|
| Halleskog C, Mulder J, Dahlström J, Mackie K, Hortobagyi T, Tanila H, et al. WNT signaling in activated microglia is proinflammatory. Glia. 2011;59:119-31 pubmed 出版商
|
| Kantarci K, Yang C, Schneider J, Senjem M, Reyes D, Lowe V, et al. Antemortem amyloid imaging and ?-amyloid pathology in a case with dementia with Lewy bodies. Neurobiol Aging. 2012;33:878-85 pubmed 出版商
|
| Andrews Zwilling Y, Bien Ly N, Xu Q, Li G, Bernardo A, Yoon S, et al. Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. J Neurosci. 2010;30:13707-17 pubmed 出版商
|
| Perez S, He B, Muhammad N, Oh K, Fahnestock M, Ikonomovic M, et al. Cholinotrophic basal forebrain system alterations in 3xTg-AD transgenic mice. Neurobiol Dis. 2011;41:338-52 pubmed 出版商
|
| Stozicka Z, Zilka N, Novak P, Kovacech B, Bugos O, Novak M. Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's disease. J Neuroinflammation. 2010;7:64 pubmed 出版商
|
| Chen X, Wagener J, Morgan D, Hui L, Ghribi O, Geiger J. Endolysosome mechanisms associated with Alzheimer's disease-like pathology in rabbits ingesting cholesterol-enriched diet. J Alzheimers Dis. 2010;22:1289-303 pubmed 出版商
|
| Peethumnongsin E, Yang L, Kallhoff Munoz V, Hu L, Takashima A, Pautler R, et al. Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function. J Neurosci. 2010;30:13409-18 pubmed 出版商
|
- 免疫组化; 小鼠; 1:200
- 免疫印迹; 小鼠; 1:5000
| Bhaskar K, Konerth M, Kokiko Cochran O, Cardona A, Ransohoff R, Lamb B. Regulation of tau pathology by the microglial fractalkine receptor. Neuron. 2010;68:19-31 pubmed 出版商
|
| Minami S, Sidahmed E, Aid S, Shimoji M, Niikura T, Mocchetti I, et al. Therapeutic versus neuroinflammatory effects of passive immunization is dependent on A?/amyloid burden in a transgenic mouse model of Alzheimer's disease. J Neuroinflammation. 2010;7:57 pubmed 出版商
|
| Van Nostrand W, Xu F, Rozemuller A, Colton C. Enhanced capillary amyloid angiopathy-associated pathology in Tg-SwDI mice with deleted nitric oxide synthase 2. Stroke. 2010;41:S135-8 pubmed 出版商
|
| Min S, Cho S, Zhou Y, Schroeder S, Haroutunian V, Seeley W, et al. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron. 2010;67:953-66 pubmed 出版商
|
| Lee S, Varvel N, Konerth M, Xu G, Cardona A, Ransohoff R, et al. CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models. Am J Pathol. 2010;177:2549-62 pubmed 出版商
|
| Currais A, Kato K, Canuet L, Ishii R, Tanaka T, Takeda M, et al. Caffeine modulates tau phosphorylation and affects Akt signaling in postmitotic neurons. J Mol Neurosci. 2011;43:326-32 pubmed 出版商
|
| Rosario E, Carroll J, Pike C. Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways. Brain Res. 2010;1359:281-90 pubmed 出版商
|
| Epis R, Marcello E, Gardoni F, Vastagh C, Malinverno M, Balducci C, et al. Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease. Brain. 2010;133:3323-35 pubmed 出版商
|
| Hurtado D, Molina Porcel L, Iba M, Aboagye A, Paul S, Trojanowski J, et al. A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model. Am J Pathol. 2010;177:1977-88 pubmed 出版商
|
| Hoftberger R, Fink S, Aboul Enein F, Botond G, Olah J, Berki T, et al. Tubulin polymerization promoting protein (TPPP/p25) as a marker for oligodendroglial changes in multiple sclerosis. Glia. 2010;58:1847-57 pubmed 出版商
|
| Wilhelmus M, Verhaar R, Andringa G, Bol J, Cras P, Shan L, et al. Presence of tissue transglutaminase in granular endoplasmic reticulum is characteristic of melanized neurons in Parkinson's disease brain. Brain Pathol. 2011;21:130-9 pubmed 出版商
|
| Ramirez J, Poulton W, Knelson E, Barton C, King M, Klein R. Focal expression of mutated tau in entorhinal cortex neurons of rats impairs spatial working memory. Behav Brain Res. 2011;216:332-40 pubmed 出版商
|
- 免疫组化; 人类; 1:100
- 免疫印迹; 人类; 1:50
| Hamilton L, Aumont A, Julien C, Vadnais A, Calon F, Fernandes K. Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer's disease. Eur J Neurosci. 2010;32:905-20 pubmed 出版商
|
| McKee A, Gavett B, Stern R, Nowinski C, Cantu R, Kowall N, et al. TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy. J Neuropathol Exp Neurol. 2010;69:918-29 pubmed 出版商
|
| Zheng Y, Amin N, Hu Y, Rudrabhatla P, Shukla V, Kanungo J, et al. A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation. J Biol Chem. 2010;285:34202-12 pubmed 出版商
|
| Blanchard J, Wanka L, Tung Y, Cárdenas Aguayo M, LaFerla F, Iqbal K, et al. Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting A? and tau pathologies in 3xTg-AD mice. Acta Neuropathol. 2010;120:605-21 pubmed 出版商
|
| Loy C, McCusker E, Kril J, Kwok J, Brooks W, McCann H, et al. Very early-onset frontotemporal dementia with no family history predicts underlying fused in sarcoma pathology. Brain. 2010;133:e158; author reply e159 pubmed 出版商
|
| Nicholson R, Kusne Y, Nowak L, LaFerla F, Reiman E, Valla J. Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models. Brain Res. 2010;1347:179-85 pubmed 出版商
|
- 免疫印迹; fruit fly ; 1:50000
| Khurana V, Elson Schwab I, Fulga T, Sharp K, Loewen C, Mulkearns E, et al. Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo. PLoS Genet. 2010;6:e1001026 pubmed 出版商
|
| van Eersel J, Ke Y, Liu X, Delerue F, Kril J, Götz J, et al. Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proc Natl Acad Sci U S A. 2010;107:13888-93 pubmed 出版商
|
| Blazquez Llorca L, Garcia Marin V, DeFelipe J. Pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of Alzheimer's disease patients. Front Neuroanat. 2010;4:20 pubmed 出版商
|
| Poorkaj P, Raskind W, Leverenz J, Matsushita M, Zabetian C, Samii A, et al. A novel X-linked four-repeat tauopathy with Parkinsonism and spasticity. Mov Disord. 2010;25:1409-17 pubmed 出版商
|
| Josephs K, Whitwell J, Boeve B, Knopman D, Petersen R, Hu W, et al. Anatomical differences between CBS-corticobasal degeneration and CBS-Alzheimer's disease. Mov Disord. 2010;25:1246-52 pubmed 出版商
|
| Barnett B, Bressler J, Chen T, Hutchins G, Crain B, Kaufmann W. ?B-crystallin negative astrocytic inclusions. Brain Dev. 2011;33:349-52 pubmed 出版商
|
| Bhaskar K, Hobbs G, Yen S, Lee G. Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy. Neuropathol Appl Neurobiol. 2010;36:462-77 pubmed 出版商
|
| Ambegaokar S, Jackson G. Interaction between eye pigment genes and tau-induced neurodegeneration in Drosophila melanogaster. Genetics. 2010;186:435-42 pubmed 出版商
|
| Pretnar Oblak J, Zaletel M, Hajnsek T, Meglic B, Hocevar Boltezar I, Popovic M. Isolated bulbar paralysis in a patient with medullar tau pathology: a case report. J Neurol Neurosurg Psychiatry. 2010;81:847-9 pubmed 出版商
|
| Parachikova A, Vasilevko V, Cribbs D, LaFerla F, Green K. Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation. J Alzheimers Dis. 2010;21:527-42 pubmed 出版商
|
- 免疫细胞化学; 大鼠; 1:30
- 免疫印迹; 大鼠; 1:200
| Bertrand J, Sénéchal P, Zummo Soucy M, Plouffe V, Leclerc N. The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau. J Neurochem. 2010;114:1353-67 pubmed 出版商
|
- 免疫组化; 小鼠; 1:100
- 免疫印迹; 小鼠; 1:1,000
| Rodriguez Navarro J, Rodriguez L, Casarejos M, Solano R, Gomez A, Perucho J, et al. Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation. Neurobiol Dis. 2010;39:423-38 pubmed 出版商
|
| Morawski M, Bruckner G, Jager C, Seeger G, Arendt T. Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease. Neuroscience. 2010;169:1347-63 pubmed 出版商
|
| Koike M, Green K, Blurton Jones M, LaFerla F. Oligemic hypoperfusion differentially affects tau and amyloid-{beta}. Am J Pathol. 2010;177:300-10 pubmed 出版商
|
| Lee H, Lee J, Lee H, Carter J, Chang J, Oh W, et al. Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation. Neurobiol Aging. 2012;33:588-602 pubmed 出版商
|
| Feuillette S, Deramecourt V, Laquerriere A, Duyckaerts C, Delisle M, Maurage C, et al. Filamin-A and Myosin VI colocalize with fibrillary Tau protein in Alzheimer's disease and FTDP-17 brains. Brain Res. 2010;1345:182-9 pubmed 出版商
|
| Mohorko N, Repovs G, Popovic M, Kovacs G, Bresjanac M. Curcumin labeling of neuronal fibrillar tau inclusions in human brain samples. J Neuropathol Exp Neurol. 2010;69:405-14 pubmed 出版商
|
| Caltagarone J, Hamilton R, Murdoch G, Jing Z, DeFranco D, Bowser R. Paxillin and hydrogen peroxide-inducible clone 5 expression and distribution in control and Alzheimer disease hippocampi. J Neuropathol Exp Neurol. 2010;69:356-71 pubmed 出版商
|
| Carroll J, Rosario E, Villamagna A, Pike C. Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice. Endocrinology. 2010;151:2713-22 pubmed 出版商
|
| Bertrand J, Plouffe V, Senechal P, Leclerc N. The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons. Neuroscience. 2010;168:323-34 pubmed 出版商
|
| van Bebber F, Paquet D, Hruscha A, Schmid B, Haass C. Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish. Neurobiol Dis. 2010;39:265-71 pubmed 出版商
|
| Braak H, Ludolph A, Thal D, Del Tredici K. Amyotrophic lateral sclerosis: dash-like accumulation of phosphorylated TDP-43 in somatodendritic and axonal compartments of somatomotor neurons of the lower brainstem and spinal cord. Acta Neuropathol. 2010;120:67-74 pubmed 出版商
|
| Heath J, Siedlak S, Zhu X, Lee H, Thakur A, Yan R, et al. Widespread distribution of reticulon-3 in various neurodegenerative diseases. Neuropathology. 2010;30:574-9 pubmed 出版商
|
| Lee J, Won S, Suh J, Son S, Moon G, Park U, et al. Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice. Exp Mol Med. 2010;42:386-94 pubmed
|
| Bigio E, Mishra M, Hatanpaa K, White C, Johnson N, Rademaker A, et al. TDP-43 pathology in primary progressive aphasia and frontotemporal dementia with pathologic Alzheimer disease. Acta Neuropathol. 2010;120:43-54 pubmed 出版商
|
| de Calignon A, Fox L, Pitstick R, Carlson G, Bacskai B, Spires Jones T, et al. Caspase activation precedes and leads to tangles. Nature. 2010;464:1201-4 pubmed 出版商
|
| Wang G, Shi S, Gao C, Zhang B, Tian C, Dong C, et al. Changes of tau profiles in brains of the hamsters infected with scrapie strains 263 K or 139 A possibly associated with the alteration of phosphate kinases. BMC Infect Dis. 2010;10:86 pubmed 出版商
|
| Escribano L, Simón A, Gimeno E, Cuadrado Tejedor M, Lopez de Maturana R, Garcia Osta A, et al. Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology. Neuropsychopharmacology. 2010;35:1593-604 pubmed 出版商
|
| Greco S, Bryan K, Sarkar S, Zhu X, Smith M, Ashford J, et al. Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease. J Alzheimers Dis. 2010;19:1155-67 pubmed 出版商
|
| Fang H, Zhang L, Meng F, Du X, Zhou J. Acute hypoxia promote the phosphorylation of tau via ERK pathway. Neurosci Lett. 2010;474:173-177 pubmed 出版商
|
| Del Tredici K, Hawkes C, Ghebremedhin E, Braak H. Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease. Acta Neuropathol. 2010;119:703-13 pubmed 出版商
|
| Dickstein D, Brautigam H, Stockton S, Schmeidler J, Hof P. Changes in dendritic complexity and spine morphology in transgenic mice expressing human wild-type tau. Brain Struct Funct. 2010;214:161-79 pubmed 出版商
|
| Silveira Moriyama L, Hughes G, Church A, Ayling H, Williams D, Petrie A, et al. Hyposmia in progressive supranuclear palsy. Mov Disord. 2010;25:570-7 pubmed 出版商
|
| Liu X, Liao K, Liu R, Wang H, Zhang Y, Zhang Q, et al. Tau dephosphorylation potentiates apoptosis by mechanisms involving a failed dephosphorylation/activation of Bcl-2. J Alzheimers Dis. 2010;19:953-62 pubmed 出版商
|
| Sharma A, Callahan L, Sul J, Kim T, Barrett L, Kim M, et al. A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases. PLoS ONE. 2010;5:e9002 pubmed 出版商
|
| Pan Montojo F, Anichtchik O, Dening Y, Knels L, Pursche S, Jung R, et al. Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice. PLoS ONE. 2010;5:e8762 pubmed 出版商
|
| Hartig W, Kacza J, Paulke B, Grosche J, Bauer U, Hoffmann A, et al. In vivo labelling of hippocampal beta-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles. Eur J Neurosci. 2010;31:99-109 pubmed 出版商
|
- 免疫组化; 人类; 1:50
- 免疫印迹; 人类; 1:1000
| Fujimura R, Reiner T, Ma F, Phillips V, de las Pozas A, Dickson D, et al. Changes in the expression of genes associated with intraneuronal amyloid-beta and tau in Alzheimer's disease. J Alzheimers Dis. 2010;19:97-109 pubmed 出版商
|
| Maj M, Gartner W, Ilhan A, Neziri D, Attems J, Wagner L. Expression of TAU in insulin-secreting cells and its interaction with the calcium-binding protein secretagogin. J Endocrinol. 2010;205:25-36 pubmed 出版商
|
| Martinez Coria H, Green K, Billings L, Kitazawa M, Albrecht M, Rammes G, et al. Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice. Am J Pathol. 2010;176:870-80 pubmed 出版商
|
| Lee J, Jin H, Endo S, Schuchman E, Carter J, Bae J. Intracerebral transplantation of bone marrow-derived mesenchymal stem cells reduces amyloid-beta deposition and rescues memory deficits in Alzheimer's disease mice by modulation of immune responses. Stem Cells. 2010;28:329-43 pubmed 出版商
|
| Bonda D, Evans T, Santocanale C, Llosá J, Vina J, Bajic V, et al. Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease. Aging (Albany NY). 2009;1:382-8 pubmed
|
- 免疫细胞化学; 人类; 1:100
- 免疫印迹; 人类
- 免疫细胞化学; 小鼠; 1:100
- 免疫印迹; 小鼠
| Vale C, Alonso E, Rubiolo J, Vieytes M, LaFerla F, Gimenez Llort L, et al. Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice. Cell Mol Neurobiol. 2010;30:577-90 pubmed 出版商
|
| Willuweit A, Velden J, Godemann R, Manook A, Jetzek F, Tintrup H, et al. Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease. PLoS ONE. 2009;4:e7931 pubmed 出版商
|
| Whitwell J, Jack C, Przybelski S, Parisi J, Senjem M, Boeve B, et al. Temporoparietal atrophy: a marker of AD pathology independent of clinical diagnosis. Neurobiol Aging. 2011;32:1531-41 pubmed 出版商
|
| Lopes J, Oliveira C, Agostinho P. Neurodegeneration in an Abeta-induced model of Alzheimer's disease: the role of Cdk5. Aging Cell. 2010;9:64-77 pubmed 出版商
|
| Lecanu L, Rammouz G, McCourty A, Sidahmed E, Greeson J, Papadopoulos V. Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease. Neuroscience. 2010;165:427-35 pubmed 出版商
|
| Whiteman I, Gervasio O, Cullen K, Guillemin G, Jeong E, Witting P, et al. Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations. J Neurosci. 2009;29:12994-3005 pubmed 出版商
|
| Campos Peña V, Tapia Ramírez J, Sanchez Torres C, Meraz Rios M. Pathological-like assembly of tau induced by a paired helical filament core expressed at the plasma membrane. J Alzheimers Dis. 2009;18:919-33 pubmed 出版商
|
| Capucchio M, Marquez M, Pregel P, Foradada L, Bravo M, Mattutino G, et al. Parenchymal and vascular lesions in ageing equine brains: histological and immunohistochemical studies. J Comp Pathol. 2010;142:61-73 pubmed 出版商
|
| Soontornniyomkij V, Lynch M, Mermash S, Pomakian J, Badkoobehi H, Clare R, et al. Cerebral microinfarcts associated with severe cerebral beta-amyloid angiopathy. Brain Pathol. 2010;20:459-67 pubmed 出版商
|
| McConnell G, Rees H, Levey A, Gutekunst C, Gross R, Bellamkonda R. Implanted neural electrodes cause chronic, local inflammation that is correlated with local neurodegeneration. J Neural Eng. 2009;6:056003 pubmed 出版商
|
- 免疫组化; 人类; 1:250
- 免疫印迹; 人类; 1:1000
| van Eersel J, Bi M, Ke Y, Hodges J, Xuereb J, Gregory G, et al. Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains. J Neural Transm (Vienna). 2009;116:1243-51 pubmed 出版商
|
| Rahman A, Ting K, Cullen K, Braidy N, Brew B, Guillemin G. The excitotoxin quinolinic acid induces tau phosphorylation in human neurons. PLoS ONE. 2009;4:e6344 pubmed 出版商
|
| Tang J, LeGros R, Louneva N, Yeh L, Cohen J, Hahn C, et al. Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression. Hum Mol Genet. 2009;18:3851-63 pubmed 出版商
|
| Kovacs G, Murrell J, Horvath S, Haraszti L, Majtenyi K, Molnar M, et al. TARDBP variation associated with frontotemporal dementia, supranuclear gaze palsy, and chorea. Mov Disord. 2009;24:1843-7 pubmed 出版商
|
| Nogalska A, Terracciano C, D Agostino C, King Engel W, Askanas V. p62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis. Acta Neuropathol. 2009;118:407-13 pubmed 出版商
|
- 免疫组化; 小鼠; 1:250
- 免疫印迹; 小鼠; 1:200
| Wilcock D, Gharkholonarehe N, Van Nostrand W, Davis J, Vitek M, Colton C. Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease. J Neurosci. 2009;29:7957-65 pubmed 出版商
|
| McKee A, Cantu R, Nowinski C, Hedley Whyte E, Gavett B, Budson A, et al. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol. 2009;68:709-35 pubmed 出版商
|
| Sasaki K, Shimura H, Itaya M, Tanaka R, Mori H, Mizuno Y, et al. Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains. FEBS Lett. 2009;583:2194-200 pubmed 出版商
|
- 免疫印迹; 人类; 1:200
- 免疫印迹; 小鼠; 1:200
| Perreault S, Bousquet O, Lauzon M, Paiement J, Leclerc N. Increased association between rough endoplasmic reticulum membranes and mitochondria in transgenic mice that express P301L tau. J Neuropathol Exp Neurol. 2009;68:503-14 pubmed 出版商
|
- 抑制或激活实验; 人类
- 免疫组化; 人类; 1:1000
- 免疫印迹; 人类; 1:1000
| Clavaguera F, Bolmont T, Crowther R, Abramowski D, Frank S, Probst A, et al. Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol. 2009;11:909-13 pubmed 出版商
|
| Ittner L, Ke Y, Götz J. Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease. J Biol Chem. 2009;284:20909-16 pubmed 出版商
|
| Kasher P, De Vos K, Wharton S, Manser C, Bennett E, Bingley M, et al. Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients. J Neurochem. 2009;110:34-44 pubmed 出版商
|
| Greco S, Sarkar S, Casadesus G, Zhu X, Smith M, Ashford J, et al. Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells. Neurosci Lett. 2009;455:191-4 pubmed 出版商
|
| Myung N, Zhu X, Kruman I, Castellani R, Petersen R, Siedlak S, et al. Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes. Age (Dordr). 2008;30:209-15 pubmed 出版商
|
| Simpson J, Ince P, Haynes L, Theaker R, Gelsthorpe C, Baxter L, et al. Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain. Neuropathol Appl Neurobiol. 2010;36:25-40 pubmed 出版商
|
| Ohmi K, Kudo L, Ryazantsev S, Zhao H, Karsten S, Neufeld E. Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathy. Proc Natl Acad Sci U S A. 2009;106:8332-7 pubmed 出版商
|
- 免疫组化; 人类; 1:400
- 免疫印迹; 人类; 1:800
| Jing Z, Caltagarone J, Bowser R. Altered subcellular distribution of c-Abl in Alzheimer's disease. J Alzheimers Dis. 2009;17:409-22 pubmed 出版商
|
| Lace G, Savva G, Forster G, De Silva R, Brayne C, Matthews F, et al. Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study. Brain. 2009;132:1324-34 pubmed 出版商
|
| Planel E, Bretteville A, Liu L, Virag L, Du A, Yu W, et al. Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia. FASEB J. 2009;23:2595-604 pubmed 出版商
|
| Filipcik P, Cente M, Krajciova G, Vanicky I, Novak M. Cortical and hippocampal neurons from truncated tau transgenic rat express multiple markers of neurodegeneration. Cell Mol Neurobiol. 2009;29:895-900 pubmed 出版商
|
| Bitner R, Nikkel A, Markosyan S, Otte S, Puttfarcken P, Gopalakrishnan M. Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo. Brain Res. 2009;1265:65-74 pubmed 出版商
|
| Capsoni S, Covaceuszach S, Ugolini G, Spirito F, Vignone D, Stefanini B, et al. Delivery of NGF to the brain: intranasal versus ocular administration in anti-NGF transgenic mice. J Alzheimers Dis. 2009;16:371-88 pubmed 出版商
|
| Josephs K, Ahlskog J, Parisi J, Boeve B, Crum B, Giannini C, et al. Rapidly progressive neurodegenerative dementias. Arch Neurol. 2009;66:201-7 pubmed 出版商
|
| Greco S, Sarkar S, Johnston J, Tezapsidis N. Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells. Biochem Biophys Res Commun. 2009;380:98-104 pubmed 出版商
|
| Ricobaraza A, Cuadrado Tejedor M, Pérez Mediavilla A, Frechilla D, Del Rio J, Garcia Osta A. Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model. Neuropsychopharmacology. 2009;34:1721-32 pubmed 出版商
|
| Liu Y, Yoo M, Savonenko A, Stirling W, Price D, Borchelt D, et al. Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease. J Neurosci. 2008;28:13805-14 pubmed 出版商
|
| Planel E, Krishnamurthy P, Miyasaka T, Liu L, Herman M, Kumar A, et al. Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. J Neurosci. 2008;28:12798-807 pubmed 出版商
|
| Lee H, Zhu X, Casadesus G, Pallas M, Camins A, O Neill M, et al. The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival. Brain Res. 2009;1249:244-50 pubmed 出版商
|
| Shehadeh L, Mitsi G, Adi N, Bishopric N, Papapetropoulos S. Expression of Lewy body protein septin 4 in postmortem brain of Parkinson's disease and control subjects. Mov Disord. 2009;24:204-10 pubmed 出版商
|
- 免疫印迹; fruit fly ; 1:2,000
| Chatterjee S, Sang T, Lawless G, Jackson G. Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model. Hum Mol Genet. 2009;18:164-77 pubmed 出版商
|
| Thakur A, Siedlak S, James S, Bonda D, Rao A, Webber K, et al. Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease. Int J Clin Exp Pathol. 2008;1:134-46 pubmed
|
- 免疫组化; 人类; 1:500
- 免疫组化; 小鼠; 1:500
| Takahashi R, Capetillo Zarate E, Lin M, Milner T, Gouras G. Co-occurrence of Alzheimer's disease ß-amyloid and ? pathologies at synapses. Neurobiol Aging. 2010;31:1145-52 pubmed 出版商
|
| Khan T, Alkon D. Early diagnostic accuracy and pathophysiologic relevance of an autopsy-confirmed Alzheimer's disease peripheral biomarker. Neurobiol Aging. 2010;31:889-900 pubmed 出版商
|
| Patil S, Balu D, Melrose J, Chan C. Brain region-specificity of palmitic acid-induced abnormalities associated with Alzheimer's disease. BMC Res Notes. 2008;1:20 pubmed 出版商
|
| Wilhelmus M, Grunberg S, Bol J, van Dam A, Hoozemans J, Rozemuller A, et al. Transglutaminases and transglutaminase-catalyzed cross-links colocalize with the pathological lesions in Alzheimer's disease brain. Brain Pathol. 2009;19:612-22 pubmed 出版商
|
| Jicha G, Parisi J, Dickson D, Cha R, Johnson K, Smith G, et al. Age and apoE associations with complex pathologic features in Alzheimer's disease. J Neurol Sci. 2008;273:34-9 pubmed 出版商
|
- 免疫组化; 小鼠; 1:100
- 免疫印迹; 小鼠; 1:1,000
| Rodriguez Navarro J, Gomez A, Rodal I, Perucho J, Martinez A, Furió V, et al. Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice. Hum Mol Genet. 2008;17:3128-43 pubmed 出版商
|
| Laporte V, Ait Ghezala G, Volmar C, Ganey C, Ganey N, Wood M, et al. CD40 ligation mediates plaque-associated tau phosphorylation in beta-amyloid overproducing mice. Brain Res. 2008;1231:132-42 pubmed 出版商
|
| Rossi G, Dalprà L, Crosti F, Lissoni S, Sciacca F, Catania M, et al. A new function of microtubule-associated protein tau: involvement in chromosome stability. Cell Cycle. 2008;7:1788-94 pubmed
|
| Sikorska B, Liberski P, Sobow T, Budka H, Ironside J. Ultrastructural study of florid plaques in variant Creutzfeldt-Jakob disease: a comparison with amyloid plaques in kuru, sporadic Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker disease. Neuropathol Appl Neurobiol. 2009;35:46-59 pubmed 出版商
|
| Lim J, Balastik M, Lee T, Nakamura K, Liou Y, Sun A, et al. Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy. J Clin Invest. 2008;118:1877-89 pubmed 出版商
|
| Vidal R, Barbeito A, Miravalle L, Ghetti B. Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2. Brain Pathol. 2009;19:58-68 pubmed 出版商
|
- 免疫细胞化学; 大鼠; 1:30
- 免疫印迹; 大鼠; 1:250
| Resende R, Ferreiro E, Pereira C, Oliveira C. ER stress is involved in Abeta-induced GSK-3beta activation and tau phosphorylation. J Neurosci Res. 2008;86:2091-9 pubmed 出版商
|
| Wilcock D, Lewis M, Van Nostrand W, Davis J, Previti M, Gharkholonarehe N, et al. Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2. J Neurosci. 2008;28:1537-45 pubmed 出版商
|
| Hinners I, Hill A, Otto U, Michalsky A, Mack T, Striggow F. Tau kinase inhibitors protect hippocampal synapses despite of insoluble tau accumulation. Mol Cell Neurosci. 2008;37:559-67 pubmed 出版商
|
| Matsuoka Y, Jouroukhin Y, Gray A, Ma L, Hirata Fukae C, Li H, et al. A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease. J Pharmacol Exp Ther. 2008;325:146-53 pubmed 出版商
|
| Planel E, Tatebayashi Y, Miyasaka T, Liu L, Wang L, Herman M, et al. Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms. J Neurosci. 2007;27:13635-48 pubmed
|
| Kovacs G, Pittman A, Revesz T, Luk C, Lees A, Kiss E, et al. MAPT S305I mutation: implications for argyrophilic grain disease. Acta Neuropathol. 2008;116:103-18 pubmed
|
| Preusser M, Kitzwoegerer M, Budka H, Brugger S. Bilateral striopallidodentate calcification (Fahr's syndrome) and multiple system atrophy in a patient with longstanding hypoparathyroidism. Neuropathology. 2007;27:453-6 pubmed
|
| Schrag M, Sharma S, Brown Borg H, Ghribi O. Hippocampus of Ames dwarf mice is resistant to beta-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels. Hippocampus. 2008;18:239-44 pubmed
|
| Josephs K, Whitwell J, Ahmed Z, Shiung M, Weigand S, Knopman D, et al. Beta-amyloid burden is not associated with rates of brain atrophy. Ann Neurol. 2008;63:204-12 pubmed
|
- 免疫组化; 小鼠; 1:40
- 免疫印迹; 小鼠; 1:40
| Bai F, Xi J, Andley U. Up-regulation of tau, a brain microtubule-associated protein, in lens cortical fractions of aged alphaA-, alphaB-, and alphaA/B-crystallin knockout mice. Mol Vis. 2007;13:1589-600 pubmed
|
| Piggott M, Ballard C, Rowan E, Holmes C, McKeith I, Jaros E, et al. Selective loss of dopamine D2 receptors in temporal cortex in dementia with Lewy bodies, association with cognitive decline. Synapse. 2007;61:903-11 pubmed
|
| Ojala J, Alafuzoff I, Herukka S, van Groen T, Tanila H, Pirttila T. Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients. Neurobiol Aging. 2009;30:198-209 pubmed
|
| Munoz D, Woulfe J, Kertesz A. Argyrophilic thorny astrocyte clusters in association with Alzheimer's disease pathology in possible primary progressive aphasia. Acta Neuropathol. 2007;114:347-57 pubmed
|
| Brandt R, Gergou A, Wacker I, Fath T, Hutter H. A Caenorhabditis elegans model of tau hyperphosphorylation: induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau. Neurobiol Aging. 2009;30:22-33 pubmed
|
| Rissman R, Lee K, Vale W, Sawchenko P. Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation. J Neurosci. 2007;27:6552-62 pubmed
|
| Moreira P, Siedlak S, Wang X, Santos M, Oliveira C, Tabaton M, et al. Autophagocytosis of mitochondria is prominent in Alzheimer disease. J Neuropathol Exp Neurol. 2007;66:525-32 pubmed
|
| Luo W, Dou F, Rodina A, Chip S, Kim J, Zhao Q, et al. Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proc Natl Acad Sci U S A. 2007;104:9511-6 pubmed
|
| Evans T, Raina A, Delacourte A, Aprelikova O, Lee H, Zhu X, et al. BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease. Int J Med Sci. 2007;4:140-5 pubmed
|
| Oddo S, Caccamo A, Cheng D, Jouleh B, Torp R, LaFerla F. Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice. J Neurochem. 2007;102:1053-63 pubmed
|
| Caccamo A, Oddo S, Tran L, LaFerla F. Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles. Am J Pathol. 2007;170:1669-75 pubmed
|
| Green K, Martinez Coria H, Khashwji H, Hall E, Yurko Mauro K, Ellis L, et al. Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels. J Neurosci. 2007;27:4385-95 pubmed
|
| Leverenz J, Yu C, Montine T, Steinbart E, Bekris L, Zabetian C, et al. A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology. Brain. 2007;130:1360-74 pubmed
|
| Magaki S, Raghavan R, Mueller C, Oberg K, Vinters H, Kirsch W. Iron, copper, and iron regulatory protein 2 in Alzheimer's disease and related dementias. Neurosci Lett. 2007;418:72-6 pubmed
|
| Planel E, Richter K, Nolan C, Finley J, Liu L, Wen Y, et al. Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia. J Neurosci. 2007;27:3090-7 pubmed
|
| Whitwell J, Jack C, Parisi J, Knopman D, Boeve B, Petersen R, et al. Rates of cerebral atrophy differ in different degenerative pathologies. Brain. 2007;130:1148-58 pubmed
|
| Leschik J, Welzel A, Weissmann C, Eckert A, Brandt R. Inverse and distinct modulation of tau-dependent neurodegeneration by presenilin 1 and amyloid-beta in cultured cortical neurons: evidence that tau phosphorylation is the limiting factor in amyloid-beta-induced cell death. J Neurochem. 2007;101:1303-15 pubmed
|
| Josephs K, Ahmed Z, Katsuse O, Parisi J, Boeve B, Knopman D, et al. Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations. J Neuropathol Exp Neurol. 2007;66:142-51 pubmed
|
| Sikorska B, Papierz W, Preusser M, Liberski P, Budka H. Synucleinopathy with features of both multiple system atrophy and dementia with Lewy bodies. Neuropathol Appl Neurobiol. 2007;33:126-9 pubmed
|
| Josephs K, Whitwell J, Parisi J, Knopman D, Boeve B, Geda Y, et al. Argyrophilic grains: a distinct disease or an additive pathology?. Neurobiol Aging. 2008;29:566-73 pubmed
|
- 免疫印迹; fruit fly ; 1:50,000
| Dias Santagata D, Fulga T, Duttaroy A, Feany M. Oxidative stress mediates tau-induced neurodegeneration in Drosophila. J Clin Invest. 2007;117:236-45 pubmed
|
| Wahle T, Thal D, Sastre M, Rentmeister A, Bogdanovic N, Famulok M, et al. GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide. J Neurosci. 2006;26:12838-46 pubmed
|
| Papapetropoulos S, Mash D. Motor fluctuations and dyskinesias in advanced/end stage Parkinson's disease: a study from a population of brain donors. J Neural Transm (Vienna). 2007;114:341-5 pubmed
|
| Barnes L, Schneider J, Boyle P, Bienias J, Bennett D. Memory complaints are related to Alzheimer disease pathology in older persons. Neurology. 2006;67:1581-5 pubmed
|
| Oddo S, Vasilevko V, Caccamo A, Kitazawa M, Cribbs D, LaFerla F. Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. J Biol Chem. 2006;281:39413-23 pubmed
|
| Parachikova A, Agadjanyan M, Cribbs D, Blurton Jones M, Perreau V, Rogers J, et al. Inflammatory changes parallel the early stages of Alzheimer disease. Neurobiol Aging. 2007;28:1821-33 pubmed
|
| Ikonomovic M, Abrahamson E, Isanski B, Debnath M, Mathis C, DeKosky S, et al. X-34 labeling of abnormal protein aggregates during the progression of Alzheimer's disease. Methods Enzymol. 2006;412:123-44 pubmed
|
| Hu W, Murray J, Greenaway M, Parisi J, Josephs K. Cognitive impairment and celiac disease. Arch Neurol. 2006;63:1440-6 pubmed
|
| Boeve B, Baker M, Dickson D, Parisi J, Giannini C, Josephs K, et al. Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study. Brain. 2006;129:3103-14 pubmed
|
| Lee H, Ueda M, Zhu X, Perry G, Smith M. Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway?. J Neurosci Res. 2006;84:1856-61 pubmed
|
| Papapetropoulos S, Mash D. Insular pathology in Parkinson's disease patients with orthostatic hypotension. Parkinsonism Relat Disord. 2007;13:308-11 pubmed
|
| Farah C, Perreault S, Liazoghli D, Desjardins M, Anton A, Lauzon M, et al. Tau interacts with Golgi membranes and mediates their association with microtubules. Cell Motil Cytoskeleton. 2006;63:710-24 pubmed
|
- 免疫组化; 小鼠
- 免疫印迹; 小鼠; 1:1,000
| Green K, Billings L, Roozendaal B, McGaugh J, LaFerla F. Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease. J Neurosci. 2006;26:9047-56 pubmed
|
| Gelpi E, Preusser M, Bauer G, Budka H. Autopsy at 2 months after death: brain is satisfactorily preserved for neuropathology. Forensic Sci Int. 2007;168:177-82 pubmed
|
| Jicha G, Petersen R, Knopman D, Boeve B, Smith G, Geda Y, et al. Argyrophilic grain disease in demented subjects presenting initially with amnestic mild cognitive impairment. J Neuropathol Exp Neurol. 2006;65:602-9 pubmed
|
- 免疫印迹; domestic rabbit; 1:100
| Ghribi O, Larsen B, Schrag M, Herman M. High cholesterol content in neurons increases BACE, beta-amyloid, and phosphorylated tau levels in rabbit hippocampus. Exp Neurol. 2006;200:460-7 pubmed
|
| Jicha G, Parisi J, Dickson D, Johnson K, Cha R, Ivnik R, et al. Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia. Arch Neurol. 2006;63:674-81 pubmed
|
| Petersen R, Parisi J, Dickson D, Johnson K, Knopman D, Boeve B, et al. Neuropathologic features of amnestic mild cognitive impairment. Arch Neurol. 2006;63:665-72 pubmed
|
| Gunn Moore D, McVee J, Bradshaw J, Pearson G, Head E, Gunn Moore F. Ageing changes in cat brains demonstrated by beta-amyloid and AT8-immunoreactive phosphorylated tau deposits. J Feline Med Surg. 2006;8:234-42 pubmed
|
| Grudzien A, Shaw P, Weintraub S, Bigio E, Mash D, Mesulam M. Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease. Neurobiol Aging. 2007;28:327-35 pubmed
|
- 免疫组化; 人类; 1:1000
- 免疫印迹; 人类; 1:1000
| Griffin W, Liu L, Li Y, Mrak R, Barger S. Interleukin-1 mediates Alzheimer and Lewy body pathologies. J Neuroinflammation. 2006;3:5 pubmed
|
| Oka T, Tamada Y, Nakajima E, Shearer T, Azuma M. Presence of calpain-induced proteolysis in retinal degeneration and dysfunction in a rat model of acute ocular hypertension. J Neurosci Res. 2006;83:1342-51 pubmed
|
| Halliday G, Song Y, Creasey H, Morris J, Brooks W, Kril J. Neuropathology in the S305S tau gene mutation. Brain. 2006;129:E40 pubmed
|
| Piggott M, Ballard C, Dickinson H, McKeith I, Perry R, Perry E. Thalamic D2 receptors in dementia with Lewy bodies, Parkinson's disease, and Parkinson's disease dementia. Int J Neuropsychopharmacol. 2007;10:231-44 pubmed
|
| Papapetropoulos S, McCorquodale D, Gonzalez J, Jean Gilles L, Mash D. Cortical and amygdalar Lewy body burden in Parkinson's disease patients with visual hallucinations. Parkinsonism Relat Disord. 2006;12:253-6 pubmed
|
| Quintana C, Bellefqih S, Laval J, Guerquin Kern J, Wu T, Avila J, et al. Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level. J Struct Biol. 2006;153:42-54 pubmed
|
| Obici L, Demarchi A, de Rosa G, Bellotti V, Marciano S, Donadei S, et al. A novel AbetaPP mutation exclusively associated with cerebral amyloid angiopathy. Ann Neurol. 2005;58:639-44 pubmed
|
| Blain J, Sullivan P, Poirier J. A deficit in astroglial organization causes the impaired reactive sprouting in human apolipoprotein E4 targeted replacement mice. Neurobiol Dis. 2006;21:505-14 pubmed
|
| Yang W, Ang L, Strong M. Tau protein aggregation in the frontal and entorhinal cortices as a function of aging. Brain Res Dev Brain Res. 2005;156:127-38 pubmed
|
| Klos K, Josephs K, Parisi J, Dickson D. Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease. Mov Disord. 2005;20:1515-20 pubmed
|
| Newman J, Rissman R, Sarsoza F, Kim R, Dick M, Bennett D, et al. Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology. Acta Neuropathol. 2005;110:135-44 pubmed
|
| Sakaue M, Okazaki M, Hara S. Very low levels of methylmercury induce cell death of cultured rat cerebellar neurons via calpain activation. Toxicology. 2005;213:97-106 pubmed
|
| Fukuda T, Shimizu J, Furuhata H, Abe T, Shimizu K, Oishi T, et al. Overexpression of heat shock proteins in pallido-nigral axonal spheroids of nonhuman aged primates. Acta Neuropathol. 2005;110:145-50 pubmed
|
- 免疫组化; 大鼠; 1:200
- 免疫印迹; 大鼠; 1:200
| Patil S, Chan C. Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons. Neurosci Lett. 2005;384:288-93 pubmed
|
| Knopman D, Boeve B, Parisi J, Dickson D, Smith G, Ivnik R, et al. Antemortem diagnosis of frontotemporal lobar degeneration. Ann Neurol. 2005;57:480-8 pubmed
|
| Frasier M, Walzer M, McCarthy L, Magnuson D, Lee J, Haas C, et al. Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein. Exp Neurol. 2005;192:274-87 pubmed
|
| Hung K, Hwang S, Liang C, Chen Y, Lee T, Liu J, et al. Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats. J Neuropathol Exp Neurol. 2005;64:15-26 pubmed
|
| Su D, Chai Y, Yang J, Wang X, Liu Y, Ma J, et al. Lentivirus-Carried microRNA-195 Rescues Memory Deficits of Alzheimer's Disease Transgenic Mouse by Attenuating the Generation of Amyloid Plaques. Front Pharmacol. 2021;12:633805 pubmed 出版商
|
| Dong Y, Liang F, Huang L, Fang F, Yang G, Tanzi R, et al. The anesthetic sevoflurane induces tau trafficking from neurons to microglia. Commun Biol. 2021;4:560 pubmed 出版商
|
| Sandusky Beltran L, Kovalenko A, Placides D, Ratnasamy K, Ma C, Hunt J, et al. Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology. J Clin Invest. 2021;131: pubmed 出版商
|
| Laversenne V, Nazeeruddin S, Källstig E, Colin P, Voize C, Schneider B. Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology. Acta Neuropathol Commun. 2020;8:198 pubmed 出版商
|
| Gratuze M, Leyns C, Sauerbeck A, St Pierre M, Xiong M, Kim N, et al. Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration. J Clin Invest. 2020;130:4954-4968 pubmed 出版商
|
| Guillemaud O, Ceyzériat K, Saint Georges T, Cambon K, Petit F, Ben Haim L, et al. Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease. Neurobiol Aging. 2020;90:135-146 pubmed 出版商
|
| Metaxas A, Thygesen C, Briting S, Landau A, Darvesh S, Finsen B. Increased Inflammation and Unchanged Density of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Postmortem Frontal Cortex of Alzheimer's Disease Patients. Front Cell Neurosci. 2019;13:538 pubmed 出版商
|
| Shi Y, Manis M, Long J, Wang K, Sullivan P, Remolina Serrano J, et al. Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model. J Exp Med. 2019;216:2546-2561 pubmed 出版商
|
| Leyns C, Gratuze M, Narasimhan S, Jain N, Koscal L, Jiang H, et al. TREM2 function impedes tau seeding in neuritic plaques. Nat Neurosci. 2019;: pubmed 出版商
|
| Christensen K, Beach T, Serrano G, Kanaan N. Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways. Acta Neuropathol Commun. 2019;7:29 pubmed 出版商
|
| Dominy S, LYNCH C, Ermini F, Benedyk M, Marczyk A, Konradi A, et al. Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Sci Adv. 2019;5:eaau3333 pubmed 出版商
|
| Murphy K, Llewellyn K, Wakser S, Pontasch J, Samanich N, Flemer M, et al. Mini-GAGR, an intranasally applied polysaccharide, activates the neuronal Nrf2-mediated antioxidant defense system. J Biol Chem. 2018;293:18242-18269 pubmed 出版商
|
| Leyns C, ULRICH J, Finn M, Stewart F, Koscal L, Remolina Serrano J, et al. TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy. Proc Natl Acad Sci U S A. 2017;114:11524-11529 pubmed 出版商
|
| Levenson J, Schroeter S, Carroll J, Cullen V, Asp E, Proschitsky M, et al. NPT088 reduces both amyloid-? and tau pathologies in transgenic mice. Alzheimers Dement (N Y). 2016;2:141-155 pubmed 出版商
|
| Shi Y, Yamada K, Liddelow S, Smith S, Zhao L, Luo W, et al. ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. Nature. 2017;549:523-527 pubmed 出版商
|
| Takeda S, Wegmann S, Cho H, DeVos S, Commins C, Roe A, et al. Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain. Nat Commun. 2015;6:8490 pubmed 出版商
|
| Cykowski M, Coon E, Powell S, Jenkins S, Benarroch E, Low P, et al. Expanding the spectrum of neuronal pathology in multiple system atrophy. Brain. 2015;138:2293-309 pubmed 出版商
|
| Nicholson A, Wold L, Walsh D, Ferreira A. ?-Amyloid carrying the Dutch mutation has diverse effects on calpain-mediated toxicity in hippocampal neurons. Mol Med. 2012;18:178-85 pubmed 出版商
|
| Zhu X, Castellani R, Moreira P, Aliev G, Shenk J, Siedlak S, et al. Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover. Free Radic Biol Med. 2012;52:699-704 pubmed 出版商
|
| Harris F, Brecht W, Xu Q, Mahley R, Huang Y. Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc. J Biol Chem. 2004;279:44795-801 pubmed
|
| Mesulam M, Shaw P, Mash D, Weintraub S. Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum. Ann Neurol. 2004;55:815-28 pubmed
|
| Vidal R, Ghetti B, Takao M, Brefel Courbon C, Uro Coste E, Glazier B, et al. Intracellular ferritin accumulation in neural and extraneural tissue characterizes a neurodegenerative disease associated with a mutation in the ferritin light polypeptide gene. J Neuropathol Exp Neurol. 2004;63:363-80 pubmed
|
| Brecht W, Harris F, Chang S, Tesseur I, Yu G, Xu Q, et al. Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice. J Neurosci. 2004;24:2527-34 pubmed
|
| Shimura H, Miura Shimura Y, Kosik K. Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival. J Biol Chem. 2004;279:17957-62 pubmed
|
| Lee H, Ogawa O, Zhu X, O Neill M, Petersen R, Castellani R, et al. Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease. Acta Neuropathol. 2004;107:365-71 pubmed
|
| Li G, Yin H, Kuret J. Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules. J Biol Chem. 2004;279:15938-45 pubmed
|
| Knopman D, Parisi J, Salviati A, Floriach Robert M, Boeve B, Ivnik R, et al. Neuropathology of cognitively normal elderly. J Neuropathol Exp Neurol. 2003;62:1087-95 pubmed
|
| Shimura H, Schwartz D, Gygi S, Kosik K. CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. J Biol Chem. 2004;279:4869-76 pubmed
|
| Heckmann J, Low W, de Villiers C, Rutherfoord S, Vorster A, Rao H, et al. Novel presenilin 1 mutation with profound neurofibrillary pathology in an indigenous Southern African family with early-onset Alzheimer's disease. Brain. 2004;127:133-42 pubmed
|
| Harris F, Brecht W, Xu Q, Tesseur I, Kekonius L, Wyss Coray T, et al. Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice. Proc Natl Acad Sci U S A. 2003;100:10966-71 pubmed
|
| Zhu X, Sun Z, Lee H, Siedlak S, Perry G, Smith M. Distribution, levels, and activation of MEK1 in Alzheimer's disease. J Neurochem. 2003;86:136-42 pubmed
|
| Tang Wai D, Josephs K, Boeve B, Petersen R, Parisi J, Dickson D. Coexistent Lewy body disease in a case of "visual variant of Alzheimer's disease". J Neurol Neurosurg Psychiatry. 2003;74:389 pubmed
|
| Agarwal Mawal A, Qureshi H, Cafferty P, Yuan Z, Han D, Lin R, et al. 14-3-3 connects glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complex. J Biol Chem. 2003;278:12722-8 pubmed
|
| Yoshida H, Goedert M. Molecular cloning and functional characterization of chicken brain tau: isoforms with up to five tandem repeats. Biochemistry. 2002;41:15203-11 pubmed
|
| Zhu X, Castellani R, Takeda A, Nunomura A, Atwood C, Perry G, et al. Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis. Mech Ageing Dev. 2001;123:39-46 pubmed
|
| Ko J, Humbert S, Bronson R, Takahashi S, Kulkarni A, Li E, et al. p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. J Neurosci. 2001;21:6758-71 pubmed
|
| Huang Y, Liu X, Wyss Coray T, Brecht W, Sanan D, Mahley R. Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons. Proc Natl Acad Sci U S A. 2001;98:8838-43 pubmed
|
| King M, Ghoshal N, Wall J, Binder L, Ksiezak Reding H. Structural analysis of Pick's disease-derived and in vitro-assembled tau filaments. Am J Pathol. 2001;158:1481-90 pubmed
|
| Braak E, Braak H, Mandelkow E. A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads. Acta Neuropathol. 1994;87:554-67 pubmed
|
| Mercken M, Vandermeeren M, Lubke U, Six J, Boons J, Van De Voorde A, et al. Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes. Acta Neuropathol. 1992;84:265-72 pubmed
|