产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8), Biotin
目录 :
MN1020B
规格 :
50µg
价格 :
美国506.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
生物素
抗原修饰 :
磷酸化
克隆名称 :
AT8
反应物种 :
仓鼠, baboons, African green monkey, 人类, 小鼠, 大鼠, , , 果蝇, , 秀丽隐杆线虫, equine, 猕猴
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 抑制或激活实验
更多信息或购买 :
文章摘录数: 429
出版应用/物种/样品/稀释参考文献
  • 免疫组化; 小鼠; 图 4c
Lang S, Harre U, Purohit P, Dietel K, Kienhöfer D, Hahn J, et al. Neurodegeneration Enhances the Development of Arthritis. J Immunol. 2017;198:2394-2402 pubmed 出版商
  • 免疫组化; 大鼠; 1:100; 图 6
Foxton R, Osborne A, Martin K, Ng Y, Shima D. Distal retinal ganglion cell axon transport loss and activation of p38 MAPK stress pathway following VEGF-A antagonism. Cell Death Dis. 2016;7:e2212 pubmed 出版商
  • 免疫印迹; 小鼠; 图 11
Makani V, Jang Y, Christopher K, Judy W, Eckstein J, Hensley K, et al. BBB-Permeable, Neuroprotective, and Neurotrophic Polysaccharide, Midi-GAGR. PLoS ONE. 2016;11:e0149715 pubmed 出版商
  • 免疫组化; 人类; 图 1
Puvenna V, Engeler M, Banjara M, Brennan C, Schreiber P, Dadas A, et al. Is phosphorylated tau unique to chronic traumatic encephalopathy? Phosphorylated tau in epileptic brain and chronic traumatic encephalopathy. Brain Res. 2016;1630:225-40 pubmed 出版商
  • 免疫组化; 人类; 1:250; 图 6
Tousseyn T, Bajsarowicz K, Sánchez H, Gheyara A, Oehler A, Geschwind M, et al. Prion Disease Induces Alzheimer Disease-Like Neuropathologic Changes. J Neuropathol Exp Neurol. 2015;74:873-88 pubmed 出版商
  • 免疫组化; 小鼠; 1:400; 图 10
Liu P, Paulson J, Forster C, Shapiro S, Ashe K, Zahs K. Characterization of a Novel Mouse Model of Alzheimer's Disease--Amyloid Pathology and Unique β-Amyloid Oligomer Profile. PLoS ONE. 2015;10:e0126317 pubmed 出版商
  • 免疫细胞化学; 人类; 1:800
Blum D, Herrera F, Francelle L, Mendes T, Basquin M, Obriot H, et al. Mutant huntingtin alters Tau phosphorylation and subcellular distribution. Hum Mol Genet. 2015;24:76-85 pubmed 出版商
  • 免疫组化; 人类; 1:1000
Lasagna Reeves C, Sengupta U, Castillo Carranza D, Gerson J, Guerrero Munoz M, Troncoso J, et al. The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes. Acta Neuropathol Commun. 2014;2:56 pubmed 出版商
  • 免疫组化; 小鼠; 1:400
  • 免疫印迹; 人类; 1:1000
Jiang T, Yu J, Zhu X, Zhang Q, Cao L, Wang H, et al. Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance. Neuropharmacology. 2014;85:121-30 pubmed 出版商
  • 免疫印迹; 小鼠
Garcia Mesa Y, Pareja Galeano H, Bonet Costa V, Revilla S, Gómez Cabrera M, Gambini J, et al. Physical exercise neuroprotects ovariectomized 3xTg-AD mice through BDNF mechanisms. Psychoneuroendocrinology. 2014;45:154-66 pubmed 出版商
  • 免疫组化; 小鼠; 1:100
  • 免疫印迹; 小鼠; 1:500
Shilling D, Müller M, Takano H, Mak D, Abel T, Coulter D, et al. Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis. J Neurosci. 2014;34:6910-23 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Lin L, Yang S, Chu J, Wang L, Ning L, Zhang T, et al. Region-specific expression of tau, amyloid-? protein precursor, and synaptic proteins at physiological condition or under endoplasmic reticulum stress in rats. J Alzheimers Dis. 2014;41:1149-63 pubmed 出版商
  • 免疫组化; 小鼠; 1:50
  • 免疫印迹; 小鼠
Inoue H, Hiradate Y, Shirakata Y, Kanai K, Kosaka K, Gotoh A, et al. Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis. FEBS Lett. 2014;588:2003-8 pubmed 出版商
  • 免疫组化; 小鼠
  • 免疫印迹; 小鼠
Kondadi A, Wang S, Montagner S, Kladt N, Korwitz A, Martinelli P, et al. Loss of the m-AAA protease subunit AFG?L? causes mitochondrial transport defects and tau hyperphosphorylation. EMBO J. 2014;33:1011-26 pubmed 出版商
  • 免疫组化; 人类; 1:200
Pan J, Lee M, Honig L, Vonsattel J, Faust P, Louis E. Alzheimer's-related changes in non-demented essential tremor patients vs. controls: links between tau and tremor?. Parkinsonism Relat Disord. 2014;20:655-8 pubmed 出版商
  • 免疫组化; 小鼠; 1:100
  • 酶联免疫吸附测定; 小鼠; 1:250
  • 免疫印迹; 小鼠; 1:1000
Castillo Carranza D, Sengupta U, Guerrero Muñoz M, Lasagna Reeves C, Gerson J, Singh G, et al. Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles. J Neurosci. 2014;34:4260-72 pubmed 出版商
  • 免疫印迹; 人类; 1:2000
Lu J, Li T, He R, Bartlett P, Götz J. Visualizing the microtubule-associated protein tau in the nucleus. Sci China Life Sci. 2014;57:422-31 pubmed 出版商
  • 免疫组化; 小鼠; 1:1000
Palm R, Chang J, Blair J, Garcia Mesa Y, Lee H, Castellani R, et al. Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice. J Neurochem. 2014;130:115-25 pubmed 出版商
  • 免疫组化; 小鼠
Kim H, Chang K, Ha T, Kim J, Ha S, Shin K, et al. S100A9 knockout decreases the memory impairment and neuropathology in crossbreed mice of Tg2576 and S100A9 knockout mice model. PLoS ONE. 2014;9:e88924 pubmed 出版商
  • 免疫组化; 人类; 1:1000
Dalby N, Volbracht C, Helboe L, Larsen P, Jensen H, Egebjerg J, et al. Altered function of hippocampal CA1 pyramidal neurons in the rTg4510 mouse model of tauopathy. J Alzheimers Dis. 2014;40:429-42 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Abbondante S, Baglietto Vargas D, Rodriguez Ortiz C, Estrada Hernandez T, Medeiros R, LaFerla F. Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes. Am J Pathol. 2014;184:819-26 pubmed 出版商
  • 免疫印迹; 小鼠; 1:200
Orr M, Salinas A, Buffenstein R, Oddo S. Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology. Neurobiol Aging. 2014;35:1233-42 pubmed 出版商
  • 免疫组化; 小鼠; 1:100
  • 免疫印迹; 小鼠; 1:1000
Yamada E, Respondek G, Müssner S, de Andrade A, Höllerhage M, Depienne C, et al. Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice. Exp Neurol. 2014;253:113-25 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Torres M, Price S, Fiol deRoque M, Marcilla Etxenike A, Ahyayauch H, Barcelo Coblijn G, et al. Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease. Biochim Biophys Acta. 2014;1838:1680-92 pubmed 出版商
  • 免疫组化; 小鼠; 1:200
Hoffmann N, Dorostkar M, Blumenstock S, Goedert M, Herms J. Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice. Acta Neuropathol Commun. 2013;1:82 pubmed 出版商
  • 免疫印迹; 小鼠
Pehar M, Ko M, Li M, Scrable H, Puglielli L. P44, the 'longevity-assurance' isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion. Aging Cell. 2014;13:449-56 pubmed 出版商
  • 免疫组化; 小鼠; 1:50
Huang X, Qian Z, He X, Gong Q, Wu K, Jiang L, et al. Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease. Neurobiol Aging. 2014;35:1045-54 pubmed 出版商
  • 免疫组化; 小鼠; 1:500
  • 免疫印迹; 小鼠; 1:500
Graham D, Gray A, Joyce J, Yu D, O Moore J, Carlson G, et al. Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy. Neuropharmacology. 2014;79:307-13 pubmed 出版商
  • 免疫印迹; 小鼠; 1:250
Trujillo Estrada L, Jimenez S, De Castro V, Torres M, Baglietto Vargas D, Moreno Gonzalez I, et al. In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology. Acta Neuropathol Commun. 2013;1:73 pubmed 出版商
  • 免疫组化; 人类; 1:2000
Yanagisawa D, Taguchi H, Ibrahim N, Morikawa S, Shiino A, Inubushi T, et al. Preferred features of a fluorine-19 MRI probe for amyloid detection in the brain. J Alzheimers Dis. 2014;39:617-31 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Baglietto Vargas D, Kitazawa M, Le E, Estrada Hernandez T, Rodriguez Ortiz C, Medeiros R, et al. Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition. Neurobiol Dis. 2014;62:407-15 pubmed 出版商
  • 免疫组化; 人类; 1:1000
Blennerhassett R, Lillo P, Halliday G, Hodges J, Kril J. Distribution of pathology in frontal variant Alzheimer's disease. J Alzheimers Dis. 2014;39:63-70 pubmed 出版商
  • 免疫组化; 人类; 1:100
Nölle A, van Haastert E, Zwart R, Hoozemans J, Scheper W. Ubiquilin 2 is not associated with tau pathology. PLoS ONE. 2013;8:e76598 pubmed 出版商
  • 免疫组化; 小鼠; 1:1000
Hensley K, Gabbita S, Venkova K, Hristov A, Johnson M, Eslami P, et al. A derivative of the brain metabolite lanthionine ketimine improves cognition and diminishes pathology in the 3 × Tg-AD mouse model of Alzheimer disease. J Neuropathol Exp Neurol. 2013;72:955-69 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Natunen T, Parrado A, Helisalmi S, Pursiheimo J, Sarajärvi T, Mäkinen P, et al. Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease. J Alzheimers Dis. 2013;37:217-32 pubmed 出版商
  • 免疫组化; 大鼠; 1:1000
Levarska L, Zilka N, Jadhav S, Neradil P, Novak M. Of rodents and men: the mysterious interneuronal pilgrimage of misfolded protein tau in Alzheimer’s disease. J Alzheimers Dis. 2013;37:569-77 pubmed 出版商
  • 免疫组化; 小鼠
Mannix R, Meehan W, MANDEVILLE J, Grant P, Gray T, Berglass J, et al. Clinical correlates in an experimental model of repetitive mild brain injury. Ann Neurol. 2013;74:65-75 pubmed 出版商
  • 免疫组化; 人类
Bonda D, Stone J, Torres S, Siedlak S, Perry G, Kryscio R, et al. Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance. J Neurochem. 2014;128:162-72 pubmed 出版商
  • 免疫组化; 人类
Anumala U, Gu J, Lo Monte F, Kramer T, Heyny von Haußen R, Hölzer J, et al. Fluorescent rhodanine-3-acetic acids visualize neurofibrillary tangles in Alzheimer's disease brains. Bioorg Med Chem. 2013;21:5139-44 pubmed 出版商
  • 免疫组化; 小鼠; 1:1000
Rantamäki T, Kemppainen S, Autio H, Stavén S, Koivisto H, Kojima M, et al. The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease. PLoS ONE. 2013;8:e68722 pubmed 出版商
  • 免疫印迹; 人类; 1:2000
Chen R, Chang W, Lin Y, Cheng P, Chen Y. Alzheimer's amyloid-? oligomers rescue cellular prion protein induced tau reduction via the Fyn pathway. ACS Chem Neurosci. 2013;4:1287-96 pubmed 出版商
  • 免疫组化; 人类; 1:1000
Barron A, Garcia Segura L, Caruso D, Jayaraman A, Lee J, Melcangi R, et al. Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease. J Neurosci. 2013;33:8891-7 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类
Ozcelik S, Fraser G, Castets P, Schaeffer V, Skachokova Z, Breu K, et al. Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice. PLoS ONE. 2013;8:e62459 pubmed 出版商
  • 免疫组化; 大鼠; 1:100
  • 酶联免疫吸附测定; 大鼠; 1:1000
  • 免疫印迹; 大鼠; 1:1000
Hawkins B, Krishnamurthy S, Castillo Carranza D, Sengupta U, Prough D, Jackson G, et al. Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies. J Biol Chem. 2013;288:17042-50 pubmed 出版商
  • 免疫印迹; 小鼠; 1:200
Tackenberg C, Grinschgl S, Trutzel A, Santuccione A, Frey M, Konietzko U, et al. NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss. Cell Death Dis. 2013;4:e608 pubmed 出版商
  • 免疫组化; 人类; 1:100
Manczak M, Reddy P. Abnormal interaction of oligomeric amyloid-? with phosphorylated tau: implications to synaptic dysfunction and neuronal damage. J Alzheimers Dis. 2013;36:285-95 pubmed 出版商
  • 免疫组化; 人类
Gu J, Anumala U, Heyny von Haußen R, Hölzer J, Goetschy Meyer V, Mall G, et al. Design, synthesis and biological evaluation of trimethine cyanine dyes as fluorescent probes for the detection of tau fibrils in Alzheimer's disease brain and olfactory epithelium. ChemMedChem. 2013;8:891-7 pubmed 出版商
  • 免疫组化; 人类; 1:50
  • 免疫印迹; 人类; 1:2000
Ando K, Brion J, Stygelbout V, Suain V, Authelet M, Dedecker R, et al. Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains. Acta Neuropathol. 2013;125:861-78 pubmed 出版商
  • 免疫组化; 人类
Iranzo A, Tolosa E, Gelpi E, Molinuevo J, Valldeoriola F, Serradell M, et al. Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study. Lancet Neurol. 2013;12:443-53 pubmed 出版商
  • 免疫印迹; 人类
Ozdemir A, Rom I, Kovalevich J, Yen W, Adiga R, Dave R, et al. PINCH in the cellular stress response to tau-hyperphosphorylation. PLoS ONE. 2013;8:e58232 pubmed 出版商
  • 免疫组化; 人类
Varges D, Schulz Schaeffer W, Wemheuer W, Damman I, Schmitz M, Cramm M, et al. Spongiform encephalopathy in siblings with no evidence of protease-resistant prion protein or a mutation in the prion protein gene. J Neurol. 2013;260:1871-9 pubmed 出版商
  • 免疫组化; 人类; 1:1000
Josephs K, Dickson D, Murray M, Senjem M, Parisi J, Petersen R, et al. Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer's disease presenting as logopenic progressive aphasia. Brain Lang. 2013;127:127-34 pubmed 出版商
  • 免疫组化; 人类; 1:2000
Feldengut S, Del Tredici K, Braak H. Paraffin sections of 70-100 ?m: a novel technique and its benefits for studying the nervous system. J Neurosci Methods. 2013;215:241-4 pubmed 出版商
  • 免疫印迹; 小鼠
Geekiyanage H, Upadhye A, Chan C. Inhibition of serine palmitoyltransferase reduces A? and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease. Neurobiol Aging. 2013;34:2037-51 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Alonso E, Vale C, Vieytes M, Botana L. Translocation of PKC by yessotoxin in an in vitro model of Alzheimer's disease with improvement of tau and ?-amyloid pathology. ACS Chem Neurosci. 2013;4:1062-70 pubmed 出版商
  • 免疫组化; 人类
Bigio E. Making the diagnosis of frontotemporal lobar degeneration. Arch Pathol Lab Med. 2013;137:314-25 pubmed 出版商
  • 免疫组化; 小鼠
Garringer H, Murrell J, Sammeta N, Gnezda A, Ghetti B, Vidal R. Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice. PLoS ONE. 2013;8:e56426 pubmed 出版商
  • 免疫组化; 小鼠; 1:1000
Zufferey V, Vallet P, Moeri M, Moulin Sallanon M, Piotton F, Marin P, et al. Maladaptive exploratory behavior and neuropathology of the PS-1 P117L Alzheimer transgenic mice. Brain Res Bull. 2013;94:17-22 pubmed 出版商
  • 免疫组化; 小鼠
Parrella E, Maxim T, Maialetti F, Zhang L, Wan J, Wei M, et al. Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model. Aging Cell. 2013;12:257-68 pubmed 出版商
  • 免疫印迹; 小鼠
Nash K, Lee D, Hunt J, Morganti J, Selenica M, Moran P, et al. Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy. Neurobiol Aging. 2013;34:1540-8 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Baglietto Vargas D, Medeiros R, Martinez Coria H, LaFerla F, Green K. Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology. Biol Psychiatry. 2013;74:357-66 pubmed 出版商
  • 免疫组化; 人类; 1:200
Schön C, Hoffmann N, Ochs S, Burgold S, Filser S, Steinbach S, et al. Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice. PLoS ONE. 2012;7:e53547 pubmed 出版商
  • 免疫组化; 人类; 1:50
Kohler C, Dinekov M, Götz J. Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice. Neurobiol Aging. 2013;34:1369-79 pubmed 出版商
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Liu D, Pitta M, Jiang H, Lee J, Zhang G, Chen X, et al. Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession. Neurobiol Aging. 2013;34:1564-80 pubmed 出版商
  • 免疫组化; 小鼠; 1:500
Yao J, Ho D, Calingasan N, Pipalia N, Lin M, Beal M. Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease. J Exp Med. 2012;209:2501-13 pubmed 出版商
  • 免疫组化; 人类; 1:500
Hong Y, Chan C, Kwon I, Li X, Song M, Lee H, et al. SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease. J Neurosci. 2012;32:17262-72 pubmed 出版商
  • 免疫组化; 小鼠; 1:45
ATTAR A, Ripoli C, Riccardi E, Maiti P, Li Puma D, Liu T, et al. Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers. Brain. 2012;135:3735-48 pubmed 出版商
  • 免疫印迹; 大鼠; 0.2 ug/ml
Borlikova G, Trejo M, Mably A, Mc Donald J, Sala Frigerio C, Regan C, et al. Alzheimer brain-derived amyloid ?-protein impairs synaptic remodeling and memory consolidation. Neurobiol Aging. 2013;34:1315-27 pubmed 出版商
  • 免疫组化; 小鼠; 1:500
  • 免疫印迹; 小鼠; 1:1000
Torres M, Jimenez S, Sanchez Varo R, Navarro V, Trujillo Estrada L, Sanchez Mejias E, et al. Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus. Mol Neurodegener. 2012;7:59 pubmed 出版商
  • 免疫组化; 人类; 1:1000
Kovari E, Herrmann F, Hof P, Bouras C. The relationship between cerebral amyloid angiopathy and cortical microinfarcts in brain ageing and Alzheimer's disease. Neuropathol Appl Neurobiol. 2013;39:498-509 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Yokota T, Akatsu H, Miyauchi T, Heese K. Characterization of the novel protein P9TLDR (temporal lobe down-regulated) with a brain-site-specific gene expression modality in Alzheimer's disease brain. FEBS Lett. 2012;586:4357-61 pubmed 出版商
  • 免疫组化; 小鼠
Merkwirth C, Martinelli P, Korwitz A, Morbin M, Brönneke H, Jordan S, et al. Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration. PLoS Genet. 2012;8:e1003021 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Rahman A, Khan K, Al Khaledi G, Khan I, Attur S. Early postnatal lead exposure induces tau phosphorylation in the brain of young rats. Acta Biol Hung. 2012;63:411-25 pubmed 出版商
  • 免疫组化; 人类
Pirker S, Perju Dumbrava L, Kovacs G, Traub Weidinger T, Asenbaum S, Pirker W. Dopamine D2 receptor SPECT in corticobasal syndrome and autopsy-confirmed corticobasal degeneration. Parkinsonism Relat Disord. 2013;19:222-6 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
López Menéndez C, Gamir Morralla A, Jurado Arjona J, Higuero A, Campanero M, Ferrer I, et al. Kidins220 accumulates with tau in human Alzheimer's disease and related models: modulation of its calpain-processing by GSK3?/PP1 imbalance. Hum Mol Genet. 2013;22:466-82 pubmed 出版商
  • 免疫组化; 人类; 1:200
  • 免疫印迹; 人类; 1:500
Choi S, Aid S, Caracciolo L, Minami S, Niikura T, Matsuoka Y, et al. Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease. J Neurochem. 2013;124:59-68 pubmed 出版商
  • 免疫组化; 人类; 1:250
Harris J, Koyama A, Maeda S, Ho K, Devidze N, Dubal D, et al. Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits. PLoS ONE. 2012;7:e45881 pubmed 出版商
  • 免疫组化; 小鼠
Inoue K, Rispoli J, Kaphzan H, Klann E, Chen E, Kim J, et al. Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway. Mol Neurodegener. 2012;7:48 pubmed 出版商
  • 免疫印迹; 小鼠
Vepsäläinen S, Koivisto H, Pekkarinen E, Mäkinen P, Dobson G, McDougall G, et al. Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease. J Nutr Biochem. 2013;24:360-70 pubmed 出版商
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产品信息
产品类型 :
抗体
产品名称 :
Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8), Biotin
目录# :
MN1020B
规格 :
50µg
价格 :
美国506.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类
应用 :
ELISA: Assay Dependent, Immunocytochemistry: Assay Dependent, Immunofluorescence: Assay Dependent, Immunohistochemistry (Paraffin): Assay Dependent, Western Blot: Assay Dependent
物种 :
人类
克隆 :
AT8
抗体亚型 :
IgG1
储存 :
4° C
描述 :
Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclindependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
免疫原 :
Partially purified human PHF-Tau
格式 :
Liquid
应用w/稀释 :
ELISA: Assay Dependent, Immunocytochemistry: Assay Dependent, Immunofluorescence: Assay Dependent, Immunohistochemistry (Paraffin): Assay Dependent, Western Blot: Assay Dependent
别名 :
G protein beta1/gamma2 subunit-interacting factor 1; PHF-tau; neurofibrillary tangle protein; paired helical filament-tau
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
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