产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Phospho-Tau (Thr231) Monoclonal Antibody (AT180)
目录 :
MN1040
规格 :
100µg
价格 :
美国506.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
抗原修饰 :
磷酸化
克隆名称 :
AT180
反应物种 :
仓鼠, 人类, 小鼠, 大鼠, , , 果蝇, , 秀丽隐杆线虫, equine, 猕猴
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片, immunohistochemistry - free floating section, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 279
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 人类; 1:1000; 图 s5b
Tseng J, Xie L, Song S, Xie Y, Allen L, Ajit D, et al. The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology. Cell Rep. 2017;20:2169-2183 pubmed 出版商
  • 免疫组化; 小鼠; 图 4c
  • 免疫印迹; 小鼠; 图 4a
Li J, Barrero C, Merali S, Pratico D. Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype. Sci Rep. 2017;7:46002 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5a
Maphis N, Jiang S, Binder J, Wright C, Gopalan B, Lamb B, et al. Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology. Front Mol Neurosci. 2017;10:69 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
Wu X, Kosaraju J, Tam K. SLM, a novel carbazole-based fluorophore attenuates okadaic acid-induced tau hyperphosphorylation via down-regulating GSK-3? activity in SH-SY5Y cells. Eur J Pharm Sci. 2017;110:101-108 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1a
Trzeciakiewicz H, Tseng J, Wander C, Madden V, Tripathy A, Yuan C, et al. A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy. Sci Rep. 2017;7:44102 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 3b
  • 免疫印迹; 小鼠; 0.2 ug/ml; 图 2b
Bodea L, Evans H, Van der Jeugd A, Ittner L, Delerue F, Kril J, et al. Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model. Aging Cell. 2017;16:377-386 pubmed 出版商
  • immunohistochemistry - free floating section; 小鼠; 1:500; 图 1a
Fu H, Rodriguez G, Herman M, Emrani S, Nahmani E, Barrett G, et al. Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease. Neuron. 2017;93:533-541.e5 pubmed 出版商
  • 免疫组化; 人类; 1:500; 图 7d
Takahashi H, Klein Z, Bhagat S, Kaufman A, Kostylev M, Ikezu T, et al. Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network. Acta Neuropathol. 2017;133:785-807 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
Rueli R, Torres D, Dewing A, Kiyohara A, Barayuga S, Bellinger M, et al. Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology. J Alzheimers Dis. 2017;55:749-762 pubmed
  • 免疫印迹; 小鼠; 1:200; 图 3a
di Meco A, Li J, Blass B, Abou Gharbia M, Lauretti E, Praticò D. 12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice. Biol Psychiatry. 2017;81:92-100 pubmed 出版商
  • 免疫组化; 小鼠; 1:1000; 图 3
Kolisnyk B, Al Onaizi M, Soreq L, Barbash S, Bekenstein U, Haberman N, et al. Cholinergic Surveillance over Hippocampal RNA Metabolism and Alzheimer's-Like Pathology. Cereb Cortex. 2017;27:3553-3567 pubmed 出版商
  • 免疫组化-石蜡切片; 果蝇; 1:1000; 图 4
  • 免疫印迹; 果蝇; 1:2000; 图 4
Chanu S, Sarkar S. Targeted Downregulation of dMyc Suppresses Pathogenesis of Human Neuronal Tauopathies in Drosophila by Limiting Heterochromatin Relaxation and Tau Hyperphosphorylation. Mol Neurobiol. 2017;54:2706-2719 pubmed 出版商
  • 免疫组化; 小鼠; 1:250; 图 5b
  • 免疫印迹; 小鼠; 1:1000; 图 5c
Wang A, Jensen E, Rexach J, Vinters H, Hsieh Wilson L. Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration. Proc Natl Acad Sci U S A. 2016;113:15120-15125 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 6b
Zimova I, Brezovakova V, Hromádka T, Weisová P, Cubinkova V, Valachova B, et al. Human Truncated Tau Induces Mature Neurofibrillary Pathology in a Mouse Model of Human Tauopathy. J Alzheimers Dis. 2016;54:831-43 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠; 1:50; 图 6
Steffen J, Krohn M, Paarmann K, Schwitlick C, Brüning T, Marreiros R, et al. Revisiting rodent models: Octodon degus as Alzheimer's disease model?. Acta Neuropathol Commun. 2016;4:91 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠; 1:1000; 图 5
McAteer K, Corrigan F, Thornton E, Turner R, Vink R. Short and Long Term Behavioral and Pathological Changes in a Novel Rodent Model of Repetitive Mild Traumatic Brain Injury. PLoS ONE. 2016;11:e0160220 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 ev1
Salta E, Sierksma A, Vanden Eynden E, De Strooper B. miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain. EMBO Mol Med. 2016;8:1005-18 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 3
  • 免疫印迹; 小鼠; 1:500; 图 6
Baker S, Götz J. A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions. Acta Neuropathol Commun. 2016;4:32 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3
Polanco J, Scicluna B, Hill A, Götz J. Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner. J Biol Chem. 2016;291:12445-66 pubmed 出版商
  • 免疫印迹; 果蝇; 图 2
Ando K, Maruko Otake A, Ohtake Y, Hayashishita M, Sekiya M, Iijima K. Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and A?42-Induced Tau Toxicity. PLoS Genet. 2016;12:e1005917 pubmed 出版商
  • 免疫印迹; 小鼠; 图 8
Winston C, Noël A, Neustadtl A, Parsadanian M, Barton D, Chellappa D, et al. Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma. Am J Pathol. 2016;186:552-67 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:500; 图 1
Van der Jeugd A, Vermaercke B, Halliday G, Staufenbiel M, Götz J. Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia. Neurobiol Learn Mem. 2016;130:34-43 pubmed 出版商
  • 免疫组化; 人类; 图 3
  • 免疫印迹; 人类; 1:1000; 图 3
  • 免疫组化; 小鼠; 图 3
  • 免疫印迹; 小鼠; 1:1000; 图 3
Jiang T, Zhang Y, Chen Q, Gao Q, Zhu X, Zhou J, et al. TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice. Neuropharmacology. 2016;105:196-206 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3
El Khoury N, Gratuze M, Petry F, Papon M, Julien C, Marcouiller F, et al. Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice. Neurobiol Dis. 2016;88:55-65 pubmed 出版商
  • 免疫印迹; 人类; 1:100; 图 2
Platt T, Beckett T, Kohler K, Niedowicz D, Murphy M. Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease. Neuroscience. 2016;315:162-74 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3
Müller Schiffmann A, Herring A, Abdel Hafiz L, Chepkova A, Schäble S, Wedel D, et al. Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity. Brain. 2016;139:509-25 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Taniguchi Watanabe S, Arai T, Kametani F, Nonaka T, Masuda Suzukake M, Tarutani A, et al. Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau. Acta Neuropathol. 2016;131:267-280 pubmed 出版商
  • 免疫组化; 仓鼠; 1:10,000; 图 2
Bullmann T, Seeger G, Stieler J, Hanics J, Reimann K, Kretzschmann T, et al. Tau phosphorylation-associated spine regression does not impair hippocampal-dependent memory in hibernating golden hamsters. Hippocampus. 2016;26:301-18 pubmed 出版商
  • 免疫组化-石蜡切片; 狗; 1:1000; 图 3
  • 免疫组化; 人类
Smolek T, Madari A, Farbáková J, Kandrac O, Jadhav S, Cente M, et al. Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment. J Comp Neurol. 2016;524:874-95 pubmed 出版商
  • 免疫印迹; 大鼠; 图 3
Chesser A, Ganeshan V, Yang J, Johnson G. Epigallocatechin-3-gallate enhances clearance of phosphorylated tau in primary neurons. Nutr Neurosci. 2016;19:21-31 pubmed 出版商
  • 免疫印迹; 小鼠; 1:200; 图 3
Di Meco A, Joshi Y, Lauretti E, Praticò D. Maternal dexamethasone exposure ameliorates cognition and tau pathology in the offspring of triple transgenic AD mice. Mol Psychiatry. 2016;21:403-10 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 表 1
  • 免疫印迹; 小鼠; 1:1000; 表 1
Piedrahita D, Castro Álvarez J, Boudreau R, Villegas Lanau A, Kosik K, Gallego Gómez J, et al. β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice. Front Cell Neurosci. 2015;9:498 pubmed 出版商
  • 免疫印迹; 人类; 图 7
Watanabe K, Uemura K, Asada M, Maesako M, Akiyama H, Shimohama S, et al. The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease. Mol Brain. 2015;8:82 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Hromadkova L, Kolarova M, Jankovicova B, Bartos A, Ricny J, Bilkova Z, et al. Identification and characterization of natural antibodies against tau protein in an intravenous immunoglobulin product. J Neuroimmunol. 2015;289:121-9 pubmed 出版商
  • 酶联免疫吸附测定; 小鼠; 图 2
  • 酶联免疫吸附测定; 人类; 图 2
Yamada K, Patel T, Hochgräfe K, Mahan T, Jiang H, Stewart F, et al. Analysis of in vivo turnover of tau in a mouse model of tauopathy. Mol Neurodegener. 2015;10:55 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3
Wagner J, Krauss S, Shi S, Ryazanov S, Steffen J, Miklitz C, et al. Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies. Acta Neuropathol. 2015;130:619-31 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3
Lee I, Jung K, Kim I, Lee H, Kim M, Yun S, et al. Human neural stem cells alleviate Alzheimer-like pathology in a mouse model. Mol Neurodegener. 2015;10:38 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1
Lauretti E, Praticò D. Glucose deprivation increases tau phosphorylation via P38 mitogen-activated protein kinase. Aging Cell. 2015;14:1067-74 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 1
Kim J, Kim S, Lee Y. Fas-associated factor 1 promotes in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice. Neuroreport. 2015;26:767-72 pubmed 出版商
  • 免疫印迹; 人类; 图 1b
Song L, Lu S, Ouyang X, Melchor J, Lee J, Terracina G, et al. Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology. Mol Neurodegener. 2015;10:14 pubmed 出版商
  • 免疫印迹; 人类; 图 3, 4
Sepúlveda Díaz J, Alavi Naini S, Huynh M, Ouidja M, Yanicostas C, Chantepie S, et al. HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology. Brain. 2015;138:1339-54 pubmed 出版商
  • 免疫印迹; 人类; 1:2500; 图 1a
Maphis N, Xu G, Kokiko Cochran O, Jiang S, Cardona A, Ransohoff R, et al. Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain. Brain. 2015;138:1738-55 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 1
Li R, Xu D, Ma T. Lovastatin suppresses the aberrant tau phosphorylation from FTDP-17 mutation and okadaic acid-induction in rat primary neurons. Neuroscience. 2015;294:14-20 pubmed 出版商
  • immunohistochemistry - free floating section; 人类; 1:500
Jay T, Miller C, Cheng P, Graham L, Bemiller S, Broihier M, et al. TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models. J Exp Med. 2015;212:287-95 pubmed 出版商
  • immunohistochemistry - free floating section; 小鼠; 1:1000
Kaufman A, Salazar S, Haas L, Yang J, Kostylev M, Jeng A, et al. Fyn inhibition rescues established memory and synapse loss in Alzheimer mice. Ann Neurol. 2015;77:953-71 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s4
Carret Rebillat A, Pace C, Gourmaud S, Ravasi L, Montagne Stora S, Longueville S, et al. Neuroinflammation and Aβ accumulation linked to systemic inflammation are decreased by genetic PKR down-regulation. Sci Rep. 2015;5:8489 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:400
Wu Z, Yang B, Liu C, Liang G, Eckenhoff M, Liu W, et al. Long-term dantrolene treatment reduced intraneuronal amyloid in aged Alzheimer triple transgenic mice. Alzheimer Dis Assoc Disord. 2015;29:184-191 pubmed 出版商
  • 免疫印迹; 小鼠
Mouton Liger F, Rebillat A, Gourmaud S, Paquet C, Leguen A, Dumurgier J, et al. PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model. Cell Death Dis. 2015;6:e1594 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s2
Sykora P, Misiak M, Wang Y, Ghosh S, Leandro G, Liu D, et al. DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes. Nucleic Acids Res. 2015;43:943-59 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:50
  • 免疫印迹; 小鼠; 1:100
Lauretti E, di Meco A, Chu J, Praticò D. Modulation of AD neuropathology and memory impairments by the isoprostane F2α is mediated by the thromboxane receptor. Neurobiol Aging. 2015;36:812-20 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠; 图 2
  • 免疫印迹; 大鼠; 图 1
Huang C, Ho Y, Ng O, Irwin M, Chang R, Wong G. Dexmedetomidine directly increases tau phosphorylation. J Alzheimers Dis. 2015;44:839-50 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Dunn H, Ager R, Baglietto Vargas D, Cheng D, Kitazawa M, Cribbs D, et al. Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model. J Alzheimers Dis. 2015;43:893-903 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 1
  • 免疫印迹; 小鼠; 图 1
Ittner A, Bertz J, Suh L, Stevens C, Götz J, Ittner L. Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice. J Neurochem. 2015;132:135-45 pubmed 出版商
  • 免疫印迹; 人类; 图 s2
Richter M, Mewes A, Fritsch M, Krügel U, Hoffmann R, Singer D. Doubly Phosphorylated Peptide Vaccines to Protect Transgenic P301S Mice against Alzheimer's Disease Like Tau Aggregation. Vaccines (Basel). 2014;2:601-23 pubmed 出版商
  • immunohistochemistry - free floating section; 小鼠; 1:500
Xu H, Rösler T, Carlsson T, de Andrade A, Fiala O, Höllerhage M, et al. Tau silencing by siRNA in the P301S mouse model of tauopathy. Curr Gene Ther. 2014;14:343-51 pubmed
  • 免疫印迹; 小鼠
Iliff J, Chen M, Plog B, Zeppenfeld D, Soltero M, Yang L, et al. Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury. J Neurosci. 2014;34:16180-93 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:1000
  • 免疫印迹; 小鼠; 1:500
Höllerhage M, Deck R, de Andrade A, Respondek G, Xu H, Rösler T, et al. Piericidin A aggravates Tau pathology in P301S transgenic mice. PLoS ONE. 2014;9:e113557 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:500; 图 2
  • 免疫印迹; 人类; 1:250; 图 4
Ohia Nwoko O, Montazari S, Lau Y, Eriksen J. Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice. Mol Neurodegener. 2014;9:54 pubmed 出版商
  • 免疫组化; 果蝇
  • 免疫印迹; 小鼠
Hu X, Li X, Zhao M, Gottesdiener A, Luo W, Paul S. Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40. Mol Neurodegener. 2014;9:52 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2
Castro Alvarez J, Uribe Arias S, Kosik K, Cardona Gómez G. Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice. Front Aging Neurosci. 2014;6:243 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Jiang T, Yu J, Zhu X, Zhang Q, Cao L, Wang H, et al. Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance. Neuropharmacology. 2014;85:121-30 pubmed 出版商
  • 免疫组化; 小鼠; 1:250
  • 免疫印迹; 小鼠; 1:500
Shilling D, Müller M, Takano H, Mak D, Abel T, Coulter D, et al. Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis. J Neurosci. 2014;34:6910-23 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 1:1000; 图 2
Petry F, Pelletier J, Bretteville A, Morin F, Calon F, Hébert S, et al. Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions. PLoS ONE. 2014;9:e94251 pubmed 出版商
  • 免疫组化; 小鼠
Inoue H, Hiradate Y, Shirakata Y, Kanai K, Kosaka K, Gotoh A, et al. Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis. FEBS Lett. 2014;588:2003-8 pubmed 出版商
  • 免疫印迹; 小鼠
Maurin H, Lechat B, Borghgraef P, Devijver H, Jaworski T, Van Leuven F. Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3?/?. Eur J Neurosci. 2014;40:2442-53 pubmed 出版商
  • 免疫组化; 小鼠; 1:1000
  • 免疫印迹; 小鼠; 1:1000
Castillo Carranza D, Sengupta U, Guerrero Muñoz M, Lasagna Reeves C, Gerson J, Singh G, et al. Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles. J Neurosci. 2014;34:4260-72 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类
Li J, Chu J, Barrero C, Merali S, Pratico D. Homocysteine exacerbates ?-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles. Ann Neurol. 2014;75:851-63 pubmed 出版商
  • 免疫印迹; 人类; 1:2000
Lu J, Li T, He R, Bartlett P, Götz J. Visualizing the microtubule-associated protein tau in the nucleus. Sci China Life Sci. 2014;57:422-31 pubmed 出版商
  • 免疫印迹; 小鼠; 1:200
di Meco A, Joshi Y, Pratico D. Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles. Neurobiol Aging. 2014;35:1813-20 pubmed 出版商
  • 免疫印迹; 人类
Chabrier M, Cheng D, Castello N, Green K, LaFerla F. Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease. Neurobiol Dis. 2014;64:107-17 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Abbondante S, Baglietto Vargas D, Rodriguez Ortiz C, Estrada Hernandez T, Medeiros R, LaFerla F. Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes. Am J Pathol. 2014;184:819-26 pubmed 出版商
  • 免疫组化; 小鼠; 1:100
  • 免疫印迹; 小鼠; 1:1000
Yamada E, Respondek G, Müssner S, de Andrade A, Höllerhage M, Depienne C, et al. Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice. Exp Neurol. 2014;253:113-25 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Farr S, Ripley J, Sultana R, Zhang Z, Niehoff M, Platt T, et al. Antisense oligonucleotide against GSK-3? in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease. Free Radic Biol Med. 2014;67:387-95 pubmed 出版商
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Hoffmann N, Dorostkar M, Blumenstock S, Goedert M, Herms J. Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice. Acta Neuropathol Commun. 2013;1:82 pubmed 出版商
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产品信息
产品类型 :
抗体
产品名称 :
Phospho-Tau (Thr231) Monoclonal Antibody (AT180)
目录# :
MN1040
规格 :
100µg
价格 :
美国506.00
克隆性 :
单克隆
纯度 :
纯化
宿主 :
小鼠
反应物种 :
人类, 大鼠
应用 :
Immunofluorescence: Assay Dependent, Immunohistochemistry: Assay Dependent, Western Blot: 1:500 - 1:1000
物种 :
人类, 大鼠
克隆 :
AT180
抗体亚型 :
IgG1, kappa
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclindependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
免疫原 :
Partially purified human PHF-Tau
格式 :
Liquid
应用w/稀释 :
Immunofluorescence: Assay Dependent, Immunohistochemistry: Assay Dependent, Western Blot: 1:500 - 1:1000
别名 :
G protein beta1/gamma2 subunit-interacting factor 1; PHF-tau; neurofibrillary tangle protein; paired helical filament-tau
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
www.thermo.com.cn
1084193588
公司总部: 美国