产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Phospho-Tau (Thr181) Monoclonal Antibody (AT270)
目录 :
MN1050
规格 :
100µg
价格 :
美国558
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
AT270
反应物种 :
African green monkey, 仓鼠, 人类, 小鼠, 大鼠, 果蝇, 秀丽隐杆线虫
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 138
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:1000; 图 5g
Baglietto Vargas D, Prieto G, Limon A, Forner S, Rodriguez Ortiz C, Ikemura K, et al. Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease. Aging Cell. 2018;17:e12791 pubmed 出版商
  • 免疫印迹; 人类; 图 1f
Wang C, Najm R, Xu Q, Jeong D, Walker D, Balestra M, et al. Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. Nat Med. 2018;24:647-657 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4
Hou Y, Lautrup S, Cordonnier S, Wang Y, Croteau D, Zavala E, et al. NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency. Proc Natl Acad Sci U S A. 2018;115:E1876-E1885 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s5b
Tseng J, Xie L, Song S, Xie Y, Allen L, Ajit D, et al. The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology. Cell Rep. 2017;20:2169-2183 pubmed 出版商
  • 免疫组化; 小鼠; 图 4c
  • 免疫印迹; 小鼠; 图 4a
Li J, Barrero C, Merali S, Pratico D. Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype. Sci Rep. 2017;7:46002 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1a
Trzeciakiewicz H, Tseng J, Wander C, Madden V, Tripathy A, Yuan C, et al. A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy. Sci Rep. 2017;7:44102 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2b
Bodea L, Evans H, Van der Jeugd A, Ittner L, Delerue F, Kril J, et al. Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model. Aging Cell. 2017;16:377-386 pubmed 出版商
  • 免疫印迹; 小鼠; 1:200; 图 3a
di Meco A, Li J, Blass B, Abou Gharbia M, Lauretti E, Praticò D. 12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice. Biol Psychiatry. 2017;81:92-100 pubmed 出版商
  • 免疫印迹; 果蝇; 图 3
Dourlen P, Fernandez Gomez F, Dupont C, Grenier Boley B, Bellenguez C, Obriot H, et al. Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology. Mol Psychiatry. 2017;22:874-883 pubmed 出版商
  • 免疫组化-石蜡切片; 果蝇; 1:1000; 图 4
  • 免疫印迹; 果蝇; 1:2000; 图 4
Chanu S, Sarkar S. Targeted Downregulation of dMyc Suppresses Pathogenesis of Human Neuronal Tauopathies in Drosophila by Limiting Heterochromatin Relaxation and Tau Hyperphosphorylation. Mol Neurobiol. 2017;54:2706-2719 pubmed 出版商
  • 免疫组化; 小鼠; 1:500; 图 5
Lipton S, Rezaie T, Nutter A, Lopez K, Parker J, Kosaka K, et al. Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease models. Cell Death Dis. 2016;7:e2499 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 ev1
  • 免疫印迹; 人类; 1:500; 图 8
Salta E, Sierksma A, Vanden Eynden E, De Strooper B. miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain. EMBO Mol Med. 2016;8:1005-18 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 5
Yetman M, Fowler S, Jankowsky J. Humanized Tau Mice with Regionalized Amyloid Exhibit Behavioral Deficits but No Pathological Interaction. PLoS ONE. 2016;11:e0153724 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3
Polanco J, Scicluna B, Hill A, Götz J. Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner. J Biol Chem. 2016;291:12445-66 pubmed 出版商
  • 免疫印迹; 小鼠; 图 8
Winston C, Noël A, Neustadtl A, Parsadanian M, Barton D, Chellappa D, et al. Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma. Am J Pathol. 2016;186:552-67 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200; 图 3
Nishikawa T, Takahashi T, Nakamori M, Hosomi N, Maruyama H, Miyazaki Y, et al. The identification of raft-derived tau-associated vesicles that are incorporated into immature tangles and paired helical filaments. Neuropathol Appl Neurobiol. 2016;42:639-653 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1
Lauretti E, Praticò D. Glucose deprivation increases tau phosphorylation via P38 mitogen-activated protein kinase. Aging Cell. 2015;14:1067-74 pubmed 出版商
  • 免疫印迹; 人类; 1:2000
Hamm M, Bailey R, Shaw G, Yen S, Lewis J, Giasson B. Physiologically relevant factors influence tau phosphorylation by leucine-rich repeat kinase 2. J Neurosci Res. 2015;93:1567-80 pubmed 出版商
  • 酶联免疫吸附测定; 人类
Sankaranarayanan S, Barten D, Vana L, Devidze N, Yang L, Cadelina G, et al. Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models. PLoS ONE. 2015;10:e0125614 pubmed 出版商
  • 免疫印迹; 人类; 图 1c
Song L, Lu S, Ouyang X, Melchor J, Lee J, Terracina G, et al. Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology. Mol Neurodegener. 2015;10:14 pubmed 出版商
  • 免疫印迹; 人类; 图 3, 4
Sepúlveda Díaz J, Alavi Naini S, Huynh M, Ouidja M, Yanicostas C, Chantepie S, et al. HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology. Brain. 2015;138:1339-54 pubmed 出版商
  • 免疫印迹; 人类; 1:200; 图 6b
Riise J, Plath N, Pakkenberg B, Parachikova A. Aberrant Wnt signaling pathway in medial temporal lobe structures of Alzheimer's disease. J Neural Transm (Vienna). 2015;122:1303-18 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:100
  • 免疫印迹; 小鼠; 1:200
Lauretti E, di Meco A, Chu J, Praticò D. Modulation of AD neuropathology and memory impairments by the isoprostane F2α is mediated by the thromboxane receptor. Neurobiol Aging. 2015;36:812-20 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Dunn H, Ager R, Baglietto Vargas D, Cheng D, Kitazawa M, Cribbs D, et al. Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model. J Alzheimers Dis. 2015;43:893-903 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 1
  • 免疫印迹; 小鼠; 图 1
Ittner A, Bertz J, Suh L, Stevens C, Götz J, Ittner L. Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice. J Neurochem. 2015;132:135-45 pubmed 出版商
  • 免疫印迹; 大鼠; 1:200
Yang S, Xia C, Li S, Du L, Zhang L, Hu Y. Mitochondrial dysfunction driven by the LRRK2-mediated pathway is associated with loss of Purkinje cells and motor coordination deficits in diabetic rat model. Cell Death Dis. 2014;5:e1217 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 1:1000; 图 2
Petry F, Pelletier J, Bretteville A, Morin F, Calon F, Hébert S, et al. Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions. PLoS ONE. 2014;9:e94251 pubmed 出版商
  • 免疫组化; 小鼠; 1:500
Inoue H, Hiradate Y, Shirakata Y, Kanai K, Kosaka K, Gotoh A, et al. Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis. FEBS Lett. 2014;588:2003-8 pubmed 出版商
  • 免疫印迹; 小鼠
Kondadi A, Wang S, Montagner S, Kladt N, Korwitz A, Martinelli P, et al. Loss of the m-AAA protease subunit AFG?L? causes mitochondrial transport defects and tau hyperphosphorylation. EMBO J. 2014;33:1011-26 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类
Li J, Chu J, Barrero C, Merali S, Pratico D. Homocysteine exacerbates ?-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles. Ann Neurol. 2014;75:851-63 pubmed 出版商
  • 免疫印迹; 人类; 1:2000
Lu J, Li T, He R, Bartlett P, Götz J. Visualizing the microtubule-associated protein tau in the nucleus. Sci China Life Sci. 2014;57:422-31 pubmed 出版商
  • 免疫印迹; 小鼠; 1:200
di Meco A, Joshi Y, Pratico D. Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles. Neurobiol Aging. 2014;35:1813-20 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Abbondante S, Baglietto Vargas D, Rodriguez Ortiz C, Estrada Hernandez T, Medeiros R, LaFerla F. Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes. Am J Pathol. 2014;184:819-26 pubmed 出版商
  • 免疫组化; 小鼠; 1:100
Yamada E, Respondek G, Müssner S, de Andrade A, Höllerhage M, Depienne C, et al. Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice. Exp Neurol. 2014;253:113-25 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500
Guo Q, Li H, Cole A, Hur J, Li Y, Zheng H. Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of A? and tau. PLoS ONE. 2013;8:e80706 pubmed 出版商
  • 免疫印迹; 小鼠
Medeiros R, Castello N, Cheng D, Kitazawa M, Baglietto Vargas D, Green K, et al. ?7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles. Am J Pathol. 2014;184:520-9 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Rice R, Berchtold N, Cotman C, Green K. Age-related downregulation of the CaV3.1 T-type calcium channel as a mediator of amyloid beta production. Neurobiol Aging. 2014;35:1002-11 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Baglietto Vargas D, Kitazawa M, Le E, Estrada Hernandez T, Rodriguez Ortiz C, Medeiros R, et al. Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition. Neurobiol Dis. 2014;62:407-15 pubmed 出版商
  • 酶联免疫吸附测定; 人类
Meredith J, Sankaranarayanan S, Guss V, Lanzetti A, Berisha F, Neely R, et al. Characterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease. PLoS ONE. 2013;8:e76523 pubmed 出版商
  • 免疫组化; 小鼠
Mannix R, Meehan W, MANDEVILLE J, Grant P, Gray T, Berglass J, et al. Clinical correlates in an experimental model of repetitive mild brain injury. Ann Neurol. 2013;74:65-75 pubmed 出版商
  • 免疫印迹; 小鼠
Nash K, Lee D, Hunt J, Morganti J, Selenica M, Moran P, et al. Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy. Neurobiol Aging. 2013;34:1540-8 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Baglietto Vargas D, Medeiros R, Martinez Coria H, LaFerla F, Green K. Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology. Biol Psychiatry. 2013;74:357-66 pubmed 出版商
  • 免疫组化; 人类; 1:200
Schön C, Hoffmann N, Ochs S, Burgold S, Filser S, Steinbach S, et al. Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice. PLoS ONE. 2012;7:e53547 pubmed 出版商
  • 免疫印迹; 小鼠
Leboucher A, Laurent C, Fernandez Gomez F, Burnouf S, Troquier L, Eddarkaoui S, et al. Detrimental effects of diet-induced obesity on ? pathology are independent of insulin resistance in ? transgenic mice. Diabetes. 2013;62:1681-8 pubmed 出版商
  • 免疫沉淀; 小鼠; 1:5000
Burnouf S, Martire A, Derisbourg M, Laurent C, Belarbi K, Leboucher A, et al. NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model. Aging Cell. 2013;12:11-23 pubmed 出版商
  • 免疫印迹; 人类
Bories C, Guitton M, Julien C, Tremblay C, Vandal M, Msaid M, et al. Sex-dependent alterations in social behaviour and cortical synaptic activity coincide at different ages in a model of Alzheimer's disease. PLoS ONE. 2012;7:e46111 pubmed 出版商
  • 免疫组化; 小鼠
Inoue K, Rispoli J, Kaphzan H, Klann E, Chen E, Kim J, et al. Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway. Mol Neurodegener. 2012;7:48 pubmed 出版商
  • 免疫组化; 小鼠; 1:10
Capsoni S, Carlo A, Vignone D, Amato G, Criscuolo C, Willnow T, et al. SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2013;33:357-71 pubmed 出版商
  • 免疫组化; African green monkey; 1:1000
Engelhardt M, Vorwald S, Sobotzik J, Bennett V, Schultz C. Ankyrin-B structurally defines terminal microdomains of peripheral somatosensory axons. Brain Struct Funct. 2013;218:1005-16 pubmed 出版商
  • 免疫印迹; 小鼠
Castello N, Green K, LaFerla F. Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter A? or tau pathology. PLoS ONE. 2012;7:e39566 pubmed 出版商
  • 免疫印迹; 小鼠
Wang H, Bakshi K, Frankfurt M, Stucky A, Goberdhan M, Shah S, et al. Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A. J Neurosci. 2012;32:9773-84 pubmed 出版商
  • 免疫印迹; 小鼠
Flunkert S, Hierzer M, Löffler T, Rabl R, Neddens J, Duller S, et al. Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model. Neurodegener Dis. 2013;11:194-205 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Bretteville A, Marcouiller F, Julien C, El Khoury N, Petry F, Poitras I, et al. Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors. Sci Rep. 2012;2:480 pubmed 出版商
  • 免疫印迹; 人类
Medeiros R, Kitazawa M, Chabrier M, Cheng D, Baglietto Vargas D, Kling A, et al. Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice. Am J Pathol. 2012;181:616-25 pubmed 出版商
  • 免疫印迹; 小鼠; 1:200
Joshi Y, Chu J, Pratico D. Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease. J Alzheimers Dis. 2012;31:167-76 pubmed 出版商
  • 免疫印迹; 人类
Löffler T, Flunkert S, Taub N, Schofield E, Ward M, Windisch M, et al. Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates. J Mol Neurosci. 2012;47:192-203 pubmed 出版商
  • 免疫印迹; 人类
Kawakami F, Yabata T, Ohta E, Maekawa T, Shimada N, Suzuki M, et al. LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth. PLoS ONE. 2012;7:e30834 pubmed 出版商
  • 免疫印迹; 人类; 1:100
Mouton Liger F, Paquet C, Dumurgier J, Lapalus P, Gray F, Laplanche J, et al. Increased cerebrospinal fluid levels of double-stranded RNA-dependant protein kinase in Alzheimer's disease. Biol Psychiatry. 2012;71:829-35 pubmed 出版商
  • 免疫印迹; 小鼠; 1:5000
Burnouf S, Belarbi K, Troquier L, Derisbourg M, Demeyer D, Leboucher A, et al. Hippocampal BDNF expression in a tau transgenic mouse model. Curr Alzheimer Res. 2012;9:406-10 pubmed
  • 免疫印迹; 大鼠; 1:1000
  • 免疫印迹; 人类; 1:1000
Jones N, Nguyen T, Corcoran N, Velakoulis D, Chen T, Grundy R, et al. Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models. Neurobiol Dis. 2012;45:897-901 pubmed 出版商
  • 免疫组化; 小鼠; 1:100
Nijholt D, van Haastert E, Rozemuller A, Scheper W, Hoozemans J. The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies. J Pathol. 2012;226:693-702 pubmed 出版商
  • 免疫组化; 小鼠
Ohmi K, Zhao H, Neufeld E. Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B. PLoS ONE. 2011;6:e27461 pubmed 出版商
  • 免疫印迹; 人类; 1:5000
Lebbadi M, Julien C, Phivilay A, Tremblay C, Emond V, Kang J, et al. Endogenous conversion of omega-6 into omega-3 fatty acids improves neuropathology in an animal model of Alzheimer's disease. J Alzheimers Dis. 2011;27:853-69 pubmed 出版商
  • 免疫印迹; 小鼠
  • 免疫印迹; 人类
Minami S, Clifford T, HOE H, Matsuoka Y, Rebeck G. Fyn knock-down increases A?, decreases phospho-tau, and worsens spatial learning in 3×Tg-AD mice. Neurobiol Aging. 2012;33:825.e15-24 pubmed 出版商
  • 免疫组化; 人类; 1:200
  • 免疫印迹; 人类; 1:1000
Kovacs G, Molnár K, Laszlo L, Strobel T, Botond G, Hönigschnabl S, et al. A peculiar constellation of tau pathology defines a subset of dementia in the elderly. Acta Neuropathol. 2011;122:205-22 pubmed 出版商
  • 酶联免疫吸附测定; 人类; 0.1 ug/ml
Wu G, Sankaranarayanan S, Hsieh S, Simon A, Savage M. Decrease in brain soluble amyloid precursor protein ? (sAPP?) in Alzheimer's disease cortex. J Neurosci Res. 2011;89:822-32 pubmed 出版商
  • 免疫印迹; 大鼠
Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe D. Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proc Natl Acad Sci U S A. 2011;108:5819-24 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1,000
Koike M, Garcia F, Kitazawa M, Green K, LaFerla F. Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia. Neurosci Lett. 2011;495:55-9 pubmed 出版商
  • 免疫印迹; 人类
Gauthier Kemper A, Weissmann C, Golovyashkina N, Sebö Lemke Z, Drewes G, Gerke V, et al. The frontotemporal dementia mutation R406W blocks tau's interaction with the membrane in an annexin A2-dependent manner. J Cell Biol. 2011;192:647-61 pubmed 出版商
  • 免疫组化; 小鼠; 1:2000
Sydow A, Van der Jeugd A, Zheng F, Ahmed T, Balschun D, Petrova O, et al. Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant. J Neurosci. 2011;31:2511-25 pubmed 出版商
  • 免疫组化; 小鼠; 1:100
  • 免疫印迹; 小鼠; 1:1,000
Kudo L, Parfenova L, Ren G, Vi N, Hui M, Ma Z, et al. Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice. Hum Mol Genet. 2011;20:1820-33 pubmed 出版商
  • 免疫印迹; 仓鼠; 1:500
Stieler J, Bullmann T, Kohl F, Tøien Ø, Brückner M, Hartig W, et al. The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation. PLoS ONE. 2011;6:e14530 pubmed 出版商
  • 免疫组化; 小鼠
  • 免疫印迹; 小鼠
Niikura T, Sidahmed E, Hirata Fukae C, Aisen P, Matsuoka Y. A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice. PLoS ONE. 2011;6:e16259 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类
Ksiezak Reding H, Ho L, Santa Maria I, Díaz Ruiz C, Wang J, Pasinetti G. Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols. Neurobiol Aging. 2012;33:1427-39 pubmed 出版商
  • 免疫印迹; 人类; 1:100000
Colodner K, Feany M. Glial fibrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy. J Neurosci. 2010;30:16102-13 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类
Caccamo A, Magrí A, Oddo S. Age-dependent changes in TDP-43 levels in a mouse model of Alzheimer disease are linked to A? oligomers accumulation. Mol Neurodegener. 2010;5:51 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类
Bose A, Mouton Liger F, Paquet C, Mazot P, Vigny M, Gray F, et al. Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease. Brain Pathol. 2011;21:189-200 pubmed 出版商
  • 免疫组化; 大鼠; 1:200
Liu D, Pitta M, Lee J, Ray B, Lahiri D, Furukawa K, et al. The KATP channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease. J Alzheimers Dis. 2010;22:443-57 pubmed 出版商
  • 免疫组化; 人类
  • 免疫组化; 小鼠
Hurtado D, Molina Porcel L, Iba M, Aboagye A, Paul S, Trojanowski J, et al. A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model. Am J Pathol. 2010;177:1977-88 pubmed 出版商
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Khurana V, Elson Schwab I, Fulga T, Sharp K, Loewen C, Mulkearns E, et al. Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo. PLoS Genet. 2010;6:e1001026 pubmed 出版商
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Parachikova A, Vasilevko V, Cribbs D, LaFerla F, Green K. Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation. J Alzheimers Dis. 2010;21:527-42 pubmed 出版商
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Koike M, Green K, Blurton Jones M, LaFerla F. Oligemic hypoperfusion differentially affects tau and amyloid-{beta}. Am J Pathol. 2010;177:300-10 pubmed 出版商
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Zilka N, Korenova M, Kovacech B, Iqbal K, Novak M. CSF phospho-tau correlates with behavioural decline and brain insoluble phospho-tau levels in a rat model of tauopathy. Acta Neuropathol. 2010;119:679-87 pubmed 出版商
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Lecanu L, Rammouz G, McCourty A, Sidahmed E, Greeson J, Papadopoulos V. Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease. Neuroscience. 2010;165:427-35 pubmed 出版商
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Run X, Liang Z, Zhang L, Iqbal K, Grundke Iqbal I, Gong C. Anesthesia induces phosphorylation of tau. J Alzheimers Dis. 2009;16:619-26 pubmed 出版商
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产品信息
产品类型 :
抗体
产品名称 :
Phospho-Tau (Thr181) Monoclonal Antibody (AT270)
目录# :
MN1050
规格 :
100µg
价格 :
美国558
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类
应用 :
Immunofluorescence: Assay Dependent, Immunohistochemistry: Assay Dependent, Western Blot: Assay Dependent
物种 :
人类
克隆 :
AT270
抗体亚型 :
IgG1, kappa
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclindependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
免疫原 :
Partially purified human PHF-Tau
格式 :
液体
应用w/稀释 :
Immunofluorescence: Assay Dependent, Immunohistochemistry: Assay Dependent, Western Blot: Assay Dependent
别名 :
G protein beta1/gamma2 subunit-interacting factor 1; PHF-tau; neurofibrillary tangle protein; paired helical filament-tau
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国