产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Phospho-Tau (Thr212, Ser214) Monoclonal Antibody (AT100)
目录 :
MN1060
规格 :
100µg
价格 :
美国558.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
抗原修饰 :
磷酸化
克隆名称 :
AT100
反应物种 :
leopard cat, 仓鼠, 人类, 小鼠, 大鼠, , 果蝇
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片, immunohistochemistry - free floating section
更多信息或购买 :
文章摘录数: 206
出版应用/物种/样品/稀释参考文献
  • 免疫组化; 小鼠; 图 4
  • 免疫印迹; 小鼠; 1:1000; 图 4b
Zhang Z, Obianyo O, Dall E, Du Y, Fu H, Liu X, et al. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun. 2017;8:14740 pubmed 出版商
  • immunohistochemistry - free floating section; 小鼠; 图 s4b
Fu H, Rodriguez G, Herman M, Emrani S, Nahmani E, Barrett G, et al. Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease. Neuron. 2017;93:533-541.e5 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6e
Laurent C, Dorothee G, Hunot S, Martin E, Monnet Y, Duchamp M, et al. Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy. Brain. 2017;140:184-200 pubmed 出版商
  • 免疫印迹; 人类; 图 s2
García Ayllón M, Botella López A, Cuchillo Ibañez I, Rábano A, Andreasen N, Blennow K, et al. HNK-1 Carrier Glycoproteins Are Decreased in the Alzheimer's Disease Brain. Mol Neurobiol. 2017;54:188-199 pubmed 出版商
  • 免疫组化; 小鼠; 1:100; 图 4e
Koukouli F, Rooy M, Maskos U. Early and progressive deficit of neuronal activity patterns in a model of local amyloid pathology in mouse prefrontal cortex. Aging (Albany NY). 2016;8:3430-3449 pubmed 出版商
  • 免疫组化; 人类; 1:200; 图 1e
Ling H, Kovacs G, Vonsattel J, DAVEY K, Mok K, Hardy J, et al. Astrogliopathy predominates the earliest stage of corticobasal degeneration pathology. Brain. 2016;139:3237-3252 pubmed
  • 免疫组化-石蜡切片; 大鼠; 1:500; 图 6
Steffen J, Krohn M, Paarmann K, Schwitlick C, Brüning T, Marreiros R, et al. Revisiting rodent models: Octodon degus as Alzheimer's disease model?. Acta Neuropathol Commun. 2016;4:91 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 ev1
Salta E, Sierksma A, Vanden Eynden E, De Strooper B. miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain. EMBO Mol Med. 2016;8:1005-18 pubmed 出版商
  • immunohistochemistry - free floating section; 小鼠; 1:250; 图 st7
  • 免疫组化-石蜡切片; 小鼠; 1:250; 图 st7
Pajares M, Jiménez Moreno N, García Yagüe A, Escoll M, De Ceballos M, Van Leuven F, et al. Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes. Autophagy. 2016;12:1902-1916 pubmed
  • 免疫印迹; 小鼠; 1:500; 图 6
Herring A, Münster Y, Akkaya T, Moghaddam S, Deinsberger K, Meyer J, et al. Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice. Alzheimers Dement. 2016;12:1273-1287 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3
Polanco J, Scicluna B, Hill A, Götz J. Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner. J Biol Chem. 2016;291:12445-66 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 1
Pisa D, Alonso R, Rábano A, Carrasco L. Corpora Amylacea of Brain Tissue from Neurodegenerative Diseases Are Stained with Specific Antifungal Antibodies. Front Neurosci. 2016;10:86 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 4
Gorsky M, Burnouf S, Dols J, Mandelkow E, Partridge L. Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo. Sci Rep. 2016;6:22685 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:500; 图 1
Van der Jeugd A, Vermaercke B, Halliday G, Staufenbiel M, Götz J. Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia. Neurobiol Learn Mem. 2016;130:34-43 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3
  • 免疫印迹; 人类; 1:1000; 图 3
Jiang T, Zhang Y, Chen Q, Gao Q, Zhu X, Zhou J, et al. TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice. Neuropharmacology. 2016;105:196-206 pubmed 出版商
  • 免疫印迹; 小鼠; 1:200; 图 1
Elahi M, Motoi Y, Matsumoto S, Hasan Z, Ishiguro K, Hattori N. Short-term treadmill exercise increased tau insolubility and neuroinflammation in tauopathy model mice. Neurosci Lett. 2016;610:207-12 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 3
Nishikawa T, Takahashi T, Nakamori M, Hosomi N, Maruyama H, Miyazaki Y, et al. The identification of raft-derived tau-associated vesicles that are incorporated into immature tangles and paired helical filaments. Neuropathol Appl Neurobiol. 2016;42:639-653 pubmed 出版商
  • 免疫组化; 仓鼠; 1:10,000; 图 2
Bullmann T, Seeger G, Stieler J, Hanics J, Reimann K, Kretzschmann T, et al. Tau phosphorylation-associated spine regression does not impair hippocampal-dependent memory in hibernating golden hamsters. Hippocampus. 2016;26:301-18 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200
Takeuchi R, Toyoshima Y, Tada M, Tanaka H, Shimizu H, Shiga A, et al. Globular Glial Mixed Four Repeat Tau and TDP-43 Proteinopathy with Motor Neuron Disease and Frontotemporal Dementia. Brain Pathol. 2016;26:82-94 pubmed 出版商
  • 免疫组化-石蜡切片; 猫; 1:100; 图 6
Chambers J, Tokuda T, Uchida K, Ishii R, Tatebe H, Takahashi E, et al. The domestic cat as a natural animal model of Alzheimer's disease. Acta Neuropathol Commun. 2015;3:78 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:50; 图 1
Pisa D, Alonso R, Rábano A, Rodal I, Carrasco L. Different Brain Regions are Infected with Fungi in Alzheimer's Disease. Sci Rep. 2015;5:15015 pubmed 出版商
  • 免疫组化; 人类; 1 ug/ml
  • 免疫印迹; 人类; 1:1000; 图 3
Wagner J, Krauss S, Shi S, Ryazanov S, Steffen J, Miklitz C, et al. Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies. Acta Neuropathol. 2015;130:619-31 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 1
Violet M, Chauderlier A, Delattre L, Tardivel M, Chouala M, Sultan A, et al. Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo. Neurobiol Dis. 2015;82:540-551 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:1000; 图 1
Brelstaff J, Ossola B, Neher J, Klingstedt T, Nilsson K, Goedert M, et al. The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice. Front Neurosci. 2015;9:184 pubmed 出版商
  • 酶联免疫吸附测定; 人类; 图 s1e
Song L, Lu S, Ouyang X, Melchor J, Lee J, Terracina G, et al. Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology. Mol Neurodegener. 2015;10:14 pubmed 出版商
  • 免疫组化; 小鼠; 1:100
Miller N, Feng Z, Edens B, Yang B, Shi H, Sze C, et al. Non-aggregating tau phosphorylation by cyclin-dependent kinase 5 contributes to motor neuron degeneration in spinal muscular atrophy. J Neurosci. 2015;35:6038-50 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:300; 图 6
Hansen H, Fabricius K, Barkholt P, Niehoff M, Morley J, Jelsing J, et al. The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2015;46:877-88 pubmed 出版商
  • 免疫印迹; 人类; 图 3, 4
Sepúlveda Díaz J, Alavi Naini S, Huynh M, Ouidja M, Yanicostas C, Chantepie S, et al. HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology. Brain. 2015;138:1339-54 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 1
Li R, Xu D, Ma T. Lovastatin suppresses the aberrant tau phosphorylation from FTDP-17 mutation and okadaic acid-induction in rat primary neurons. Neuroscience. 2015;294:14-20 pubmed 出版商
  • 免疫印迹; 小鼠
Mouton Liger F, Rebillat A, Gourmaud S, Paquet C, Leguen A, Dumurgier J, et al. PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model. Cell Death Dis. 2015;6:e1594 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000; 图 5
Falcon B, Cavallini A, Angers R, Glover S, Murray T, Barnham L, et al. Conformation determines the seeding potencies of native and recombinant Tau aggregates. J Biol Chem. 2015;290:1049-65 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Dunn H, Ager R, Baglietto Vargas D, Cheng D, Kitazawa M, Cribbs D, et al. Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model. J Alzheimers Dis. 2015;43:893-903 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 1
  • 免疫印迹; 小鼠; 图 1
Ittner A, Bertz J, Suh L, Stevens C, Götz J, Ittner L. Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice. J Neurochem. 2015;132:135-45 pubmed 出版商
  • 免疫印迹; 人类; 图 s2
Richter M, Mewes A, Fritsch M, Krügel U, Hoffmann R, Singer D. Doubly Phosphorylated Peptide Vaccines to Protect Transgenic P301S Mice against Alzheimer's Disease Like Tau Aggregation. Vaccines (Basel). 2014;2:601-23 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:100
  • 免疫印迹; 小鼠; 1:1000
Höllerhage M, Deck R, de Andrade A, Respondek G, Xu H, Rösler T, et al. Piericidin A aggravates Tau pathology in P301S transgenic mice. PLoS ONE. 2014;9:e113557 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:500; 图 2
  • 免疫印迹; 人类; 1:1000; 图 4
Ohia Nwoko O, Montazari S, Lau Y, Eriksen J. Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice. Mol Neurodegener. 2014;9:54 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2
Castro Alvarez J, Uribe Arias S, Kosik K, Cardona Gómez G. Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice. Front Aging Neurosci. 2014;6:243 pubmed 出版商
  • immunohistochemistry - free floating section; 大鼠; 1:70
Forny Germano L, Lyra e Silva N, Batista A, Brito Moreira J, Gralle M, Boehnke S, et al. Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates. J Neurosci. 2014;34:13629-43 pubmed 出版商
  • 免疫细胞化学; 人类; 1:250
Kohler C, Dinekov M, Götz J. Granulovacuolar degeneration and unfolded protein response in mouse models of tauopathy and A? amyloidosis. Neurobiol Dis. 2014;71:169-79 pubmed 出版商
  • 免疫印迹; 小鼠
Rao M, McBrayer M, Campbell J, Kumar A, Hashim A, Sershen H, et al. Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice. J Neurosci. 2014;34:9222-34 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Jiang T, Yu J, Zhu X, Zhang Q, Cao L, Wang H, et al. Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance. Neuropharmacology. 2014;85:121-30 pubmed 出版商
  • 免疫组化; 小鼠; 1:50
Inoue H, Hiradate Y, Shirakata Y, Kanai K, Kosaka K, Gotoh A, et al. Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis. FEBS Lett. 2014;588:2003-8 pubmed 出版商
  • 免疫组化; 小鼠; 1:1000
  • 免疫印迹; 小鼠; 1:1000
Castillo Carranza D, Sengupta U, Guerrero Muñoz M, Lasagna Reeves C, Gerson J, Singh G, et al. Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles. J Neurosci. 2014;34:4260-72 pubmed 出版商
  • immunohistochemistry - free floating section; 人类; 图 1
Stancu I, Ris L, Vasconcelos B, Marinangeli C, Goeminne L, Laporte V, et al. Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease. FASEB J. 2014;28:2620-31 pubmed 出版商
  • 免疫组化; 大鼠; 1:400
Dujardin S, Lécolle K, Caillierez R, Bégard S, Zommer N, Lachaud C, et al. Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies. Acta Neuropathol Commun. 2014;2:14 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Abbondante S, Baglietto Vargas D, Rodriguez Ortiz C, Estrada Hernandez T, Medeiros R, LaFerla F. Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes. Am J Pathol. 2014;184:819-26 pubmed 出版商
  • 免疫组化; 小鼠; 1:100
Yamada E, Respondek G, Müssner S, de Andrade A, Höllerhage M, Depienne C, et al. Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice. Exp Neurol. 2014;253:113-25 pubmed 出版商
  • 免疫组化; 小鼠; 1:200
Hoffmann N, Dorostkar M, Blumenstock S, Goedert M, Herms J. Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice. Acta Neuropathol Commun. 2013;1:82 pubmed 出版商
  • 免疫组化; 人类; 1:1000
Notter T, Knuesel I. Reelin immunoreactivity in neuritic varicosities in the human hippocampal formation of non-demented subjects and Alzheimer's disease patients. Acta Neuropathol Commun. 2013;1:27 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Baglietto Vargas D, Kitazawa M, Le E, Estrada Hernandez T, Rodriguez Ortiz C, Medeiros R, et al. Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition. Neurobiol Dis. 2014;62:407-15 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类
Ozcelik S, Fraser G, Castets P, Schaeffer V, Skachokova Z, Breu K, et al. Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice. PLoS ONE. 2013;8:e62459 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 4
Clippinger A, D Alton S, Lin W, Gendron T, Howard J, Borchelt D, et al. Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy. Acta Neuropathol. 2013;126:39-50 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
  • 免疫组化; 大鼠; 1:400
Caillierez R, Bégard S, Lécolle K, Deramecourt V, Zommer N, Dujardin S, et al. Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain. Mol Ther. 2013;21:1358-68 pubmed 出版商
  • 免疫印迹; 人类
Ozdemir A, Rom I, Kovalevich J, Yen W, Adiga R, Dave R, et al. PINCH in the cellular stress response to tau-hyperphosphorylation. PLoS ONE. 2013;8:e58232 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Alonso E, Vale C, Vieytes M, Botana L. Translocation of PKC by yessotoxin in an in vitro model of Alzheimer's disease with improvement of tau and ?-amyloid pathology. ACS Chem Neurosci. 2013;4:1062-70 pubmed 出版商
  • 免疫细胞化学; 果蝇; 图 s4
Wu T, Lu Y, Chuang C, Wu C, Chiang A, Krantz D, et al. Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau. Acta Neuropathol. 2013;125:711-25 pubmed 出版商
  • 免疫组化; 人类; 1:100
Klingstedt T, Blechschmidt C, Nogalska A, Prokop S, Häggqvist B, Danielsson O, et al. Luminescent conjugated oligothiophenes for sensitive fluorescent assignment of protein inclusion bodies. Chembiochem. 2013;14:607-16 pubmed 出版商
  • 免疫组化; 小鼠
Garringer H, Murrell J, Sammeta N, Gnezda A, Ghetti B, Vidal R. Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice. PLoS ONE. 2013;8:e56426 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000
Desrumaux C, Pisoni A, Meunier J, Deckert V, Athias A, Perrier V, et al. Increased amyloid-? peptide-induced memory deficits in phospholipid transfer protein (PLTP) gene knockout mice. Neuropsychopharmacology. 2013;38:817-25 pubmed 出版商
  • 免疫印迹; 大鼠; 1:3000
Zussy C, Brureau A, Keller E, Marchal S, Blayo C, Delair B, et al. Alzheimer's disease related markers, cellular toxicity and behavioral deficits induced six weeks after oligomeric amyloid-? peptide injection in rats. PLoS ONE. 2013;8:e53117 pubmed 出版商
  • 免疫组化; 人类; 1:200
Schön C, Hoffmann N, Ochs S, Burgold S, Filser S, Steinbach S, et al. Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice. PLoS ONE. 2012;7:e53547 pubmed 出版商
  • 免疫组化; 小鼠; 1:250; 图 5a
  • 免疫组化; 人类; 1:100
  • 免疫印迹; 人类; 1:1000
Kohler C, Dinekov M, Götz J. Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice. Neurobiol Aging. 2013;34:1369-79 pubmed 出版商
  • 免疫印迹; 小鼠
Leboucher A, Laurent C, Fernandez Gomez F, Burnouf S, Troquier L, Eddarkaoui S, et al. Detrimental effects of diet-induced obesity on ? pathology are independent of insulin resistance in ? transgenic mice. Diabetes. 2013;62:1681-8 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Rahman A, Khan K, Al Khaledi G, Khan I, Attur S. Early postnatal lead exposure induces tau phosphorylation in the brain of young rats. Acta Biol Hung. 2012;63:411-25 pubmed 出版商
  • 免疫组化; 小鼠; 1:1000
Burnouf S, Martire A, Derisbourg M, Laurent C, Belarbi K, Leboucher A, et al. NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model. Aging Cell. 2013;12:11-23 pubmed 出版商
  • 免疫组化-石蜡切片; leopard cat; 1:100; 图 6
Chambers J, Uchida K, Harada T, Tsuboi M, Sato M, Kubo M, et al. Neurofibrillary tangles and the deposition of a beta amyloid peptide with a novel N-terminal epitope in the brains of wild Tsushima leopard cats. PLoS ONE. 2012;7:e46452 pubmed 出版商
  • 免疫组化; 小鼠
Inoue K, Rispoli J, Kaphzan H, Klann E, Chen E, Kim J, et al. Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway. Mol Neurodegener. 2012;7:48 pubmed 出版商
  • 免疫组化; 人类; 1:100
Collins M, Riascos D, Kovalik T, An J, Krupa K, Krupa K, et al. The RNA-binding motif 45 (RBM45) protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients. Acta Neuropathol. 2012;124:717-32 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100
Mondragón Rodríguez S, Trillaud Doppia E, Dudilot A, Bourgeois C, Lauzon M, Leclerc N, et al. Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation. J Biol Chem. 2012;287:32040-53 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Bretteville A, Marcouiller F, Julien C, El Khoury N, Petry F, Poitras I, et al. Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors. Sci Rep. 2012;2:480 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Krstic D, Madhusudan A, Doehner J, Vogel P, Notter T, Imhof C, et al. Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice. J Neuroinflammation. 2012;9:151 pubmed 出版商
  • 免疫组化; 人类; 1:400
Deramecourt V, Lebert F, Maurage C, Fernandez Gomez F, Dujardin S, Colin M, et al. Clinical, neuropathological, and biochemical characterization of the novel tau mutation P332S. J Alzheimers Dis. 2012;31:741-9 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500
Cancino G, Miller F, Kaplan D. p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease. Neurobiol Aging. 2013;34:387-99 pubmed 出版商
  • 免疫印迹; 小鼠
Fine J, Baillargeon A, Renner D, Hoerster N, Tokarev J, Colton S, et al. Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1?, and phosphorylates GSK3? in P301L tau transgenic mice. Exp Brain Res. 2012;219:381-90 pubmed 出版商
  • 免疫组化; 小鼠
Vidal R, Sammeta N, Garringer H, Sambamurti K, Miravalle L, Lamb B, et al. The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice. FASEB J. 2012;26:2899-910 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Rahman A, Khan K, Al Khaledi G, Khan I, Al Shemary T. Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats. Neurotoxicology. 2012;33:370-83 pubmed 出版商
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产品信息
产品类型 :
抗体
产品名称 :
Phospho-Tau (Thr212, Ser214) Monoclonal Antibody (AT100)
目录# :
MN1060
规格 :
100µg
价格 :
美国558.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类
应用 :
ELISA: Assay Dependent, Immunohistochemistry: Assay Dependent, Western Blot: Assay Dependent
物种 :
人类
克隆 :
AT100
抗体亚型 :
IgG1, kappa
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclindependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
免疫原 :
Purified human Tau
格式 :
Liquid
应用w/稀释 :
ELISA: Assay Dependent, Immunohistochemistry: Assay Dependent, Western Blot: Assay Dependent
别名 :
G protein beta1/gamma2 subunit-interacting factor 1; PHF-tau; neurofibrillary tangle protein; paired helical filament-tau
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
www.thermo.com.cn
1084193588
公司总部: 美国