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抗体

IL-1乙单克隆抗体(DF8)

MP425

500µg

美国345

单克隆

小鼠

未共轭

DF8

IL-1乙单克隆抗体(DF8)

MP425

500µg

美国345

单克隆

蛋白质G

小鼠

猪

Western Blot: Assay Dependent

猪

DF8

IgG1, kappa

-20°C

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.

重组猪IL-1乙

液体

Western Blot: Assay Dependent

BOS_11619; Catabolin; il 1b; IL 1ß; IL-1; IL1 B; IL-1 beta; Il1b; Il-1b; IL1beta; IL-1beta; IL1-BETA; IL1F2; IL1ß; ILN; Interleukin; interleukin 1 beta; interleukin 1, beta; Interleukin1 beta; Interleukin-1 beta; interleukin-1 beta proprotein; interleukin-1 beta-like; Interleukin-1b; interleukin-beta; LOC100052414; Lymphocyte proliferation-potentiating factor; preinterleukin 1 beta; prointerleukin-1 beta; pro-interleukin-1-beta