产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
TIMP1单克隆抗体(102D1)
目录 :
MS608PABX
规格 :
200µg
价格 :
美国558
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
102D1
反应物种 :
人类, 小鼠, 大鼠, ,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 44
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 人类
El Rebey H, Aiad H, Abulkheir I, Asaad N, El Wahed M, Abulkasem F, et al. The Predictive and Prognostic Role of Topoisomerase IIα and Tissue Inhibitor of Metalloproteinases 1 Expression in Locally Advanced Breast Carcinoma of Egyptian Patients Treated With Anthracycline-based Neoadjuvant Chemotherapy. Appl Immunohistochem Mol Morphol. 2016;24:167-78 pubmed 出版商
  • 免疫组化; 人类; 1:25
Kim G, Lee J, Choi Y, Lee K, Lee J, Nam J, et al. Expression of matrix metalloproteinases and their inhibitors in different immunohistochemical-based molecular subtypes of breast cancer. BMC Cancer. 2014;14:959 pubmed 出版商
  • 免疫印迹; 人类
Verdelli D, Nobili L, Todoerti K, Mosca L, Fabris S, D Anca M, et al. Molecular events underlying interleukin-6 independence in a subclone of the CMA-03 multiple myeloma cell line. Genes Chromosomes Cancer. 2014;53:154-67 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:600
Roggério A, Sambiase N, Palomino S, de Castro M, da Silva E, Stolf N, et al. Correlation of bacterial coinfection versus matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 expression in aortic aneurysm and atherosclerosis. Ann Vasc Surg. 2013;27:964-71 pubmed 出版商
  • 免疫组化; 人类; 1:50
Suárez Roa M, Asbun Bojalil J, Ruiz Godoy L, Meneses García A. Immunoexpression of matrix metalloproteinases and their inhibitors in different areas of oral squamous cell carcinoma. Aust Dent J. 2012;57:300-7 pubmed 出版商
  • 免疫印迹; 犬
Jung Y, Liu X, Chirco R, Warner R, Fridman R, Kim H. TIMP-1 induces an EMT-like phenotypic conversion in MDCK cells independent of its MMP-inhibitory domain. PLoS ONE. 2012;7:e38773 pubmed 出版商
  • 免疫组化; 人类; 1:100
Fernández Guinea O, Alvarez Cofiño A, Eiró N, Gonzalez L, del Casar J, Fernandez Garcia B, et al. Low microvascular density at the tumor center is related to the expression of metalloproteases and their inhibitors and with the occurrence of distant metastasis in breast carcinomas. Int J Clin Oncol. 2013;18:629-40 pubmed 出版商
  • 免疫组化; 人类; 1:100
Gonzalez L, Eiró N, Gonzalez L, Andicoechea A, Barbón E, García Muñiz J, et al. Effect of the expression of matrix metalloproteases and their tissue inhibitors on survival of patients with resectable colorectal cancer. Dig Dis Sci. 2012;57:2063-71 pubmed 出版商
  • 免疫组化; 人类; 8 ug/ml
Brun J, Cortez A, Lesieur B, Uzan S, Rouzier R, Darai E. Expression of MMP-2, -7, -9, MT1-MMP and TIMP-1 and -2 has no prognostic relevance in patients with advanced epithelial ovarian cancer. Oncol Rep. 2012;27:1049-57 pubmed 出版商
  • 免疫细胞化学; 鸡; 1:100
  • 免疫印迹; 鸡; 1:1000
Akkoc A, Kahraman M. Matrix metalloproteinase expression in primary lung fibroblasts of layer type chickens. Biotech Histochem. 2012;87:201-7 pubmed 出版商
  • 免疫组化; 人类
Dimo B, Ioannidis I, Karameris A, Vilaras G, Tzoumakari P, Nonni A, et al. Comparative study of the immunohistochemical expression of tissue inhibitors of metalloproteinases 1 and 2 between clearly invasive carcinomas and "in situ" trophoblast invasion. Med Oncol. 2012;29:2270-5 pubmed 出版商
  • 免疫印迹; 人类; 1:200
Liu L, Sun L, Zhao P, Yao L, Jin H, Liang S, et al. Hypoxia promotes metastasis in human gastric cancer by up-regulating the 67-kDa laminin receptor. Cancer Sci. 2010;101:1653-60 pubmed 出版商
  • 免疫组化; 人类; 1:100
Gonzalez L, Junquera S, del Casar J, Gonzalez L, Marín L, Gonzalez Reyes S, et al. Immunohistochemical study of matrix metalloproteinases and their inhibitors in pure and mixed invasive and in situ ductal carcinomas of the breast. Hum Pathol. 2010;41:980-9 pubmed 出版商
  • 免疫组化; 人类; 1:100
Escaff S, Fernandez J, Gonzalez L, Suarez A, Gonzalez Reyes S, Gonzalez J, et al. Study of matrix metalloproteinases and their inhibitors in prostate cancer. Br J Cancer. 2010;102:922-9 pubmed 出版商
  • 免疫组化; 人类; 1:100
Gonzalez L, Gonzalez Reyes S, Junquera S, Marin L, Gonzalez L, del Casar J, et al. Expression of metalloproteases and their inhibitors by tumor and stromal cells in ductal carcinoma in situ of the breast and their relationship with microinvasive events. J Cancer Res Clin Oncol. 2010;136:1313-21 pubmed 出版商
  • 免疫组化; 人类; 1:100
del Casar J, Carreño G, Gonzalez L, Junquera S, Gonzalez Reyes S, Gonzalez J, et al. Expression of metalloproteases and their inhibitors in primary tumors and in local recurrences after mastectomy for breast cancer. J Cancer Res Clin Oncol. 2010;136:1049-58 pubmed 出版商
  • 免疫组化; 人类; 1:100
del Casar J, Gonzalez Reyes S, Gonzalez L, Gonzalez J, Junquera S, Bongera M, et al. Expression of metalloproteases and their inhibitors in different histological types of breast cancer. J Cancer Res Clin Oncol. 2010;136:811-9 pubmed 出版商
  • 免疫组化; 人类; 1:50
Almeida Issa M, Pineiro Maceira J, Farias R, Pureza M, Raggio Luiz R, Manela Azulay M. Immunohistochemical expression of matrix metalloproteinases in photodamaged skin by photodynamic therapy. Br J Dermatol. 2009;161:647-53 pubmed 出版商
  • 免疫组化; 人类; 1:100
Altadill A, Rodriguez M, Gonzalez L, Junquera S, Corte M, González Diéguez M, et al. Liver expression of matrix metalloproteases and their inhibitors in hepatocellular carcinoma. Dig Liver Dis. 2009;41:740-8 pubmed 出版商
  • 免疫组化; 人类; 1:100
del Casar J, Gonzalez L, Alvarez E, Junquera S, Marin L, Gonzalez L, et al. Comparative analysis and clinical value of the expression of metalloproteases and their inhibitors by intratumor stromal fibroblasts and those at the invasive front of breast carcinomas. Breast Cancer Res Treat. 2009;116:39-52 pubmed 出版商
  • 免疫组化; 人类; 8.0 ug/ml
Brun J, Galant C, Delvaux D, Lemoine P, Henriet P, Courtoy P, et al. Menstrual activity of matrix metalloproteinases is decreased in endometrium regenerating after thermal ablation. Hum Reprod. 2009;24:333-40 pubmed 出版商
  • 免疫组化; 人类
Brun J, Cortez A, Commo F, Uzan S, Rouzier R, Darai E. Serous and mucinous ovarian tumors express different profiles of MMP-2, -7, -9, MT1-MMP, and TIMP-1 and -2. Int J Oncol. 2008;33:1239-46 pubmed
  • 免疫组化; 小鼠
Faca V, Song K, Wang H, Zhang Q, Krasnoselsky A, Newcomb L, et al. A mouse to human search for plasma proteome changes associated with pancreatic tumor development. PLoS Med. 2008;5:e123 pubmed 出版商
  • 免疫组化; 人类; 1:100
Gonzalez L, Corte M, Vazquez J, Junquera S, Sanchez R, Alvarez A, et al. Androgen receptor expresion in breast cancer: relationship with clinicopathological characteristics of the tumors, prognosis, and expression of metalloproteases and their inhibitors. BMC Cancer. 2008;8:149 pubmed 出版商
  • 免疫组化; 人类
Unsal D, Akyurek N, Uner A, Erpolat O, Han U, Akmansu M, et al. Gelatinase B expression as a prognostic factor in patients with stage II/III rectal carcinoma treated by postoperative adjuvant therapy. Am J Clin Oncol. 2008;31:55-63 pubmed 出版商
  • 免疫印迹; 人类; 2 ug/ml
Denny P, Hagen F, Hardt M, Liao L, Yan W, Arellanno M, et al. The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions. J Proteome Res. 2008;7:1994-2006 pubmed 出版商
  • 免疫组化; 人类; 1:100
Gonzalez L, Pidal I, Junquera S, Corte M, Vazquez J, Rodriguez J, et al. Overexpression of matrix metalloproteinases and their inhibitors in mononuclear inflammatory cells in breast cancer correlates with metastasis-relapse. Br J Cancer. 2007;97:957-63 pubmed
  • 免疫组化; 人类
Zhu X, Price N, Gilman R, Recarvarren S, Friedland J. Multinucleate giant cells release functionally unopposed matrix metalloproteinase-9 in vitro and in vivo. J Infect Dis. 2007;196:1076-9 pubmed
  • 免疫组化; 人类; 1:100
Vizoso F, Gonzalez L, Corte M, Rodriguez J, Vazquez J, Lamelas M, et al. Study of matrix metalloproteinases and their inhibitors in breast cancer. Br J Cancer. 2007;96:903-11 pubmed
  • 免疫组化; 人类; 1:10
Seo Y, Park J, Kim J, Kim J, Yeon J, Kim J, et al. Usefulness of MMP-9/TIMP-1 in predicting tumor recurrence in patients undergoing curative surgical resection for gastric carcinoma. Dig Dis Sci. 2007;52:753-9 pubmed
  • 免疫组化; 人类
Unsal Kilic D, Uner A, Akyurek N, Erpolat P, Dursun A, Pak Y. Matrix metalloproteinase-9 expression correlated with tumor response in patients with locally advanced rectal cancer undergoing preoperative chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2007;67:196-203 pubmed
  • 免疫组化; 人类; 1:100
Rönkkö S, Rekonen P, Kaarniranta K, Puustjarvi T, Teräsvirta M, Uusitalo H. Matrix metalloproteinases and their inhibitors in the chamber angle of normal eyes and patients with primary open-angle glaucoma and exfoliation glaucoma. Graefes Arch Clin Exp Ophthalmol. 2007;245:697-704 pubmed
  • 免疫组化; 大鼠
  • 免疫印迹; 大鼠; 1:2000
Gantus M, Nasciutti L, Cruz C, Persechini P, Martinez A. Modulation of extracellular matrix components by metalloproteinases and their tissue inhibitors during degeneration and regeneration of rat sural nerve. Brain Res. 2006;1122:36-46 pubmed
  • 免疫组化; 人类
Qian J, Niu J, Li M, Chiao P, Tsao M. In vitro modeling of human pancreatic duct epithelial cell transformation defines gene expression changes induced by K-ras oncogenic activation in pancreatic carcinogenesis. Cancer Res. 2005;65:5045-53 pubmed
  • 免疫印迹; 人类
Liu X, Taube M, Jung K, Dong Z, Lee Y, Roshy S, et al. Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells from extrinsic cell death: a potential oncogenic activity of tissue inhibitor of metalloproteinase-1. Cancer Res. 2005;65:898-906 pubmed
Chuang S, Yang S, Chen T, Pang J. Cilostazol inhibits matrix invasion and modulates the gene expressions of MMP-9 and TIMP-1 in PMA-differentiated THP-1 cells. Eur J Pharmacol. 2011;670:419-26 pubmed 出版商
Haviernik P, Lahoda C, Bradley H, Hawley T, Ramezani A, Hawley R, et al. Tissue inhibitor of matrix metalloproteinase-1 overexpression in M1 myeloblasts impairs IL-6-induced differentiation. Oncogene. 2004;23:9212-9 pubmed
Aljada I, Ramnath N, Donohue K, Harvey S, Brooks J, Wiseman S, et al. Upregulation of the tissue inhibitor of metalloproteinase-1 protein is associated with progression of human non-small-cell lung cancer. J Clin Oncol. 2004;22:3218-29 pubmed
Price N, Gilman R, Uddin J, Recavarren S, Friedland J. Unopposed matrix metalloproteinase-9 expression in human tuberculous granuloma and the role of TNF-alpha-dependent monocyte networks. J Immunol. 2003;171:5579-86 pubmed
Liu X, Bernardo M, Fridman R, Kim H. Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells against intrinsic apoptotic cell death via the focal adhesion kinase/phosphatidylinositol 3-kinase and MAPK signaling pathway. J Biol Chem. 2003;278:40364-72 pubmed
Jo H, Park J, Kim E, Jung M, Lee S, Seong S, et al. The in vitro effects of dehydroepiandrosterone on human osteoarthritic chondrocytes. Osteoarthritis Cartilage. 2003;11:585-94 pubmed
Zhang S, Li L, Lin J, Lin H. Imbalance between expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in invasiveness and metastasis of human gastric carcinoma. World J Gastroenterol. 2003;9:899-904 pubmed
Gavin P, Crawford S, Shulman S, Garcia F, Rowley A. Systemic arterial expression of matrix metalloproteinases 2 and 9 in acute Kawasaki disease. Arterioscler Thromb Vasc Biol. 2003;23:576-81 pubmed
Hashimoto T, Wen G, Lawton M, Boudreau N, Bollen A, Yang G, et al. Abnormal expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in brain arteriovenous malformations. Stroke. 2003;34:925-31 pubmed
产品信息
产品类型 :
抗体
产品名称 :
TIMP1单克隆抗体(102D1)
目录# :
MS608PABX
规格 :
200µg
价格 :
美国558
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类
应用 :
Immunocytochemistry: 1:250, Immunofluorescence: 1:250, Immunohistochemistry (Paraffin): 1:100, Western Blot: 1:500
物种 :
人类
克隆 :
102D1
抗体亚型 :
IgG1
储存 :
-20°C
描述 :
TIMP1 (metalloproteinase inhibitor 1) is a metalloproteinase inhibitor that functions by forms one-to-one complexes with target metallproteinases, such as collagenases, and irreversible inactivates them by binding to their catalytic zinc cofactor. TIMP1 acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP14, and MMP16. It also functions as a growth factor that regulates cell differenation, migration, and cell death. TIMP1 activates cellular signaling cascades via CD63 and ITGB1.
免疫原 :
重组人类金属蛋白酶组织抑制剂-1
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:250, Immunofluorescence: 1:250, Immunohistochemistry (Paraffin): 1:100, Western Blot: 1:500
别名 :
BOS_25915; CLGI; Collagenase inhibitor; Collagenase inhibitor 16C8 fibroblast; EG-1; Embryogenin-1; EPA; EPO; erythroid potentiating activity; Erythroid-potentiating activity; Fibroblast collagenase inhibitor; FLJ90373; HCI; LOC100009047; Metalloproteinase inhibitor; Metalloproteinase inhibitor 1; metalloproteinase tissue inhibitor; metalloproteinase tissue inhibitor 1; MMP inhibitor; RP1-230G1.3; Timp; TIMP 1; TIMP metallopeptidase inhibitor 1; TIMP1; Timp-1; tissue inhibitor of matrix metalloproteinase-1; tissue inhibitor of metallopeptidase 1; tissue inhibitor of metalloproteinase 1; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor); tissue inhibitor of metalloproteinase-1; Tissue inhibitor of metalloproteinases 1; TPA-induced protein; TPA-S1
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国