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抗体

ATG3多克隆抗体

OSA00005W

150微升

375美元

多克隆

家羊

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化

ATG3多克隆抗体

OSA00005W

150微升

375美元

多克隆

羊

人类, 小鼠, 大鼠

Immunohistochemistry: 1:200-1:2000, Western Blot: 1:200-1:2000

人类, 小鼠, 大鼠

IgG

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

ATG3 (APG3) is a widely expressed conjugating enzyme for APG8 lipidation, an essential step for the initiation of autophagy. Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. Autophagy is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG3 functions as an E2-like enzyme during the initial stages of autophagosome formation by catalyzing the formation of the Atg8-phosphatidylethanolamine (Atg8-PE) conjugate, which is critical for autophagy.

A synthetic peptide from human autophagy-related protein 3

冻干

Immunohistochemistry: 1:200-1:2000, Western Blot: 1:200-1:2000

2610016C12Rik; APG3; Apg3l; APG3-LIKE; Apg3p; ATG3; ATG3 autophagy related 3 homolog; atg3.S; Atg3l; autophagy related 3; autophagy related 3 S homeolog; autophagy-related 3; autophagy-related protein 3; DKFZp564M1178; FLJ22125; hApg3; MGC15201; PC3-96; Pig1; PIG-1; Preconditioning-inducible gene 1 protein; Protein PC3-96; Ubiquitin-like-conjugating enzyme ATG3; XELAEV_18014721mg