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抗体

RALA多克隆抗体

OSR00268W

100微升

美国446

多克隆

domestic rabbit

未共轭

RALA多克隆抗体

OSR00268W

100微升

美国446

多克隆

兔

人类, 小鼠, 大鼠

Immunocytochemistry: 1:200, Immunofluorescence: 1:200, Immunohistochemistry (Paraffin): 1:2,000, Western Blot: 1:300 - 1:2000

人类, 小鼠, 大鼠

IgG

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.

A synthetic peptide from human RalA conjugated to blue carrier protein was used as the antigen.

冻干

Immunocytochemistry: 1:200, Immunofluorescence: 1:200, Immunohistochemistry (Paraffin): 1:2,000, Western Blot: 1:300 - 1:2000

3010001O15Rik; AW322615; MGC48949; Ral; -ral simian leukemia viral oncogene homolog A (ras related); Rala; Ral-a; ral-A protein; RALA Ras like proto-oncogene A; Ras family small GTP binding protein RALA; ras related GTP binding protein A; Rasl1; RAS-like protein A; RAS-like, family 1; ras-related protein Ral-A; v-ral simian leukemia viral oncogene homolog A (ras related)