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抗体

Phospho-Synaptotagmin 1 (Thr202) Polyclonal Antibody

P21956

100微升

美国400

多克隆

domestic rabbit

未共轭

磷酸化

免疫印迹, 免疫组化

Phospho-Synaptotagmin 1 (Thr202) Polyclonal Antibody

P21956

100微升

美国400

多克隆

纯化

兔

大鼠

Immunohistochemistry: Assay Dependent, Western Blot: Assay Dependent

大鼠

IgG

Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein that is widely expressed throughout the CNS and is generally thought to act as the Ca2+ sensor in the regulation of exocytosis and neurotransmitter release. Studies indicate that synaptotagmin’s Ca2+ mediated binding of SNAP25 is essential for the Ca2+ dependent triggering of membrane. It has been demonstrated that discrete residues within the c(2)b binding domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size. Synaptotagmin 1 may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Further, Synaptotagmin 1 binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has been reported. Synaptotagmin 1 can also bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Diseases associated with the dysfunction of Synaptotagmin 1 include food-borne botulism and infant botulism.

Phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr202 of synaptotagmin.

液体

Immunohistochemistry: Assay Dependent, Western Blot: Assay Dependent

AW124717; DKFZp781D2042; FLJ42519; G630098F17Rik; P65; SV DKFZp781D2042; SV SYT; svp65; Syb1; synaptotagmin 1; synaptotagmin 1 L homeolog; synaptotagmin 2; synaptotagmin I; synaptotagmin I protein; synaptotagmin I variant b; Synaptotagmin II; Synaptotagmin XI; synaptotagmin-1; Synaptotagmin-2; SYT; syt1; syt1.L; SYT2; sytI; SytII; XELAEV_18022019mg