产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
iNOS多克隆抗体
目录 :
PA1-036
规格 :
200微升
价格 :
美国450
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 45
出版应用/物种/样本/稀释参考文献
  • 免疫组化-冰冻切片; 大鼠; 1:50; 图 6e
Hannawi Y, Ewees M, Moore J, Zweier J. Characterizing CD38 Expression and Enzymatic Activity in the Brain of Spontaneously Hypertensive Stroke-Prone Rats. Front Pharmacol. 2022;13:881708 pubmed 出版商
  • 免疫组化; 小鼠; 1:400; 图 1h
He L, Bhat K, Duhacheck Muggy S, Ioannidis A, Zhang L, Nguyen N, et al. Tumor necrosis factor receptor signaling modulates carcinogenesis in a mouse model of breast cancer. Neoplasia. 2021;23:197-209 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠; 1:200; 图 2d
Amer M, Mohamed N, Shaalan A. Gestational protein restriction: study of the probable effects on cardiac muscle structure and function in adult rats. Histol Histopathol. 2017;32:1293-1303 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:200; 图 5a
Menzel L, Kleber L, Friedrich C, Hummel R, Dangel L, Winter J, et al. Progranulin protects against exaggerated axonal injury and astrogliosis following traumatic brain injury. Glia. 2017;65:278-292 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠; 图 3
Takır S, Gürel Gürevin E, Toprak A, Demirci Tansel C, UydeÅŸ DoÄŸan B. The elevation of intraocular pressure is associated with apoptosis and increased immunoreactivity for nitric oxide synthase in rat retina whereas the effectiveness of retina derived relaxing factor is unaffected. Exp Eye Res. 2016;145:401-411 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1 ug/ml; 图 s1
Soendergaard C, Kvist P, Seidelin J, Pelzer H, Nielsen O. Systemic and intestinal levels of factor XIII-A: the impact of inflammation on expression in macrophage subtypes. J Gastroenterol. 2016;51:796-807 pubmed 出版商
AlQot H, Rylett R. A novel transgenic mouse model expressing primate-specific nuclear choline acetyltransferase: insights into potential cholinergic vulnerability. Sci Rep. 2023;13:3037 pubmed 出版商
Wang L, Wang D, Sonzogni O, Ke S, Wang Q, Thavamani A, et al. PARP-inhibition reprograms macrophages toward an anti-tumor phenotype. Cell Rep. 2022;41:111462 pubmed 出版商
He Y, Yao M, Zhou J, Xie J, Liang C, Yin D, et al. Mg(OH)2 nanosheets on Ti with immunomodulatory function for orthopedic applications. Regen Biomater. 2022;9:rbac027 pubmed 出版商
Chen X, Li C, Cao X, Jia X, Chen X, Wang Z, et al. Mitochondria-targeted supramolecular coordination container encapsulated with exogenous itaconate for synergistic therapy of joint inflammation. Theranostics. 2022;12:3251-3272 pubmed 出版商
Xue M, Sheng W, Song X, Shi Y, Geng Z, Shen L, et al. Atractylenolide III ameliorates spinal cord injury in rats by modulating microglial/macrophage polarization. CNS Neurosci Ther. 2022;28:1059-1071 pubmed 出版商
Ding X, Zhou J, Zhao L, Chen M, Wang S, Zhang M, et al. Intestinal Flora Composition Determines Microglia Activation and Improves Epileptic Episode Progress. Front Cell Infect Microbiol. 2022;12:835217 pubmed 出版商
Huang X, Yang Q, Xie L, Lei S. Histone methyltransferase enhancer of zeste 2 polycomb repressive complex 2 subunit exacerbates inflammation in depression rats by modulating microglia polarization. Bioengineered. 2022;13:5509-5524 pubmed 出版商
Park G, Tarafder S, Eyen S, Park S, Kim R, Siddiqui Z, et al. Oxo-M and 4-PPBP Delivery via Multi-Domain Peptide Hydrogel Toward Tendon Regeneration. Front Bioeng Biotechnol. 2022;10:773004 pubmed 出版商
Zhang P, Ohkawa Y, Yamamoto S, Momota H, Kato A, Kaneko K, et al. St8sia1-deficiency in mice alters tumor environments of gliomas, leading to reduced disease severity. Nagoya J Med Sci. 2021;83:535-549 pubmed 出版商
Davis T, Conradie D, Shridas P, de Beer F, Engelbrecht A, de Villiers W. Serum Amyloid A Promotes Inflammation-Associated Damage and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer. Cell Mol Gastroenterol Hepatol. 2021;12:1329-1341 pubmed 出版商
Li M, McGhee E, Shinno L, Lee K, Lin Y. Exposure to Microbial Metabolite Butyrate Prolongs the Survival Time and Changes the Growth Pattern of Human Papillomavirus 16 E6/E7-Immortalized Keratinocytes in Vivo. Am J Pathol. 2021;191:1822-1836 pubmed 出版商
Tran V, Kang Y, Kim H, Kim H, Cho H. Oral Pathogenic Bacteria-Inducing Neurodegenerative Microgliosis in Human Neural Cell Platform. Int J Mol Sci. 2021;22: pubmed 出版商
Eitner A, M xfc ller S, K xf6 nig C, Wilharm A, Raab R, Hofmann G, et al. Inhibition of Inducible Nitric Oxide Synthase Prevents IL-1β-Induced Mitochondrial Dysfunction in Human Chondrocytes. Int J Mol Sci. 2021;22: pubmed 出版商
Varinthra P, Ganesan K, Huang S, Chompoopong S, Eurtivong C, Suresh P, et al. The 4-(Phenylsulfanyl) butan-2-one Improves Impaired Fear Memory Retrieval and Reduces Excessive Inflammatory Response in Triple Transgenic Alzheimer's Disease Mice. Front Aging Neurosci. 2021;13:615079 pubmed 出版商
Nabil M, El Raey M, Abdo W, Abdelfattah M, El Shazly A, Sobeh M, et al. Gastro-Protective Effects of Albizia anthelmintica Leaf Extract on Indomethacin-Induced Gastric Ulcer in Wistar Rats: In Silico and In Vivo Studies. Antioxidants (Basel). 2021;10: pubmed 出版商
Cheng S, Zhang D, Li M, Liu X, Zhang Y, Qian S, et al. Osteogenesis, angiogenesis and immune response of Mg-Al layered double hydroxide coating on pure Mg. Bioact Mater. 2021;6:91-105 pubmed 出版商
Na L, Wang S, Liu T, Zhang L. Ultrashort Wave Combined with Human Umbilical Cord Mesenchymal Stem Cell (HUC-MSC) Transplantation Inhibits NLRP3 Inflammasome and Improves Spinal Cord Injury via MK2/TTP Signalling Pathway. Biomed Res Int. 2020;2020:3021750 pubmed 出版商
Battaglia C, Cursano S, Calzia E, Catanese A, Boeckers T. Corticotropin-releasing hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons. Cell Death Dis. 2020;11:1004 pubmed 出版商
Delage C, Cornil C. Estrogen-dependent sex difference in microglia in the developing brain of Japanese quail (Coturnix japonica). Dev Neurobiol. 2020;80:239-262 pubmed 出版商
Yang P, Wang X, Wang D, Shi Y, Zhang M, Yu T, et al. Topical insulin application accelerates diabetic wound healing by promoting anti-inflammatory macrophage polarization. J Cell Sci. 2020;133: pubmed 出版商
Lee J, Jeon Y, Kang J, Lee S, Lee H, Son C. Aquilariae Lignum Methylene Chloride Fraction Attenuates IL-1β-Driven Neuroinflammation in BV2 Microglial Cells. Int J Mol Sci. 2020;21: pubmed 出版商
Mariod A, Salama S. The Efficacy of Processing Strategies on the Gastroprotective Potentiality of Chenopodium quinoa Seeds. ScientificWorldJournal. 2020;2020:6326452 pubmed 出版商
Wang T, Jia Q, Chen T, Yin H, Tian X, Lin X, et al. Alleviation of Synovial Inflammation of Juanbi-Tang on Collagen-Induced Arthritis and TNF-Tg Mice Model. Front Pharmacol. 2020;11:45 pubmed 出版商
Zheng X, Fernando V, Sharma V, Walia Y, Letson J, Furuta S. Correction of arginine metabolism with sepiapterin-the precursor of nitric oxide synthase cofactor BH4-induces immunostimulatory-shift of breast cancer. Biochem Pharmacol. 2020;176:113887 pubmed 出版商
Zhang X, Li J, Luo S, Wang M, Huang Q, Deng Z, et al. IgE Contributes to Atherosclerosis and Obesity by Affecting Macrophage Polarization, Macrophage Protein Network, and Foam Cell Formation. Arterioscler Thromb Vasc Biol. 2020;40:597-610 pubmed 出版商
Jiménez Altayó F, Ortiz Romero P, Puertas Umbert L, Dantas A, Perez B, Vila E, et al. Stenosis coexists with compromised α1-adrenergic contractions in the ascending aorta of a mouse model of Williams-Beuren syndrome. Sci Rep. 2020;10:889 pubmed 出版商
Di Gioia M, Spreafico R, Springstead J, Mendelson M, Joehanes R, Levy D, et al. Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation. Nat Immunol. 2020;21:42-53 pubmed 出版商
Lima Cabello E, Alché J, Morales Santana S, Clemente A, Jimenez Lopez J. Narrow-Leafed Lupin (Lupinus angustifolius L.) Seeds Gamma-Conglutin is an Anti-Inflammatory Protein Promoting Insulin Resistance Improvement and Oxidative Stress Amelioration in PANC-1 Pancreatic Cell-Line. Antioxidants (Basel). 2019;9: pubmed 出版商
Wang C, Zhang L, Ndong J, Hettinghouse A, Sun G, Chen C, et al. Progranulin deficiency exacerbates spinal cord injury by promoting neuroinflammation and cell apoptosis in mice. J Neuroinflammation. 2019;16:238 pubmed 出版商
Giménez Gómez P, Pérez Hernández M, O Shea E, Caso J, Martín Hernández D, Cervera L, et al. Changes in brain kynurenine levels via gut microbiota and gut-barrier disruption induced by chronic ethanol exposure in mice. FASEB J. 2019;33:12900-12914 pubmed 出版商
Wang H, Fu L, Cheng C, Gao R, Lin M, Su H, et al. Inhibition of LPS-Induced Oxidative Damages and Potential Anti-Inflammatory Effects of Phyllanthus emblica Extract via Down-Regulating NF-κB, COX-2, and iNOS in RAW 264.7 Cells. Antioxidants (Basel). 2019;8: pubmed 出版商
Grancieri M, Martino H, Gonzalez de Mejia E. Chia (Salvia hispanica L.) Seed Total Protein and Protein Fractions Digests Reduce Biomarkers of Inflammation and Atherosclerosis in Macrophages In Vitro. Mol Nutr Food Res. 2019;63:e1900021 pubmed 出版商
Song J, Kang H, Ju H, Park A, Park H, Hong J, et al. Umbilical cord-derived mesenchymal stem cell extracts ameliorate atopic dermatitis in mice by reducing the T cell responses. Sci Rep. 2019;9:6623 pubmed 出版商
Cheng Z, Yang Y, Duan F, Lou B, Zeng J, Huang Y, et al. Inhibition of Notch1 Signaling Alleviates Endotoxin-Induced Inflammation Through Modulating Retinal Microglia Polarization. Front Immunol. 2019;10:389 pubmed 出版商
Lau W, Khazaeli M, Savoj J, Manekia K, Bangash M, Thakurta R, et al. Dietary tetrahydrocurcumin reduces renal fibrosis and cardiac hypertrophy in 5/6 nephrectomized rats. Pharmacol Res Perspect. 2018;6:e00385 pubmed 出版商
Bwalya E, Kim S, Fang J, Wijekoon H, Hosoya K, Okumura M. Pentosan polysulfate inhibits IL-1?-induced iNOS, c-Jun and HIF-1? upregulation in canine articular chondrocytes. PLoS ONE. 2017;12:e0177144 pubmed 出版商
Asano S, Arvapalli R, Manne N, Maheshwari M, Ma B, Rice K, et al. Cerium oxide nanoparticle treatment ameliorates peritonitis-induced diaphragm dysfunction. Int J Nanomedicine. 2015;10:6215-25 pubmed 出版商
Manrique W, Claudiano G, de Castro M, Petrillo T, Pereira Figueiredo M, Belo M, et al. Expression of cellular components in granulomatous inflammatory response in Piaractus mesopotamicus model. PLoS ONE. 2015;10:e0121625 pubmed 出版商
Lau W, Liu S, Pahlevan S, Yuan J, Khazaeli M, Ni Z, et al. Role of Nrf2 dysfunction in uremia-associated intestinal inflammation and epithelial barrier disruption. Dig Dis Sci. 2015;60:1215-22 pubmed 出版商
图像
图像 1 :
赛默飞世尔 PA1-036 图像 1
Immunofluorescent analysis of iNOS in NIH-3T3 Cells. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with a iNOS polyclonal antibody (Product # PA1-036) at a dilution of 1:20 overnight at 4 C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody (Product # 35503). iNOS staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Images were taken at 60X magnification.
产品信息
产品类型 :
抗体
产品名称 :
iNOS多克隆抗体
目录# :
PA1-036
规格 :
200微升
价格 :
美国450
克隆性 :
多克隆
纯度 :
硫酸铵沉淀
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
应用 :
Immunocytochemistry: 1:50, Immunofluorescence: 1:50, Immunohistochemistry: 1:20, Western Blot: 1:200-1:1,000
物种 :
人类, 小鼠, 大鼠
抗体亚型 :
IgG
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
iNOS (Inducible Nitric oxide, NO, NOS) is an inorganic, gaseous free radical that carries a variety of messages between cells. Vasorelaxation, neurotransmission and cytotoxicity can all be potentiated through cellular response to NO. NO production is mediated by members of the nitric oxide synthase (NOS) family. iNOS is expressed in liver and inducible by a combination of lipopolysaccharide and certain cytokines. NOS catalyzes the oxidization of L-arginine to produce L-citrulline and NO. Two constitutive isoforms, brain or neuronal NOS (b or nNOS, type I) and endothelial cell NOS (eNOS, type III), and one inducible isoform (iNOS, type II), have been cloned. All NOS isoforms contain calmodulin, nicotinamide adenine dinucleotide phosphate (NADPH), flavin adenine dinucleotide (FAD), and flavin mononucleotide (FMN) binding domains. iNOS is found in a variety of cell types including macrophages, hepatocytes, synoviocytes, and smooth muscle cells. Cytokines such as interferon-gamma (IFN), tumor necrosis factor (TNF), interleukin-1 and -2, and lipopolysaccarides (LPS) cause an increase in iNOS mRNA, protein, and activity levels. Protein kinase C-stimulating agents exhibit the same effect on iNOS activity. After cytokine induction, iNOS exhibits a delayed activity response which is then followed by a significant increase in NO production over a long period of time. Three related iNOS pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. Diseases associated with iNOS dysfunction include achalasia and impotence.
免疫原 :
Synthetic peptide corresponding to residues D(17) L K E E K D I N N N V K K T(31) of mouse iNOS.
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:50, Immunofluorescence: 1:50, Immunohistochemistry: 1:20, Western Blot: 1:200-1:1,000
别名 :
Hepatocyte NOS; hepatocytes; HEP-NOS; inducible nitric oxide synthase; Inducible NO synthase; inducible NOS; iNos; i-NOS; Inosl; MAC-NOS; macrophage NOS; nitric oxide synthase 2; nitric oxide synthase 2, inducible; nitric oxide synthase 2, inducible, macrophage; nitric oxide synthase 2A (inducible, hepatocytes); nitric oxide synthase, inducible; nitric oxide synthase, macrophage; nitric oxide synthase-inducible; NOS; NOS type II; NOS, type II; NOS2; Nos-2; NOS2A; NOS-II; OTTMUSP00000000202; Peptidyl-cysteine S-nitrosylase NOS2
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国