产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
HIF-2甲多克隆抗体
目录 :
PA1-16510
规格 :
100微升
价格 :
美国496.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
中国人仓鼠, 人类, 小鼠, 大鼠, 家羊, domestic rabbit
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 10
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1000; 图 6b
Rychtarčíková Z, Lettlova S, Tomkova V, Korenkova V, Langerova L, Simonova E, et al. Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism. Oncotarget. 2017;8:6376-6398 pubmed 出版商
  • 免疫组化; 小鼠; 图 s2a
Nakazawa M, Eisinger Mathason T, Sadri N, Ochocki J, Gade T, Amin R, et al. Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth. Nat Commun. 2016;7:10539 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4
Ortmann B, Bensaddek D, Carvalhal S, Moser S, Mudie S, Griffis E, et al. CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells. J Cell Sci. 2016;129:191-205 pubmed 出版商
Nam J, Kim A, Choi S, Kim J, Han S, Park S, et al. Pharmacologic Inhibition of HIF-1α Attenuates Radiation-Induced Pulmonary Fibrosis in a Preclinical Image Guided Radiation Therapy. Int J Radiat Oncol Biol Phys. 2021;109:553-566 pubmed 出版商
Wu J, Contratto M, Shanbhogue K, Manji G, O Neil B, NOONAN A, et al. Evaluation of a locked nucleic acid form of antisense oligo targeting HIF-1α in advanced hepatocellular carcinoma. World J Clin Oncol. 2019;10:149-160 pubmed 出版商
Lin N, Shay J, Xie H, Lee D, Skuli N, Tang Q, et al. Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental Colitis. Front Immunol. 2018;9:2565 pubmed 出版商
Altintop I, Tatli M, Karakukcu C, Soyer Sarica Z, Hanım Yay A, Balcioğlu E, et al. Serum and Tissue HIF-2 Alpha Expression in CIN, N-Acetyl Cysteine, and Sildenafil-Treated Rat Models: An Experimental Study. Medicina (Kaunas). 2018;54: pubmed 出版商
Biddlestone J, Batie M, Bandarra D, Munoz I, Rocha S. SINHCAF/FAM60A and SIN3A specifically repress HIF-2α expression. Biochem J. 2018;475:2073-2090 pubmed 出版商
Moniz S, Bandarra D, Biddlestone J, Campbell K, Komander D, Bremm A, et al. Cezanne regulates E2F1-dependent HIF2α expression. J Cell Sci. 2015;128:3082-93 pubmed 出版商
Sun Y, George J, Rocha S. Dose-dependent effects of allopurinol on human foreskin fibroblast cells and human umbilical vein endothelial cells under hypoxia. PLoS ONE. 2015;10:e0123649 pubmed 出版商
图像
图像 1 :
赛默飞世尔 PA1-16510 图像 1
Detection of HIF-2 Alpha (Green) in RCC4 cells using PA1-16510. Nuclei (Blue) are counterstained with Hoechst 33258.
图像 2 :
赛默飞世尔 PA1-16510 图像 2
Hif-2 alpha immunoreactivity in human cardiac myocytes stained with PA1-16510.
图像 3 :
赛默飞世尔 PA1-16510 图像 3
Western blot analysis of HIF-2 alpha on Lane 1, Cobalt chloride treated COS7 nuclear extracts and Lane 2, Untreated COS7 nuclear extracts using PA1-16510.
产品信息
产品类型 :
抗体
产品名称 :
HIF-2甲多克隆抗体
目录# :
PA1-16510
规格 :
100微升
价格 :
美国496.00
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
反应物种 :
Fish, Hamster, Human, Mouse, Non-human primate, Ovine, Rabbit, Rat, Reptile
应用 :
ChIP Assay: 1:10-1:500, ELISA: 1:100-1:2,000, Flow Cytometry: Assay-Dependent, Gel Shift: Assay-Dependent, Immunocytochemistry: 1:100, Immunohistochemistry (Frozen): 1:100, Immunohistochemistry (Paraffin): 1:100, Immunoprecipitation: 5 µg/1 mg lysate, In vitro Assay: Assay-Dependent, Western Blot: 1-2 µg/mL
物种 :
Fish, Hamster, Human, Mouse, Non-human primate, Ovine, Rabbit, Rat, Reptile
抗体亚型 :
IgG
储存 :
-20°C
描述 :
HIF-2 alpha (Epas1) is a transcription factor involved in the induction of genes regulated by oxygen. HIF-2 alpha contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. It also regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of the lungs. Mutations in this gene are associated with erythrocytosis familial type 4.
免疫原 :
A peptide derived from the C-terminus of mouse/human HIF-2 alpha protein.
格式 :
液体
应用w/稀释 :
ChIP Assay: 1:10-1:500, ELISA: 1:100-1:2,000, Flow Cytometry: Assay-Dependent, Gel Shift: Assay-Dependent, Immunocytochemistry: 1:100, Immunohistochemistry (Frozen): 1:100, Immunohistochemistry (Paraffin): 1:100, Immunoprecipitation: 5 µg/1 mg lysate, In vitro Assay: Assay-Dependent, Western Blot: 1-2 µg/mL
别名 :
basic-helix-loop-helix-PAS protein MOP2; bHLHe73; Class E basic helix-loop-helix protein 73; ECYT4; endothelial PAS domain protein 1; endothelial PAS domain protein 1b; endothelial PAS domain-containing protein 1; endothelial PAS domain-containing protein 1b; EPAS; Epas1; EPAS-1; epas1b; Hif like protein; HIF1 alpha-like factor; HIF-1-alpha-like factor; HIF-1alpha-like factor; HIF1alpha-like factor; HIF2 alpha; HIF-2 alpha; HIF2A; hif-2a; hif-2ab; HIF-2alpha; HIF-2-alpha; HIF2-alpha; HIF-related factor; HLF; HLF (HIF1alpha-like factor); HRF; hypoxia inducible factor 2 alpha; hypoxia inducible factor 2, alpha subunit; hypoxia inducible factor 2a; hypoxia inducible transcription factor 2alpha; hypoxia-inducible factor 2 alpha; hypoxia-inducible factor 2-alpha; Member of PAS protein 2; mHLF; MOP2; PAS domain-containing protein 2; PASD2; wu:fq36f01
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国