产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
53BP1多克隆抗体
目录 :
PA1-16565
规格 :
100微升
价格 :
美国450.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
domestic goat, 人类, 小鼠, 大鼠, 犬, 牛
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片
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文章摘录数: 2
| 出版应用/物种/样本/稀释 | 参考文献 |
|---|---|
| |
图像
图像 1 :
Detection of Human [deleted mouse] 53BP1 by Western Blot Sample: Whole cell lysate (20 ug/lane) from U2OS or 293T cells resolved on a 3 to 8% tris-acetate gel. (PA1-16565) used at 0.5 ug/ml.
图像 2 :
Flow cytometric detection of 53BP1. 1 million Jurkat cells were fixed, permeabilized, and stained with 1.5 mcg/ml anti-53BP1 PA1-16565 in a 150 mcl reaction. Isotype control (black), anti-53BP1 (red).
图像 3 :
53BP1 foci in proliferating MEFs; both normal and exposed to 10 Gy of IR and double-color immunofluorescence stained after 2 hours. Images captured in a Kodak digital image system on a Leica fluorescent microscope.
产品信息
产品类型 :
抗体
产品名称 :
53BP1多克隆抗体
目录# :
PA1-16565
规格 :
100微升
价格 :
美国450.00
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
兔
反应物种 :
Bat, Bovine, Canine, Fish, Goat, Human, Mouse, Non-human primate, Rat
应用 :
ChIP Assay: Assay-Dependent, Flow Cytometry: 1.5 µg/mL, Immunocytochemistry: 1:1,000-1:5,000, Immunohistochemistry (Frozen): Assay-Dependent, Immunohistochemistry (Paraffin): 1:1,000-1:5,000, Immunoprecipitation: Assay-Dependent, In Situ Hybridization (ISH): Assay-Dependent, Western Blot: 1:5,000-1:25,000
物种 :
Bat, Bovine, Canine, Fish, Goat, Human, Mouse, Non-human primate, Rat
抗体亚型 :
IgG
储存 :
-20°C
描述 :
53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.
免疫原 :
The epitope recognized by this antibody maps to a region between residues 350 and 400 of human tumor protein p53 binding protein 1 using the numbering given in entry NP_005648.1 (GeneID 7158).
格式 :
液体
应用w/稀释 :
ChIP Assay: Assay-Dependent, Flow Cytometry: 1.5 µg/mL, Immunocytochemistry: 1:1,000-1:5,000, Immunohistochemistry (Frozen): Assay-Dependent, Immunohistochemistry (Paraffin): 1:1,000-1:5,000, Immunoprecipitation: Assay-Dependent, In Situ Hybridization (ISH): Assay-Dependent, Western Blot: 1:5,000-1:25,000
别名 :
53BP1; FLJ41424; m53BP1; MGC138366; murine p53-binding protein; p202; p53-binding protein 1; p53BP1; TDRD30; TP53; TP53-binding protein 1; Tp53bp1; transformation related protein 53 binding protein 1; transformation related protein 53 binding-protein 1; Trp53bp1; tumor protein 53-binding protein, 1; tumor protein p53 binding protein 1; tumor protein p53-binding protein, 1; tumor suppressor p53-binding protein 1
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公司信息
赛默飞世尔