产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
碳酸酐酶IX多克隆抗体
目录 :
PA1-16592
规格 :
100微升
价格 :
美国496.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, proximity ligation assay
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 8
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 小鼠; 1:2000; 图 2a
Hoefflin R, Harlander S, Abhari B, Peighambari A, Adlesic M, Seidel P, et al. Therapeutic Effects of Inhibition of Sphingosine-1-Phosphate Signaling in HIF-2α Inhibitor-Resistant Clear Cell Renal Cell Carcinoma. Cancers (Basel). 2021;13: pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:400; 图 s4a
Carter P, Schnell U, Chaney C, TONG B, Pan X, ye J, et al. Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma. J Clin Invest. 2021;131: pubmed 出版商
Abu El Maaty M, Terzic J, Keime C, Rovito D, Lutzing R, Yanushko D, et al. Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progression. Sci Adv. 2022;8:eabo2295 pubmed 出版商
Refet Mollof E, Najyb O, Chermat R, Glory A, Lafontaine J, Wong P, et al. Hypoxic Jumbo Spheroids On-A-Chip (HOnAChip): Insights into Treatment Efficacy. Cancers (Basel). 2021;13: pubmed 出版商
Hoefflin R, Harlander S, Schäfer S, Metzger P, Kuo F, Schönenberger D, et al. HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice. Nat Commun. 2020;11:4111 pubmed 出版商
Yao M, Sattler T, Rabbani Z, Pulliam T, Walker G, Gamcsik M. Mixing and delivery of multiple controlled oxygen environments to a single multiwell culture plate. Am J Physiol Cell Physiol. 2018;315:C766-C775 pubmed 出版商
Wang H, Shepard M, Zhang C, Dong L, Walker D, Guedez L, et al. Deletion of the von Hippel-Lindau Gene in Hemangioblasts Causes Hemangioblastoma-like Lesions in Murine Retina. Cancer Res. 2018;78:1266-1274 pubmed 出版商
Gu Y, Cohn S, Christie A, McKenzie T, Wolff N, Do Q, et al. Modeling Renal Cell Carcinoma in Mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade. Cancer Discov. 2017;7:900-917 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
碳酸酐酶IX多克隆抗体
目录# :
PA1-16592
规格 :
100微升
价格 :
美国496.00
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
兔
反应物种 :
人类, 小鼠, 植物, 大鼠
应用 :
ChIP Assay: 1:10-1:500, ELISA: Assay-Dependent, Flow Cytometry: 1:1,000, Gel Shift: Assay-Dependent, Immunocytochemistry: 2-5 µg/mL, Immunohistochemistry (Frozen): 1:200-1:500, Immunohistochemistry (Paraffin): 1:200-1:500, Proximity Ligation Assay (PLA): Assay-Dependent, Western Blot: 1-3 µg/mL
物种 :
人类, 小鼠, 植物, 大鼠
抗体亚型 :
IgG
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. There are many genes that are inducible by hypoxia, via HIF-1 alpha. CA IX is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia. Therefore, CA IX has become a reliable histochemical marker of hypoxia.
免疫原 :
A synthetic peptide derived from a C-terminal sequence of the human CA IX.
格式 :
液体
应用w/稀释 :
ChIP Assay: 1:10-1:500, ELISA: Assay-Dependent, Flow Cytometry: 1:1,000, Gel Shift: Assay-Dependent, Immunocytochemistry: 2-5 µg/mL, Immunohistochemistry (Frozen): 1:200-1:500, Immunohistochemistry (Paraffin): 1:200-1:500, Proximity Ligation Assay (PLA): Assay-Dependent, Western Blot: 1-3 µg/mL
别名 :
Ca9; CA-9; CAIX; CA-IX; Car9; Carbonate dehydratase IX; carbonic anhydrase 9; Carbonic anhydrase IX; carbonic dehydratase; G250; Membrane antigen MN; membrane antigen MN homolog; MN; MN/CA9; P54 / 58N; P54/58N; pMW1; RCC-associated antigen G250; RCC-associated protein G250; renal cell carcinoma-associated antigen G250
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国