产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
存活素多克隆抗体
目录 :
PA1-16836
规格 :
100微升
价格 :
美国496.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
豚鼠, 人类, 小鼠, 大鼠, 犬, 猫
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片
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文章摘录数: 6
| 出版应用/物种/样本/稀释 | 参考文献 |
|---|---|
| |
图像
图像 1 :
Telophase with accumulation of survivin in the midbodies of two daughter cells. Survivin detection using PA1-16836.
图像 2 :
Western Blot detection of survivin in HeLa whole cell lysate (30 ug) using PA1-16836 at 1ug/ml (1 minute exposure).
图像 3 :
The top photo is a no primary antibody control stain and the bottom photo is anti-survivin staining of melanoma.
产品信息
产品类型 :
抗体
产品名称 :
存活素多克隆抗体
目录# :
PA1-16836
规格 :
100微升
价格 :
美国496.00
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
兔
反应物种 :
狗, 猫, 豚鼠, 仓鼠, 人类, 小鼠, 大鼠
应用 :
ChIP Assay: 1:10-1:500, ELISA: Assay-Dependent, Flow Cytometry: Assay-Dependent, Immunocytochemistry: 1:50-1:250, Immunohistochemistry (Frozen): Assay-Dependent, Immunohistochemistry (Paraffin): 1:50-1:500, Immunoprecipitation: 1:10-1:500, Western Blot: 1:1,000
物种 :
狗, 猫, 豚鼠, 仓鼠, 人类, 小鼠, 大鼠
抗体亚型 :
IgG
储存 :
-20°C or -80°C if preferred
描述 :
Survivin (IAP4) is the smallest member of the Inhibitors of Apoptosis Protein (IAP) gene family. The IAPs are involved in multiple cell functions such as cell signaling, cell division, metabolism, and exhibits differential expression in nearly all human cancers, but not in most normal tissues. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but the Survivin gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of survivin’s gene expression. Survivin is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. Survivin may counteract a default induction of apoptosis in G2/M phase. Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury. Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein). Survivin might affect regulation of neural cell proliferative responses after brain injury. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favor aberrant progression of transformed cells through mitosis.
免疫原 :
重组人类存活素, 全长
格式 :
液体
应用w/稀释 :
ChIP Assay: 1:10-1:500, ELISA: Assay-Dependent, Flow Cytometry: Assay-Dependent, Immunocytochemistry: 1:50-1:250, Immunohistochemistry (Frozen): Assay-Dependent, Immunohistochemistry (Paraffin): 1:50-1:500, Immunoprecipitation: 1:10-1:500, Western Blot: 1:1,000
别名 :
AAC-11; AP14; Api4; apoptosis inhibitor 4; Apoptosis inhibitor survivin; baculoviral IAP repeat containing 5; baculoviral IAP repeat-containing 5; baculoviral IAP repeat-containing 5 (survivin); baculoviral IAP repeat-containing protein 5; BIRC 5; BIRC5; EPR 1; EPR-1; Iap4; inhibitor of apoptosis; survivin; survivin variant 3 alpha; survivin40; SVV; TIAP
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公司信息
赛默飞世尔