LC3A/LC3B多克隆抗体 | 赛默飞世尔 PA1-16931 产品信息

产品简要

公司名称 :

赛默飞世尔

其他品牌 :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

产品类型 :

抗体

产品名称 :

LC3A/LC3B多克隆抗体

PA1-16931

规格 :

100微升

价格 :

美国455.00

克隆性 :

多克隆

宿主 :

domestic rabbit

共轭标签 :

未共轭

反应物种 :

人类, 小鼠, 大鼠, 犬, 斑马鱼

应用 :

免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片

更多信息或购买 :

赛默飞世尔产品网页

文章摘录数: 18

出版应用/物种/样本/稀释	参考文献
免疫印迹; 人类; 图 4a	Zou P, Liu L, Zheng L, Payne K, Manjili M, Idowu M, et al. Coordinated Upregulation of Mitochondrial Biogenesis and Autophagy in Breast Cancer Cells: The Role of Dynamin Related Protein-1 and Implication for Breast Cancer Treatment. Oxid Med Cell Longev. 2016;2016:4085727 pubmed
免疫印迹; 大鼠; 图 8	Shruthi K, Reddy S, Reddy P, Shivalingam P, Harishankar N, Reddy G. Amelioration of neuronal cell death in a spontaneous obese rat model by dietary restriction through modulation of ubiquitin proteasome system. J Nutr Biochem. 2016;33:73-81 pubmed 出版商
免疫印迹; 人类; 图 s2a	Pereira D, Simões A, Gomes S, Castro R, Carvalho T, Rodrigues C, et al. MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism. Oncotarget. 2016;7:34322-40 pubmed 出版商
	Ma Q, Zhou J, Yang Z, Xue Y, Xie X, Li T, et al. Mingmu Xiaoyao granules regulate the PI3K/Akt/mTOR signaling pathway to reduce anxiety and depression and reverse retinal abnormalities in rats. Front Pharmacol. 2022;13:1003614 pubmed 出版商
	Balkrishna A, Mulay V, Verma S, Srivastava J, Lochab S, Varshney A. Penta-O-Galloyl-β-D-Glucose in Pistacia integerrima Targets AMPK-ULK1 and ERK/STAT3 Signaling Axes to Induce ROS-Independent Autophagic Cell Death in Human Lung Cancer Cells. Front Pharmacol. 2022;13:889335 pubmed 出版商
	Liu X, Balaraman K, Lynch C, Hebron M, Shah P, Hu S, et al. Inhibition of Ubiquitin-Specific Protease-13 Improves Behavioral Performance in Alpha-Synuclein Expressing Mice. Int J Mol Sci. 2022;23: pubmed 出版商
	Martins Marques T, Costa M, Catarino S, Simões I, Aasen T, Enguita F, et al. Cx43-mediated sorting of miRNAs into extracellular vesicles. EMBO Rep. 2022;23:e54312 pubmed 出版商
	Leung Z, Abu Rafea B, Watson A, Betts D. Free fatty acid treatment of mouse preimplantation embryos demonstrates contrasting effects of palmitic acid and oleic acid on autophagy. Am J Physiol Cell Physiol. 2022;322:C833-C848 pubmed 出版商
	Liu Y, Wang Y, Yao D, Chen X, Zhang F, Feng Y, et al. Diane-35 and Metformin Induce Autophagy and Apoptosis in Polycystic Ovary Syndrome Women with Early-Stage Endometrial Carcinoma. Genes (Basel). 2022;13: pubmed 出版商
	Ikeh K, Lamkin E, Crompton A, Deutsch J, Fisher K, Gray M, et al. REV1 Inhibition Enhances Radioresistance and Autophagy. Cancers (Basel). 2021;13: pubmed 出版商
	Wang S, Qian H, Zhang L, Liu P, Zhuang D, Zhang Q, et al. Inhibition of Calcineurin/NFAT Signaling Blocks Oncogenic H-Ras Induced Autophagy in Primary Human Keratinocytes. Front Cell Dev Biol. 2021;9:720111 pubmed 出版商
	Dubytska L, Thune R. Early Intracellular Trafficking and Subsequent Activity of Programmed Cell Death in Channel Catfish Macrophages Infected with Edwardsiella ictaluri. Microorganisms. 2020;8: pubmed 出版商
	An Y, Liu H, Zhou Z, Wang J, Jiang G, Li Z, et al. Sinoporphyrin sodium is a promising sensitizer for photodynamic and sonodynamic therapy in glioma. Oncol Rep. 2020;44:1596-1604 pubmed 出版商
	Schwarze K, Kribben A, Ritter O, Muller G, Patschan D. Autophagy activation in circulating proangiogenic cells aggravates AKI in type I diabetes mellitus. Am J Physiol Renal Physiol. 2018;315:F1139-F1148 pubmed 出版商
	Deng X, Meng X, Venardos N, Song R, Yamanaka K, Fullerton D, et al. Autophagy negatively regulates pro-osteogenic activity in human aortic valve interstitial cells. J Surg Res. 2017;218:285-291 pubmed 出版商
	Javidnia M, Hebron M, Xin Y, Kinney N, Moussa C. Pazopanib Reduces Phosphorylated Tau Levels and Alters Astrocytes in a Mouse Model of Tauopathy. J Alzheimers Dis. 2017;60:461-481 pubmed 出版商
	Ferreira J, Soares A, Ramalho J, Pereira P, Girao H. K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy. Sci Rep. 2015;5:10210 pubmed 出版商
	Morgado A, Xavier J, Dionísio P, Ribeiro M, Dias R, Sebastião A, et al. MicroRNA-34a Modulates Neural Stem Cell Differentiation by Regulating Expression of Synaptic and Autophagic Proteins. Mol Neurobiol. 2015;51:1168-83 pubmed 出版商

图像

图像 1 :

Immunohistochemistry staining of human brain, cerebral cortex, cell crocesses in gray matter.

图像 2 :

Western blot of mouse ES cell lysate showing specific labeling of the LC3-1 and LC3-2 proteins.

产品信息

产品类型 :

抗体

产品名称 :

LC3A/LC3B多克隆抗体

目录# :

PA1-16931

规格 :

100微升

价格 :

美国455.00

克隆性 :

多克隆

纯度 :

抗原亲和色谱

宿主 :

兔

反应物种 :

狗, 鱼类, 人类, 小鼠, 植物, 大鼠, 斑马鱼

应用 :

ChIP Assay: Assay-Dependent, ELISA: Assay-Dependent, Flow Cytometry: Assay-Dependent, Immunocytochemistry: 1:100-1:300, Immunohistochemistry (Frozen): Assay-Dependent, Immunohistochemistry (Paraffin): 1:200-1:400, Immunoprecipitation: 20 µg/500 µg of lysate, Western Blot: 2 µg/mL

物种 :

狗, 鱼类, 人类, 小鼠, 植物, 大鼠, 斑马鱼

抗体亚型 :

IgG

储存 :

-20°C or -80°C if preferred

描述 :

Autophagy is a process of intracellular bulk degradation in which cytoplasmic components, including organelles, are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. During macroautophagy, the sequestering vesicles, termed autophagosomes, fuse with the lysosome or vacuole resulting in the delivery of an inner vesicle (autophagic body) into the lumen of the degradative compartment. There are 16 proteins participating in the autophagy pathway in human. The autophagy protein LC3, a mammalian homologue of Atg8, was originally identified as microtubule-associated protein 1 light chain 3. It is a component of both the MAP1A and MAP1B microtubule-binding domains and the heavy-chain independent regulation of LC3 expression might modify MAP1 microtubule-binding activity during development. LC3 is the only known mammalian protein identified that stably associates with the autophagosome membranes. LC3-I is cytosolic and LC3-II is membrane bound and enriched in the autophagic vacuole fraction. The detection of LC3-I to LC3-II conversion is a useful and sensitive marker for distinguishing autophagy in mammalian cells.

免疫原 :

Synthetic peptide corresponding to a region between residues 25-121 of human LC3 protein.

格式 :

液体

应用w/稀释 :

别名 :

1010001C15Rik; 1010001H21Rik; 4922501H04Rik; Atg8; ATG8E; ATG8F; Autophagy-related protein LC3 A; autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 A; autophagy-related ubiquitin-like modifier LC3 B; LC3; LC3a; LC3b; MAP1 light chain 3-like protein 1; MAP1 light chain 3-like protein 2; MAP1A/1B light chain 3 A; MAP1A/1B light chain 3 B; MAP1A/1BLC3; MAP1A/MAP1B LC3 A; MAP1A/MAP1B LC3 B; MAP1A/MAP1B light chain 3 A; MAP1A/MAP1B light chain 3 B; Map1alc3; MAP1BLC3; Map1lc3; Map1lc3a; MAP1LC3B; MAP1LC3B-a; microtubule associated protein 1 light chain 3 alpha; microtubule associated protein 1 light chain 3 beta; microtubule-associated protein 1 light chain 3; microtubule-associated protein 1 light chain 3 alpha; Microtubule-associated protein 1 light chain 3 beta; microtubule-associated protein 1-light chain 3A; microtubule-associated proteins 1A/1B light chain 3; microtubule-associated proteins 1A/1B light chain 3A; Microtubule-associated proteins 1A/1B light chain 3B; Mpl3; wu:fb60g11; zbs559; zgc:56434; zgc:77094

更多信息或购买 :

赛默飞世尔产品网页

公司信息

赛默飞世尔

上海浦东新金桥路27号7号楼

analyze.cn@thermofisher.com

http://www.thermo.com.cn

1084193588

公司总部: 美国