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抗体

酪氨酸羟化酶多克隆抗体

PA1-18315

100微升

美国496.00

多克隆

domestic rabbit

未共轭

豚鼠, 人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫组化-冰冻切片

酪氨酸羟化酶多克隆抗体

PA1-18315

100微升

美国496.00

多克隆

兔

豚鼠, 人类, 小鼠, 大鼠

Immunohistochemistry (Frozen): 1:2,000-1:5,000, Western Blot: 1:1,000

豚鼠, 人类, 小鼠, 大鼠

IgG

-20° C, 避免反复冷冻/解冻

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.

合成多肽对应于氨基酸残基P(63)R F I G R R Q S L I E D A R K(78)人的酪氨酸羟化酶,KLH偶联

冻干

Immunohistochemistry (Frozen): 1:2,000-1:5,000, Western Blot: 1:1,000

dystonia 14; DYT14; DYT5b; EC 1.14.16.2; HGNC:11782; Th; TH isoform 3; TH isoform a; th1; TH-4; The; TY3H; TYH; TYH antibody; Tyrosine 3-hydroxylase; tyrosine 3-monooxygenase; tyrosine hydroxylase