产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
雌激素受体α多克隆抗体
目录 :
PA1-309
规格 :
50µg
价格 :
美国381.00
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
鹿, 人类, 大鼠, ,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 15
出版应用/物种/样品/稀释参考文献
  • 免疫组化-石蜡切片; 大鼠; 1:200; 图 5b
Helle J, Keiler A, Zierau O, Dörfelt P, Vollmer G, Lehmann L, et al. Effects of the aryl hydrocarbon receptor agonist 3-methylcholanthrene on the 17?-estradiol regulated mRNA transcriptome of the rat uterus. J Steroid Biochem Mol Biol. 2017;171:133-143 pubmed 出版商
  • 免疫组化; 羊
  • 免疫印迹; 羊
Cárdenas H, Pope W. Amounts of an estrogen receptor ? isoform increased in the theca of preovulatory follicles of sheep. Anim Reprod Sci. 2012;131:143-52 pubmed 出版商
  • 免疫组化; 鹿
Yanagawa Y, Matsuura Y, Suzuki M, Katagiri S, Tsubota T. Immunohistochemical localization of the estrogen receptor alpha (ERalpha) and progesterone receptor (PR) in the uterus of sika deer (Cervus nippon) during pregnancy. Jpn J Vet Res. 2008;56:139-49 pubmed
  • 免疫组化; 大鼠; 1:500
  • 免疫印迹; 大鼠; 1:5000
Sakuma S, Tokuhara D, Hattori H, Matsuoka O, Yamano T. Expression of estrogen receptor alpha and beta in reactive astrocytes at the male rat hippocampus after status epilepticus. Neuropathology. 2009;29:55-62 pubmed 出版商
  • 免疫印迹; 人类
Youn H, Hong K, Yoo J, Lee C. ICAM-1 expression in vaginal cells as a potential biomarker for inflammatory response. Biomarkers. 2008;13:257-69 pubmed
Glinskii O, Abraha T, Turk J, Rubin L, Huxley V, Glinsky V. Microvascular network remodeling in dura mater of ovariectomized pigs: role for angiopoietin-1 in estrogen-dependent control of vascular stability. Am J Physiol Heart Circ Physiol. 2007;293:H1131-7 pubmed
Han G, Ma H, Chintala R, Miyake K, Fulton D, Barman S, et al. Nongenomic, endothelium-independent effects of estrogen on human coronary smooth muscle are mediated by type I (neuronal) NOS and PI3-kinase-Akt signaling. Am J Physiol Heart Circ Physiol. 2007;293:H314-21 pubmed
Han G, Yu X, Lu L, Li S, Ma H, Zhu S, et al. Estrogen receptor alpha mediates acute potassium channel stimulation in human coronary artery smooth muscle cells. J Pharmacol Exp Ther. 2006;316:1025-30 pubmed
Cárdenas H, Pope W. Estrogen receptors in the uterus and ovarian follicles of gilts treated with dihydrotestosterone. Domest Anim Endocrinol. 2005;29:523-33 pubmed
Geffroy N, Guédin A, Dacquet C, Lefebvre P. Cell cycle regulation of breast cancer cells through estrogen-induced activities of ERK and Akt protein kinases. Mol Cell Endocrinol. 2005;237:11-23 pubmed
Reed C, Berndtson A, Nephew K. Dose-dependent effects of 4-hydroxytamoxifen, the active metabolite of tamoxifen, on estrogen receptor-alpha expression in the rat uterus. Anticancer Drugs. 2005;16:559-67 pubmed
Hong Goka B, Chang F. Estrogen receptors alpha and beta in choroid plexus epithelial cells in Alzheimer's disease. Neurosci Lett. 2004;360:113-6 pubmed
Cárdenas H, Pope W. Attenuation of estrogenic effects by dihydrotestosterone in the pig uterus is associated with downregulation of the estrogen receptors. Biol Reprod. 2004;70:297-302 pubmed
Takao T, Nanamiya W, Nazarloo H, Matsumoto R, Asaba K, Hashimoto K. Exposure to the environmental estrogen bisphenol A differentially modulated estrogen receptor-alpha and -beta immunoreactivity and mRNA in male mouse testis. Life Sci. 2003;72:1159-69 pubmed
Bailey J, Nephew K. Strain differences in tamoxifen sensitivity of Sprague-Dawley and Fischer 344 rats. Anticancer Drugs. 2002;13:939-47 pubmed
图像
图像 1 :
赛默飞世尔 PA1-309 图像 1
产品信息
产品类型 :
抗体
产品名称 :
雌激素受体α多克隆抗体
目录# :
PA1-309
规格 :
50µg
价格 :
美国381.00
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
反应物种 :
人类, 猪, 大鼠
应用 :
Immunocytochemistry: 1:1000-1:4000, Immunofluorescence: 1:1000-1:4000, Immunohistochemistry (Paraffin): 1-5 µg/mL, Western Blot: 1 µg/mL
物种 :
人类, 猪, 大鼠
抗体亚型 :
IgG
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 estrogen receptor-alpha isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
免疫原 :
合成多肽对应于氨基酸残基N(21)E L E P L N R P Q L K(32)C人的ER甲
格式 :
Liquid
应用w/稀释 :
Immunocytochemistry: 1:1000-1:4000, Immunofluorescence: 1:1000-1:4000, Immunohistochemistry (Paraffin): 1-5 µg/mL, Western Blot: 1 µg/mL
别名 :
ER甲, ER, 雌激素受体, ESR1
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
www.thermo.com.cn
1084193588
公司总部: 美国