产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
雌激素受体β多克隆抗体
目录 :
PA1-310B
规格 :
100微克
价格 :
美国500.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 15
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 人类; 图 3a
Youssef S, El Khateeb E, Aly D, Moussa M. Striae distensae: Immunohistochemical assessment of hormone receptors in multigravida and nulligravida. J Cosmet Dermatol. 2017;16:279-286 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:150; 图 6a
Bruner Tran K, Duleba A, Taylor H, Osteen K. Developmental Toxicant Exposure Is Associated with Transgenerational Adenomyosis in a Murine Model. Biol Reprod. 2016;95:73 pubmed 出版商
  • 免疫印迹; 人类; 1:100; 图 4
Peretz J, Pekosz A, Lane A, Klein S. Estrogenic compounds reduce influenza A virus replication in primary human nasal epithelial cells derived from female, but not male, donors. Am J Physiol Lung Cell Mol Physiol. 2016;310:L415-25 pubmed 出版商
Shin H, Yang W, Chay D, Lee E, Chung J, Kim H, et al. Tetraspanin 1 promotes endometriosis leading to ovarian clear cell carcinoma. Mol Oncol. 2020;: pubmed 出版商
Zhou X, Yang X, Zheng Y, Qin Z, Sha W, Chen G, et al. Jie-Yu Pill, A Proprietary Herbal Medicine, Ameliorates Mood Disorder-Like Behavior and Cognitive Impairment in Estrogen-Deprived Mice Exposed to Chronic Unpredictable Mild Stress: Implication for a Potential Therapy of Menopause Syndrome. Front Psychiatry. 2020;11:579995 pubmed 出版商
Girardi B, Pricci M, Giorgio F, Piazzolla M, Iannone A, Losurdo G, et al. Silymarin, boswellic acid and curcumin enriched dietetic formulation reduces the growth of inherited intestinal polyps in an animal model. World J Gastroenterol. 2020;26:1601-1612 pubmed 出版商
Balit T, Abdel Wahhab M, Radenahmad N. Young Coconut Juice Reduces Some Histopathological Changes Associated with Alzheimer's Disease through the Modulation of Estrogen Receptors in Orchidectomized Rat Brains. J Aging Res. 2019;2019:7416419 pubmed 出版商
Kim K, Cho Y, Lee J, Jeong H, Lee Y, Kim S, et al. Sexually dimorphic leanness and hypermobility in p16Ink4a/CDKN2A-deficient mice coincides with phenotypic changes in the cerebellum. Sci Rep. 2019;9:11167 pubmed 出版商
Alofe O, Kisanga E, Inayat Hussain S, Fukumura M, Garcia Milian R, Perera L, et al. Determining the endocrine disruption potential of industrial chemicals using an integrative approach: Public databases, in vitro exposure, and modeling receptor interactions. Environ Int. 2019;131:104969 pubmed 出版商
Ye Z, Cudmore R, Linden D. Estrogen-Dependent Functional Spine Dynamics in Neocortical Pyramidal Neurons of the Mouse. J Neurosci. 2019;39:4874-4888 pubmed 出版商
Evola C, Hudson T, Huang L, Corbett A, Mayes D. Gender- and region-specific changes in estrogen signaling in aging rat brain mitochondria. Aging (Albany NY). 2018;10:2148-2169 pubmed 出版商
Warns J, Marwarha G, Freking N, Ghribi O. 27-hydroxycholesterol decreases cell proliferation in colon cancer cell lines. Biochimie. 2018;153:171-180 pubmed 出版商
Cookman C, Belcher S. Estrogen Receptor-β Up-Regulates IGF1R Expression and Activity to Inhibit Apoptosis and Increase Growth of Medulloblastoma. Endocrinology. 2015;156:2395-408 pubmed 出版商
Maliqueo M, Sundström Poromaa I, Vanky E, Fornes R, Benrick A, Ã…kerud H, et al. Placental STAT3 signaling is activated in women with polycystic ovary syndrome. Hum Reprod. 2015;30:692-700 pubmed 出版商
Harvey C, Chen J, Bagnell C, Uzumcu M. Methoxychlor and its metabolite HPTE inhibit cAMP production and expression of estrogen receptors α and β in the rat granulosa cell in vitro. Reprod Toxicol. 2015;51:72-8 pubmed 出版商
图像
图像 1 :
赛默飞世尔 PA1-310B 图像 1
Immunofluorescent analysis using ER-beta polyclonal antibody (Product# PA1-310B) shows nuclear localization of ER-beta in MCF7 cells. Formalin fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 10 minutes at room temperature. Cells were blocked with 1% Blocker BSA (Product # 37525) for 15 minutes at room temperature. Cells were probed with a rabbit polyclonal antibody recognizing ER-beta (Product# PA1-310B), at a dilution of 1:100 for 1 hour at room temperature. Cells were washed with PBS and incubated with DyLight 488 goat-anti-rabbit IgG secondary antibody (Product # 35503) at a dilution of 1:400 for 30 minutes at room temperature. Nuclei (blue) were stained with Hoechst 33342 dye (Product # 62249). Images were taken on a Thermo Scientific ArrayScan at 20X magnification.
产品信息
产品类型 :
抗体
产品名称 :
雌激素受体β多克隆抗体
目录# :
PA1-310B
规格 :
100微克
价格 :
美国500.00
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
反应物种 :
人类, 小鼠, 大鼠
应用 :
Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Frozen): 1:50, Immunohistochemistry (Paraffin): 1:50, Western Blot: 1 µg/mL
物种 :
人类, 小鼠, 大鼠
抗体亚型 :
IgG
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55kD, though multiple isoforms ranging from 36-59kD have been described. Human ER beta was initially cloned and characterized from testis. Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Estrogen receptor beta (ER beta) binds estrogens with an affinity similar to that of estrogen receptor alpha. Some ER beta isoforms dominantly inhibit the activity of estrogen receptor alpha in reproductive tissues. ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in many cancer types such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease and risk of cardiovascular disease.
免疫原 :
Synthetic peptide corresponding to residues C(467) S S T E D S K N K E S S Q N L Q S Q(485) of rat ER beta.
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Frozen): 1:50, Immunohistochemistry (Paraffin): 1:50, Western Blot: 1 µg/mL
别名 :
ER; ER beta; ER[b]; Erb; Erb2; Erbeta; ER-beta; Esr2; ESRB; ESR-BETA; ESTRB; estrogen receptor 2; estrogen receptor 2 (beta); estrogen receptor 2 (ER beta); estrogen receptor 2 beta; estrogen receptor beta; estrogen receptor beta 1 isoform deletion variant; estrogen receptor beta 4; NR3A2; Nuclear receptor subfamily 3 group A member 2; oestrogen receptor beta; steroid receptor
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国