产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
雌激素受体β多克隆抗体
目录 :
PA1-313
规格 :
50µg
价格 :
380美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, EMSA, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 25
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 人类; 图 1
Wisinski K, Xu W, Tevaarwerk A, Saha S, Kim K, Traynor A, et al. Targeting Estrogen Receptor Beta in a Phase 2 Study of High-Dose Estradiol in Metastatic Triple-Negative Breast Cancer: A Wisconsin Oncology Network Study. Clin Breast Cancer. 2016;16:256-61 pubmed 出版商
  • 免疫组化; 人类; 1:200; 图 2
  • 免疫印迹; 人类; 图 1
Manna S, Kim J, Baugé C, Cam M, Zhao Y, Shetty J, et al. Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation. Nat Commun. 2015;6:8152 pubmed 出版商
  • 免疫组化; 人类; 1:200; 图 2
  • 免疫印迹; 人类; 图 1
Shanle E, Onitilo A, Huang W, Kim K, Zang C, Engel J, et al. Prognostic significance of full-length estrogen receptor beta expression in stage I-III triple negative breast cancer. Am J Transl Res. 2015;7:1246-59 pubmed
  • EMSA; 人类
Kruer T, Cummins T, Powell D, Wittliff J. Characterization of estrogen response element binding proteins as biomarkers of breast cancer behavior. Clin Biochem. 2013;46:1739-46 pubmed 出版商
  • 免疫组化; 羊
  • 免疫印迹; 羊
Cárdenas H, Pope W. Amounts of an estrogen receptor ? isoform increased in the theca of preovulatory follicles of sheep. Anim Reprod Sci. 2012;131:143-52 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类
Gallo D, De Stefano I, Grazia Prisco M, Scambia G, Ferrandina G. Estrogen receptor beta in cancer: an attractive target for therapy. Curr Pharm Des. 2012;18:2734-57 pubmed
  • 免疫印迹; 人类; 0.05 ug/ml
Barone T, Gorski J, Greenberg S, Plunkett R. Estrogen increases survival in an orthotopic model of glioblastoma. J Neurooncol. 2009;95:37-48 pubmed 出版商
  • 免疫组化; 大鼠; 1:250
Wang M, Yu B, Westerlind K, Strange R, Khan G, Patil D, et al. Prepubertal physical activity up-regulates estrogen receptor beta, BRCA1 and p53 mRNA expression in the rat mammary gland. Breast Cancer Res Treat. 2009;115:213-20 pubmed 出版商
Yusuf R, Frenkel K. Morphologic transformation of human breast epithelial cells MCF-10A: dependence on an oxidative microenvironment and estrogen/epidermal growth factor receptors. Cancer Cell Int. 2010;10:30 pubmed 出版商
Power K, Chen J, Saarinen N, Thompson L. Changes in biomarkers of estrogen receptor and growth factor signaling pathways in MCF-7 tumors after short- and long-term treatment with soy and flaxseed. J Steroid Biochem Mol Biol. 2008;112:13-9 pubmed 出版商
Li J, Wang H, Johnson S, Horner Glister E, Thompson J, White I, et al. Differing transcriptional responses to pulsed or continuous estradiol exposure in human umbilical vein endothelial cells. J Steroid Biochem Mol Biol. 2008;111:41-9 pubmed 出版商
Ewies A, Elshafie M, Li J, Stanley A, Thompson J, Styles J, et al. Changes in transcription profile and cytoskeleton morphology in pelvic ligament fibroblasts in response to stretch: the effects of estradiol and levormeloxifene. Mol Hum Reprod. 2008;14:127-35 pubmed 出版商
Schwartz A, Prysak G, Murphy V, Lonardo F, Pass H, Schwartz J, et al. Nuclear estrogen receptor beta in lung cancer: expression and survival differences by sex. Clin Cancer Res. 2005;11:7280-7 pubmed
Cárdenas H, Pope W. Estrogen receptors in the uterus and ovarian follicles of gilts treated with dihydrotestosterone. Domest Anim Endocrinol. 2005;29:523-33 pubmed
Huang J, Li X, Maguire C, Hilf R, Bambara R, Muyan M. Binding of estrogen receptor beta to estrogen response element in situ is independent of estradiol and impaired by its amino terminus. Mol Endocrinol. 2005;19:2696-712 pubmed
Li X, Huang J, Yi P, Bambara R, Hilf R, Muyan M. Single-chain estrogen receptors (ERs) reveal that the ERalpha/beta heterodimer emulates functions of the ERalpha dimer in genomic estrogen signaling pathways. Mol Cell Biol. 2004;24:7681-94 pubmed
Speirs V, Carder P, Lane S, Dodwell D, Lansdown M, Hanby A. Oestrogen receptor beta: what it means for patients with breast cancer. Lancet Oncol. 2004;5:174-81 pubmed
Wu Z, Maric C, Roesch D, Zheng W, Verbalis J, Sandberg K. Estrogen regulates adrenal angiotensin AT1 receptors by modulating AT1 receptor translation. Endocrinology. 2003;144:3251-61 pubmed
Gargett C, Zaitseva M, Bucak K, Chu S, Fuller P, Rogers P. 17Beta-estradiol up-regulates vascular endothelial growth factor receptor-2 expression in human myometrial microvascular endothelial cells: role of estrogen receptor-alpha and -beta. J Clin Endocrinol Metab. 2002;87:4341-9 pubmed
Kramer P, Wray S. 17-Beta-estradiol regulates expression of genes that function in macrophage activation and cholesterol homeostasis. J Steroid Biochem Mol Biol. 2002;81:203-16 pubmed
Stenberg A, Wang H, Fish J, Schrott Fischer A, Sahlin L, Hultcrantz M. Estrogen receptors in the normal adult and developing human inner ear and in Turner's syndrome. Hear Res. 2001;157:87-92 pubmed
Pasquali D, Rossi V, Esposito D, Abbondanza C, Puca G, Bellastella A, et al. Loss of estrogen receptor beta expression in malignant human prostate cells in primary cultures and in prostate cancer tissues. J Clin Endocrinol Metab. 2001;86:2051-5 pubmed
Wang H, Stjernholm Y, Ekman G, Eriksson H, Sahlin L. Different regulation of oestrogen receptors alpha and beta in the human cervix at term pregnancy. Mol Hum Reprod. 2001;7:293-300 pubmed
Järvinen T, Pelto Huikko M, Holli K, Isola J. Estrogen receptor beta is coexpressed with ERalpha and PR and associated with nodal status, grade, and proliferation rate in breast cancer. Am J Pathol. 2000;156:29-35 pubmed
Albrecht E, Babischkin J, Davies W, Leavitt M, Pepe G. Identification and developmental expression of the estrogen receptor alpha and beta in the baboon fetal adrenal gland. Endocrinology. 1999;140:5953-61 pubmed
图像
图像 1 :
赛默飞世尔 PA1-313 图像 1
产品信息
产品类型 :
抗体
产品名称 :
雌激素受体β多克隆抗体
目录# :
PA1-313
规格 :
50µg
价格 :
380美元
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
反应物种 :
人类, 小鼠, 大鼠
应用 :
Immunocytochemistry: 1:100, Immunofluorescence: 1:100, Immunohistochemistry (Frozen): 2-5 µg/mL, Immunohistochemistry (Paraffin): 2-5 µg/mL, Western Blot: 1 µg/mL
物种 :
人类, 小鼠, 大鼠
抗体亚型 :
IgG
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55kD, though multiple isoforms ranging from 36-59kD have been described. Human ER beta was initially cloned and characterized from testis. Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Estrogen receptor beta (ER beta) binds estrogens with an affinity similar to that of estrogen receptor alpha. Some ER beta isoforms dominantly inhibit the activity of estrogen receptor alpha in reproductive tissues. ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in many cancer types such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease and risk of cardiovascular disease.
免疫原 :
合成多肽对应于氨基酸残基C(459)S P A E D S K S K E G S Q N P Q S Q(477)人的ER乙
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:100, Immunofluorescence: 1:100, Immunohistochemistry (Frozen): 2-5 µg/mL, Immunohistochemistry (Paraffin): 2-5 µg/mL, Western Blot: 1 µg/mL
别名 :
ER乙, ER, ESR2, ESR乙
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国