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抗体

AKT1/AKT2多克隆抗体

PA1-37053

1毫升

美国399.00

多克隆

domestic rabbit

未共轭

免疫组化, 免疫组化-石蜡切片

AKT1/AKT2多克隆抗体

PA1-37053

1毫升

美国399.00

多克隆

抗原亲和色谱

兔

人类

免疫组化(石蜡): 1:50

人类

IgG

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity.

合成肽来自N末端人的Akt1

液体

免疫组化(石蜡): 1:50

AKT; AKT serine/threonine kinase 1; AKT serine/threonine kinase 2; AKT1; AKT1m; AKT2; CWS6; HIHGHH; murine thymoma viral (v-akt) homolog-2; PKB; PKB alpha; PKB beta; PKB-ALPHA; PKBB; PKBBETA; PRKBA; PRKBB; Protein kinase Akt-2; Protein kinase B; Protein kinase B alpha; protein kinase B beta; Proto-oncogene c-Akt; putative v-akt murine thymoma viral oncoprotein 2; RAC; rac protein kinase alpha; rac protein kinase beta; RAC-ALPHA; RAC-alpha serine/threonine-protein kinase; RAC-BETA; RAC-beta serine/threonine-protein kinase; RAC-PK-alpha; RAC-PK-beta; serine-threonine protein kinase; v-akt murine thymoma viral oncogene homolog 1; v-akt murine thymoma viral oncogene homolog 2; v-akt murine thymoma viral oncogene-like protein 1