产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Toll样受体5多克隆抗体
目录 :
PA1-41139
规格 :
100微克
价格 :
美国440.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠, pigs
应用 :
免疫印迹, 免疫组化, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 2
| 参考文献 |
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图像
图像 1 :
Flow cytometric analysis of mouse splenocytes stained intracellularly with PA1-41139. Unstained cells (shaded histogram), Isotype control (green histogram), and anti-TLR5 stained cells (red histogram).
图像 2 :
IHC(P) analysis of formalin-fixed human stomach tumor tissue stained with isotype control (top) or PA1-41139 (bottom).
图像 3 :
Western blot of Ramos (A), Raw (B), mouse spleen (C), mouse lung (D), and rat lung (E) whole cell lysates probed with PA1-41139.
产品信息
产品类型 :
抗体
产品名称 :
Toll样受体5多克隆抗体
目录# :
PA1-41139
规格 :
100微克
价格 :
美国440.00
克隆性 :
多克隆
纯度 :
蛋白质G
宿主 :
兔
反应物种 :
人类, 小鼠, 猪, 大鼠
应用 :
Flow Cytometry: 1-2 µg per million cells, Immunohistochemistry (Paraffin): 10 µg/mL, In vitro Assay: Assay-Dependent, Western Blot: 1-3 µg/mL
物种 :
人类, 小鼠, 猪, 大鼠
抗体亚型 :
IgG
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
TLR5 is a Type I membrane protein belonging to the Toll-like receptor family, participates in the innate immune response to microbial agents. TLR5 also plays a role in mediating detection of bacterial flagellins. TLR5 acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. TLR5 protein binds to TIRAP and MyD88 via their respective TIR domains TLR5 is highly expressed in liver, and is detected in lung and at very low levels in most other tissues. The TLR5 gene lies in a locus that is associated with susceptibility to Salmonella. Inbred strains of mice can be classified into 3 categories according to their resistance to infection with S.typhimurium: susceptible (BALB/c, C57BL/6, C3H/He), intermediate (DBA/2, C75L) and resistant (A, CBA). The strain MOLF/Ei is highly susceptible to the infection, has a unique TLR5 haplotype and a lower expression of TRL5. A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is associated with susceptibility to Legionnaires’ disease and demonstrates the importance of TLR5 in the innate immune response.
免疫原 :
Synthetic peptide, KLH-conjugated, corresponding to residues 300-350 of human TLR5.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 1-2 µg per million cells, Immunohistochemistry (Paraffin): 10 µg/mL, In vitro Assay: Assay-Dependent, Western Blot: 1-3 µg/mL
别名 :
FLJ10052; MELIOS; MGC126430; MGC126431; RP11-239E10.1; SLE1; SLEB1; systemic lupus erythematosus susceptibility 1; TIL3; Tlr5; toll like receptor 5; Toll/interleukin-1 receptor-like protein 3; toll-like receptor 5
更多信息或购买 :
公司信息
赛默飞世尔