产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
LC3B多克隆抗体
目录 :
PA1-46286
规格 :
100µL
价格 :
425.00美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠, , , pigs , 斑马鱼
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 5
参考文献
Kinzler M, Zielke S, Kardo S, Meyer N, Kogel D, van Wijk S, et al. STF-62247 and pimozide induce autophagy and autophagic cell death in mouse embryonic fibroblasts. Sci Rep. 2020;10:687 pubmed 出版商
Izdebska M, Hałas Wiśniewska M, Zielińska W, Klimaszewska Wisniewska A, Grzanka D, Gagat M. Lidocaine induces protective autophagy in rat C6 glioma cell line. Int J Oncol. 2019;54:1099-1111 pubmed 出版商
Zielke S, Meyer N, Mari M, Abou El Ardat K, Reggiori F, van Wijk S, et al. Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells. Cell Death Dis. 2018;9:994 pubmed 出版商
Marsh N, Wareham A, White B, Miskiewicz E, Landry J, MacPhee D. HSPB8 and the Cochaperone BAG3 Are Highly Expressed During the Synthetic Phase of Rat Myometrium Programming During Pregnancy. Biol Reprod. 2015;92:131 pubmed 出版商
Varga M, Fodor E, Vellai T. Autophagy in zebrafish. Methods. 2015;75:172-80 pubmed 出版商
图像
图像 1 :
赛默飞世尔 PA1-46286 图像 1
FACS staining of NTERA-2 cells using PA1-46286 at a 1:200 dilution detected using Dylight-488 conjugated goat anti-rabbit IgG secondary
图像 2 :
赛默飞世尔 PA1-46286 图像 2
Western Blot detection of LC3B in treated U87-MG (human glioblastoma astrocytoma) lysates using PA1-46286.
图像 3 :
赛默飞世尔 PA1-46286 图像 3
LC3B staining in treated U87-MG cultured & subcutaneous tumors using PA1-46286.
产品信息
产品类型 :
抗体
产品名称 :
LC3B多克隆抗体
目录# :
PA1-46286
规格 :
100µL
价格(美元) :
425.00美元
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
反应物种 :
Bovine, Canine, Human, Mouse, Non-human primate, Porcine, Rat, Zebrafish
应用 :
Flow Cytometry: 1:200, Immunocytochemistry: 0.1-2 µg/mL, Immunofluorescence: 0.1-2 µg/mL, Immunohistochemistry (Frozen): 1:400, Immunohistochemistry (Paraffin): 1:200-1:400, Immunomicroscopy: Assay-Dependent, Western Blot: 1:1000
物种 :
Bovine, Canine, Human, Mouse, Non-human primate, Porcine, Rat, Zebrafish
抗体亚型 :
IgG
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
LC3B (Autophagy Marker Light Chain 3B, MAP1A/MAP1B LC3 B) in humans, is encoded by the gene MAP1LC3B (Microtubule-associated proteins 1A/1B light chain 3B). LC3B is associated with microtubule assembly and important is in neurogenesis. Recent studies indicate that LC3B plays a vital role in autophagy, a process that involves the bulk degradation of cytoplasmic component. Three human LC3 isoforms undergo post-translational modifications during autophagy. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). LC3B is a microtubule-associated protein that mediate the physical interactions between microtubules and components of the cytoskeleton. LC3B may play a role in processes involving cancer, aging, metabolic and neurodegenerative disorders and cardiovascular/pulmonary diseases.
免疫原 :
N-terminal region of the human LC3, isoform B protein.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 1:200, Immunocytochemistry: 0.1-2 µg/mL, Immunofluorescence: 0.1-2 µg/mL, Immunohistochemistry (Frozen): 1:400, Immunohistochemistry (Paraffin): 1:200-1:400, Immunomicroscopy: Assay-Dependent, Western Blot: 1:1000
别名 :
1010001C15Rik; Atg8; ATG8E; ATG8F; ATG8G; Autophagy-related protein LC3 B; autophagy-related ubiquitin-like modifier LC3 B; LC3; LC3 beta; LC3A; LC3B; light chain 3; MAP1 light chain 3-like protein 2; MAP1A/1B light chain 3 B; MAP1A/1BLC3; MAP1A/MAP1B LC3 A; MAP1A/MAP1B LC3 B; MAP1A/MAP1B light chain 3 B; Map1alc3; MAP1BLC3; Map1lc3; MAP1LC3A; MAP1LC3B; MAP1LC3B2; MAP1LC3B-a; microtubule associated protein 1 light chain 3 beta; microtubule associated protein 1 light chain 3 beta 2; microtubule-associated protein 1 light chain 3; microtubule-associated protein 1 light chain 3 beta; microtubule-associated protein 1 light chain 3 beta 2; microtubule-associated proteins 1A/1B light chain 3; Microtubule-associated proteins 1A/1B light chain 3 beta 2; Microtubule-associated proteins 1A/1B light chain 3B; Microtubule-associated proteins 1A/1B light chain 3B-like; Microtubule-associated proteins 1A/1B light chain 3B-like protein; Mpl3; RP11-346K17.1; wu:fb60g11; zbs559; zgc:56434
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国