产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
NPM1(突变体)多克隆抗体
目录 :
PA1-46356
规格 :
100µL
价格 :
美国345
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 1
参考文献
Huang M, Thomas D, Li M, Feng W, Chan S, Majeti R, et al. Role of cysteine 288 in nucleophosmin cytoplasmic mutations: sensitization to toxicity induced by arsenic trioxide and bortezomib. Leukemia. 2013;27:1970-80 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
NPM1(突变体)多克隆抗体
目录# :
PA1-46356
规格 :
100µL
价格 :
美国345
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
反应物种 :
人类
应用 :
Flow Cytometry: 1:100, Immunocytochemistry: 1:50-1:100, Immunofluorescence: 1:50-1:100, Immunohistochemistry (Paraffin): 1:50-1:100, Immunoprecipitation: 1:50, Western Blot: 1:500
物种 :
人类
抗体亚型 :
IgG
储存 :
短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻
描述 :
NPM1 (Nucleophosmin 1, B23, nutramin, NO38) is a ubiquitously expressed phosphoprotein involved in ribosome assembly/transport, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication, and regulation of p53. NPM1 continuously shuttles between the nucleus, cytoplasm, nucleolus and chaperoning core histones from the nucleus to the cytoplasm. NPM1 has been shown to bind nucleic acid, prevent protein aggregation via its chaperon activities, protect enzymes during thermal denaturation, and facilitate renaturation of chemically denatured proteins. In its cellular structure role, there is evidence suggesting NPM1 is associated with the centrosome, and is the substrate of CDK2/cyclin E during duplication of centrosomes (cellular division). Due to the NPM1 gene interaction with several tumor-associated chromosome translocations, NPM1 is thought to be a portion of several fusion proteins: NPM-ALK, NPM-RAR, and NPM-MLF1. While it is not thought to be part of the transforming potential of these fusion proteins, NPM1 is believed to act as the interface for oligomerization and oncogenic conversion of these tumor promoting fusion proteins. Further, NPM1 is also known to sequester the tumor suppressor RF in the nucleolus, protecting it from degradation until it is necessary. Dysfunction of the NPM1 protein is associated with diseases such as acute myeloid leukemia and lymphomatoid papulosis.
免疫原 :
Synthetic peptide corresponding to a C-terminal region (within residues 250-294) of human mutant nucleophosmin.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 1:100, Immunocytochemistry: 1:50-1:100, Immunofluorescence: 1:50-1:100, Immunohistochemistry (Paraffin): 1:50-1:100, Immunoprecipitation: 1:50, Western Blot: 1:500
别名 :
mNPM1 antibody, mNPM antibody, B23 antibody, numatrin antibody, NO38 antibody
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国