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抗体

磷酸化alpha突触核蛋白(Ser129)多克隆抗体

PA1-4686

100微升

美国450.00

多克隆

domestic rabbit

未共轭

磷酸化

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学

磷酸化alpha突触核蛋白(Ser129)多克隆抗体

PA1-4686

100微升

美国450.00

多克隆

亲和色谱

兔

人类, 小鼠, 大鼠

Immunohistochemistry: 1:200, Western Blot: 1:1,000

人类, 小鼠, 大鼠

IgG

-20° C, 避免反复冷冻/解冻

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser129 of rat SNCA conjugated to KLH

液体

Immunohistochemistry: 1:200, Western Blot: 1:1,000

Alpha synuclein; alphaSYN; alpha-synuclein; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; Snca; Syn; synuclein alpha; synuclein alpha-140; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor)