产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
PDE6B多克隆抗体
目录 :
PA1-722
规格 :
100微克
价格 :
美国430.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 13
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:1000; 图 5a
Xiao Y, Liang J, Gao M, Sun J, Liu Y, Chen J, et al. Deletion of prominin-1 in mice results in disrupted photoreceptor outer segment protein homeostasis. Int J Ophthalmol. 2021;14:1334-1344 pubmed 出版商
  • 免疫组化; 小鼠; 1:2000; 图 3a
Völkner M, Kurth T, Schor J, Ebner L, Bardtke L, Kavak C, et al. Mouse Retinal Organoid Growth and Maintenance in Longer-Term Culture. Front Cell Dev Biol. 2021;9:645704 pubmed 出版商
  • 免疫组化; 小鼠; 1:2000
Díaz Lezama N, Wolf A, Koch S, Pfaller A, Biber J, Guillonneau X, et al. PDGF Receptor Alpha Signaling Is Key for Müller Cell Homeostasis Functions. Int J Mol Sci. 2021;22: pubmed 出版商
Su J, She K, Song L, Jin X, Li R, Zhao Q, et al. In vivo base editing rescues photoreceptors in a mouse model of retinitis pigmentosa. Mol Ther Nucleic Acids. 2023;31:596-609 pubmed 出版商
Kajtna J, Tsang S, Koch S. Late-stage rescue of visually guided behavior in the context of a significantly remodeled retinitis pigmentosa mouse model. Cell Mol Life Sci. 2022;79:148 pubmed 出版商
Yadav R, Boyd K, Artemyev N. Molecular insights into the maturation of phosphodiesterase 6 by the specialized chaperone complex of HSP90 with AIPL1. J Biol Chem. 2022;298:101620 pubmed 出版商
Popova E, Imamura Kawasawa Y, Zhang S, Barnstable C. Inhibition of Epigenetic Modifiers LSD1 and HDAC1 Blocks Rod Photoreceptor Death in Mouse Models of Retinitis Pigmentosa. J Neurosci. 2021;41:6775-6792 pubmed 出版商
Sundar J, Matalkah F, Jeong B, Stoilov P, Ramamurthy V. The Musashi proteins MSI1 and MSI2 are required for photoreceptor morphogenesis and vision in mice. J Biol Chem. 2021;296:100048 pubmed 出版商
Boehm A, Bialas J, Catone N, Sacristán Reviriego A, van der Spuy J, Groettrup M, et al. The ubiquitin-like modifier FAT10 inhibits retinal PDE6 activity and mediates its proteasomal degradation. J Biol Chem. 2020;295:14402-14418 pubmed 出版商
Dilan T, Moye A, Salido E, Saravanan T, Kolandaivelu S, Goldberg A, et al. ARL13B, a Joubert Syndrome-Associated Protein, Is Critical for Retinogenesis and Elaboration of Mouse Photoreceptor Outer Segments. J Neurosci. 2019;39:1347-1364 pubmed 出版商
Koch S, Duong J, Hsu C, Tsai Y, Lin C, Wahl Schott C, et al. Genetic rescue models refute nonautonomous rod cell death in retinitis pigmentosa. Proc Natl Acad Sci U S A. 2017;114:5259-5264 pubmed 出版商
Koch S, Tsai Y, Duong J, Wu W, Hsu C, Wu W, et al. Halting progressive neurodegeneration in advanced retinitis pigmentosa. J Clin Invest. 2015;125:3704-13 pubmed 出版商
Nishiguchi K, Carvalho L, Rizzi M, Powell K, Holthaus S, Azam S, et al. Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179. Nat Commun. 2015;6:6006 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
PDE6B多克隆抗体
目录# :
PA1-722
规格 :
100微克
价格 :
美国430.00
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
兔
反应物种 :
人类, 小鼠
应用 :
Immunocytochemistry: 1:250, Immunohistochemistry: Assay-dependent, Western Blot: 2 µg/mL
物种 :
人类, 小鼠
抗体亚型 :
IgG
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
The second messengers cAMP and cGMP are key regulatory molecules that are involved in a wide variety of signal transduction pathways. Levels of cAMP and cGMP are regulated by their rate of synthesis by nucleotide cyclases and by their rate of hydrolysis by cyclic nucleotide phosphodiesterases (PDEs). PDEs form a superfamily of enzymes that catalyze the conversion of 3-prime, 5-prime-cyclic nucleotides to the corresponding nucleoside 5-prime-monophosphates. PDE6 is the effector enzyme in the G protein-mediated signal transduction cascade in the visual system. There are five different subunits consisting of rod and cone specific catalytic subunits: alpha' (Cone), alpha (Rod), and beta (Rod), the inhibitory subunit gamma, and subunit delta of unknown function (which likely interacts with many other proteins besides the PDE6 family). The catalytic core of the PDE6 system is comprised of alpha'/alpha' homodimers in the cone and alpha/beta heterodimers in the rod. The C-terminus of both the catalytic and inhibitory subunits is modified by methylation, myristyolation and prenylation which have been shown to be critical for proper complex assembly and membrane association.
免疫原 :
Synthetic Peptides: H(20) Q Y F G (K/R) K L S P E N V A G A C(36)
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:250, Immunohistochemistry: Assay-dependent, Western Blot: 2 µg/mL
别名 :
cGMP-phosphodiesterase beta-subunit; CSNB3; CSNBAD2; GMP-PDE beta; Mpb; PDE6B; PDEB; phosphodiesterase 6B; phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide; phosphodiesterase 6B, cGMP-specific, rod, beta; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd1; rd-1; rd10; retinal degeneration 1; rod cGMP-phosphodiesterase beta-subunit; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta; RP40
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国