产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
HDAC1多克隆抗体
目录 :
PA1-860
规格 :
100微克
价格 :
美国471.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
中国人仓鼠, 人类, 小鼠, 大鼠,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 染色质免疫沉淀 , 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 29
出版应用/物种/样本/稀释参考文献
  • 染色质免疫沉淀 ; 人类; 图 5
Schettino R, Verni M, Acin Albiac M, Vincentini O, Krona A, Knaapila A, et al. Bioprocessed Brewers' Spent Grain Improves Nutritional and Antioxidant Properties of Pasta. Antioxidants (Basel). 2021;10: pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 5
Ramaker R, Hardigan A, Gordon E, Wright C, Myers R, Cooper S. Pooled CRISPR screening in pancreatic cancer cells implicates co-repressor complexes as a cause of multiple drug resistance via regulation of epithelial-to-mesenchymal transition. BMC Cancer. 2021;21:632 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 5
Vitale F, Ortolan J, Volpe B, Marambaud P, Giliberto L, d Abramo C. Intramuscular injection of vectorized-scFvMC1 reduces pathological tau in two different tau transgenic models. Acta Neuropathol Commun. 2020;8:126 pubmed 出版商
  • 免疫印迹; 人类; 图 2f
Li X, Eberhardt A, Hansen J, Bohmann D, Li H, Schor N. Methylation of the phosphatase-transcription activator EYA1 by protein arginine methyltransferase 1: mechanistic, functional, and structural studies. FASEB J. 2017;31:2327-2339 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6
E L, Swerdlow R. Lactate's effect on human neuroblastoma cell bioenergetic fluxes. Biochem Pharmacol. 2016;99:88-100 pubmed 出版商
Luo J, Li J, Li T, Zhang Z, Chen G, Li Q, et al. PIAS1 Alleviates Hepatic Ischemia-Reperfusion Injury in Mice through a Mechanism Involving NFATc1 SUMOylation. Dis Markers. 2022;2022:4988539 pubmed 出版商
Paniagua I, Tayeh Z, Falcone M, Hern xe1 ndez P xe9 rez S, Cerutti A, Jacobs J. MAD2L2 promotes replication fork protection and recovery in a shieldin-independent and REV3L-dependent manner. Nat Commun. 2022;13:5167 pubmed 出版商
Xu x8bb8 x6f47 x4f9d X, He x4f55 x946b X, Zhang x5f20 x6cfd x5f66 Z, Chen x9648 x5f66 x4f0a Y, Li x9ece x4fca x5b87 J, Ma x9a6c x73ca x73ca S, et al. CREB inactivation by HDAC1/PP1γ contributes to dopaminergic neurodegeneration in Parkinson's disease. J Neurosci. 2022;42:4594-604 pubmed 出版商
Litke C, Hagenston A, Kenkel A, Páldy E, Lu J, Kuner R, et al. Organic anion transporter 1 is an HDAC4-regulated mediator of nociceptive hypersensitivity in mice. Nat Commun. 2022;13:875 pubmed 出版商
Sobczak M, Strachowska M, Gronkowska K, Karwaciak I, Pu x142 aski x, Robaszkiewicz A. LSD1 Facilitates Pro-Inflammatory Polarization of Macrophages by Repressing Catalase. Cells. 2021;10: pubmed 出版商
Guo F, Zhang Y, Liu K, Huang X, Li R, Wang S, et al. Chronic Exposure to Alcohol Inhibits New Myelin Generation in Adult Mouse Brain. Front Cell Neurosci. 2021;15:732602 pubmed 出版商
Lüdtke T, Wojahn I, Kleppa M, Schierstaedt J, Christoffels V, Künzler P, et al. Combined genomic and proteomic approaches reveal DNA binding sites and interaction partners of TBX2 in the developing lung. Respir Res. 2021;22:85 pubmed 出版商
Ohashi M, Hayes M, McChesney K, Johannsen E. Epstein-Barr virus nuclear antigen 3C (EBNA3C) interacts with the metabolism sensing C-terminal binding protein (CtBP) repressor to upregulate host genes. PLoS Pathog. 2021;17:e1009419 pubmed 出版商
Wu C, Jin L, Wang I, Wei W, Ho P, Liu Y, et al. HDAC1 dysregulation induces aberrant cell cycle and DNA damage in progress of TDP-43 proteinopathies. EMBO Mol Med. 2020;12:e10622 pubmed 出版商
Pao P, Patnaik D, Watson L, Gao F, Pan L, Wang J, et al. HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease. Nat Commun. 2020;11:2484 pubmed 出版商
Gilbert T, Zürcher N, Catanese M, Tseng C, Di Biase M, Lyall A, et al. Neuroepigenetic signatures of age and sex in the living human brain. Nat Commun. 2019;10:2945 pubmed 出版商
Iershov A, Nemazanyy I, Alkhoury C, Girard M, Barth E, Cagnard N, et al. The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα. Nat Commun. 2019;10:1566 pubmed 出版商
Patel N, Wang J, Shiozawa K, Jones K, Zhang Y, Prokop J, et al. HDAC2 Regulates Site-Specific Acetylation of MDM2 and Its Ubiquitination Signaling in Tumor Suppression. iScience. 2019;13:43-54 pubmed 出版商
Tempka D, Tokarz P, Chmielewska K, Kluska M, Pietrzak J, Rygielska Ż, et al. Downregulation of PARP1 transcription by CDK4/6 inhibitors sensitizes human lung cancer cells to anticancer drug-induced death by impairing OGG1-dependent base excision repair. Redox Biol. 2018;15:316-326 pubmed 出版商
Gao M, Chen T, Wu L, Zhao X, Mao H, Xing C. Effect of pioglitazone on the calcification of rat vascular smooth muscle cells through the downregulation of the Wnt/β‑catenin signaling pathway. Mol Med Rep. 2017;16:6208-6213 pubmed 出版商
Wiśnik E, Płoszaj T, Robaszkiewicz A. Downregulation of PARP1 transcription by promoter-associated E2F4-RBL2-HDAC1-BRM complex contributes to repression of pluripotency stem cell factors in human monocytes. Sci Rep. 2017;7:9483 pubmed 出版商
Zhu Y, Vidaurre O, Adula K, Kezunovic N, Wentling M, Huntley G, et al. Subcellular Distribution of HDAC1 in Neurotoxic Conditions Is Dependent on Serine Phosphorylation. J Neurosci. 2017;37:7547-7559 pubmed 出版商
Li J, He F, Zhang P, Chen S, Shi H, Sun Y, et al. Loss of Asxl2 leads to myeloid malignancies in mice. Nat Commun. 2017;8:15456 pubmed 出版商
Koh J, Hancock C, Terada S, Higashida K, Holloszy J, Han D. PPARβ Is Essential for Maintaining Normal Levels of PGC-1α and Mitochondria and for the Increase in Muscle Mitochondria Induced by Exercise. Cell Metab. 2017;25:1176-1185.e5 pubmed 出版商
Dubey A, Copeland P. The Selenocysteine-Specific Elongation Factor Contains Unique Sequences That Are Required for Both Nuclear Export and Selenocysteine Incorporation. PLoS ONE. 2016;11:e0165642 pubmed 出版商
Patrick N, Griggs C, Icenogle A, Gilpatrick M, Kadiyala V, Jaime Frias R, et al. Class I lysine deacetylases promote glucocorticoid-induced transcriptional repression through functional interaction with LSD1. J Steroid Biochem Mol Biol. 2017;167:1-13 pubmed 出版商
Lebrun Julien F, Suter U. Combined HDAC1 and HDAC2 Depletion Promotes Retinal Ganglion Cell Survival After Injury Through Reduction of p53 Target Gene Expression. ASN Neuro. 2015;7: pubmed 出版商
Zimberlin C, Lancini C, Sno R, Rosekrans S, McLean C, Vlaming H, et al. HDAC1 and HDAC2 collectively regulate intestinal stem cell homeostasis. FASEB J. 2015;29:2070-80 pubmed 出版商
Levendusky M, Basle J, Chang S, Mandalaywala N, Voigt J, DEARBORN R. Expression and regulation of vitamin D3 upregulated protein 1 (VDUP1) is conserved in mammalian and insect brain. J Comp Neurol. 2009;517:581-600 pubmed 出版商
图像
图像 1 :
赛默飞世尔 PA1-860 图像 1
Immunofluorescent analysis of HDAC1 in HeLa Cells. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with a HDAC1 polyclonal antibody (Product # PA1-860) at a dilution of 1:20 overnight at 4 C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody (Product # 35503). HDAC1 staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Images were taken at 60X magnification.
产品信息
产品类型 :
抗体
产品名称 :
HDAC1多克隆抗体
目录# :
PA1-860
规格 :
100微克
价格 :
美国471.00
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
反应物种 :
狗, 仓鼠, 人类, 小鼠, 大鼠
应用 :
ChIP Assay: 2.5 µg/10^6 cells, Immunocytochemistry: 2.0 µg/mL, Immunohistochemistry (Frozen): 0.2 µg/mL, Immunohistochemistry (Paraffin): 1:200, Immunoprecipitation: Assay-dependent, Western Blot: 1 µg/mL
物种 :
狗, 仓鼠, 人类, 小鼠, 大鼠
抗体亚型 :
IgG
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.
免疫原 :
合成多肽对应于氨基酸残基C E(467)E K P E A K G V K E E V K L A(482)人的HDAC1
格式 :
液体
应用w/稀释 :
ChIP Assay: 2.5 µg/10^6 cells, Immunocytochemistry: 2.0 µg/mL, Immunohistochemistry (Frozen): 0.2 µg/mL, Immunohistochemistry (Paraffin): 1:200, Immunoprecipitation: Assay-dependent, Western Blot: 1 µg/mL
别名 :
DKFZp686H12203; GON-10; HD1; Hdac1; Hdac1-ps; Histone deacetylase 1; histone deacetylase 1-like protein; MommeD5; reduced potassium dependency, yeast homolog-like 1; RP4-811H24.2; RPD3; RPD3L1
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国