产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CHFR多克隆抗体
目录 :
PA5-106807
规格 :
100微升
价格 :
美国446.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫细胞化学
更多信息或购买 :
产品信息
产品类型 :
抗体
产品名称 :
CHFR多克隆抗体
目录# :
PA5-106807
规格 :
100微升
价格 :
美国446.00
克隆性 :
多克隆
纯度 :
亲和色谱
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
应用 :
Immunocytochemistry: 1:100-1:500, Western Blot: 1:500-1:1,000
物种 :
人类, 小鼠, 大鼠
抗体亚型 :
IgG
储存 :
-20°C
描述 :
E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.
免疫原 :
A synthesized peptide derived from human CHFR(Accession Q96EP1), corresponding to amino acid residues C344-V394.
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:100-1:500, Western Blot: 1:500-1:1,000
别名 :
5730484M20Rik; C230082M18; checkpoint with forkhead and ring finger domains; Checkpoint with forkhead and RING finger domains protein; checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase; Chfr; E3 ubiquitin-protein ligase CHFR; fc43f10; FLJ10796; FLJ33629; RING finger protein 196; RING-type E3 ubiquitin transferase CHFR; RNF116; RNF196; si:dkey-69h6.7; wu:fc43f10
更多信息或购买 :
公司信息
赛默飞世尔