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抗体

PDIR多克隆抗体

PA5-118150

100微升

美国416.00

多克隆

domestic rabbit

未共轭

免疫印迹, 免疫沉淀

PDIR多克隆抗体

PA5-118150

100微升

美国416.00

多克隆

抗原亲和色谱, 蛋白质A

兔

人类

Immunoprecipitation: 1-5 μL/mg of lysate, Western Blot: 1:500-1:2,000

人类

IgG

-20° C, 避免反复冷冻/解冻

PDIR (protein disulfide isomerase-related protein) is a novel PDI protein that was originally isolated from a human placental cDNA library. It has been suggested that from its nucleotide sequence, PDIR has three CXXC-like motifs (Cys-Ser-Met-Cys, Cys-Gly-His-Cys and Cys-Pro-His-Cys), which are found in the PDI superfamily of proteins. The CXXC motif is responsible for oxidoreductase activity. PDIR is also shown to have a putative endoplasmic reticulum (ER) retention signal 'Lys-Glu-Glu-Leu' at its carboxyl terminus, indicative of ER resident proteins. Northern blot analysis of PDIR indicates that it is preferentially expressed in cells actively secreting proteins. It has also been shown that expression of PDIR is stress-inducible. Data suggest that PDIR, like other PDIs, has oxidoreductase activity of disulfide bonds and facilitates the protein folding process within the lumen of the ER.

E. coli-derived Human PDIA5 fragment

液体

Immunoprecipitation: 1-5 μL/mg of lysate, Western Blot: 1:500-1:2,000

2700053F16Rik; AU015525; Pdia5; PDIR; protein disulfide isomerase A5; protein disulfide isomerase associated 5; protein disulfide isomerase family A member 5; protein disulfide isomerase family A, member 5; protein disulfide isomerase-associated 5; protein disulfide isomerase-related protein; Protein disulfide-isomerase A5