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抗体

c-Mpl Polyclonal Antibody

PA5-141051

100微升

美国440.00

多克隆

domestic rabbit

未共轭

免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片

c-Mpl Polyclonal Antibody

PA5-141051

100微升

美国440.00

多克隆

蛋白质A

兔

人类

Immunocytochemistry: 1:200, Immunohistochemistry (Paraffin): 1:200, Western Blot: 1:1,000

人类

IgG

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

Synthetic peptide within Human MPL aa 551-600/635.

液体

Immunocytochemistry: 1:200, Immunohistochemistry (Paraffin): 1:200, Western Blot: 1:1,000

CD110; c-mpl; hlb219; MPL; MPL proto-oncogene, thrombopoietin receptor; MPLV; myeloproliferative leukemia protein; myeloproliferative leukemia virus oncogene; proto-oncogene c-Mpl; THCYT2; thrombopoietin receptor; TPOR; TPO-R