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抗体

p27 Kip1多克隆抗体

PA5-16717

500微升

美国496

多克隆

domestic rabbit

未共轭

人类, 小鼠

免疫组化, 免疫组化-石蜡切片

p27 Kip1多克隆抗体

PA5-16717

500微升

美国496

多克隆

亲和色谱

兔

人类, 小鼠

免疫组化(石蜡): 1:100

人类, 小鼠

IgG

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

p27 Kip1 functions as a negative regulator of G1 mouse expression and has been proposed to function as a possible mediator of TGFb induced G1 arrest. p27 Kip1 is an important regulator of cell cycle progression, a potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. p27 Kip1 forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. p27 Kip1 acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. p27 Kip1 has a molecular weight of approximately 27kDa and the degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.

Synthetic peptide derived from C-terminal of human p27Kip1

液体

免疫组化(石蜡): 1:100

AA408329; AI843786; Cdki1b; Cdkn1b; CDKN4; CDN1B; cyclin dependent kinase inhibitor 1B; cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor 1B (p27 Kip1); cyclin-dependent kinase inhibitor 1B (p27, Kip1); Cyclin-dependent kinase inhibitor p27; cyclin-dependent kinase inhibitor p27/Kip1; KIP1; MEN1B; MEN4; p27; P27 CDKN1B; p27(KIP1); P27KIP1; putative cyclin-dependent kinase inhibitor p27