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抗体

c-Cbl Polyclonal Antibody

PA5-17453

100微升

美国496.00

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫细胞化学, 免疫沉淀

c-Cbl Polyclonal Antibody

PA5-17453

100微升

美国496.00

多克隆

抗原亲和色谱

兔

Human, Mouse, Non-human primate, Rat

Immunocytochemistry: 1:50, Immunoprecipitation: 1:50, Western Blot: 1:1,000

Human, Mouse, Non-human primate, Rat

IgG

-20°C

Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.

Synthetic peptide corresponding to the carboxy terminus of human c-Cbl

液体

Immunocytochemistry: 1:50, Immunoprecipitation: 1:50, Western Blot: 1:1,000

4732447J05Rik; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma; casitas B-lineage lymphoma proto-oncogene; CBL; Cbl proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL2; Cbl-2; CBL-3; CBLC; c-Cbl; E3 ubiquitin-protein ligase CBL; FRA11B; fragile site, folic acid type, rare, fra(11)(q23.3); NSLL; oncogene CBL2; proto-oncogene c-Cbl; RGD1561386; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF55; RNF57; signal transduction protein CBL