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抗体

磷酸化SHC(Tyr239, Tyr240)多克隆抗体

PA5-17712

100微升

美国500.00

多克隆

domestic rabbit

未共轭

磷酸化

人类, 小鼠, 大鼠

免疫印迹, 免疫细胞化学

磷酸化SHC(Tyr239, Tyr240)多克隆抗体

PA5-17712

100微升

美国500.00

多克隆

抗原亲和色谱

兔

人类, 小鼠, 大鼠

Immunocytochemistry: 1:100, Western Blot: 1:1,000

人类, 小鼠, 大鼠

IgG

-20°C

Skp2 (S-phase Kinase-associated Protein 2) belongs to the family of F-box proteins that interact with the Cyclin A-Cdk2 complex. Skp2 is essential for the G1-S transition in both transformed cells and diploid fibroblasts. Biochemical and genetic experiments have demonstrated that Skp2 is required for the ubiquitination and consequent degradation of p27 in cultured mammalian cells and in vitro reconstitution assays. In normal tissues, Skp2 is expressed in tonsil and placenta. In tumor tissues, Skp2 is expressed widely, in some colon, prostate, pancreas, and skin cancers, with high expression in lung, breast, ovarian, and endometrial cancers. Research suggests that Skp2 plays a role in oncogenesis, particularly in the pathogenesis of lymphomas and breast cancers.

Synthetic phosphopeptide corresponding to residues surrounding pTyr239/240 of human Shc

液体

Immunocytochemistry: 1:100, Western Blot: 1:1,000

FLJ26504; OTTHUMP00000035472; p66; P66shc; RP11-307C12.1; SH2 domain protein C1; SHC; SHC (Src homology 2 domain containing) transforming protein 1; SHC (Src homology 2 domain-containing) transforming protein 1; SHC adaptor protein 1; SHC1; SHCA; SHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A; src homology 2 domain-containing transforming protein C1; src homology 2 domain-containing-transforming protein C1