产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
胱氨酸-天冬氨酸蛋白酶9(切断的Asp315)多克隆抗体
目录 :
PA5-17913
规格 :
100微升
价格 :
美国496.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
文章摘录数: 5
| 出版应用/物种/样本/稀释 | 参考文献 |
|---|---|
| Wu C, Luo J. Long Non-Coding RNA (lncRNA) Urothelial Carcinoma-Associated 1 (UCA1) Enhances Tamoxifen Resistance in Breast Cancer Cells via Inhibiting mTOR Signaling Pathway. Med Sci Monit. 2016;22:3860-3867 pubmed
|
图像
图像 1 :
Immunofluorescence staining of cleaved (active) caspase 9 in HeLa cells treated with vehicle (0.1% DMSO in media) or with 1 µM staurosporine for 4 hours. Cells were stained according to the kit protocol and imaged using a Cellomics ArrayScan HCS Reader. Cells treated with stautosporine results in caspase 9 activation and an increase in staining.
产品信息
产品类型 :
抗体
产品名称 :
胱氨酸-天冬氨酸蛋白酶9(切断的Asp315)多克隆抗体
目录# :
PA5-17913
规格 :
100微升
价格 :
美国496.00
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
兔
反应物种 :
人类
应用 :
Immunocytochemistry: 1:100, Immunoprecipitation: 1:100, Western Blot: 1:1,000
物种 :
人类
抗体亚型 :
IgG
储存 :
-20°C
描述 :
Caspase 9 (ICE-like apoptotic protease 6, ICE LAP6, apoptotic protease Mch6, apoptotic protease activating factor 3, Apaf3) is a member of the peptidase family C14 that contains a CARD domain. Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspase 9 is active as a heterotetramer, is present in the cytosol and, upon activation, translocates to the mitochondria. Caspase 9 is involved in the caspase activation cascade responsible for apoptosis execution and cleaves/activates Caspase 3 and Caspase 6. Further, Caspase 9 is involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Caspase 9 promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner, and proteolytically cleaves poly(ADP- ribose) polymerase (PARP). Caspase 9 is expressed in variety of human tissues. An isoform of rat Caspase-9 has been identified in which the C terminus of full-length Caspase-9 is replaced with an alternative peptide sequence. Mutations in Caspase 9 affect brain development. In mice, insufficient Caspase 9 have resulted in abnormal cerebrum development and neuron development. In humans, dysfunctional Caspase 9 expression vary from tissue to tissue. Low levels of Caspase 9 may play a role in cancer development and neurodegenerative diseases such as Alzheimer’s Disease (AD).
免疫原 :
Synthetic peptide corresponding to residues surrounding Asp315 of human caspase-9
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:100, Immunoprecipitation: 1:100, Western Blot: 1:1,000
别名 :
APAF3; APAF-3; apoptosis-related cysteine protease; apoptotic protease activating factor 3; apoptotic protease MCH-6; Apoptotic protease-activating factor 3; cas9; CASP9; CASP-9; caspase 9; caspase 9, apoptosis-related cysteine peptidase; caspase-9; Caspase-9 subunit p10; Caspase-9 subunit p35; ICE-LAP6; ICE-like apoptotic protease 6; MCH6; OTTHUMP00000002324; PPP1R56; protein phosphatase 1, regulatory subunit 56
更多信息或购买 :
公司信息
赛默飞世尔