NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

抗体

黄蜂多克隆抗体

PA5-18354

100微克

美国446.00

多克隆

domestic goat

未共轭

免疫组化, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片

黄蜂多克隆抗体

PA5-18354

100微克

美国446.00

多克隆

硫酸铵沉淀

山羊

人类

Flow Cytometry: 10 µg/mL, Immunocytochemistry: 10 µg/mL, Immunohistochemistry (Paraffin): 5 µg/mL

人类

IgG

-20° C, 避免反复冷冻/解冻

The Wiskott-Aldrich syndrome family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.

合成肽序列(SPADKKRSGKKKI)对应于。。。的内部氨基酸WAS

液体

Flow Cytometry: 10 µg/mL, Immunocytochemistry: 10 µg/mL, Immunohistochemistry (Paraffin): 5 µg/mL

2900021I12Rik; 3110031I02Rik; eczema-thrombocytopenia; IMD2; neural Wiskott-Aldrich syndrome protein; NWASP; N-WASP; SCNX; THC; THC1; thrombocytopenia 1 (X-linked); TRS4; U42471; Was; WASL; Wasp; WASPA; WASPB; Wiskott-Aldrich syndrome; Wiskott-Aldrich syndrome homolog; Wiskott-Aldrich syndrome homolog (human); Wiskott-Aldrich syndrome like; wiskott-Aldrich syndrome protein; Wiskott-Aldrich syndrome protein homolog; Wiskott-Aldrich syndrome-like; Wiskott-Aldrich syndrome-like (human)